WDR49

This gene encodes a member of the WD repeat protein family with nine WD repeats. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Description

WD repeat domain 49

Tissue specificity

Group enriched (brain, choroid plexus, fallopian tube)

Subcell location

Nucleoplasm, Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

3 (167478684 - 167653983)

Ensembl ID

ENSG00000174776  (ver. 103.38)

Orthologs

Mouse Wdr49: ENSMUSG00000104301

UniProt

Q8IV35

neXtProt

NX_Q8IV35

Human splice variants
Mouse splice variants

Protein structure