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- Antigen structure
- References [8]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 25897-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- KIF5C antibody
- Antibody type
- Polyclonal
- Description
- KIF5C antibody (Cat. #25897-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI.
MFN2-dependent recruitment of ATAT1 coordinates mitochondria motility with alpha-tubulin acetylation and is disrupted in CMT2A.
Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA(A) receptor transport in a murine model.
Overexpression of MicroRNA-155 aggravates pulpitis by targeting kinesin superfamily Proteins-5C based on illumina high-throughput sequencing.
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
Mitochondrial transport mediates survival of retinal ganglion cells in affected LHON patients.
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
Liu G, He M, Wu C, Lv P, Sun H, Wang H, Xin X, Liao H
Experimental neurology 2024 Feb;372:114618
Experimental neurology 2024 Feb;372:114618
MFN2-dependent recruitment of ATAT1 coordinates mitochondria motility with alpha-tubulin acetylation and is disrupted in CMT2A.
Kumar A, Larrea D, Pero ME, Infante P, Conenna M, Shin GJ, Grueber WB, Di Marcotullio L, Area-Gomez E, Bartolini F
bioRxiv : the preprint server for biology 2023 Mar 16;
bioRxiv : the preprint server for biology 2023 Mar 16;
Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA(A) receptor transport in a murine model.
Liu J, Ke P, Guo H, Gu J, Liu Y, Tian X, Wang X, Xiao F
Experimental & molecular medicine 2023 Jun;55(6):1159-1173
Experimental & molecular medicine 2023 Jun;55(6):1159-1173
Overexpression of MicroRNA-155 aggravates pulpitis by targeting kinesin superfamily Proteins-5C based on illumina high-throughput sequencing.
Jiang Y, He Y, Chen Y, Zeng J, Huang W, Huang L, Luo J, Ma Y, Wu L, Yang X
International endodontic journal 2023 Jul;56(7):837-853
International endodontic journal 2023 Jul;56(7):837-853
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.
Shen M, Sirois CL, Guo Y, Li M, Dong Q, Méndez-Albelo NM, Gao Y, Khullar S, Kissel L, Sandoval SO, Wolkoff NE, Huang SX, Xu Z, Bryan JE, Contractor AM, Korabelnikov T, Glass IA, Doherty D, Birth Defects Research Laboratory, Levine JE, Sousa AMM, Chang Q, Bhattacharyya A, Wang D, Werling DM, Zhao X
Neuron 2023 Dec 20;111(24):3988-4005.e11
Neuron 2023 Dec 20;111(24):3988-4005.e11
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
Chen XQ, Das U, Park G, Mobley WC
Alzheimer's research & therapy 2021 Mar 10;13(1):59
Alzheimer's research & therapy 2021 Mar 10;13(1):59
Mitochondrial transport mediates survival of retinal ganglion cells in affected LHON patients.
Yang TC, Yarmishyn AA, Yang YP, Lu PC, Chou SJ, Wang ML, Lin TC, Hwang DK, Chou YB, Chen SJ, Yu WK, Wang AG, Hsu CC, Chiou SH
Human molecular genetics 2020 Jun 3;29(9):1454-1464
Human molecular genetics 2020 Jun 3;29(9):1454-1464
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
Wang Q, Tian J, Chen H, Du H, Guo L
Neurobiology of disease 2019 Jul;127:410-418
Neurobiology of disease 2019 Jul;127:410-418
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat brain tissue were subjected to SDS PAGE followed by western blot with 25897-1-AP( KIF5C Antibody) at dilution of 1:1500
- Validation comment
- WB
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of SH-SY5Y cells using 25897-1-AP( KIF5C Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
- Validation comment
- IF
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human testis tissue slide using 25897-1-AP( KIF5C Antibody) at dilution of 1:50 (under 10x lens)
- Validation comment
- IHC
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human testis tissue slide using 25897-1-AP( KIF5C Antibody) at dilution of 1:50 (under 40x lens)
- Validation comment
- IHC
