20566-1-AP
antibody from Proteintech Group
Targeting: DDX58
DKFZp434J1111, FLJ13599, RIG-1, RIG-I, RIG1
Antibody data
- Antibody Data
- Antigen structure
- References [86]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
Submit
Validation data
Reference
Comment
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- Product number
- 20566-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20566-1-AP, RRID:AB_10700006
- Product name
- RIG-1/DDX58 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RIG-1/DDX58 antibody (Cat. #20566-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TGEV activates RIG-I/IFN-β/STAT1 axis to promote NLRC5-mediated SLA-I upregulation.
Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State.
The segmented flavivirus ALSV-encoded nucleoprotein VP2 inhibits type I interferon production by targeting RIG-I.
A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling.
PEDV infection induces ferroptosis in Vero cells via an ACSL4-mediated lipid peroxidation pathway.
RNF213 Is an Interferon-Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection.
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
Sec8: a novel positive regulator of RIG-I in anti-RNA viral defense.
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Targeting G9a Exerts Pleiotropic Suppression in Triple-Negative Breast Cancer Cells: Cooperatively Inducing Pyroptosis and Apoptosis.
Calycosin inhibits porcine reproductive and respiratory syndrome virus replication and activates RIG-I/IRF3 signaling pathway.
Ipriflavone Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection via RIG-I/IRF3-Mediated Interferon Signaling.
Reprogramming Iron Metabolism via the RIG-I/c-Myc/FTH Axis Mitigates Renal Ischemia-Reperfusion Injury.
SSBP1 promotes bovine ephemeral fever virus replication by antagonizing antiviral immune responses via degrading MAVS.
API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs.
Nuclear receptor ESRRA promotes ERα-positive breast cancer through dual action on super enhancers and promoters to regulate gene transcriptional programs.
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury.
Diverse strategies utilized by coronaviruses to evade antiviral responses and suppress pyroptosis.
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
IDR-driven TOLLIP condensates antagonize the innate antiviral immunity by promoting the deSUMOylation of MAVS.
The P132H mutation of SARS-CoV-2 NSP5 relieves its inhibition on interferon-β activation via blocking MAVS degradation.
Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation.
Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus.
m6A methyltransferase METTL3 promotes non-small-cell lung carcinoma progression by inhibiting the RIG-I-MAVS innate immune pathway.
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication.
ZIKV infection causes placental inflammation through activating PANoptosis.
Mitochondrial RNA cytosolic leakage drives the SASP.
miR-30a enhanced RIG-I-mediated type I interferon antiviral response by targeting USP14.
Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma.
BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly.
NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
REXO2 up-regulation is positively correlated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma.
Hyperacetylated microtubules assist porcine deltacoronavirus nsp8 to degrade MDA5 via SQSTM1/p62-dependent selective autophagy.
Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Transmissible gastroenteritis virus induces inflammatory responses via RIG-I/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo.
Comparison of Neuroinflammation Induced by Hyperphosphorylated Tau Protein Versus Ab42 in Alzheimer's Disease.
Glaesserella parasuis serotype 5 induces pyroptosis via the RIG-I/MAVS/NLRP3 pathway in swine tracheal epithelial cells.
Nsp10-interacting host protein SAP18 restricts PEDV replication in Marc-145 cells via enhancing dephosphorylation of RIG-I.
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
miR-26a exerts broad-spectrum antiviral effects via the enhancement of RIG-I-mediated type I interferon response by targeting USP15.
Ro 90-7501 suppresses colon cancer progression by inducing immunogenic cell death and promoting RIG-1-mediated autophagy.
Mitochondrial RNA cytosolic leakage drives the SASP.
PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8(+)T cells.
Therapeutic efficacy of a novel self-assembled immunostimulatory siRNA combining apoptosis promotion with RIG-I activation in gliomas.
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis.
Label-free quantitative proteomic analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii.
Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity.
RIG-I promotes cell proliferation in esophageal squamous cell carcinoma by facilitating p21 degradation.
Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.
Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells.
TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination.
Prediction and Verification of Curcumin as a Potential Drug for Inhibition of PDCoV Replication in LLC-PK1 Cells.
Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses.
The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I-Mediated Immune Response.
The differential expression of toll like receptors and RIG-1 in the placenta of neonates with in utero infections.
Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation.
The differential expression of toll like receptors and RIG-1 correlates to the severity of infectious diseases.
ARIH1 inhibits influenza A virus replication and facilitates RIG-I dependent immune signaling by interacting with SQSTM1/p62.
Activation of DDX58/RIG‑I suppresses the growth of tumor cells by inhibiting STAT3/CSE signaling in colon cancer.
Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy.
Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME.
STING1 is essential for an RNA-virus triggered autophagy.
Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages.
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
The natural compound Cirsitakaoside enhances antiviral innate responses against vesicular stomatitis virus in vitro and in vivo.
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
Butyrate Reprograms Expression of Specific Interferon-Stimulated Genes.
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Wang W, Ma M, Bai H, Sun Y, Liu B, Gao A, Pan Q, Zheng D, Li M, Jiang W, Ma S, Wei Z, Zhang H, Zheng L
Veterinary research 2026 Mar 9;57(1)
Veterinary research 2026 Mar 9;57(1)
Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State.
Solotchi M, Jing H, Gebauer E, Novick SJ, Pascal BD, Tung W, Hanpude P, Madura T, Zhang Y, Alba C, Saracino A, Laghetti P, Shaw ER, Rosen LB, Holland SM, Lisco A, Dalgard CL, Marcotrigiano J, Griffin PR, Su HC, Patel SS
medRxiv : the preprint server for health sciences 2026 Mar 6;
medRxiv : the preprint server for health sciences 2026 Mar 6;
The segmented flavivirus ALSV-encoded nucleoprotein VP2 inhibits type I interferon production by targeting RIG-I.
Pan M, Song Z, Wang M, Zhao M, Fang S, Jin F, Tan Q, Xu W, Che L, Liu N, Sui L, Liu Q, Hou Z, Zhao Y
Microbiology spectrum 2026 Mar 3;14(3):e0248425
Microbiology spectrum 2026 Mar 3;14(3):e0248425
A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling.
Han K, Chang Z, Li N, Xiao D, Song M, Wang T, Guo K, Zhang L, Deng W
Journal of virology 2026 Mar 24;100(3):e0006926
Journal of virology 2026 Mar 24;100(3):e0006926
PEDV infection induces ferroptosis in Vero cells via an ACSL4-mediated lipid peroxidation pathway.
Weng Q, Li Y, Wei Y, Wang S, Hu T, Pei Z, Wang K, Hu G
Archives of virology 2026 Mar 18;171(4)
Archives of virology 2026 Mar 18;171(4)
RNF213 Is an Interferon-Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection.
Li H, Zhang Y, Wang J, Zhang Q, Sun H, Wei F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 18;:e11012
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 18;:e11012
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
Du J, Li C, Zhang J, Luo J, Zhang H, Chen H, Li X, Qian P
Cell & bioscience 2026 Jan 4;16(1):13
Cell & bioscience 2026 Jan 4;16(1):13
Sec8: a novel positive regulator of RIG-I in anti-RNA viral defense.
Wang L, Ma W, Hou P, Jin R, Wei X, Li X, He DC, Wang H, He H
Cell death & disease 2026 Jan 24;17(1):165
Cell death & disease 2026 Jan 24;17(1):165
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Xu G, Guo F, He C, Wang X, Xiang B, Fan L, Chen B, Peng J, Sun Y, Shi J, Xing X, Yao Y, Dai P, Li H, Xiong W, Liu H, Xiao R, Qing G, Jiang C, Jiang B, Lei X, Zhang J
Nature cancer 2026 Feb;7(2):283-303
Nature cancer 2026 Feb;7(2):283-303
Targeting G9a Exerts Pleiotropic Suppression in Triple-Negative Breast Cancer Cells: Cooperatively Inducing Pyroptosis and Apoptosis.
Li J, Zhang G, Liu T, Yan X, Ma M
Biomolecules 2026 Feb 25;16(3)
Biomolecules 2026 Feb 25;16(3)
Calycosin inhibits porcine reproductive and respiratory syndrome virus replication and activates RIG-I/IRF3 signaling pathway.
Chang Y, Li Z, Wang M, Pei K, Chang X, Ma J
Frontiers in veterinary science 2025;12:1674259
Frontiers in veterinary science 2025;12:1674259
Ipriflavone Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection via RIG-I/IRF3-Mediated Interferon Signaling.
Chang Y, Li Z, Pei K, Wang M, Chang X
Animals : an open access journal from MDPI 2025 Sep 29;15(19)
Animals : an open access journal from MDPI 2025 Sep 29;15(19)
Reprogramming Iron Metabolism via the RIG-I/c-Myc/FTH Axis Mitigates Renal Ischemia-Reperfusion Injury.
Zhang Y, Xing J, Yao L, Zou Y, Peng H, Yi X, Bai L, Yu Y, Liu H, Li X, Zhai X
Antioxidants & redox signaling 2025 Oct;43(10-12):622-636
Antioxidants & redox signaling 2025 Oct;43(10-12):622-636
SSBP1 promotes bovine ephemeral fever virus replication by antagonizing antiviral immune responses via degrading MAVS.
Li X, Song X, Ma X, Ma W, Gao S, Shi L, Yao X, Chu F, Wang H, He H
Veterinary microbiology 2025 Oct;309:110684
Veterinary microbiology 2025 Oct;309:110684
API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs.
Deng T, Xu J, Qin L, Wang X, Lu C, Huang Y, Liu D, Yan Y, Dong W, Xu P, Zhou J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e05479
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e05479
Nuclear receptor ESRRA promotes ERα-positive breast cancer through dual action on super enhancers and promoters to regulate gene transcriptional programs.
Zheng ZZ, Chen L, Hu GS, Peng BL, Huang QX, Wang A, Wang C, Liu W
Science bulletin 2025 Nov 30;70(22):3822-3839
Science bulletin 2025 Nov 30;70(22):3822-3839
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
Song H, Li ZW, Xie YT, Tang X, Hu YT, Tan Y, Huang Y, Cheng YL, Pei G, Kuang M
International immunopharmacology 2025 Nov 14;165:115446
International immunopharmacology 2025 Nov 14;165:115446
Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury.
Cui J, Deng Y, Li X, Gao L, Li J, Li Z, Qu H, Chu Y, Gu Y, Meng M, Li R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156573
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156573
Diverse strategies utilized by coronaviruses to evade antiviral responses and suppress pyroptosis.
Fu X, Xu W, Yang Y, Li D, Shi W, Li X, Chen N, Lv Q, Shi Y, Xu J, Xu J, Yan Y, Shi F, Li X
International journal of biological macromolecules 2025 Mar;296:139743
International journal of biological macromolecules 2025 Mar;296:139743
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
Xu J, Ren Y, Lu J, Qin F, Yang D, Tang C, Yang Y, Xu J, Liu T, Yi P
Clinical and translational medicine 2025 Mar;15(3):e70249
Clinical and translational medicine 2025 Mar;15(3):e70249
IDR-driven TOLLIP condensates antagonize the innate antiviral immunity by promoting the deSUMOylation of MAVS.
Hou J, Zheng S, Zhang X, Zhuang M, Zhao X, Deng J, Yang H, Xia X, Gao C, Wang PH, Zheng Y
Cell reports 2025 Mar 25;44(3):115348
Cell reports 2025 Mar 25;44(3):115348
The P132H mutation of SARS-CoV-2 NSP5 relieves its inhibition on interferon-β activation via blocking MAVS degradation.
Zhang Y, Wang TY, Yan H, Guo Z, Lian Z, Yao H, Yuan S, Ge XY, Qiu Y
Cellular and molecular life sciences : CMLS 2025 Jul 30;82(1):293
Cellular and molecular life sciences : CMLS 2025 Jul 30;82(1):293
Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation.
Zhu Z, Chen L, Zhang M, Lin Q, Yan Y, Wang W, Wen W, Zhang Z, Li X
Veterinary research 2025 Jul 3;56(1):136
Veterinary research 2025 Jul 3;56(1):136
Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus.
Lin D, Tang C, Wang J, Yang Y, Yang H, Zhou Y, Yu W, Li B, Huang Q, Wang H, An R, Liang X, Yan Y, Yuan L, Du X, Yuan Y, Li Y, Lu S
MedComm 2025 Jan;6(1):e70013
MedComm 2025 Jan;6(1):e70013
m6A methyltransferase METTL3 promotes non-small-cell lung carcinoma progression by inhibiting the RIG-I-MAVS innate immune pathway.
Huang T, Ao X, Liu J, Sun C, Dong Y, Yin X, Zhang Y, Wang X, Li W, Cao J, Pan F, Hu Z, Guo Z, He L
Translational oncology 2025 Jan;51:102230
Translational oncology 2025 Jan;51:102230
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication.
Liu S, Luo A, Que T, Liang Y, Song Y, Liu T, Li J, Li N, Zhang Z, Liu Y, Zhang Z, Zhou Y, Wang X, Zhu Z
Antiviral research 2025 Jan;233:106054
Antiviral research 2025 Jan;233:106054
ZIKV infection causes placental inflammation through activating PANoptosis.
Zhang S, Chen D, Zhang K, Liu M, Liang H, Liang L, Liang J, Liang M, An S, Lyu M, Zhu J, Li S, Hu D, Zhu X, Wu J, He Z, Li M
Journal of virology 2025 Dec 23;99(12):e0175925
Journal of virology 2025 Dec 23;99(12):e0175925
Mitochondrial RNA cytosolic leakage drives the SASP.
Victorelli S, Eppard M, Martini H, Woo SH, Everts SPA, Lee G, Pirius N, Han N, Liang EY, Franco AC, Han Y, Saul D, Nóvoa E, Nogueiras R, Splinter PL, O'Hara SP, Morgenthaler O, Valenzuela-Pérez L, Kim Lee HS, Jurk D, LaRusso NF, Hirsova P, Passos JF
Nature communications 2025 Dec 15;16(1):10992
Nature communications 2025 Dec 15;16(1):10992
miR-30a enhanced RIG-I-mediated type I interferon antiviral response by targeting USP14.
Zhang J, Wang Y, Sun N, Zou B, Wang Z, Yin H, Xie J, Xia B, Sun N
Microbiology spectrum 2025 Aug 5;13(8):e0018825
Microbiology spectrum 2025 Aug 5;13(8):e0018825
Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma.
Jiao M, Pirozzi CJ, Yu C, Bao X, Hu M, Pan D, Littleton S, Reynolds N, Saban DR, Li F, Li CY
Cancer research 2024 Nov 4;84(21):3640-3656
Cancer research 2024 Nov 4;84(21):3640-3656
BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly.
Zhou Y, Li T, Zhang Y, Zhang N, Guo Y, Gao X, Peng W, Shu S, Zhao C, Cui D, Sun H, Sun Y, Liu J, Tang J, Zhang R, Pu J
PLoS pathogens 2024 Mar;20(3):e1012110
PLoS pathogens 2024 Mar;20(3):e1012110
NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
Zhu J, Li J, Yang K, Chen Y, Wang J, He Y, Shen K, Wang K, Shi T, Chen W
Cancer letters 2024 Mar 31;585:216693
Cancer letters 2024 Mar 31;585:216693
REXO2 up-regulation is positively correlated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma.
Zhang T, Zhang R, Zhang Z, Li D, Guo X, Zhang Z, Zhu X, Tan S
International immunopharmacology 2024 Mar 30;130:111740
International immunopharmacology 2024 Mar 30;130:111740
Hyperacetylated microtubules assist porcine deltacoronavirus nsp8 to degrade MDA5 via SQSTM1/p62-dependent selective autophagy.
Li Z, Lai Y, Qiu R, Tang W, Ren J, Xiao S, Fang P, Fang L
Journal of virology 2024 Mar 19;98(3):e0000324
Journal of virology 2024 Mar 19;98(3):e0000324
Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Wu B, Li D, Bai H, Mo R, Li H, Xie J, Zhang X, Yang Y, Li H, Idris A, Li X, Feng R
Molecular immunology 2024 Jun;170:131-143
Molecular immunology 2024 Jun;170:131-143
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Li D, Mo R, Li X, Cheng R, Xie J, Li H, Yang Y, Li S, Li H, Yan Z, Wei S, Idris A, Li X, Feng R
mSphere 2024 Jun 25;9(6):e0023624
mSphere 2024 Jun 25;9(6):e0023624
Transmissible gastroenteritis virus induces inflammatory responses via RIG-I/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo.
Zhang Y, Yang N, Li Y, Tan C, Cai Y, Rui X, Liu Y, Fu Y, Liu G
Journal of virology 2024 Jun 13;98(6):e0046124
Journal of virology 2024 Jun 13;98(6):e0046124
Comparison of Neuroinflammation Induced by Hyperphosphorylated Tau Protein Versus Ab42 in Alzheimer's Disease.
Rice M, Nuovo GJ, Sawant D, Mishra A, Tili E
Molecular neurobiology 2024 Jul;61(7):4589-4601
Molecular neurobiology 2024 Jul;61(7):4589-4601
Glaesserella parasuis serotype 5 induces pyroptosis via the RIG-I/MAVS/NLRP3 pathway in swine tracheal epithelial cells.
Li Y, Guo M, Wang Q, Zhou H, Wu W, Lin H, Fan H
Veterinary microbiology 2024 Jul;294:110127
Veterinary microbiology 2024 Jul;294:110127
Nsp10-interacting host protein SAP18 restricts PEDV replication in Marc-145 cells via enhancing dephosphorylation of RIG-I.
Yang N, Zhang Q, Wang Q, Zhang Y, Li S, Zhao Y, Shi X, Li Q, Xu X
Veterinary microbiology 2024 Jul;294:110124
Veterinary microbiology 2024 Jul;294:110124
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Ming S, Zhang S, Xing J, Yang G, Zeng L, Wang J, Chu B
iScience 2024 Jul 19;27(7):110144
iScience 2024 Jul 19;27(7):110144
miR-26a exerts broad-spectrum antiviral effects via the enhancement of RIG-I-mediated type I interferon response by targeting USP15.
Zhang J, Li C, Hou Y, Liu D, Li Q, Wang Z, Tang R, Zheng K, Guo H, Wang W
Microbiology spectrum 2024 Jan 11;12(1):e0312423
Microbiology spectrum 2024 Jan 11;12(1):e0312423
Ro 90-7501 suppresses colon cancer progression by inducing immunogenic cell death and promoting RIG-1-mediated autophagy.
Zhao X, Zhang Z, Wang J, Feng S, Jiang L, Chen L, Lei K, Wang T
International immunopharmacology 2024 Dec 25;143(Pt 3):113631
International immunopharmacology 2024 Dec 25;143(Pt 3):113631
Mitochondrial RNA cytosolic leakage drives the SASP.
Victorelli S, Eppard M, Woo SH, Everts SPA, Martini H, Pirius N, Franco AC, Han Y, Saul D, Splinter PL, O'Hara SP, Valenzuela-Pérez L, Lee HSK, Jurk D, LaRusso NF, Hirsova P, Passos JF
Research square 2024 Aug 27;
Research square 2024 Aug 27;
PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8(+)T cells.
Liu SS, Bai TT, Que TL, Luo A, Liang YX, Song YX, Liu TY, Chen JW, Li J, Li N, Zhang ZC, Chen NN, Liu Y, Zhang ZC, Zhou YL, Wang X, Zhu ZB
Veterinary microbiology 2024 Apr;291:110034
Veterinary microbiology 2024 Apr;291:110034
Therapeutic efficacy of a novel self-assembled immunostimulatory siRNA combining apoptosis promotion with RIG-I activation in gliomas.
Chen J, Liu Z, Fang H, Su Q, Fan Y, Song L, He S
Journal of translational medicine 2024 Apr 29;22(1):395
Journal of translational medicine 2024 Apr 29;22(1):395
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
Zheng C, Wang J, Zhou Y, Duan Y, Zheng R, Xie Y, Wei X, Wu J, Shen H, Ye M, Kong B, Liu Y, Xu P, Zhang Q, Liang T
Cell reports 2024 Apr 23;43(4):114088
Cell reports 2024 Apr 23;43(4):114088
Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis.
Luo X, Ji R, Liu Q, Xiao X, Song W, An H, Li Y, Zhou J
Journal of innate immunity 2023;15(1):380-396
Journal of innate immunity 2023;15(1):380-396
Label-free quantitative proteomic analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii.
Xie H, Sun H, Dong H, Dai L, Xu H, Zhang L, Wang Q, Zhang J, Zhao G, Xu C, Yin K
PLoS neglected tropical diseases 2023 Sep;17(9):e0011102
PLoS neglected tropical diseases 2023 Sep;17(9):e0011102
Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity.
Zhang YG, Zhang HX, Chen HW, Lv P, Su J, Chen YR, Fu ZF, Cui M
Journal of neuroinflammation 2023 Sep 27;20(1):216
Journal of neuroinflammation 2023 Sep 27;20(1):216
RIG-I promotes cell proliferation in esophageal squamous cell carcinoma by facilitating p21 degradation.
Wang M, Zhang Y, Gao L, Zhang H, Yang Z, Liu J, Shan W, Zeng L, Zhang R, Li Y, Liu J
Medical oncology (Northwood, London, England) 2023 Sep 1;40(10):288
Medical oncology (Northwood, London, England) 2023 Sep 1;40(10):288
Naringenin Improves Innate Immune Suppression after PRRSV Infection by Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.
Yu J, Shi H, Song K, Yang Y, Li X, Peng L, Fu B, Yi P
Viruses 2023 Oct 29;15(11)
Viruses 2023 Oct 29;15(11)
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection.
Zhang MQ, Jia X, Cheng CQ, Wang YX, Li YY, Kong LD, Li QQ, Xie F, Yu YL, He YT, Dong QT, Jia ZH, Wang Y, Xu AL
Acta pharmacologica Sinica 2023 Nov;44(11):2253-2264
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 20566-1-AP(DDX58 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunofluorescent analysis of HepG2 cells, using DDX58 antibody 20566-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line