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- References [93]
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- Product number
- 23408-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- RANKL antibody
- Antibody type
- Polyclonal
- Description
- RANKL antibody (Cat. #23408-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Plasma Proteomics Identifies Thousand-and-One-Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target.
RANKL Attenuates Sepsis-Associated Acute Lung Injury Through the OPG/RANKL/RANK/TLR4 Pathway.
Tumor Radiotherapy-Induced Sympathetic Hyperactivation Orchestrates Rapid Systemic Bone Loss.
The single cell transcriptomic landscape of recurrent giant cell tumor of bone following neoadjuvant denosumab therapy.
HK2-mediated Glycolysis Inhibits Mineralization of Cementoblasts Under Compression by Suppressing the Piezo1/Wnt Signaling.
Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force.
The Effects and Mechanisms of Patchouli Alcohol on Experimental Periodontitis Rats Based on the OPG/RANK/RANKL/P38 MAPK Signaling Pathway.
Lang-chuang-ding restores bone homeostasis in systemic lupus erythematosus associated osteoporosis by targeting NF-κB signaling: a network pharmacology and experimental study.
JARID1D-dependent androgen receptor and JunD signaling activation of osteoclast differentiation inhibits prostate cancer bone metastasis through demethylating H3K4.
Fracture-Induced Immunological Cascades Trigger Rapid Systemic Bone Loss via Osteocyte-Regulated Osteoclastogenesis.
KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification.
Loss of SMN Impairs Osteoblast-Osteoclast Coupling via IGF1-Akt-OPG Axis in Spinal Muscular Atrophy.
Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.
Neuro-skeletal crosstalk: Brain-derived 5-HT mediates the bone-protective effects of β-Sitosterol against postmenopausal osteoporosis.
Lipid droplet accumulation impairs osseointegration by disturbing the osteogenesis-osteoclasis balance on titanium implant surface in hyperlipidemia.
Hyperbaric oxygen potentiates platelet-rich plasma composition and accelerates bone healing.
Adiponectin receptors agonist alters microbiota to improve implant osseointegration in diabetic mice.
Neferine reduces synovial inflammation and cardiac complications in a collagen-induced arthritis mouse model via inhibiting NF-κB/NLRP3 inflammasome axis.
Verification of Pain-Related Neuromodulation Mechanisms of Calcitonin in Knee Osteoarthritis.
Tectorigenin Ameliorates Glucocorticoid-Induced Osteoporosis by Inhibiting the NF-κB Signal Pathway and Modulating Treg-Th17 Cell Balance.
Urolithin A Attenuates Periodontitis in Mice via Dual Anti-Inflammatory and Osteoclastogenesis Inhibition: A Natural Metabolite-Based Therapeutic Strategy.
Serum MicroRNA signatures associated with hypertrophic callus formation in polytrauma patients with traumatic brain injury.
Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling.
Titanium Particles Activate Osteocytic Connexin 43 to Induce Oxidative Stress and Osteoclastogenesis Through the JAK-STAT Pathway.
Alterations of bone proteins in medication-related osteonecrosis of the jaw.
Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritis via the OPG/RANKL/RANK system.
RETRACTED: Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway.
Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells.
Small nucleolar RNA host gene 5 plays a role in orthodontic tooth movement by inhibiting osteoclast differentiation.
Nlrp3 Deficiency Does Not Substantially Affect Femoral Fracture Healing in Mice.
G protein-coupled receptor 91 activations suppressed mineralization in Porphyromonas gingivalis-infected osteoblasts.
NF-κB Decoy Oligodeoxynucleotide-Loaded Poly Lactic-co-glycolic Acid Nanospheres Facilitate Socket Healing in Orthodontic Tooth Movement.
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
Epstein-barr virus infections induce aberrant osteoclastogenesis in immune system-humanized NOD/Shi-scid/IL-2RγC(null) mice.
Role of OPG/RANKL/RANK/TLR4 signaling pathway in sepsis-associated acute kidney injury.
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma.
Role and Therapeutic Potential for Targeting Fibroblast Growth Factor 10/FGFR1 in Relapsed Rheumatoid Arthritis.
Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics.
Validation of Peripheral Neuromodulation Mechanisms of Icariin in Knee Osteoarthritis-Related Chronic Pain.
3,3'-Diindolylmethane promotes bone formation - A assessment in MC3T3-E1 cells and zebrafish.
Targeting Osteoblast-Osteoclast Cross-Talk Bone Homeostasis Repair Microcarriers Promotes Intervertebral Fusion in Osteoporotic Rats.
Establishing patient-derived tumor organoids of bone metastasis from lung adenocarcinoma reveals the transcriptomic changes underlying denosumab treatment.
Mechanically induced M2 macrophages are involved in bone remodeling of the midpalatal suture during palatal expansion.
A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration.
Confirmation of pain-related neuromodulation mechanism of Bushen Zhuangjin Decoction on knee osteoarthritis.
Cartilage Damage Pathological Characteristics of Diabetic Neuropathic Osteoarthropathy.
Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.
Fluoride-induced osteoporosis via interfering with the RANKL/RANK/OPG pathway in ovariectomized rats: Oophorectomy shifted skeletal fluorosis from osteosclerosis to osteoporosis.
BML-111 inhibits osteoclast differentiation by suppressing the MAPK and NF-κB pathways, alleviating deterioration of the knee joints in a CIA rat model.
An innovative immunotherapeutic strategy for rheumatoid arthritis: Selectively suppressing angiogenesis and osteoclast differentiation by fully human antibody targeting thymocyte antigen-1.
Effects of green tea extract epigallocatechin-3-gallate (EGCG) on orthodontic tooth movement and root resorption in rats.
Pulsed frequency modulated ultrasound promotes therapeutic effects of osteoporosis induced by ovarian failure in mice.
Patellar instability-induced bone loss in the femoral trochlea is associated with the activation of the JAK1/STAT3 signaling pathway in growing mice.
Clearance of senescent cells by navitoclax (ABT263) rejuvenates UHMWPE-induced osteolysis.
BRG1 is involved in vascular calcification in chronic renal disease via autophagy of vascular smooth muscle cells.
S-Equol enhances osteoblastic bone formation and prevents bone loss through OPG/RANKL via the PI3K/Akt pathway in streptozotocin-induced diabetic rats.
RETRACTED: Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption.
Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs.
Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function.
Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-κB/COX-2/RANKL signaling in Sertoli cells.
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF‑κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis.
Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model.
Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-κB and Ang/Tie-2 pathways.
Ubiquitin-specific protease 47 is associated with vascular calcification in chronic kidney disease by regulating osteogenic transdifferentiation of vascular smooth muscle cells.
Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes.
Asperuloside Prevents Peri-Implantitis via Suppression of NF-κB and ERK1/2 on Rats.
Rutin ameliorates the promotion effect of fine particulate matter on vascular calcification in calcifying vascular cells and ApoE(-/-) mice.
Total Saponins from Nigella glandulifera Seeds Ameliorate Adjuvant-Induced Rheumatoid Arthritis in Rats by Inhibition of an Inflammatory Response and Bone Erosion.
Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway.
Tomatidine Suppresses the Destructive Behaviors of Fibroblast-Like Synoviocytes and Ameliorates Type II Collagen-Induced Arthritis in Rats.
Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis.
Loss of chemerin triggers bone remodeling in vivo and in vitro.
Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition.
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p.
Anti-rheumatoid arthritis effects of iridoid glucosides from Lamiophlomis rotata (Benth.) kudo on adjuvant-induced arthritis in rats by OPG/RANKL/NF-κB signaling pathways.
Milk Polar Lipids Supplementation to Obese Rats During Pregnancy and Lactation Benefited Skeletal Outcomes of Male Offspring.
Plasma Exosomes Derived From Patients With End-Stage Renal Disease and Renal Transplant Recipients Have Different Effects on Vascular Calcification.
Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin.
The effects of binge alcohol exposure on tooth movement and associated root resorption in rats.
Glyburide inhibits the bone resorption induced by traumatic occlusion in rats.
MicroRNA‑21 serves an important role during PAOO‑facilitated orthodontic tooth movement.
Sialic acid-modified chitosan oligosaccharide-based biphasic calcium phosphate promote synergetic bone formation in rheumatoid arthritis therapy.
Gingival crevicular fluid levels of SLIT3 are increased in periodontal disease.
Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway.
Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β-catenin signaling.
Effects Of Triptolide On Tooth Movement And Root Resorption In Rats.
Elevated ATF4 Expression in Odontogenic Keratocysts Epithelia: Potential Involvement in Tissue Hypoxia and Stromal M2 Macrophage Infiltration.
LOX-1 is involved in TLR2 induced RANKL regulation in peri-implantitis.
Increased level of cell-derived microparticles in the cyst fluids of odontogenic keratocysts.
β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway.
Role of endoplasmic reticulum stress in disuse osteoporosis.
Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis.
Xin P, Li W, A X, Shen J, Meng X, Bian Y, Han H, Xiang Z, Ran L, Sun S, Xie J, Yue T, Zhu Q, Zhang X, Xie L, Xiao L
Arthritis & rheumatology (Hoboken, N.J.) 2026 May;78(5):1045-1061
Arthritis & rheumatology (Hoboken, N.J.) 2026 May;78(5):1045-1061
RANKL Attenuates Sepsis-Associated Acute Lung Injury Through the OPG/RANKL/RANK/TLR4 Pathway.
Niu X, Turson N, Chen W, Li H
Immunity, inflammation and disease 2026 Mar;14(3):e70356
Immunity, inflammation and disease 2026 Mar;14(3):e70356
Tumor Radiotherapy-Induced Sympathetic Hyperactivation Orchestrates Rapid Systemic Bone Loss.
Wang C, Kuang S, Sun L, Li Y, Wang G, Sun J, Zhou F, Zhang C
Calcified tissue international 2026 Mar 31;117(1)
Calcified tissue international 2026 Mar 31;117(1)
The single cell transcriptomic landscape of recurrent giant cell tumor of bone following neoadjuvant denosumab therapy.
Hu X, Wu H, Zheng B, Liang C, Shi B, Ye Q, Wang S, Cai W, Hu T, Chen Y, Cheng M, Yan W, Huang W
Journal of genetics and genomics = Yi chuan xue bao 2026 Mar 3;
Journal of genetics and genomics = Yi chuan xue bao 2026 Mar 3;
HK2-mediated Glycolysis Inhibits Mineralization of Cementoblasts Under Compression by Suppressing the Piezo1/Wnt Signaling.
Huang Z, Hu H, Meng Y, Li H, Lei L
International journal of medical sciences 2025;22(13):3316-3328
International journal of medical sciences 2025;22(13):3316-3328
Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force.
Yang Z, Chen M, Liao X, Ma L, Liang C, Li Y, Hu J
Open medicine (Warsaw, Poland) 2025;20(1):20251252
Open medicine (Warsaw, Poland) 2025;20(1):20251252
The Effects and Mechanisms of Patchouli Alcohol on Experimental Periodontitis Rats Based on the OPG/RANK/RANKL/P38 MAPK Signaling Pathway.
Zhang S, Duan F, He T, Sun C, Zhen M, Liang E, Liu X, Dai Y, Zhan R, Hu N, Xia Y, Liu S
Journal of inflammation research 2025;18:12599-12617
Journal of inflammation research 2025;18:12599-12617
Lang-chuang-ding restores bone homeostasis in systemic lupus erythematosus associated osteoporosis by targeting NF-κB signaling: a network pharmacology and experimental study.
Luo H, Zhou H, Shen S, Zeng L, Ruan H
Frontiers in endocrinology 2025;16:1639261
Frontiers in endocrinology 2025;16:1639261
JARID1D-dependent androgen receptor and JunD signaling activation of osteoclast differentiation inhibits prostate cancer bone metastasis through demethylating H3K4.
Hu Y, Zhao Z, Xie Q, Li H, Zhang C, He X, Ma Y, Zhang C, Li Q, Shi C
Theranostics 2025;15(4):1320-1337
Theranostics 2025;15(4):1320-1337
Fracture-Induced Immunological Cascades Trigger Rapid Systemic Bone Loss via Osteocyte-Regulated Osteoclastogenesis.
Sun L, Kuang S, Li Y, Wang G, Sun J, Zhou F, Zhang C
ImmunoTargets and therapy 2025;14:849-875
ImmunoTargets and therapy 2025;14:849-875
KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification.
Liu F, Lv Y, Lin Y, Wang C, Wang S, Zeng K, Zhou B, Lin L, Feng J, Sun G, Chang X, Cao M, Li H, Hu X, Kato S, Zhao Y, Tian W
Cell death discovery 2025 Oct 7;11(1):452
Cell death discovery 2025 Oct 7;11(1):452
Loss of SMN Impairs Osteoblast-Osteoclast Coupling via IGF1-Akt-OPG Axis in Spinal Muscular Atrophy.
Xiang T, Zhou Z, Li Y, Suo Y, Dai J, Shi X, Zhou X, Sheng L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71095
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71095
Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.
Shi X, Xie H, Liu C, Wu K, Huang W
Ecotoxicology and environmental safety 2025 Oct 15;305:119240
Ecotoxicology and environmental safety 2025 Oct 15;305:119240
Neuro-skeletal crosstalk: Brain-derived 5-HT mediates the bone-protective effects of β-Sitosterol against postmenopausal osteoporosis.
Wang K, Wang L, Zhou S, Chen X, Qian L, Zhang T, Sun X, Li M, Liu M, Guo Y, Hu Y, Ma Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157248
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157248
Lipid droplet accumulation impairs osseointegration by disturbing the osteogenesis-osteoclasis balance on titanium implant surface in hyperlipidemia.
Wang YN, Liu S
BMC oral health 2025 May 28;25(1):823
BMC oral health 2025 May 28;25(1):823
Hyperbaric oxygen potentiates platelet-rich plasma composition and accelerates bone healing.
Chang WS, Huang CC, Chen TH, Chao SH, Lin CH, Chang CP, Chien CS
Journal of orthopaedic translation 2025 Mar;51:1-12
Journal of orthopaedic translation 2025 Mar;51:1-12
Adiponectin receptors agonist alters microbiota to improve implant osseointegration in diabetic mice.
Wang X, Lin L, Yao Q
Oral diseases 2025 Mar;31(3):1006-1016
Oral diseases 2025 Mar;31(3):1006-1016
Neferine reduces synovial inflammation and cardiac complications in a collagen-induced arthritis mouse model via inhibiting NF-κB/NLRP3 inflammasome axis.
Cao J, Zhang H, Ni Y, Ning X
Molecular immunology 2025 Jun;182:117-125
Molecular immunology 2025 Jun;182:117-125
Verification of Pain-Related Neuromodulation Mechanisms of Calcitonin in Knee Osteoarthritis.
Lin Q, Tan X, Ma D, Huang Y, Wang L, Zheng D, Lin J, Zhu Z, Mao M, Yi Z, Wang J, Li X
Molecular neurobiology 2025 Jul;62(7):8341-8358
Molecular neurobiology 2025 Jul;62(7):8341-8358
Tectorigenin Ameliorates Glucocorticoid-Induced Osteoporosis by Inhibiting the NF-κB Signal Pathway and Modulating Treg-Th17 Cell Balance.
Peng P, Wong P, Lv Z, Tian J, He W, Wei Q, Mo H, He M
Journal of cellular and molecular medicine 2025 Jul;29(13):e70705
Journal of cellular and molecular medicine 2025 Jul;29(13):e70705
Urolithin A Attenuates Periodontitis in Mice via Dual Anti-Inflammatory and Osteoclastogenesis Inhibition: A Natural Metabolite-Based Therapeutic Strategy.
Xia Y, Wu D, Zhou L, Wu X, Chen J
Molecules (Basel, Switzerland) 2025 Jul 7;30(13)
Molecules (Basel, Switzerland) 2025 Jul 7;30(13)
Serum MicroRNA signatures associated with hypertrophic callus formation in polytrauma patients with traumatic brain injury.
Lettner T, Dussing F, Gehwolf R, Deininger C, Deluca A, Wally V, Hofmann V, Hackl M, Traweger A, Wichlas F
Scientific reports 2025 Dec 4;15(1):43154
Scientific reports 2025 Dec 4;15(1):43154
Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling.
Hu Y, Chen W, Lan S, Ming C, Xu D, Li H, Xu H, Shi D, Liu W, Dai Z, Wang J, He Z, Xu W, Shao Z, Liu Y, Tian H, Tong W
Nature communications 2025 Dec 17;16(1):11394
Nature communications 2025 Dec 17;16(1):11394
Titanium Particles Activate Osteocytic Connexin 43 to Induce Oxidative Stress and Osteoclastogenesis Through the JAK-STAT Pathway.
Ouyang J, Chai H, Sun C, Wang S, She C, Geng D, Xu W
Antioxidants & redox signaling 2025 Aug;43(4-6):215-238
Antioxidants & redox signaling 2025 Aug;43(4-6):215-238
Alterations of bone proteins in medication-related osteonecrosis of the jaw.
Schubert A, Brockmeyer P, Kauffmann P, Wiegel J, Lautenbacher F, Miosge N, Schminke B
European journal of oral sciences 2025 Apr;133(2):e70003
European journal of oral sciences 2025 Apr;133(2):e70003
Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritis via the OPG/RANKL/RANK system.
Wu Q, Yao X, Shan N, Cai Y, Fan Y
Folia histochemica et cytobiologica 2024;62(3):154-164
Folia histochemica et cytobiologica 2024;62(3):154-164
RETRACTED: Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway.
Ding D, Liu G, Yan J, Zhang Q, Meng F, Wang L
PloS one 2024;19(9):e0309807
PloS one 2024;19(9):e0309807
Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells.
Xu W, Gong L, Tang W, Lu G
BMC cardiovascular disorders 2024 Sep 17;24(1):494
BMC cardiovascular disorders 2024 Sep 17;24(1):494
Small nucleolar RNA host gene 5 plays a role in orthodontic tooth movement by inhibiting osteoclast differentiation.
Feng J, Tan A, Li W, Zheng Y
Orthodontics & craniofacial research 2024 Oct;27(5):775-784
Orthodontics & craniofacial research 2024 Oct;27(5):775-784
Nlrp3 Deficiency Does Not Substantially Affect Femoral Fracture Healing in Mice.
Menger MM, Speicher R, Hans S, Histing T, El Kayali MKD, Ehnert S, Menger MD, Ampofo E, Wrublewsky S, Laschke MW
International journal of molecular sciences 2024 Nov 2;25(21)
International journal of molecular sciences 2024 Nov 2;25(21)
G protein-coupled receptor 91 activations suppressed mineralization in Porphyromonas gingivalis-infected osteoblasts.
Su W, Zhang D, Wang Y, Lei L, Li H
Scientific reports 2024 Nov 11;14(1):27606
Scientific reports 2024 Nov 11;14(1):27606
NF-κB Decoy Oligodeoxynucleotide-Loaded Poly Lactic-co-glycolic Acid Nanospheres Facilitate Socket Healing in Orthodontic Tooth Movement.
Huang AC, Ishida Y, Hatano-Sato K, Oishi S, Hosomichi J, Usumi-Fujita R, Yamaguchi H, Tsujimoto H, Sasai A, Ochi A, Ono T
International journal of molecular sciences 2024 May 10;25(10)
International journal of molecular sciences 2024 May 10;25(10)
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
Jiang Z, Qi G, He X, Yu Y, Cao Y, Zhang C, Zou W, Yuan H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(12):e2307388
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(12):e2307388
Epstein-barr virus infections induce aberrant osteoclastogenesis in immune system-humanized NOD/Shi-scid/IL-2RγC(null) mice.
Nagatsuka Y, Iwata M, Nagasawa Y, Tsuzuki H, Kitamura N, Komatsu A, Kawana K, Ito R, Fujiwara S, Nakamura H, Takei M
Biochemical and biophysical research communications 2024 Jun 30;715:149984
Biochemical and biophysical research communications 2024 Jun 30;715:149984
Role of OPG/RANKL/RANK/TLR4 signaling pathway in sepsis-associated acute kidney injury.
Niu X, Wang C, Li H, Chen W
BMC nephrology 2024 Jun 23;25(1):205
BMC nephrology 2024 Jun 23;25(1):205
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma.
Deng S, Lu X, Wang X, Liang B, Xu H, Yang D, Cui G, Yonemura A, Paine H, Zhou Y, Zhang Y, Simile MM, Urigo F, Evert M, Calvisi DF, Green BL, Chen X
Cell death & disease 2024 Jun 22;15(6):441
Cell death & disease 2024 Jun 22;15(6):441
Role and Therapeutic Potential for Targeting Fibroblast Growth Factor 10/FGFR1 in Relapsed Rheumatoid Arthritis.
Meng X, Chen Z, Li T, Nie Z, Han H, Zhong S, Yin Z, Sun S, Xie J, Shen J, Xu X, Gao C, Ran L, Xu B, Xiang Z, Wang J, Sun P, Xin P, A X, Zhang C, Qiu G, Gao H, Bian Y, Xu M, Cao B, Li F, Zheng L, Zhang X, Xiao L
Arthritis & rheumatology (Hoboken, N.J.) 2024 Jan;76(1):32-47
Arthritis & rheumatology (Hoboken, N.J.) 2024 Jan;76(1):32-47
Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics.
Shao X, Tian Y, Liu J, Yan Z, Ding Y, Hao X, Wang D, Shen L, Luo E, Guo XE, Luo P, Luo W, Cai J, Jing D
Nature communications 2024 Jan 30;15(1):890
Nature communications 2024 Jan 30;15(1):890
Validation of Peripheral Neuromodulation Mechanisms of Icariin in Knee Osteoarthritis-Related Chronic Pain.
Ma D, Zhu Z, Tan X, Lin Q, Huang Y, Mao M, Yi Z, Wang L, Liu L, Li X
Journal of cellular and molecular medicine 2024 Dec;28(23):e70223
Journal of cellular and molecular medicine 2024 Dec;28(23):e70223
3,3'-Diindolylmethane promotes bone formation - A assessment in MC3T3-E1 cells and zebrafish.
Ma Y, Zhu Y, Wang F, Zhao G, Huang L, Lu R, Wang D, Tian X, Ye Y
Biochemical pharmacology 2024 Dec;230(Pt 3):116618
Biochemical pharmacology 2024 Dec;230(Pt 3):116618
Targeting Osteoblast-Osteoclast Cross-Talk Bone Homeostasis Repair Microcarriers Promotes Intervertebral Fusion in Osteoporotic Rats.
Zheng J, Li X, Zhang F, Li C, Zhang X, Wang F, Qi J, Cui W, Deng L
Advanced healthcare materials 2024 Dec;13(31):e2402117
Advanced healthcare materials 2024 Dec;13(31):e2402117
Establishing patient-derived tumor organoids of bone metastasis from lung adenocarcinoma reveals the transcriptomic changes underlying denosumab treatment.
Hu X, Wu H, Hu K, Kang Y, Hua G, Cheng M, Yan W, Huang W
Clinical & experimental metastasis 2024 Dec 30;42(1):8
Clinical & experimental metastasis 2024 Dec 30;42(1):8
Mechanically induced M2 macrophages are involved in bone remodeling of the midpalatal suture during palatal expansion.
Li L, Zhai M, Cheng C, Cui S, Wang J, Zhang Z, Liu J, Wei F
Progress in orthodontics 2024 Aug 5;25(1):30
Progress in orthodontics 2024 Aug 5;25(1):30
A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration.
Hao Z, Feng Q, Wang Y, Wang Y, Li H, Hu Y, Chen T, Wang J, Chen R, Lv X, Yang Z, Chen J, Guo X, Li J
Bioactive materials 2024 Apr;34:181-203
Bioactive materials 2024 Apr;34:181-203
Confirmation of pain-related neuromodulation mechanism of Bushen Zhuangjin Decoction on knee osteoarthritis.
Tan X, Zheng D, Lin Q, Wang L, Zhu Z, Huang Y, Lin J, Zeng Y, Mao M, Yi Z, Liu L, Ma D, Wang J, Li X
Journal of ethnopharmacology 2024 Apr 24;324:117772
Journal of ethnopharmacology 2024 Apr 24;324:117772
Cartilage Damage Pathological Characteristics of Diabetic Neuropathic Osteoarthropathy.
Liu PL, Diao JY, Wang Q, Liu H, Zhang Y, Liang JQ, Zhang F, Liang XJ, Zhao HM
Analytical cellular pathology (Amsterdam) 2023;2023:7573165
Analytical cellular pathology (Amsterdam) 2023;2023:7573165
Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.
Li J, Zhang J, Xue Q, Liu B, Qin R, Li Y, Qiu Y, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2023 Sep;22(9):e13912
Aging cell 2023 Sep;22(9):e13912
Fluoride-induced osteoporosis via interfering with the RANKL/RANK/OPG pathway in ovariectomized rats: Oophorectomy shifted skeletal fluorosis from osteosclerosis to osteoporosis.
Jin Y, Zhou BH, Zhao J, Ommati MM, Wang S, Wang HW
Environmental pollution (Barking, Essex : 1987) 2023 Nov 1;336:122407
Environmental pollution (Barking, Essex : 1987) 2023 Nov 1;336:122407
BML-111 inhibits osteoclast differentiation by suppressing the MAPK and NF-κB pathways, alleviating deterioration of the knee joints in a CIA rat model.
Wang L, Su W, Zheng X, Lin W, Lv C, Yang S, Chen B, Zhang C
Cell biology international 2023 May;47(5):954-968
Cell biology international 2023 May;47(5):954-968
An innovative immunotherapeutic strategy for rheumatoid arthritis: Selectively suppressing angiogenesis and osteoclast differentiation by fully human antibody targeting thymocyte antigen-1.
Hu X, Li M, Zhang Y, Sang K, Zhang Y, Li W, Liu B, Wan L, Du B, Qian J, Meng F, Fu Y, Dai M, Gao G, Ye H
Experimental cell research 2023 Mar 1;424(1):113490
Experimental cell research 2023 Mar 1;424(1):113490
Effects of green tea extract epigallocatechin-3-gallate (EGCG) on orthodontic tooth movement and root resorption in rats.
Zou JH, Chen F, Li YL, Chen H, Sun TK, Du SM, Zhang J
Archives of oral biology 2023 Jun;150:105691
Archives of oral biology 2023 Jun;150:105691
Pulsed frequency modulated ultrasound promotes therapeutic effects of osteoporosis induced by ovarian failure in mice.
Zhou X, Sun S, Chen Y, Liu C, Li D, Cheng Q, He M, Li Y, Xu K, Ta D
Ultrasonics 2023 Jul;132:106973
Ultrasonics 2023 Jul;132:106973
Patellar instability-induced bone loss in the femoral trochlea is associated with the activation of the JAK1/STAT3 signaling pathway in growing mice.
Ma C, Kou W, Cui Z, Liu W, Liu C, Wang S, Wang F
Journal of orthopaedic surgery and research 2023 Jul 24;18(1):526
Journal of orthopaedic surgery and research 2023 Jul 24;18(1):526
Clearance of senescent cells by navitoclax (ABT263) rejuvenates UHMWPE-induced osteolysis.
Su W, Hu Y, Fan X, Xie J
International immunopharmacology 2023 Feb;115:109694
International immunopharmacology 2023 Feb;115:109694
BRG1 is involved in vascular calcification in chronic renal disease via autophagy of vascular smooth muscle cells.
Feng Y, Yu M, Wang C, Xia J, Huang L, Tang Y, Xiao Q, Pu L, Wang L, Li G, Li Y
iScience 2023 Apr 21;26(4):106485
iScience 2023 Apr 21;26(4):106485
S-Equol enhances osteoblastic bone formation and prevents bone loss through OPG/RANKL via the PI3K/Akt pathway in streptozotocin-induced diabetic rats.
Xu Z, Xu J, Li S, Cui H, Zhang G, Ni X, Wang J
Frontiers in nutrition 2022;9:986192
Frontiers in nutrition 2022;9:986192
RETRACTED: Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption.
Ding D, Wang L, Yan J, Zhou Y, Feng G, Ma L, Yang Y, Pei X, Jin Q
PloS one 2022;17(7):e0271485
PloS one 2022;17(7):e0271485
Sinomenine Inhibits Orthodontic Tooth Movement and Root Resorption in Rats and Enhances Osteogenic Differentiation of PDLSCs.
Li H, Li Y, Zou J, Yang Y, Han R, Zhang J
Drug design, development and therapy 2022;16:2949-2965
Drug design, development and therapy 2022;16:2949-2965
Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function.
Zhang YW, Cao MM, Li YJ, Lu PP, Dai GC, Zhang M, Wang H, Rui YF
Journal of orthopaedic translation 2022 Nov;37:46-60
Journal of orthopaedic translation 2022 Nov;37:46-60
Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-κB/COX-2/RANKL signaling in Sertoli cells.
Xie Z, Liu S, Hua S, Wu L, Zhang Y, Zhu Y, Shi F, Jiang J
Toxicology 2022 May 30;474:153213
Toxicology 2022 May 30;474:153213
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
Yu Y, Jiang L, Li J, Lei L, Li H
Journal of periodontology 2022 Jul;93(7):1036-1047
Journal of periodontology 2022 Jul;93(7):1036-1047
Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF‑κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis.
Ding D, Yan J, Feng G, Zhou Y, Ma L, Jin Q
International journal of molecular medicine 2022 Jan;49(1)
International journal of molecular medicine 2022 Jan;49(1)
Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model.
Lin C, Chen Z, Guo D, Zhou L, Lin S, Li C, Li S, Wang X, Lin B, Ding Y
Aging 2022 Jan 4;14(1):253-271
Aging 2022 Jan 4;14(1):253-271
Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-κB and Ang/Tie-2 pathways.
Jiang H, Xu F, Zeng L, Li C, Chen Y, Wang L, Li Z, Liu R
Journal of ethnopharmacology 2022 Jan 30;283:114714
Journal of ethnopharmacology 2022 Jan 30;283:114714
Ubiquitin-specific protease 47 is associated with vascular calcification in chronic kidney disease by regulating osteogenic transdifferentiation of vascular smooth muscle cells.
Xiao Q, Tang Y, Xia J, Luo H, Yu M, Chen S, Wang W, Pu L, Wang L, Li G, Li Y
Renal failure 2022 Dec;44(1):752-766
Renal failure 2022 Dec;44(1):752-766
Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes.
Liu Z, Tang Y, He L, Geng B, Lu F, He J, Yi Q, Liu X, Zhang K, Wang L, Xia Y, Jiang J
Channels (Austin, Tex.) 2022 Dec;16(1):127-136
Channels (Austin, Tex.) 2022 Dec;16(1):127-136
Asperuloside Prevents Peri-Implantitis via Suppression of NF-κB and ERK1/2 on Rats.
Wang X, Chen X, Zhang Z, Chen J, Ge Z, Huang S, Wei H, Li D
Pharmaceuticals (Basel, Switzerland) 2022 Aug 20;15(8)
Pharmaceuticals (Basel, Switzerland) 2022 Aug 20;15(8)
Rutin ameliorates the promotion effect of fine particulate matter on vascular calcification in calcifying vascular cells and ApoE(-/-) mice.
Su R, Jin X, Zhao W, Wu X, Zhai F, Li Z
Ecotoxicology and environmental safety 2022 Apr 1;234:113410
Ecotoxicology and environmental safety 2022 Apr 1;234:113410
Total Saponins from Nigella glandulifera Seeds Ameliorate Adjuvant-Induced Rheumatoid Arthritis in Rats by Inhibition of an Inflammatory Response and Bone Erosion.
Zeng L, Li C, Jiang H, Chen Y, Li Z, Xu F, Liu R
BioMed research international 2021;2021:6613527
BioMed research international 2021;2021:6613527
Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway.
Guo H, Ding D, Wang L, Yan J, Ma L, Jin Q
PloS one 2021;16(12):e0261127
PloS one 2021;16(12):e0261127
Tomatidine Suppresses the Destructive Behaviors of Fibroblast-Like Synoviocytes and Ameliorates Type II Collagen-Induced Arthritis in Rats.
Yu X, Zhou J, Zhao F, Liu X, Mao Y, Diao L, Wen C, Liu M
Frontiers in pharmacology 2021;12:670707
Frontiers in pharmacology 2021;12:670707
Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis.
Kitayama K, Kawamoto T, Kawakami Y, Hara H, Takemori T, Fujiwara S, Yahiro S, Miyamoto T, Mifune Y, Hoshino Y, Kakutani K, Matsumoto T, Matsushita T, Niikura T, Kuroda R, Akisue T
International journal of oncology 2021 Nov;59(5)
International journal of oncology 2021 Nov;59(5)
Loss of chemerin triggers bone remodeling in vivo and in vitro.
Han L, Zhang Y, Wan S, Wei Q, Shang W, Huang G, Fang P, Min W
Molecular metabolism 2021 Nov;53:101322
Molecular metabolism 2021 Nov;53:101322
Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition.
Jia X, Zhu H, Li G, Lan M, Li X, Huang M, Xu W, Wu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111321
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111321
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p.
Yu L, Sui B, Fan W, Lei L, Zhou L, Yang L, Diao Y, Zhang Y, Li Z, Liu J, Hao X
Journal of extracellular vesicles 2021 Jan;10(3):e12056
Journal of extracellular vesicles 2021 Jan;10(3):e12056
Anti-rheumatoid arthritis effects of iridoid glucosides from Lamiophlomis rotata (Benth.) kudo on adjuvant-induced arthritis in rats by OPG/RANKL/NF-κB signaling pathways.
Zhao X, Jiang S, Dong Q, Dang J, Liu Z, Han H, Tao Y, Yue H
Journal of ethnopharmacology 2021 Feb 10;266:113402
Journal of ethnopharmacology 2021 Feb 10;266:113402
Milk Polar Lipids Supplementation to Obese Rats During Pregnancy and Lactation Benefited Skeletal Outcomes of Male Offspring.
Han L, Du M, Ren F, Mao X
Molecular nutrition & food research 2021 Aug;65(15):e2001208
Molecular nutrition & food research 2021 Aug;65(15):e2001208
Plasma Exosomes Derived From Patients With End-Stage Renal Disease and Renal Transplant Recipients Have Different Effects on Vascular Calcification.
Lin X, Zhu T, Xu F, Zhong JY, Li F, Shan SK, Wu F, Guo B, Zheng MH, Wang Y, Xu QS, Liao XB, Lu HY, Xie XB, Yuan LQ
Frontiers in cell and developmental biology 2020;8:618228
Frontiers in cell and developmental biology 2020;8:618228
Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin.
Lu R, Zheng Z, Yin Y, Jiang Z
Food & nutrition research 2020;64
Food & nutrition research 2020;64
The effects of binge alcohol exposure on tooth movement and associated root resorption in rats.
Yang F, Wang XX, Li J, Nie FJ, Cui Q, Fu YJ, Zhang J
Alcohol (Fayetteville, N.Y.) 2020 Nov;88:1-9
Alcohol (Fayetteville, N.Y.) 2020 Nov;88:1-9
Glyburide inhibits the bone resorption induced by traumatic occlusion in rats.
Arita Y, Yoshinaga Y, Kaneko T, Kawahara Y, Nakamura K, Ohgi K, Arita S, Ryu T, Takase M, Sakagami R
Journal of periodontal research 2020 Jun;55(3):464-471
Journal of periodontal research 2020 Jun;55(3):464-471
MicroRNA‑21 serves an important role during PAOO‑facilitated orthodontic tooth movement.
Zhang Y, Tian Y, Yang X, Zhao Z, Feng C, Zhang Y
Molecular medicine reports 2020 Jul;22(1):474-482
Molecular medicine reports 2020 Jul;22(1):474-482
Sialic acid-modified chitosan oligosaccharide-based biphasic calcium phosphate promote synergetic bone formation in rheumatoid arthritis therapy.
Xu XL, Shu GF, Wang XJ, Qi J, Jin FY, Shen QY, Ying XY, Ji JS, Du YZ
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:578-590
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:578-590
Gingival crevicular fluid levels of SLIT3 are increased in periodontal disease.
Zhong W, Peng Y, Yue E, Huang B, Zhang W, Zhao Z, Jiang J, Wang Q, Zhao H
Oral diseases 2020 Jan;26(1):182-192
Oral diseases 2020 Jan;26(1):182-192
Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway.
Ma C, Geng B, Zhang X, Li R, Yang X, Xia Y
Medical science monitor : international medical journal of experimental and clinical research 2020 Jan 8;26:e918370
Medical science monitor : international medical journal of experimental and clinical research 2020 Jan 8;26:e918370
Knee loading repairs osteoporotic osteoarthritis by relieving abnormal remodeling of subchondral bone via Wnt/β-catenin signaling.
Zheng W, Ding B, Li X, Liu D, Yokota H, Zhang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):3399-3412
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):3399-3412
Effects Of Triptolide On Tooth Movement And Root Resorption In Rats.
Yang F, Wang XX, Ma D, Cui Q, Zheng H, Liu XC, Zhang J
Drug design, development and therapy 2019;13:3963-3975
Drug design, development and therapy 2019;13:3963-3975
Elevated ATF4 Expression in Odontogenic Keratocysts Epithelia: Potential Involvement in Tissue Hypoxia and Stromal M2 Macrophage Infiltration.
Zhong WQ, Li ZZ, Jiang H, Zou YP, Wang HT, Cai Y, Zhao Y, Zhao JH
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2019 Nov;67(11):801-812
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2019 Nov;67(11):801-812
LOX-1 is involved in TLR2 induced RANKL regulation in peri-implantitis.
Zhang Q, Liu J, Ma L, Bai N, Xu H
International immunopharmacology 2019 Dec;77:105956
International immunopharmacology 2019 Dec;77:105956
Increased level of cell-derived microparticles in the cyst fluids of odontogenic keratocysts.
Man QW, Zhong WQ, Ren JG, Liu JY, Zheng YY, Li RF, Nyimi BF, Chen G, Zhao YF, Liu B
International journal of oncology 2018 Jun;52(6):1863-1874
International journal of oncology 2018 Jun;52(6):1863-1874
β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway.
Wang C, Zhou Y, Guan X, Yu M, Wang H
Toxicology 2018 Feb 1;394:1-10
Toxicology 2018 Feb 1;394:1-10
Role of endoplasmic reticulum stress in disuse osteoporosis.
Li J, Yang S, Li X, Liu D, Wang Z, Guo J, Tan N, Gao Z, Zhao X, Zhang J, Gou F, Yokota H, Zhang P
Bone 2017 Apr;97:2-14
Bone 2017 Apr;97:2-14
Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis.
Li X, Yang J, Liu D, Li J, Niu K, Feng S, Yokota H, Zhang P
Scientific reports 2016 Apr 18;6:24668
Scientific reports 2016 Apr 18;6:24668
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 23408-1-AP( RANKL Antibody) at dilution of 1:700
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RANKL antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human RANKL. This antibody recognizes human antigen. The RANKL antibody has been validated for the following applications: ELISA, WB, IHC analysis.
