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Western blot
Immunocytochemistry
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Immunocytochemistry [1]
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- Product number
- ALX-210-929-C100 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-210-929-C100, RRID:AB_2050916
- Product name
- Cardif (human) polyclonal antibody (AT107)
- Antibody type
- Polyclonal
- Antigen
- Recombinant protein fragment
- Description
- Protein A-affinity purified.
- Reactivity
- Human
- Host
- Rabbit
- Vial size
- 100 μg
- Storage
- -20°C
- Handling
- Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20¡C.
Submitted references Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system.
Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes.
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors.
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Bellecave P, Sarasin-Filipowicz M, Donzé O, Kennel A, Gouttenoire J, Meylan E, Terracciano L, Tschopp J, Sarrazin C, Berg T, Moradpour D, Heim MH
Hepatology (Baltimore, Md.) 2010 Apr;51(4):1127-36
Hepatology (Baltimore, Md.) 2010 Apr;51(4):1127-36
Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes.
Ahlén G, Derk E, Weiland M, Jiao J, Rahbin N, Aleman S, Peterson DL, Pokrovskaja K, Grandér D, Frelin L, Sällberg M
Gut 2009 Apr;58(4):560-9
Gut 2009 Apr;58(4):560-9
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Rebsamen M, Meylan E, Curran J, Tschopp J
Cell death and differentiation 2008 Nov;15(11):1804-11
Cell death and differentiation 2008 Nov;15(11):1804-11
Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors.
Liang Y, Ishida H, Lenz O, Lin TI, Nyanguile O, Simmen K, Pyles RB, Bourne N, Yi M, Li K, Lemon SM
Gastroenterology 2008 Nov;135(5):1710-1718.e2
Gastroenterology 2008 Nov;135(5):1710-1718.e2
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Loo YM, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez-Sobrido L, Akira S, Gill MA, García-Sastre A, Katze MG, Gale M Jr
Journal of virology 2008 Jan;82(1):335-45
Journal of virology 2008 Jan;82(1):335-45
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Saha SK, Pietras EM, He JQ, Kang JR, Liu SY, Oganesyan G, Shahangian A, Zarnegar B, Shiba TL, Wang Y, Cheng G
The EMBO journal 2006 Jul 26;25(14):3257-63
The EMBO journal 2006 Jul 26;25(14):3257-63
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Supportive validation
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Western blot analysis of Cardif (human), pAb (AT107) (Prod. No. ALX-210-929): Lane 1: MW marker; Lane 2: HepG2; Lane 3: PALA; and Lane 4: HeLa. Additional bands observed probably represent isoforms or cleaved products of Cardif.
