Antibody data
- Antibody Data
- Antigen structure
- References [40]
- Comments [0]
- Validations [0]
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- Product number
- 66776-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- MFN1 antibody
- Antibody type
- Monoclonal
- Description
- MFN1 antibody (Cat. #66776-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3F11C11
- Vial size
- 20ul, 150ul
Submitted references Dendrobium officinale polysaccharides alleviate atopic dermatitis in vivo and in vitro through inhibition of inflammation and mitochondrial dysfunction.
CtBP1 sustains activity-dependent muscle properties and dampens synaptic, contractile and metabolic changes triggered by denervation.
Icariin inhibits autophagy and promotes apoptosis by regulating mitochondrial division in Triple-negative breast cancer.
The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.
Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeting Drp-1.
Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma.
Reniformin A Suppresses Triple-Negative Breast Cancer Progression by Inducing DRP1-Mediated Mitochondrial Dysfunction and Apoptosis.
Role of FGF19 in regulating mitochondrial dynamics and macrophage polarization through FGFR4/AMPKα-p38/MAPK Axis in bleomycin-induced pulmonary fibrosis.
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway.
Preconception paternal exposure to zearalenone impairs male fertility and IVF embryo survival in mice.
One day of environment-induced heat stress causes injury to the murine kidney.
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Ginsenoside Rg5 alleviates radiation-induced acute lung vascular endothelium injury by reducing mitochondrial apoptosis via Sirt1.
Astragaloside IV Relieves Mitochondrial Oxidative Stress Damage and Dysfunction in Diabetic Mice Endothelial Progenitor Cells by Regulating the GSK-3β/Nrf2 Axis.
circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes.
Pathogenicity analysis of three SCA14-associated missense mutations in PRKCG gene of Chinese patients with ataxia.
DMT1 Maintains Iron Homeostasis to Regulate Mitochondrial Function in Porcine Oocytes.
Deciphering transcription activity of mammalian early embryos unveils on/off of zygotic genome activation by protein translation/degradation.
Nrf2 activator tertiary butylhydroquinone enhances neural stem cell differentiation and implantation in Alzheimer's disease by boosting mitochondrial function.
High-Frequency rTMS can Improve Depressive Symptoms by Promoting Mitochondrial Fusion.
Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice.
One day of environment-induced heat stress damages the murine myocardium.
Fibroblast growth factor 7 protects osteoblasts against oxidative damage through targeting mitochondria.
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
O-GlcNAcylation orchestrates porcine oocyte maturation through maintaining mitochondrial dynamics and function.
RUNX3 alleviates mitochondrial dysfunction and tubular damage by inhibiting TLR4/NF-κB signalling pathway in diabetic kidney disease.
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells.
Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.
miR-494-5p mediates the antioxidant activity of EPA by targeting the mitochondrial elongation factor 1 gene MIEF1 in HepG2 cells.
Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice.
Zinc deficiency compromises the maturational competence of porcine oocyte by inducing mitophagy and apoptosis.
Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility.
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Xiangsha Liujunzi Decoction improves gastrointestinal motility in functional dyspepsia with spleen deficiency syndrome by restoring mitochondrial quality control homeostasis.
Nujiangexanthone A Inhibits Cervical Cancer Cell Proliferation by Promoting Mitophagy.
BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects.
Zeng B, Jiang G, Wang C, Zhou H, Zhang Y, Yan YN, Chen Z, Zhang L, Li X, Xie M, Yang Z, Wang H
Journal of molecular histology 2026 Mar 26;57(2)
Journal of molecular histology 2026 Mar 26;57(2)
CtBP1 sustains activity-dependent muscle properties and dampens synaptic, contractile and metabolic changes triggered by denervation.
Cattaneo O, Lopez G, Rajendran J, Chabry F, Liaudet N, Startchik S, Prola A, Castets P
Skeletal muscle 2026 Mar 23;16(1)
Skeletal muscle 2026 Mar 23;16(1)
Icariin inhibits autophagy and promotes apoptosis by regulating mitochondrial division in Triple-negative breast cancer.
Wang W, Zhang X, Gao S, Liu J, Jiang S, Meng Q, Zhang H, Li Y, Shi W, Lv Y
Biochemical pharmacology 2026 Jan;243(Pt 2):117549
Biochemical pharmacology 2026 Jan;243(Pt 2):117549
The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.
Zhang H, Fu J, Guo Y, Liu S, Mei X, Zeng X, Ren W
Cell chemical biology 2026 Feb 19;33(2):169-182.e5
Cell chemical biology 2026 Feb 19;33(2):169-182.e5
Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeting Drp-1.
Qin D, Ding W, Wu X, Peng C, Bo Y, Wang D, Qin Y
Drug development research 2026 Apr;87(2):e70258
Drug development research 2026 Apr;87(2):e70258
Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma.
Wang Z, Jin Y, He D, Zhu Y, Xiao M, Liu X, Cheng Y, Cao K
International journal of biological sciences 2025;21(5):1894-1913
International journal of biological sciences 2025;21(5):1894-1913
Reniformin A Suppresses Triple-Negative Breast Cancer Progression by Inducing DRP1-Mediated Mitochondrial Dysfunction and Apoptosis.
Guan Y, Liu L, Wang W, Zheng R, Lin P, Liu Y, Chen S, Zhu H, Liu X, Huang H
Phytotherapy research : PTR 2025 Sep;39(9):4011-4027
Phytotherapy research : PTR 2025 Sep;39(9):4011-4027
Role of FGF19 in regulating mitochondrial dynamics and macrophage polarization through FGFR4/AMPKα-p38/MAPK Axis in bleomycin-induced pulmonary fibrosis.
Li Y, Zhang H, Li B, Yi X, Zhang X
Cytokine 2025 Sep;193:156978
Cytokine 2025 Sep;193:156978
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Li H, Cai S, Mu H, Chang T, Wang X, Tang T, Dong T, Zhang Y, Zhang L, Li H, Zhou L, Xiang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway.
Yang L, Lai X, Lin F, Shi N, Xu X, Wang H, Li X, Shen D, Qian H, Jin X, Chen J, Huang Z, Duan X, Zhang Q
Cell proliferation 2025 Oct;58(10):e70044
Cell proliferation 2025 Oct;58(10):e70044
Preconception paternal exposure to zearalenone impairs male fertility and IVF embryo survival in mice.
Wang P, Chen Y, Jiao Y, Zhu Y, Wang M, Ji D, Zou W, Cao Y, Liu Y, Liang D
Chemico-biological interactions 2025 Oct 22;420:111646
Chemico-biological interactions 2025 Oct 22;420:111646
One day of environment-induced heat stress causes injury to the murine kidney.
Roths M, Michael A, Schlader ZJ, Selsby JT
Experimental physiology 2025 Oct 2;
Experimental physiology 2025 Oct 2;
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Zhang Y, Tian S, Niu M, Yang H, Liu L, Kang Y, Yin Y
Neuroscience 2025 Nov 10;587:108-122
Neuroscience 2025 Nov 10;587:108-122
Ginsenoside Rg5 alleviates radiation-induced acute lung vascular endothelium injury by reducing mitochondrial apoptosis via Sirt1.
Li C, Zhao B, Xiong J, Li L, Pang D, Unger K, Jung M, Lyu J, Kuang H, Liang L, Li T, Chen L, Bai H
Journal of ginseng research 2025 May;49(3):260-270
Journal of ginseng research 2025 May;49(3):260-270
Astragaloside IV Relieves Mitochondrial Oxidative Stress Damage and Dysfunction in Diabetic Mice Endothelial Progenitor Cells by Regulating the GSK-3β/Nrf2 Axis.
Zou X, Liu X, Qu W, Zhang X, Zou Y, Lin X, Hu W, Gao R, He Y, Zhou S, Huang Y, Xiong W
Applied biochemistry and biotechnology 2025 Jun;197(6):3964-3981
Applied biochemistry and biotechnology 2025 Jun;197(6):3964-3981
circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes.
Yu Z, Xu W, Teng Y, Li T, Guo R, Li J, Li X, Li Y, Hao Y
European journal of histochemistry : EJH 2025 Jun 17;69(3)
European journal of histochemistry : EJH 2025 Jun 17;69(3)
Pathogenicity analysis of three SCA14-associated missense mutations in PRKCG gene of Chinese patients with ataxia.
Yuan H, Chen Z, Wan L, Peng L, Long Z, He L, Wang C, Qiu R, Tang B, Jiang H
Gene 2025 Jul 20;958:149483
Gene 2025 Jul 20;958:149483
DMT1 Maintains Iron Homeostasis to Regulate Mitochondrial Function in Porcine Oocytes.
Zhang JX, Lan MF, Shang JZ, Lai XL, Li LS, Duan TT, Xu RH, Chen KL, Duan X
Journal of cellular physiology 2025 Jan;240(1):e31494
Journal of cellular physiology 2025 Jan;240(1):e31494
Deciphering transcription activity of mammalian early embryos unveils on/off of zygotic genome activation by protein translation/degradation.
Zhang YR, Guo SM, Shi XY, Ding YW, Li HB, Li L, Xu JW, He X, Ma BX, Yin Y, Zhou LQ
Cell reports 2025 Jan 28;44(1):115215
Cell reports 2025 Jan 28;44(1):115215
Nrf2 activator tertiary butylhydroquinone enhances neural stem cell differentiation and implantation in Alzheimer's disease by boosting mitochondrial function.
Lin L, Li J, Yu Z, He J, Li Y, Jiang J, Xia Y
Brain research 2025 Feb 15;1849:149341
Brain research 2025 Feb 15;1849:149341
High-Frequency rTMS can Improve Depressive Symptoms by Promoting Mitochondrial Fusion.
Song J, Wang Y, Li S, Yuan J, Zhang Z, Pan Y, Lu J, Zhang Y
Actas espanolas de psiquiatria 2025 Dec;53(6):1252-1264
Actas espanolas de psiquiatria 2025 Dec;53(6):1252-1264
Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice.
Ding SM, Shi LG, Xing F, Cui SS, Cheng HR, Liu Y, Ji DM, Liang D, Cao YX, Liu YJ
Reproductive sciences (Thousand Oaks, Calif.) 2024 Oct;31(10):3191-3201
Reproductive sciences (Thousand Oaks, Calif.) 2024 Oct;31(10):3191-3201
One day of environment-induced heat stress damages the murine myocardium.
Roths M, Rudolph TE, Krishna S, Michael A, Selsby JT
American journal of physiology. Heart and circulatory physiology 2024 Oct 1;327(4):H978-H988
American journal of physiology. Heart and circulatory physiology 2024 Oct 1;327(4):H978-H988
Fibroblast growth factor 7 protects osteoblasts against oxidative damage through targeting mitochondria.
Liu X, Hu X, Niu C, Yang Y, Huang Z, Xie J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23524
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23524
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
Ding SM, Shi LG, Cao ZP, Zhu NN, Liu YY, Wang MY, Cui SS, Cheng HR, Liang D, Cao YX, Liu YJ
Heliyon 2024 Jun 30;10(12):e33132
Heliyon 2024 Jun 30;10(12):e33132
O-GlcNAcylation orchestrates porcine oocyte maturation through maintaining mitochondrial dynamics and function.
Xiong WJ, Lai XL, Lu J, Li LS, Zhang JX, Duan X
Molecular human reproduction 2024 Feb 1;30(2)
Molecular human reproduction 2024 Feb 1;30(2)
RUNX3 alleviates mitochondrial dysfunction and tubular damage by inhibiting TLR4/NF-κB signalling pathway in diabetic kidney disease.
Xiao L, Ye G
Nephrology (Carlton, Vic.) 2024 Aug;29(8):470-481
Nephrology (Carlton, Vic.) 2024 Aug;29(8):470-481
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Xie B, Chen Q, Dai Z, Jiang C, Chen X
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells.
Hu F, Hu W, Xu H
The Journal of membrane biology 2024 Apr;257(1-2):107-114
The Journal of membrane biology 2024 Apr;257(1-2):107-114
Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.
Mu N, Wang Y, Li X, Du Z, Wu Y, Su M, Wang Y, Sun X, Su L, Liu X
Cell death & disease 2023 Sep 30;14(9):645
Cell death & disease 2023 Sep 30;14(9):645
miR-494-5p mediates the antioxidant activity of EPA by targeting the mitochondrial elongation factor 1 gene MIEF1 in HepG2 cells.
Lin Y, Wu X, Lin L, Mei Y, Zhou J, Chen C, Li J, Wu D, Liu J, Li G
The Journal of nutritional biochemistry 2023 May;115:109279
The Journal of nutritional biochemistry 2023 May;115:109279
Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice.
Wang L, Wei Q, Xu R, Chen Y, Li S, Bu Q, Zhao Y, Li H, Zhao Y, Jiang L, Chen Y, Dai Y, Zhao Y, Cen X
ACS chemical neuroscience 2023 May 3;14(9):1585-1601
ACS chemical neuroscience 2023 May 3;14(9):1585-1601
Zinc deficiency compromises the maturational competence of porcine oocyte by inducing mitophagy and apoptosis.
Lai XL, Xiong WJ, Li LS, Lan MF, Zhang JX, Zhou YT, Niu D, Duan X
Ecotoxicology and environmental safety 2023 Mar 1;252:114593
Ecotoxicology and environmental safety 2023 Mar 1;252:114593
Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.
Fihurka O, Wang Y, Hong Y, Lin X, Shen N, Yang H, Brown B, Mommer M, Zieneldien T, Li Y, Kim J, Li M, Cai J, Zhou Q, Cao C
Biomolecules 2023 Jan 25;13(2)
Biomolecules 2023 Jan 25;13(2)
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y
Redox biology 2023 Dec;68:102944
Redox biology 2023 Dec;68:102944
Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility.
Ding Y, He Z, Sha Y, Kee K, Li L
Development (Cambridge, England) 2023 Dec 1;150(23)
Development (Cambridge, England) 2023 Dec 1;150(23)
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Wang F, Han J, Wang X, Liu Y, Zhang Z
Journal of molecular histology 2022 Oct;53(5):833-842
Journal of molecular histology 2022 Oct;53(5):833-842
Xiangsha Liujunzi Decoction improves gastrointestinal motility in functional dyspepsia with spleen deficiency syndrome by restoring mitochondrial quality control homeostasis.
Zhang J, Wang X, Wang F, Tang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154374
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154374
Nujiangexanthone A Inhibits Cervical Cancer Cell Proliferation by Promoting Mitophagy.
Feng J, Mansouripour A, Xi Z, Zhang L, Xu G, Zhou H, Xu H
Molecules (Basel, Switzerland) 2021 May 12;26(10)
Molecules (Basel, Switzerland) 2021 May 12;26(10)
BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects.
Choi GE, Lee HJ, Chae CW, Cho JH, Jung YH, Kim JS, Kim SY, Lim JR, Han HJ
Nature communications 2021 Jan 20;12(1):487
Nature communications 2021 Jan 20;12(1):487
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