BS6310

antibody from Bioworld Technology, Inc

Targeting: TNFAIP6 TSG-6, TSG6

Western blot

Immunohistochemistry

Antibody data

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Validation data

Product number: BS6310 - Provider product page
Provider: Bioworld Technology, Inc
Product name: TNFAIP6 polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human TNFAIP6.
Description: The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNFÏ« and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNFÏ«, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-Ï«-inhibitor (IÏ«I)). TSG-6 potentiates the inhibitory effect of lÏ«l on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and lÏ«l can modulate the protease network and thus inhibit inflammation.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

TNFAIP6 protein structure - BS6310 shown in red.