13797-1-AP

antibody from Proteintech Group

Targeting: PTX3 TNFAIP5, TSG-14

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

13797-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#13797-1-AP, RRID:AB_2165302

Product name

Pentraxin 3 antibody

Antibody type

Polyclonal

Description

KD/KO validated Pentraxin 3 antibody (Cat. #13797-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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Human mutation 2026;2026:8861747

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TAF15 promotes the healing of diabetic foot ulcers by mediating the transcriptional activation of APOE through CEBPB to regulate PTX3.

Lu X, Xu Y, Liu J, Chen J
Molecular genetics and genomics : MGG 2026 Mar 10;301(1)

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EGCG-loaded nanoparticles attenuate post-SAH white matter injury by targeting HO-1/S100A10 to suppress oxidative stress-induced reactive astrocytes.

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An Activity-Dependent NEPAS-PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment.

Hu B, Chen Z, Sun B, Gao J, Xu J, Guo X, Gao F, Wang Z, Wu J, Ji X, Liu P, Huang B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 7;:e21069

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The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.

Sun H, Qiao X, Peng X, Zhu H, Zhang L, Jiang L, Wang L, Xue C, Yang J, Yi W, Zhang B, Liu J, Duan W
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Activation of YAP1 and TAZ enhances the in vitro maturation of yak oocytes and influences subsequent embryonic development.

Zhong D, Pan Y, Wang M, Zhang H, Xu R, Zuo Q, Li T, Yu S, Cui Y
Theriogenology 2025 Oct 15;246:117548

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CUDC-907 inhibits osteosarcoma through upregulation of PTX3 and inhibition of PI3K-AKT signaling.

Zhou Z, Li J, Wang Q, Zhang S, Li Y, Jin S, Wang Z, Chen J, Yang W, Liu T, Wang X, Qiu C, Zhang F, Zhuang Y, Liu J
European journal of pharmacology 2025 Nov 15;1007:178260

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Beneficial effects of Glc-1,6-P(2) modulation on mutant phosphomannomutase-2.

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TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis.

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Genes & diseases 2025 Jan;12(1):101251

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BMC medical genomics 2025 Feb 24;18(1):37

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A study on the establishment of a traumatic brain injury model of tree shrews and the observation of neuroinflammatory responses.

Yu W, Yang L, Zhang X, Zhang J, Zhang J, Wang L, Huang Y, Hong S, Chen L, Wu H, Li J
IBRO neuroscience reports 2025 Dec;19:912-918

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Pentraxin 3 ameliorates glucocorticoid-induced osteonecrosis of the femoral head via TLR4/NF-κB/FGF21 signaling axis.

Li J, Zhou Z, Kong Y, Li Y, Wang Z, Yang Y, Wang J, Liu T, Wang X, Luo D, Zhang F, Qiu C, Liu J
Communications biology 2025 Dec 2;9(1):27

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Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.

Chen H, Duan Z, Jia Q, Zhang X, Xu D, Zheng L, Qi Z, Yang Y, Yang L, Wu C
Molecular neurobiology 2025 Aug;62(8):10834-10855

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Incontinence-Associated Dermatitis-Like Skin Changes Induced by the Application of Absorbent Pads Containing Bacteria and Artificial Urine in Rats.

Horinouchi A, Mugita Y, Tomida S, Takizawa C, Haba D, Sanada H, Nakagami G
Experimental dermatology 2024 Nov;33(11):e70013

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Increased DNMT1 acetylation leads to global DNA methylation suppression in follicular granulosa cells during reproductive aging in mammals.

Zhao S, Cui H, Fang X, Xia W, Tao C, Li J
BMC genomics 2024 Nov 4;25(1):1030

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Pentraxin 3 exacerbates psoriasiform dermatitis through regulation of macrophage polarization.

Liu J, Qiu C, Zhou Z, Li J, Zhen Y, Wang R, Zhuang Y, Zhang F
International immunopharmacology 2024 Mar 30;130:111805

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Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer.

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The Journal of clinical investigation 2024 Apr 25;134(12)

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Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway.

Rao Y, Li J, Qiao R, Luo J, Liu Y
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Pentraxin 3 plays a key role in tubular cell senescence and renal fibrosis through inducing β-catenin signaling.

Luo P, Zhang H, Liang Y, Li X, Wen Z, Xia C, Lan X, Yang Y, Xiong Y, Huang J, Ling X, Zhou S, Miao J, Shen W, Hou FF, Liu Y, Zhou L, Liang M
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166807

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RNA m(6)A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis.

Han X, Liu L, Huang S, Xiao W, Gao Y, Zhou W, Zhang C, Zheng H, Yang L, Xie X, Liang Q, Tu Z, Yu H, Fu J, Wang L, Zhang X, Qian L, Zhou Y
Nature communications 2023 Nov 13;14(1):7328

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NeuroD1 administration ameliorated neuroinflammation and boosted neurogenesis in a mouse model of subarachnoid hemorrhage.

Chen P, Liu XY, Lin MH, Li YX, Kang DZ, Ye ZC, Lin QS
Journal of neuroinflammation 2023 Nov 12;20(1):261

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Urchin-like ceria nanoparticles for enhanced gene therapy of osteoarthritis.

Chen H, Ye T, Hu F, Chen K, Li B, Qiu M, Chen Z, Sun Y, Ye W, Wang H, Ni D, Guo L
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Neuron-Derived Exosomes Promote the Recovery of Spinal Cord Injury by Modulating Nerve Cells in the Cellular Microenvironment of the Lesion Area.

Xu Y, Zhu ZH, Xu X, Sun HT, Zheng HM, Zhang JL, Wang HH, Fang JW, Liu YZ, Huang LL, Song ZW, Liu JB
Molecular neurobiology 2023 Aug;60(8):4502-4516

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TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway.

Cui H, Zhang L, Chen B, Zhang F, Xu H, Ma G, Cao L, Wang M
Contrast media & molecular imaging 2022;2022:5697034

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PTX3 mediates the infiltration, migration, and inflammation-resolving-polarization of macrophages in glioblastoma.

Zhang H, Wang Y, Zhao Y, Liu T, Wang Z, Zhang N, Dai Z, Wu W, Cao H, Feng S, Zhang L, Cheng Q, Liu Z
CNS neuroscience & therapeutics 2022 Nov;28(11):1748-1766

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Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32.

Yin J, Zeng H, Fan K, Xie H, Shao Y, Lu Y, Zhu J, Yao Z, Liu L, Zhang H, Luo B, Wang X, Zeng C, Bai X, Zhang H, Cai D
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PTX3 alleviates hard metal-induced acute lung injury through potentiating efferocytosis.

Yan W, Ma D, Liu Y, Sun W, Cheng D, Li G, Zhou S, Wang Y, Wang H, Ni C
Ecotoxicology and environmental safety 2022 Jan 15;230:113139

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Sphingosine kinase 1 promotes growth of glioblastoma by increasing inflammation mediated by the NF-κB /IL-6/STAT3 and JNK/PTX3 pathways.

Li W, Cai H, Ren L, Yang Y, Yang H, Liu J, Li S, Zhang Y, Zheng X, Tan W, Du G, Wang J
Acta pharmaceutica Sinica. B 2022 Dec;12(12):4390-4406

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Melatonin Maintains Homeostasis and Potentiates the Anti-inflammatory Response in Staphylococcus aureus-Induced Mastitis through microRNA-16b/YAP1.

Chen Z, Wang K, Guo J, Zhou J, Loor JJ, Yang Z, Yang Y
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15255-15270

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Pentraxin-3 inhibits milky spots metastasis of gastric cancer by inhibiting M2 macrophage polarization.

Cui X, Qin T, Zhao Z, Yang G, Sanches JGP, Zhang Q, Fan S, Cao L, Hu X
Journal of Cancer 2021;12(15):4686-4697

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Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy.

Wang Z, Wang X, Zhang N, Zhang H, Dai Z, Zhang M, Feng S, Cheng Q
Frontiers in cell and developmental biology 2020;8:795

---

Cytokine TNF-α promotes invasion and metastasis of gastric cancer by down-regulating Pentraxin3.

Cui X, Zhang H, Cao A, Cao L, Hu X
Journal of Cancer 2020;11(7):1800-1807

---

SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation.

Zhang P, Liu Y, Lian C, Cao X, Wang Y, Li X, Cong M, Tian P, Zhang X, Wei G, Liu T, Hu G
Nature communications 2020 May 19;11(1):2487

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Silencing of PTX3 alleviates LPS-induced inflammatory pain by regulating TLR4/NF-κB signaling pathway in mice.

Qi S, Zhao F, Li Z, Liang F, Yu S
Bioscience reports 2020 Feb 28;40(2)

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Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer.

Kampo S, Ahmmed B, Zhou T, Owusu L, Anabah TW, Doudou NR, Kuugbee ED, Cui Y, Lu Z, Yan Q, Wen QP
Frontiers in oncology 2019;9:21

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Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose.

Zhou Y, Qi C, Li S, Shao X, Ni Z
Mediators of inflammation 2019;2019:9893682

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Tunicamycin enhances the suppressive effects of cisplatin on lung cancer growth through PTX3 glycosylation via AKT/NF-κB signaling pathway.

Ahmmed B, Khan MN, Nisar MA, Kampo S, Zheng Q, Li Y, Yan Q
International journal of oncology 2019 Feb;54(2):431-442

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Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling.

Kugeratski FG, Atkinson SJ, Neilson LJ, Lilla S, Knight JRP, Serneels J, Juin A, Ismail S, Bryant DM, Markert EK, Machesky LM, Mazzone M, Sansom OJ, Zanivan S
Science signaling 2019 Feb 5;12(567)

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The Versican G1 Fragment and Serum-Derived Hyaluronan-Associated Proteins Interact and Form a Complex in Granulation Tissue of Pressure Ulcers.

Murasawa Y, Nakamura H, Watanabe K, Kanoh H, Koyama E, Fujii S, Kimata K, Zako M, Yoneda M, Isogai Z
The American journal of pathology 2018 Feb;188(2):432-449

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Pathological Features of Staphylococcus aureus Induced Mastitis in Dairy Cows and Isobaric-Tags-for-Relative-and-Absolute-Quantitation Proteomic Analyses.

Chen Z, Xia H, Shen H, Xu X, Arbab AAI, Li M, Zhang H, Mao Y, Yang Z
Journal of agricultural and food chemistry 2018 Apr 18;66(15):3880-3890

---

Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.

Chen SX, Xu XE, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang PY, Liu F
Journal of proteomics 2014 Oct 14;110:155-71

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Pentraxin 3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Pentraxin 3. This antibody recognizes human,mouse,rat antigen. The Pentraxin 3 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

13797-1-AP.pdf

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