66610-1-Ig

antibody from Proteintech Group

Targeting: TNFSF11 CD254, ODF, OPGL, RANKL, TRANCE

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

66610-1-Ig

Provider

Proteintech Group

Product name

RANKL antibody

Antibody type

Monoclonal

Description

KD/KO validated RANKL antibody (Cat. #66610-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3F2E1

Vial size

20ul, 150ul

References

Submitted references

A Cross-Tissue Multiomics Analysis Reveals the Protective Role of TGFBR3 in Postmenopausal Osteoporosis.

Liu Y, Xie C, Yang K, Liu Z, Liu R, Hou X, Xing L, Gao J, Lian Q, Hu Y, Wang Y, Zhang L, Tian F
International journal of genomics 2026;2026:6364895

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Engineering multifunctional microspheres for sequential regulation of osteoimmune microenvironment and bone remodeling balance to promote regeneration of osteoporotic bone defects.

Luo Z, Ma J, Yang Y, Zhang H, Du Y, Dai J, Wang Y, Zhang W, Ma X, Lai Y
Journal of orthopaedic translation 2026 Mar;57:101054

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Piezo1-mediated mechanotransduction regulates diabetic osteoporosis and hyperglycemia via low-intensity pulsed ultrasound.

Cao M, Pang F, Duan X, Sun L, Fan X, Tang L, Ta D
Bone 2026 Jan;202:117664

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Taurine-loaded covalent organic frameworks for alleviating post-radiation bone regeneration disorder.

Chen H, Yang X, Ruan H, Wang X, Zheng M, Zeng G, He Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114492

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Hypoxia enhances osteoblast differentiation via osteoprotegerin upregulation.

Yamaki R, Kajiya H, Tominaga C, Kono Y, Fujita T, Tamaoki S
Journal of oral biosciences 2026 Apr;68(2):100768

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Crosstalk between OPG/RANKL/RANK in bone marrow mesenchymal stem cells and Wnt/b-catenin pathway in prostate cancer cells regulates bone metastasis of prostate cancer.

Ye S, Lin Q, Deng M, Huang S, Mao C, Zhang J, Zhan W, Chen G
Polish journal of pathology : official journal of the Polish Society of Pathologists 2025;76(1):25-37

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Effects of Occlusal Hypofunction on Osteoclastogenesis Induced by Periodontal Ligament Cells.

Takahashi T, Iizuka T
International journal of dentistry 2025;2025:9926168

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Hylotelephium mingjinianum Extract Attenuates Oxidative Stress and Inflammation in Experimental Periodontitis.

Yuan L, Kong C, Shi N, Chen J, Zhang T, Wang X
Journal of inflammation research 2025;18:8263-8276

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Deciphering oligomeric proanthocyanidins' dual osteoprotective mechanisms at single-cell resolution: NR4A1-mediated PTGS2 suppression and β-catenin-Runx2 activation.

Huang L, Sun Y, Zheng Y, Qiu S, Zheng J, Sun C, Chen M, Zheng S, Zeng Y
Frontiers in immunology 2025;16:1679987

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Paederoside, an active metabolite of Paederia scandens, alleviates osteoporosis by modulating Wnt/β-catenin signaling.

Liu Z, He W, Zhang J, Su B, Mu J, Wang X
Frontiers in pharmacology 2025;16:1670279

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Fracture-Induced Immunological Cascades Trigger Rapid Systemic Bone Loss via Osteocyte-Regulated Osteoclastogenesis.

Sun L, Kuang S, Li Y, Wang G, Sun J, Zhou F, Zhang C
ImmunoTargets and therapy 2025;14:849-875

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Th17/IL-17A Drives Alveolar Bone Loss via the JAK/STAT3-RANKL Axis in the Periodontal Ligament.

Lv D, Zhang J, Zhang Y, Zhou Y, Wei W, Zhang L, Xia X, Chen J, Chen Q, Zhang P, Yue Y, Feng X
Oral diseases 2025 Nov 26;

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Adipocyte Deficiency Promotes Early Development of Mammary Gland Alveolar Epithelial Cell.

Xu J, Sun Q, Xu L, Liu L, Liu L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 15;39(21):e71219

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Colla Carapacis et Plastri ameliorates postmenopausal osteoporosis and macrophage immunity by modulating the RANK/RANKL/OPG signaling pathway in ovariectomized rats.

Wan W, Peng Z, Luo J, Luo J, Zhu Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Jul 1;29(4):443-454

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Black tea rich in polygonatum sibiricum polysaccharides inhibits osteoporosis in ovariectomized mice through immune regulation and gut microbiota suppression.

Gao S, Yu Y, Shu J, Yang B, Zhang B, Xu J, Wang Z
Scientific reports 2025 Jul 1;15(1):20701

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Structured Polymers Enable the Sustained Delivery of Glucocorticoids within the Intra-Articular Space.

Crastin A, Martin CS, Suresh S, Davies SP, Kearns D, Parlak A, Adcock H, Filer A, Jones SW, Raza K, Moakes RJ, Grover LM, Hardy RS
Advanced healthcare materials 2025 Feb;14(4):e2403000

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microRNA-576-5p ameliorates dexamethasone-induced BMSC injury by suppressing ANXA2.

Zhang Y, Deng Y, Yao W, Xia K, Zhang L, Wang G
Scientific reports 2025 Aug 20;15(1):30612

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Zinc Glycine supplementation improves bone quality in meat geese by modulating gut microbiota, SCFA's, and gut barrier function through Wnt10b/NF-κB axis.

Zulfiqar Z, Asif MA, Liu M, Zhang S, Naeini HRR, Cui Y, Liu B, Shi Y
Poultry science 2025 Apr;104(4):104925

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Platelet-rich plasma ameliorates cartilage degradation in rat models of osteoarthritis via the OPG/RANKL/RANK system.

Wu Q, Yao X, Shan N, Cai Y, Fan Y
Folia histochemica et cytobiologica 2024;62(3):154-164

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Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.

Xiang L, Pan W, Chen H, Du W, Xie S, Liang X, Yang F, Niu R, Huang C, Luo M, Xu Y, Geng L, Gong S, Xu W, Zhao J
Mediators of inflammation 2024;2024:7524314

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Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss.

Lewis JW, Frost K, Neag G, Wahid M, Finlay M, Northall EH, Abudu O, Kemble S, Davis ET, Powell E, Palmer C, Lu J, Rainger GE, Iqbal AJ, Chimen M, Mahmood A, Jones SW, Edwards JR, Naylor AJ, McGettrick HM
Cell reports. Medicine 2024 May 21;5(5):101574

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Gut microbial alterations in arginine metabolism determine bone mechanical adaptation.

Wang D, Cai J, Pei Q, Yan Z, Zhu F, Zhao Z, Liu R, Guo X, Sun T, Liu J, Tian Y, Liu H, Shao X, Huang J, Hao X, Chang Q, Luo Z, Jing D
Cell metabolism 2024 Jun 4;36(6):1252-1268.e8

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Role of Piezo1 in modulating the RANKL/OPG ratio in mouse osteoblast cells exposed to Porphyromonas gingivalis lipopolysaccharide and mechanical stress.

Uchinuma M, Taketani Y, Kanaya R, Yamane Y, Shiota K, Suzuki R, Ishii M, Inomata M, Hayashi J, Shin K
Journal of periodontal research 2024 Aug;59(4):749-757

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KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement.

Tan K, Wang J, Su X, Zheng Y, Li W
Progress in orthodontics 2024 Aug 12;25(1):29

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Effect of periostin on bone metabolic and autophagy factors during tooth eruption in mice.

Qin H, Cai J
Open life sciences 2023;18(1):20220663

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Gut microbiota deficiency ameliorates multiple myeloma and myeloma-related bone disease by Th17 cells in mice models.

Liu J, Xie F, Yi ZG, Ma T, Tie WT, Li YH, Bai J, Zhang LS
Journal of Cancer 2023;14(17):3191-3202

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RANK promotes colorectal cancer migration and invasion by activating the Ca(2+)-calcineurin/NFATC1-ACP5 axis.

Liang Q, Wang Y, Lu Y, Zhu Q, Xie W, Tang N, Huang L, An T, Zhang D, Yan A, Liu S, Ye L, Zhu C
Cell death & disease 2021 Apr 1;12(4):336