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Learn12256-1-AP
antibody from Proteintech Group
Targeting: NLRP1
CARD7, CLR17.1, DEFCAP, DKFZp586O1822, KIAA0926, NAC, NALP1, SLEV1, VAMAS1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12256-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12256-1-AP, RRID:AB_2298504
- Product name
- NLRP1 antibody
- Antibody type
- Polyclonal
- Description
- NLRP1 antibody (Cat. #12256-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury.
Correlation Analysis of Pyroptosis-Related Genes CASP1, NLRP3, AIM2, and NLRP1 With Lung Adenocarcinoma.
Inflammasome signaling in astrocytes modulates hippocampal plasticity.
The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex.
Iodine activates NLRP3 inflammasomes in PBMCs of patients with autoimmune thyroiditis and regulates Th1 and Th17 cell differentiation.
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis.
S100A9 aggravates early brain injury after subarachnoid hemorrhage via inducing neuroinflammation and inflammasome activation.
Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage.
Protein corona exacerbated inflammatory response in macrophages elicited by CdTe quantum dots.
SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus.
Targeting CB2R in astrocytes for Parkinson's disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation.
Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Overexpression of MicroRNA-9a-5p Ameliorates NLRP1 Inflammasome-mediated Ischemic Injury in Rats Following Ischemic Stroke.
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.
Huang Y, Zhao E, Zhao G, Zhuo W, Zhao Y, Wang H, Lv G, Hu R, Zeng Z, Han S, Hu Y, Zhao G
Theranostics 2026;16(9):4768-4786
Theranostics 2026;16(9):4768-4786
Correlation Analysis of Pyroptosis-Related Genes CASP1, NLRP3, AIM2, and NLRP1 With Lung Adenocarcinoma.
Zhu L, Zhang Y, Chen X, Li Y, Pan H, Wang Y, Chen N, Wu Y, Li Y, Zhao M
International journal of genomics 2025;2025:8282590
International journal of genomics 2025;2025:8282590
Inflammasome signaling in astrocytes modulates hippocampal plasticity.
Zengeler KE, Hollis A, Deutsch TCJ, Samuels JD, Ennerfelt H, Moore KA, Steacy EJ, Sabapathy V, Sharma R, Patel MK, Lukens JR
Immunity 2025 Jun 10;58(6):1519-1535.e11
Immunity 2025 Jun 10;58(6):1519-1535.e11
The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex.
Liu PP, Jiang SP, Li B, Gui WT, Qin XR, Yu XJ
PLoS pathogens 2025 Jul;21(7):e1013258
PLoS pathogens 2025 Jul;21(7):e1013258
Iodine activates NLRP3 inflammasomes in PBMCs of patients with autoimmune thyroiditis and regulates Th1 and Th17 cell differentiation.
Wu Y, Guo Q, Liu Y, Gong X, Sun W, Li Y, Fan C, Teng W, Shan Z
Endocrine connections 2025 Feb 1;14(2)
Endocrine connections 2025 Feb 1;14(2)
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
Peng S, Liu X, Chang L, Liu B, Zhang M, Mao Y, Shen X
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis.
Titiz M, Landini L, Souza Monteiro de Araujo D, Marini M, Seravalli V, Chieca M, Pensieri P, Montini M, De Siena G, Pasquini B, Vannuccini S, Iannone LF, Cunha TM, Brancolini G, Bellantoni E, Scuffi I, Mastricci A, Tesi M, Di Tommaso M, Petraglia F, Geppetti P, Nassini R, De Logu F
Nature communications 2024 Nov 25;15(1):10142
Nature communications 2024 Nov 25;15(1):10142
S100A9 aggravates early brain injury after subarachnoid hemorrhage via inducing neuroinflammation and inflammasome activation.
Wang G, Huang K, Tian Q, Guo Y, Liu C, Li Z, Yu Z, Zhang Z, Li M
iScience 2024 Mar 15;27(3):109165
iScience 2024 Mar 15;27(3):109165
Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage.
Wang Y, Zhao M, Li J, Liu Y
Clinical and experimental pharmacology & physiology 2024 Jun;51(6):e13858
Clinical and experimental pharmacology & physiology 2024 Jun;51(6):e13858
Protein corona exacerbated inflammatory response in macrophages elicited by CdTe quantum dots.
Liu N, Liang Y, Wei T, Huang X, Zhang T, Tang M
NanoImpact 2024 Jan;33:100494
NanoImpact 2024 Jan;33:100494
SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus.
Ye X, Lin JY, Chen LX, Wu XC, Ma KJ, Li BX, Fang YX
Heliyon 2024 Jan 15;10(1):e23945
Heliyon 2024 Jan 15;10(1):e23945
Targeting CB2R in astrocytes for Parkinson's disease therapy: unraveling the Foxg1-mediated neuroprotective mechanism through autophagy-mediated NLRP3 degradation.
Zhu H, Xiao F, Xiao Y, Guo Y, Shan X, Zhang Z, Zhang L, Guo H
Journal of neuroinflammation 2023 Dec 19;20(1):304
Journal of neuroinflammation 2023 Dec 19;20(1):304
Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.
Liu X, Song W, Yu Y, Su J, Shi X, Yang X, Wang H, Liu P, Zou L
Neurotoxicity research 2022 Oct;40(5):1163-1173
Neurotoxicity research 2022 Oct;40(5):1163-1173
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692
Inflammation 2021 Apr;44(2):682-692
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Ding PH, Yang MX, Wang NN, Jin LJ, Dong Y, Cai X, Chen LL
Frontiers in microbiology 2020;11:1881
Frontiers in microbiology 2020;11:1881
Overexpression of MicroRNA-9a-5p Ameliorates NLRP1 Inflammasome-mediated Ischemic Injury in Rats Following Ischemic Stroke.
Cao Y, Zhang H, Lu X, Wang J, Zhang X, Sun S, Bao Z, Tian W, Ning S, Wang L, Cui L
Neuroscience 2020 Sep 15;444:106-117
Neuroscience 2020 Sep 15;444:106-117
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, Fan C, Guan H, Li Y, Shan Z, Teng W
Frontiers in immunology 2018;9:1197
Frontiers in immunology 2018;9:1197
Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
Bando H, Lee Y, Sakaguchi N, Pradipta A, Ma JS, Tanaka S, Cai Y, Liu J, Shen J, Nishikawa Y, Sasai M, Yamamoto M
mBio 2018 Oct 9;9(5)
mBio 2018 Oct 9;9(5)
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.
Saresella M, La Rosa F, Piancone F, Zoppis M, Marventano I, Calabrese E, Rainone V, Nemni R, Mancuso R, Clerici M
Molecular neurodegeneration 2016 Mar 3;11:23
Molecular neurodegeneration 2016 Mar 3;11:23
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 12256-1-AP( NLRP1 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NLRP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NLRP1. This antibody recognizes human antigen. The NLRP1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
