Antibody data
- Antibody Data
- Antigen structure
- References [29]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- NB100-56512 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-56512, RRID:AB_839050
- Product name
- Mouse Monoclonal TRANCE/TNFSF11/RANK L Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Intermittent hypoxia retards mandibular growth and alters RANKL expression in adolescent and juvenile rats.
Spatiotemporal characterization of microdamage accumulation and its targeted remodeling mechanisms in diabetic fatigued bone.
Baicalin inhibits root resorption during tooth movement in a rodent model.
Role of interleukin-33 in the clinical pathogenesis of chronic apical periodontitis.
Effect of high-frequency near-infrared diode laser irradiation on periodontal tissues during experimental tooth movement in rats.
RANKL-mediated osteoclastogenic differentiation of macrophages in the abdominal aorta of angiotensin II-infused apolipoprotein E knockout mice.
HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression.
Increased calcification in osteoprotegerin-deficient smooth muscle cells: Dependence on receptor activator of NF-κB ligand and interleukin 6.
Involvement of ERK and p38 MAPK pathways on Interleukin-33-induced RANKL expression in osteoblastic cells.
The effect of dose on rhBMP-2 signaling, delivered via collagen sponge, on osteoclast activation and in vivo bone resorption.
Convergent RANK- and c-Met-mediated signaling components predict survival of patients with prostate cancer: an interracial comparative study.
Lesional infiltration of receptor activator of nuclear factor-κB ligand⁺ cells in experimental autoimmune neuritis rats.
T regulatory cells and related immunoregulatory factors in polymorphic light eruption following ultraviolet A1 challenge.
Denosumab treatment for fibrous dysplasia.
Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer.
The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone invasion by oral squamous cell carcinoma cells.
Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T-cell leukemia.
Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol.
Expression of cathepsin K and matrix metalloproteinase 1 indicate persistent osteodestructive activity in long-standing ankylosing spondylitis.
Ameloblastoma induces osteoclastogenesis: a possible role of ameloblastoma in expanding in the bone.
Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis.
Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression.
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors.
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors.
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
Hong H, Hosomichi J, Maeda H, Lekvijittada K, Oishi S, Ishida Y, Usumi-Fujita R, Kaneko S, Suzuki JI, Yoshida KI, Ono T
European journal of orthodontics 2020 Mar 27;
European journal of orthodontics 2020 Mar 27;
Spatiotemporal characterization of microdamage accumulation and its targeted remodeling mechanisms in diabetic fatigued bone.
Liu X, Li W, Cai J, Yan Z, Shao X, Xie K, Guo XE, Luo E, Jing D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2579-2594
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2579-2594
Baicalin inhibits root resorption during tooth movement in a rodent model.
Kunimatsu R, Kimura A, Tsuka Y, Horie K, Yoshimi Y, Awada T, Gunji H, Abe T, Nakajima K, Sakata S, Nakatani A, Tanimoto K
Archives of oral biology 2020 Aug;116:104770
Archives of oral biology 2020 Aug;116:104770
Role of interleukin-33 in the clinical pathogenesis of chronic apical periodontitis.
Gegen T, Zhu Y, Sun Q, Hou B
The Journal of international medical research 2019 Jul;47(7):3332-3343
The Journal of international medical research 2019 Jul;47(7):3332-3343
Effect of high-frequency near-infrared diode laser irradiation on periodontal tissues during experimental tooth movement in rats.
Gunji H, Kunimatsu R, Tsuka Y, Yoshimi Y, Sumi K, Awada T, Nakajima K, Kimura A, Hiraki T, Hirose N, Yanoshita M, Tanimoto K
Lasers in surgery and medicine 2018 Feb 5;
Lasers in surgery and medicine 2018 Feb 5;
RANKL-mediated osteoclastogenic differentiation of macrophages in the abdominal aorta of angiotensin II-infused apolipoprotein E knockout mice.
Tanaka T, Kelly M, Takei Y, Yamanouchi D
Journal of vascular surgery 2018 Dec;68(6S):48S-59S.e1
Journal of vascular surgery 2018 Dec;68(6S):48S-59S.e1
HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression.
Shao J, Zhang Y, Yang T, Qi J, Zhang L, Deng L
In vitro cellular & developmental biology. Animal 2015 Sep;51(8):808-14
In vitro cellular & developmental biology. Animal 2015 Sep;51(8):808-14
Increased calcification in osteoprotegerin-deficient smooth muscle cells: Dependence on receptor activator of NF-κB ligand and interleukin 6.
Callegari A, Coons ML, Ricks JL, Rosenfeld ME, Scatena M
Journal of vascular research 2014;51(2):118-31
Journal of vascular research 2014;51(2):118-31
Involvement of ERK and p38 MAPK pathways on Interleukin-33-induced RANKL expression in osteoblastic cells.
Mine Y, Makihira S, Yamaguchi Y, Tanaka H, Nikawa H
Cell biology international 2014 May;38(5):655-62
Cell biology international 2014 May;38(5):655-62
The effect of dose on rhBMP-2 signaling, delivered via collagen sponge, on osteoclast activation and in vivo bone resorption.
Kim RY, Oh JH, Lee BS, Seo YK, Hwang SJ, Kim IS
Biomaterials 2014 Feb;35(6):1869-81
Biomaterials 2014 Feb;35(6):1869-81
Convergent RANK- and c-Met-mediated signaling components predict survival of patients with prostate cancer: an interracial comparative study.
Hu P, Chung LW, Berel D, Frierson HF, Yang H, Liu C, Wang R, Li Q, Rogatko A, Zhau HE
PloS one 2013;8(9):e73081
PloS one 2013;8(9):e73081
Lesional infiltration of receptor activator of nuclear factor-κB ligand⁺ cells in experimental autoimmune neuritis rats.
Yin Y, Schluesener HJ, Zhang ZY, Zhang Z
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013 Jun;34(6):905-9
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013 Jun;34(6):905-9
T regulatory cells and related immunoregulatory factors in polymorphic light eruption following ultraviolet A1 challenge.
Gambichler T, Terras S, Kampilafkos P, Kreuter A, Skrygan M
The British journal of dermatology 2013 Dec;169(6):1288-94
The British journal of dermatology 2013 Dec;169(6):1288-94
Denosumab treatment for fibrous dysplasia.
Boyce AM, Chong WH, Yao J, Gafni RI, Kelly MH, Chamberlain CE, Bassim C, Cherman N, Ellsworth M, Kasa-Vubu JZ, Farley FA, Molinolo AA, Bhattacharyya N, Collins MT
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 Jul;27(7):1462-70
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 Jul;27(7):1462-70
Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer.
Hu P, Chu GC, Zhu G, Yang H, Luthringer D, Prins G, Habib F, Wang Y, Wang R, Chung LW, Zhau HE
PloS one 2011;6(12):e28670
PloS one 2011;6(12):e28670
The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone invasion by oral squamous cell carcinoma cells.
Shin M, Matsuo K, Tada T, Fukushima H, Furuta H, Ozeki S, Kadowaki T, Yamamoto K, Okamoto M, Jimi E
Carcinogenesis 2011 Nov;32(11):1634-40
Carcinogenesis 2011 Nov;32(11):1634-40
Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T-cell leukemia.
Parrula C, Zimmerman B, Nadella P, Shu S, Rosol T, Fernandez S, Lairmore M, Niewiesk S
Veterinary pathology 2009 Sep;46(5):1003-14
Veterinary pathology 2009 Sep;46(5):1003-14
Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol.
Ghoreishi M, Bach P, Obst J, Komba M, Fleet JC, Dutz JP
Journal of immunology (Baltimore, Md. : 1950) 2009 May 15;182(10):6071-8
Journal of immunology (Baltimore, Md. : 1950) 2009 May 15;182(10):6071-8
Expression of cathepsin K and matrix metalloproteinase 1 indicate persistent osteodestructive activity in long-standing ankylosing spondylitis.
Neidhart M, Baraliakos X, Seemayer C, Zelder C, Gay RE, Michel BA, Boehm H, Gay S, Braun J
Annals of the rheumatic diseases 2009 Aug;68(8):1334-9
Annals of the rheumatic diseases 2009 Aug;68(8):1334-9
Ameloblastoma induces osteoclastogenesis: a possible role of ameloblastoma in expanding in the bone.
Sandra F, Hendarmin L, Kukita T, Nakao Y, Nakamura N, Nakamura S
Oral oncology 2005 Jul;41(6):637-44
Oral oncology 2005 Jul;41(6):637-44
Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis.
Rubin J, Chung LW, Fan X, Zhu L, Murphy TC, Nanes MS, Rosen CJ
The Prostate 2004 Jan 1;58(1):41-9
The Prostate 2004 Jan 1;58(1):41-9
Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.
Niida S, Kawahara M, Ishizuka Y, Ikeda Y, Kondo T, Hibi T, Suzuki Y, Ikeda K, Taniguchi N
The Journal of biological chemistry 2004 Feb 13;279(7):5752-6
The Journal of biological chemistry 2004 Feb 13;279(7):5752-6
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression.
Pearse RN, Sordillo EM, Yaccoby S, Wong BR, Liau DF, Colman N, Michaeli J, Epstein J, Choi Y
Proceedings of the National Academy of Sciences of the United States of America 2001 Sep 25;98(20):11581-6
Proceedings of the National Academy of Sciences of the United States of America 2001 Sep 25;98(20):11581-6
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.
Fiumara P, Snell V, Li Y, Mukhopadhyay A, Younes M, Gillenwater AM, Cabanillas F, Aggarwal BB, Younes A
Blood 2001 Nov 1;98(9):2784-90
Blood 2001 Nov 1;98(9):2784-90
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.
Fiumara P, Snell V, Li Y, Mukhopadhyay A, Younes M, Gillenwater AM, Cabanillas F, Aggarwal BB, Younes A
Blood 2001 Nov 1;98(9):2784-90
Blood 2001 Nov 1;98(9):2784-90
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors.
Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, Matsuoka M, Yamamoto G, Hishikawa T, Noguchi T, Yoshikai Y
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):3574-9
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):3574-9
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors.
Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, Matsuoka M, Yamamoto G, Hishikawa T, Noguchi T, Yoshikai Y
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):3574-9
Journal of immunology (Baltimore, Md. : 1950) 2001 Mar 1;166(5):3574-9
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ
Proceedings of the National Academy of Sciences of the United States of America 1999 Mar 30;96(7):3540-5
Proceedings of the National Academy of Sciences of the United States of America 1999 Mar 30;96(7):3540-5
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ
Proceedings of the National Academy of Sciences of the United States of America 1999 Mar 30;96(7):3540-5
Proceedings of the National Academy of Sciences of the United States of America 1999 Mar 30;96(7):3540-5
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: TRANCE/TNFSF11/RANK L Antibody (12A668) [NB100-56512] - Analysis using Azide Free version of NB100-56512. Human lymph node lysate (35ug per lane, RIPA buffer). Band detected at ~35kDa and ~28kDa. (Expected MW of 35.5kDa according to NP_003692.1 and of 27.7kDa according to NP_143026.1)
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: TRANCE/TNFSF11/RANK L Antibody (12A668) [NB100-56512] - Analysis of transfected cell lysate was probed with TRANCE/TNFSF11/RANK L antibody.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody (12A668) [NB100-56512] - Analysis using Azide Free version of NB100-56512. FFPE human lymph node probed with TRANCE/TNFSF11/RANK L antibody.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody (12A668) [NB100-56512] - Analysis using Azide Free version of NB100-56512. FFPE human liver stained with TRANCE/TNFSF11/RANK L antibody, peroxidase-conjugate and DAB chromogen. A 2 hr incubation at RT was used.