AF2106
antibody from R&D Systems
Targeting: TNFSF13B
BAFF, BLYS, CD257, TALL-1, TALL1, THANK, TNFSF20
Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF2106 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse BAFF/BLyS/TNFSF13B Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse BAFF/BLyS/TNFSF13B in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant human (rh) BAFF is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q9WU72
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells.
Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.
Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia.
Saulep-Easton D, Vincent FB, Quah PS, Wei A, Ting SB, Croce CM, Tam C, Mackay F
Leukemia 2016 Jan;30(1):163-72
Leukemia 2016 Jan;30(1):163-72
Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.
Hägglöf T, Sedimbi SK, Yates JL, Parsa R, Salas BH, Harris RA, Leadbetter EA, Karlsson MC
Nature immunology 2016 Dec;17(12):1407-1414
Nature immunology 2016 Dec;17(12):1407-1414
Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia.
Kim KS, Park JY, Jou I, Park SM
Journal of leukocyte biology 2009 Aug;86(2):349-59
Journal of leukocyte biology 2009 Aug;86(2):349-59
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Cell Proliferation Induced by BAFF/BLyS/TNFSF13B and Neutralization by Mouse BAFF/BLyS/TNFSF13B Antibody. In the presence of Goat F(ab')2 Anti-mouse IgM, Recombinant Mouse BAFF/BLyS/ TNFSF13B (Catalog # 8876-BF) stimulates pro-liferation in mouse B cells in a dose-dependent manner (orange line). Under these conditions, proliferation elicited by Recombinant Goat Anti-Mouse BAFF/BLyS/TNFSF13B (3 ng/mL) is neutralized (green line) by increasing concentrations of Mouse BAFF/BLyS/TNFSF13B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2106). The ND50 is typically 0.01-0.04 µg/mL.