DPH5

This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Diphthamide biosynthesis 5

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Golgi apparatus

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (100989623 - 101026088)

Ensembl ID

ENSG00000117543  (ver. 103.38)

Orthologs

Mouse Dph5: ENSMUSG00000033554

UniProt

Q9H2P9

neXtProt

NX_Q9H2P9

Human splice variants
Mouse splice variants

Protein structure