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- Product number
- 10500-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10500-1-AP, RRID:AB_2174862
- Product name
- ASC/TMS1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ASC/TMS1 antibody (Cat. #10500-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism.
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota.
Sakuranetin ameliorates joint inflammation and bone erosion in rheumatoid arthritis by suppressing NLRP3 inflammasome-mediated inflammatory signaling.
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.
Hungatella hathewayi: A Tumor-Derived Bacterium Enriched in Colorectal Cancer Tissues and a Potential Diagnostic Biomarker.
T-cadherin deprivation in endothelial cells promotes vascular injury in Kawasaki disease through SOD2/ROS/NLRP3 pathway-mediated pyroptosis.
Qiming granules regulate Müller cell pyroptosis and the P2X7R/NLRP3 immune inflammatory pathway in diabetic retinopathy.
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Rhubarb ameliorates ischemic stroke-induced tryptophan-kynurenine metabolic reprogramming and neuroinflammation via modulation of the IDO-1/TREM-1 pathway.
Anacardic acid mitigates traumatic brain injury-induced inflammatory damage: involvement of TLR4/MyD88/NF-κB pathway regulation and inhibition of P300 HAT activity on NF-κB acetylation.
Epigenetic reprogramming by organic arsenic CZ2 elicits potent antitumor responses in DLBCL through TMS1 restoration.
Xue-Jie-San alleviates Crohn's disease through suppressing endothelial cell pyroptosis via the TLR4/NF-κB/NLRP3 pathway.
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury.
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes.
ZFP36-mediated ZBP1 degradation inhibits microglia pro-inflammatory and NLRP3 inflammasome activation in Alzheimer's disease.
STING knockdown blocks disease progression and inflammation in mice with alcoholic liver disease by relieving pyroptosis via suppressing NLRP3.
Targeted inflammatory microenvironment remodeling and NIR-II photothermal therapy for abdominal aortic aneurysm.
Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Loaded with Emodin Alleviate Intestinal Injury in Acute Pancreatitis.
Sulfated Pelvetia siliquosa Polysaccharides Attenuate Pyroptosis via NF-κB Pathway Inhibition Against Calcium Oxalate Stone Formation.
Targeting macrophage glycogen metabolism attenuates ulcerative colitis by suppressing IL-1β production through UDPG-P2Y(14) signaling.
Shh-S100A10 axis curbs neuronal PANoptosis after ischemic stroke.
Targeted delivery of nebivolol via lactoferrin-modified liposomes inhibits NEK7-mediated pyroptosis to ameliorate inflammatory bowel disease.
Dehydroepiandrosterone alleviates pulmonary fibrosis by modulating the TLR4/NF-κB/NLRP3 signaling cascade in macrophages.
Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis.
Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis.
Deciphering the Therapeutic Mechanisms of Banxia Xiexin Decoction Against Ulcerative Colitis: Targeting Pyroptosis and Necroptosis.
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.
Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.
ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway.
Treadmill exercise alleviates Alzheimer's disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming.
Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism.
Low-dose extracorporeal shock wave attenuates sepsis-related acute lung injury by targeting mitochondrial dysfunction and pyroptosis crosstalk in type II alveolar epithelial cells.
Comprehensive multiomics analysis identifies PYCARD as a key pyroptosis-related gene in osteoarthritis synovial macrophages.
Acetylcholine in the gingival epithelium drives the pathogenesis of periodontitis.
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands.
M2 Macrophages-Derived Exosomes Inhibited Podocyte Pyroptosis via lncRNA AFAP1-AS1/EZH2 Axis.
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication.
SPHK2 inhibition alleviates chronic intermittent hypoxia-induced inflammation in adipose tissue by decreasing endoplasmic reticulum stress.
Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway.
Caffeic acid ameliorates intestinal barrier injury to attenuate acute pancreatitis via inhibiting GSDMD-mediated pyroptotic pathway.
Emodin enhances the therapeutic efficacy of human umbilical cord mesenchymal stem cell-derived extracellular vesicles in acute pancreatitis-induced lung injury.
A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure.
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Baicalein Reduces Pyroptosis of Acinar Cells in Hyperlipidemic Acute Pancreatitis by Inhibiting M1 Polarization of Macrophages via the HMGB1/TLR4/NLRP3 Pathway.
NR4A1 mediates PRRSV-induced ileal injury in piglets by transcriptional regulation of NLRP3.
AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure.
Indole-3 propionate inhibits NF-κB/NLRP3-mediated osteoclastogenesis and improves bone quality in high-fat-diet induced obese mice.
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
LncRNA MIR17HG accelerates the development of atherosclerosis by promoting macrophage pyroptosis through the miR-301a-3p/TXNIP pathway.
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
The effect of puerarin on the NLRP3 Inflammasome pathway and MMP-9 in aortic dissection of ApoE(-/-) mice.
Rv2647-Mediated NLRP3 Ubiquitination Inhibits Macrophage Pyroptosis and Promotes Mycobacterium tuberculosis Survival.
PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1/ROS pathway.
Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss.
CDK8 mediated inflammatory microenvironment aggravates osteoarthritis progression.
Cytopathic bovine viral diarrhea virus-induced NLRP3 inflammasome activation triggers GSDMD-mediated pyroptosis, amplifying the inflammatory response.
Ellagic acid mediated pyroptosis in hepatocellular carcinoma via the ESR1/G6PD pathway.
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Modulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen's Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats.
Curcumin Alleviates Bisphenol A-Induced Blood-Testis Barrier Disruption in Mice by Targeting Surfactant Protein B (SFTPB) to Suppress Oxidative Stress-Activated NLRP3 Inflammasome.
PROM2 exacerbates CCl4-Induced liver fibrosis via NLRP3 inflammasome activation and hepatocyte pyroptosis.
MiR-193b-3p Regulates Gasdermin-D/NLRP3 by Targeting the Signaling Axis Inhibition of Pyroptosis Attenuates Myocardial Ischemia-Reperfusion Injury.
Repurposing of FDA-approved drugs by targeting SIRT2 to alleviate inflammatory response and kidney injury.
Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function.
AdipoRon attenuates depression-like behavior in T2DM mice via inhibiting inflammation and regulating autophagy.
Deoxynivalenol-induced pyroptosis and autophagy inhibition collectively promote inflammatory injury in the glandular stomach of chicken embryos.
Terminalia chebula Retz. extract relieves gout arthritis by inhibiting xanthine oxidase, the uric acid transporter, and NLRP3 inflammasome activation.
Icariin alleviates cardiomyocyte pyroptosis through AMPK-NLRP3 pathway to ameliorates diabetic cardiomyopathy.
Green tea epigallocatechin gallate attenuate metabolic dysfunction-associated steatotic liver disease by regulation of pyroptosis.
Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway.
Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.
Glaesserella parasuis serotype 5 promotes pyroptosis via degrading Caveolin-1 in 3D4/21 cells.
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Coal dust particles can upregulate the expression of NLRP3 inflammasome components in rat alveolar macrophages through phagocytosis.
Citrinin-Induced Intestinal Onset of Pyroptosis via the IP3R1-GRP75-VDAC1 Complex-Mediated Mitochondrial Oxidative Stress.
Blocking GATA6 Alleviates Pyroptosis and Inhibits Abdominal Wall Endometriosis Lesion Growth Through Inactivating the PI3K/AKT Pathway.
Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells.
Probiotic Combination of Limosilactobacillus fermentum HF07 and Lactococcus lactis HF08 Targeting Gut Microbiota-Secondary Bile Acid Metabolism Ameliorates Inflammation and Intestinal Barrier Dysfunction in Aging Colitis.
Nigericin Induces Paraptosis-Like Cell Death Instead of Pyroptosis in Corneal Keratocytes.
Investigating the Mechanism of Emodin in Rheumatoid Arthritis Through the HIF-1α/NLRP3 Pathway and Mitochondrial Autophagy.
Calycosin treats acute myocardial infarction via NLRP3 inflammasome: Bioinformatics, network pharmacology and experimental validation.
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis.
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
E2-Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells.
Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells.
Koumine mediates the generation of mtROS through the IP3R1-GRP75-VDAC1 complex to improve Citrinin induced intestinal inflammation.
Xiongshao Zhitong granules alleviate nitroglycerin-induced migraine by regulating the TRPV1-mediated NLRP3 inflammatory pathway in rats.
Mechanism of hydroxychloroquine in the treatment of obstetric antiphospholipid syndrome by inhibiting NETs-induced trophoblast pyroptosis.
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells.
S-COS-Se mitigates cadmium-induced oxidative stress, inflammation, and immunotoxicity by restoring immune balance and inhibiting mitochondria-pyroptosis crosstalk.
Defective RuO(2) Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.
Ginsenoside Rg1 improves hypoxia-induced pulmonary vascular endothelial dysfunction through TXNIP/NLRP3 pathway-modulated mitophagy.
Highly BBB-permeable nanomedicine reverses neuroapoptosis and neuroinflammation to treat Alzheimer's disease.
PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation.
Chemerin-9 is neuroprotective in APP/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of Aβ.
Huashi baidu granule alleviates inflammation and lung edema by suppressing the NLRP3/caspase-1/GSDMD-N pathway and promoting fluid clearance in a porcine reproductive and respiratory syndrome (PRRS) model.
Tangzu granule alleviate neuroinflammation in diabetic peripheral neuropathy by suppressing pyroptosis through P2X7R /NLRP3 signaling pathway.
Novel Nanoliposomes Synergistically Modulated by Sitogluside and Dioscin: Stability, Bioavailability, and Capacity To Alleviate Hyperuricaemia.
Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.
Therapeutic effects of tripterygium glycosides on periodontitis: Exploring the role of ursolic acid and the RIPK3/NLRP3 signaling pathway.
Pirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation.
Ganoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling.
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Inhibition of tumor necrosis factor receptor-associated factor 6 alleviates secondary brain injury by reducing neuronal pyroptosis after intracerebral hemorrhage.
Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression.
Molecular insights of T-2 toxin exposure-induced neurotoxicity and the neuroprotective effect of dimethyl fumarate.
A Heparan Sulfate Mimetic RAFT Copolymer Inhibits SARS-CoV-2 Infection and Ameliorates Viral-Induced Inflammation.
Structural Characterization and Anti-Gouty Nephropathy Potential of Polysaccharides from Atractylodes chinensis.
The absence of IRG1 exacerbates bone loss in a mouse model of ovariectomy-induced osteoporosis by increasing osteoclastogenesis through the potentiation of NLRP3 inflammasome activation.
Dapagliflozin attenuates skeletal muscle atrophy in diabetic nephropathy mice through suppressing Gasdermin D-mediated pyroptosis.
PCBP2 Promotes NRG4 mRNA Stability to Diminish Angiotensin II-Induced Hypertrophy, NLRP3 Inflammasome Activation, and Oxidative Stress of AC16 Cardiomyocytes.
Anti-inflammatory Effects of Membrane Vesicles from Eubacterium rectale via the NLRP3 Signal Pathway.
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling.
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Metformin Nanodelivery System Alleviates Morphine-Induced Analgesic Tolerance via Inhibiting the TXNIP/NLRP3/GSDMD Axis.
Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation.
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Fibroblast Growth Factor 21 Confers Protection Against Asthma Through Inhibition of NLRP3 Inflammasome Activation.
Colchicine Alleviates Interstitial Lung Disease in an Experimental Autoimmune Myositis Murine Model by Inhibiting the Formation of Neutrophil Extracellular Traps.
Atorvastatin Alleviates Age-Related Macular Degeneration via AIM2-Regulated Pyroptosis.
GPR40 inhibits microglia-mediated neuroinflammation via the NLRP3/IL-1β/glutaminase pathway after subarachnoid hemorrhage.
RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis.
Emodin-Enhanced hUC-MSC extracellular vesicles alleviate acute pancreatitis by targeting inflammation and pyroptosis.
Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners.
The role of glutathione S-transferase mu 2 in mitigating fatty acid-induced hepatic inflammation in dairy cows.
Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40.
Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivation.
Poly-(ADP-ribose) polymerases inhibition by olaparib attenuates activities of the NLRP3 inflammasome and of NF-κB in THP-1 monocytes.
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Cynaroside: a potential therapeutic agent targeting arachidonate 15-lipoxygenase to mitigate cerebral ischemia/reperfusion injury.
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation.
Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation.
Dexmedetomidine improves mitophagy and pyroptosis through the ALKBH5/FUNDC1 axis during epidural-related maternal fever.
Pseudorabies Virus UL4 protein promotes the ASC-dependent inflammasome activation and pyroptosis to exacerbate inflammation.
Targeted-lung delivery of bardoxolone methyl using PECAM-1 antibody-conjugated nanostructure lipid carriers for the treatment of lung inflammation.
Attenuation of PM2.5-Induced Lung Injury by 4-Phenylbutyric Acid: Maintenance of [Ca(2+)]i Stability between Endoplasmic Reticulum and Mitochondria.
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
Deleting fibroblast growth factor 2 in macrophages aggravates septic acute lung injury by increasing M1 polarization and inflammatory cytokine secretion.
Acupuncture ameliorates depression-like behavior of poststroke depression model rats through the regulation of gut microbiota and NLRP3 inflammasome in the colon.
miRNA-193a-mediated WT1 suppression triggers podocyte injury through activation of the EZH2/β-catenin/NLRP3 pathway in children with diabetic nephropathy.
Gut microbiome and metabolites mediate the benefits of caloric restriction in mice after acute kidney injury.
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway.
Salidroside promotes liver regeneration after partial hepatectomy in mice by modulating NLRP3 inflammasome-mediated pyroptosis pathway.
Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy.
Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway.
UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis.
Bovine DDX3X Restrains Bovine SP110c-Mediated Activation of Inflammasome in Macrophages.
Exosomal long non-coding RNA AU020206 alleviates macrophage pyroptosis in atherosclerosis by suppressing CEBPB-mediated NLRP3 transcription.
Triclosan induces liver injury in long-life exposed mice via activation of TLR4/NF-κB/NLRP3 pathway.
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy.
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Tmem30a protects against podocyte injury through suppression of pyroptosis.
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome.
Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K(+) Efflux Induced by PLO via Signal Point Mutations.
Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress.
Asprosin promotes vascular inflammation via TLR4-NFκB-mediated NLRP3 inflammasome activation in hypertension.
Mahuang Fuzi Xixin decoction alleviates allergic rhinitis by inhibiting NLRP3/Caspase-1/GSDMD-N-mediated pyroptosis.
P2Y6 Receptor Activation Aggravates NLRP3-dependent Microglial Pyroptosis via Downregulation of the PI3K/AKT Pathway in a Mouse Model of Intracerebral Hemorrhage.
Glaesserella parasuis serotype 5 induces pyroptosis via the RIG-I/MAVS/NLRP3 pathway in swine tracheal epithelial cells.
Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties.
4-Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders.
Diallyl trisulfide induces pyroptosis and impairs lung CSC-like properties by activating the ROS/Caspase 1 signaling pathway.
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway.
Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis.
Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2.
Colchicine ameliorates short-term abdominal aortic aneurysms by inhibiting the expression of NLRP3 inflammasome components in mice.
ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis.
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome.
LncRNA MALAT1 to Enhance Pyroptosis in Viral Myocarditis Through UPF1-Mediated SIRT6 mRNA Decay and Wnt-β-Catenin Signal Pathway.
Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway.
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
Aminoadipic acid aggravates atherosclerotic vascular inflammation through ROS/TXNIP/NLRP3 pathway, a harmful microbial metabolite reduced by paeonol.
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
Jianwei Shoutai Pills alleviates miscarriage by modulating gut microbial production of BAs and NLRP3-inflammasome at the maternal-fetal interface of rats.
Triggering receptor expressed on myeloid cells-1 aggravates obliterative bronchiolitis via enhancing the proinflammatory phenotype of macrophages.
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
Hydrogen Attenuates Cognitive Impairment in Rat Models of Vascular Dementia by Inhibiting Oxidative Stress and NLRP3 Inflammasome Activation.
Polygonatum sibiricum Polysaccharides Alleviate Depressive-like Symptoms in Chronic Restraint Stress-Induced Mice via Microglial Regulation in Prefrontal Cortex.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury.
Human Umbilical Cord Mesenchymal Stem Cells Repair Endothelial Injury and Dysfunction by Regulating NLRP3 to Inhibit Endothelial Cell Pyroptosis in Kawasaki Disease.
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells.
Molecular mechanism of miRNA-23a in sepsis-induced lung injury.
Weight bearing training alleviates muscle atrophy and pyroptosis of middle-aged rats.
Role of NLRP3 inflammasome activation in HCC cell progression.
PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia.
Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis.
Pseudorabies virus infection activates the NLRP3 and IFI16 inflammasomes to trigger pyroptosis.
Maslinic acid alleviates LPS-induced mice mastitis by inhibiting inflammatory response, maintaining the integrity of the blood-milk barrier and regulating intestinal flora.
Through regulation of the SIRT1 pathway plant sterol ester of α-linolenic acid inhibits pyroptosis thereby attenuating the development of NASH in mice.
Lunasin reduces the susceptibility of IL-10 deficient mice to inflammatory bowel disease and modulates the activation of the NLRP3 inflammasome.
Ursolic Acid Alleviates Neuroinflammation after Intracerebral Hemorrhage by Mediating Microglial Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway.
Sodium thiosulfate ameliorates atopic dermatitis via inhibiting the activation of NLRP3 inflammasome.
Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease.
VCAM-1(+) hUC-MSCs Exert Considerable Neuroprotection Against Cerebral Infarction in Rats by Suppression of NLRP3-Induced Pyroptosis.
A novel pyroptosis-associated lncRNA LINC01133 promotes pancreatic adenocarcinoma development via miR-30b-5p/SIRT1 axis.
Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model.
Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway.
RORα overexpression reduced interleukin-33 expression and prevented mast cell degranulation and inflammation by inducing autophagy in allergic rhinitis.
Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways.
CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis.
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
The Expression of High Mobility Group Box-1 (HMG1) in the Peripheral Blood and Its Relation with Systemic Vasculitis Patients.
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice.
Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro.
Identification of CRKL as an oncogenic biomarker for prognosis and immunotherapy in melanoma, and its potential molecular mechanism.
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout.
LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis.
Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS-14036/miR-1228-5p/PRKCDBP pathway.
Analgesic Effect of Perineural Injection of BoNT/A on Neuropathic Pain Induced by Chronic Constriction Injury of Sciatic Nerve in Rats.
Oxidative Stress Initiates Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Mediated Corneal Epithelial Necroptosis and Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Signaling during Fungal Keratitis.
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Alternate-day fasting for the protection of cognitive impairment in c57BL/6J mice following whole-brain radiotherapy.
Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3/GSDMD pathway.
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury.
MicroRNA-29b regulates pyroptosis involving calcific aortic valve disease through the STAT3/SOCS1 pathway.
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
The combined effect of deoxynivalenol and Fumonisin B(1) on small intestinal inflammation mediated by pyroptosis in vivo and in vitro.
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.
Renal NLRP3 Inflammasome activation is associated with disease activity in lupus nephritis.
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway.
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
The Comparative Effects of Schwann Cells and Wharton's Jelly Mesenchymal Stem Cells on the AIM2 Inflammasome Activity in an Experimental Model of Spinal Cord Injury.
Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3.
USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.
Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury.
PRRSV infection activates NLRP3 inflammasome through inducing cytosolic mitochondrial DNA stress.
Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome.
Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells.
Detection of ASC Oligomerization by Western Blotting.
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication.
Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization.
Dendrobium Nobile Lindl. Alkaloid Suppresses NLRP3-Mediated Pyroptosis to Alleviate LPS-Induced Neurotoxicity.
Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway.
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Modified Baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis.
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer.
Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway.
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
Lactobacillus rhamnosus GR-1 attenuates foodborne Bacillus cereus-induced NLRP3 inflammasome activity in bovine mammary epithelial cells by protecting intercellular tight junctions.
VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis.
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway.
Neutrophil Extracellular Traps Mediate Bovine Endometrial Epithelial Cell Pyroptosis in Dairy Cows with Endometritis.
Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.
Enhanced autophagy alleviated corneal allograft rejection via inhibiting NLRP3 inflammasome activity.
Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk.
BtpB inhibits innate inflammatory responses in goat alveolar macrophages through the TLR/NF-κB pathway and NLRP3 inflammasome during Brucella infection.
Inhibition of the P2X7/NLRP3 Inflammasome Signaling Pathway by Deacetylgedunin from Toona sinensis.
GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.
Effect of NLRP3 repression on NLRP3 inflammasome activation in human corneal epithelial cells with black carbon exposure.
Curcumin improves the function of umbilical vein endothelial cells by inhibiting H(2)O(2)‑induced pyroptosis.
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Preconditioning with procyanidin B2 protects MAC-T cells against heat exposure-induced mitochondrial dysfunction and inflammation.
Selenomethionine alleviated Ochratoxin A induced pyroptosis and renal fibrotic factors expressions in MDCK cells.
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Lactobacillus rhamnosus Ameliorates Multi-Drug-Resistant Bacillus cereus-Induced Cell Damage through Inhibition of NLRP3 Inflammasomes and Apoptosis in Bovine Endometritis.
Enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting NLRP3 inflammasome.
Staphylococcus aureus mediates pyroptosis in bovine mammary epithelial cell via activation of NLRP3 inflammasome.
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
Identification of key proteins of cytopathic biotype bovine viral diarrhoea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response.
A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner.
Demethyleneberberine blocked the maturation of IL-1β in inflammation by inhibiting TLR4-mitochondria signaling.
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model.
N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways.
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
Immunohistochemical analysis of pyroptosis-related protein expression in IgG4-related sialadenitis.
Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.
Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4/Akt/HIF1a/NLRP3 pathway.
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration.
Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy.
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
The Essential Oil of Artemisia argyi H.Lév. and Vaniot Attenuates NLRP3 Inflammasome Activation in THP-1 Cells.
Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.
Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis.
LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.
H(2)S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway.
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma.
Deletion of inflammasome adaptor protein ASC enhances functional recovery after spinal cord injury in mice.
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Cordyceps acid alleviates lung cancer in nude mice.
Stress increases blood beta-hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model.
Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cells.
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Activation of Interleukin-1β Release and Pyroptosis by Transmissible Gastroenteritis Virus Is Dependent on the NOD-Like Receptor Protein 3 Inflammasome in Porcine Intestinal Epithelial Cell Line.
Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway.
Microcystin-LR Induces NLRP3 Inflammasome Activation via FOXO1 Phosphorylation, Resulting in Interleukin-1β Secretion and Pyroptosis in Hepatocytes.
Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.
Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway.
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.
Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-κB Pathway.
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells.
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
MiR-21-5p Induces Pyroptosis in Colorectal Cancer via TGFBI.
A novel mechanism of protection against isoproterenol-induced cardiac inflammation via regulation of the SIRT1/NRF2 signaling pathway with a natural SIRT1 agonist.
hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis.
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
Lactobacillus johnsonii L531 Ameliorates Escherichia coli-Induced Cell Damage via Inhibiting NLRP3 Inflammasome Activity and Promoting ATG5/ATG16L1-Mediated Autophagy in Porcine Mammary Epithelial Cells.
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Correlation Between the NLRP3 Inflammasome and the Prognosis of Patients With LSCC.
Suppressive Effect of Huzhentongfeng on Experimental Gouty Arthritis: An In Vivo and In Vitro Study.
Weighted Gene Co-expression Network Analysis for RNA-Sequencing Data of the Varicose Veins Transcriptome.
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation.
Activation of P2X(7)R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH).
Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway.
Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway.
NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis.
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.
Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine.
LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-κB/NLRP3 inflammasome pathway.
Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.
Schwann cell transplantation exerts neuroprotective roles in rat model of spinal cord injury by combating inflammasome activation and improving motor recovery and remyelination.
Intrathecal transplantation of Wharton's jelly mesenchymal stem cells suppresses the NLRP1 inflammasome in the rat model of spinal cord injury.
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.
Chronic Kidney Disease Increases Atrial Fibrillation Inducibility: Involvement of Inflammation, Atrial Fibrosis, and Connexins.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease.
MCL Plays an Anti-Inflammatory Role in Mycobacterium tuberculosis-Induced Immune Response by Inhibiting NF-κB and NLRP3 Inflammasome Activation.
Anti-inflammatory capacity of Lactobacillus rhamnosus GG in monophasic variant Salmonella infected piglets is correlated with impeding NLRP6-mediated host inflammatory responses.
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.
Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer's disease.
Pepsin-pancreatin hydrolysis reduced the ability of lunasin-enriched material to inhibit activation of the inflammasomes in THP-1 human macrophages.
NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis.
Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.
NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis.
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway.
Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.
A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing.
OxLDL-induced IL-1 beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation.
Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury.
Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma.
SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation.
Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha.
Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells.
Expression of apoptotic tumour necrosis factor receptor-associated factor, caspase recruitment domain and cell death-inducing DFF-45 effector genes in therapy-treated renal cell carcinoma.
Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.
Wei Q, Zhou H, Sun J, Qin L
Frontiers in immunology 2026;17:1707203
Frontiers in immunology 2026;17:1707203
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota.
Qiu M, Yi Q, Luo M, Duan S, Zhang Z, Wu X, Chen T, Ma C, Cui T, Zhang B, Zhang Y, Li J, Guo S, Gao Y, Zhang D
Journal of ethnopharmacology 2026 May 23;363:121373
Journal of ethnopharmacology 2026 May 23;363:121373
Sakuranetin ameliorates joint inflammation and bone erosion in rheumatoid arthritis by suppressing NLRP3 inflammasome-mediated inflammatory signaling.
Mao K, Yu C, Han Z, Li T, Lin J, Hu S
International immunopharmacology 2026 May 15;177:116542
International immunopharmacology 2026 May 15;177:116542
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.
Zhang M, Wang B, Sun D, Chen X, Zhou Y, Yao J, Du L, Zhang Z, Li H, Qu Z, Chen L, Luo Q, Zhang J, Jin X, Cheng X, Niu J, Xing Q, Tan X, Wang T, Liu J, Li L, Song Q, Chen X, Chen Y
JCI insight 2026 Mar 23;11(6)
JCI insight 2026 Mar 23;11(6)
Hungatella hathewayi: A Tumor-Derived Bacterium Enriched in Colorectal Cancer Tissues and a Potential Diagnostic Biomarker.
Zhang W, Liu J, Sha S, Yan Q, Ma Y
Microorganisms 2026 Mar 21;14(3)
Microorganisms 2026 Mar 21;14(3)
T-cadherin deprivation in endothelial cells promotes vascular injury in Kawasaki disease through SOD2/ROS/NLRP3 pathway-mediated pyroptosis.
Lin Y, Wang F, Luo X, Yang X, Yang W, Lu Z, Wang Z, Zhou H, Ruan M, Chen K, Fu L, Pi L, Che D, Yu H, Gu X
Journal of molecular cell biology 2026 Mar 19;17(9)
Journal of molecular cell biology 2026 Mar 19;17(9)
Qiming granules regulate Müller cell pyroptosis and the P2X7R/NLRP3 immune inflammatory pathway in diabetic retinopathy.
Zhou Q, Tang M, Wang Y, Lv H, Yang G, Wang F, Ye H
Chinese medicine 2026 Mar 16;21(1)
Chinese medicine 2026 Mar 16;21(1)
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Zhang K, Sun S, Qiu H, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2026 Mar 1;358:120981
Journal of ethnopharmacology 2026 Mar 1;358:120981
Rhubarb ameliorates ischemic stroke-induced tryptophan-kynurenine metabolic reprogramming and neuroinflammation via modulation of the IDO-1/TREM-1 pathway.
Liu X, Wang X, Wang Y, Zhu H, Xiang Q, Li Q, Wang X, Xu W, Jiang M, Wang W, Gao J, Wang T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158133
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158133
Anacardic acid mitigates traumatic brain injury-induced inflammatory damage: involvement of TLR4/MyD88/NF-κB pathway regulation and inhibition of P300 HAT activity on NF-κB acetylation.
Yang C, Ru J, Zhang X, Kong X, Zhu C, Gao Z, Chen F, Zheng K, Jin K, Zhuge Q, Yang S, Huang L
International immunopharmacology 2026 Jun 15;179:116613
International immunopharmacology 2026 Jun 15;179:116613
Epigenetic reprogramming by organic arsenic CZ2 elicits potent antitumor responses in DLBCL through TMS1 restoration.
Mei W, Zhang M, Zhang D
Bioorganic chemistry 2026 Jun 15;174:109734
Bioorganic chemistry 2026 Jun 15;174:109734
Xue-Jie-San alleviates Crohn's disease through suppressing endothelial cell pyroptosis via the TLR4/NF-κB/NLRP3 pathway.
Gao Y, Zhu YQ, Liu KH, Wu D, Wang Z, Zheng HY, Yang X, Wen K, Sun XL
Journal of ethnopharmacology 2026 Jul 15;366:121648
Journal of ethnopharmacology 2026 Jul 15;366:121648
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Yu S, Zhang Y, Xi J, Feng J, Xie T, Pan D, Zhao D, Ren J, Dong Z, Liu M, Wang S
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury.
He S, Wang L, Wang Z, Yu S, Zhu Q, Xu Y, Jiang Y, Wu Y, Xiang H
Molecular medicine reports 2026 Jan;33(1)
Molecular medicine reports 2026 Jan;33(1)
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Qin L, Zhao B, Xiong Y, Chen L, Qi S, Ma Y, Zeng H, Song Y, Liu W, Tian T, Ge G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Free Fatty Acids and Endotoxins Synergically Induce Pyroptosis in Bovine Hepatocytes.
Li D, Tian Y, Tian L, Yu H, Zhang L, Wang S, Lei C, Long P, Peng T, Liu L, Zhou Y
Metabolites 2026 Jan 8;16(1)
Metabolites 2026 Jan 8;16(1)
ZFP36-mediated ZBP1 degradation inhibits microglia pro-inflammatory and NLRP3 inflammasome activation in Alzheimer's disease.
Liu T, Chen D, Liu F, Sun Y
Cell biology and toxicology 2026 Jan 20;42(1):25
Cell biology and toxicology 2026 Jan 20;42(1):25
STING knockdown blocks disease progression and inflammation in mice with alcoholic liver disease by relieving pyroptosis via suppressing NLRP3.
Song Y, Liu M, Zhou M, Ren X, Feng B, Xie Y
International immunopharmacology 2026 Jan 1;168(Pt 2):115858
International immunopharmacology 2026 Jan 1;168(Pt 2):115858
Targeted inflammatory microenvironment remodeling and NIR-II photothermal therapy for abdominal aortic aneurysm.
Liu Y, Qiu P, Hao H, Ding A, Wu Z, Lei J, Peng Z, Pu H, Zeng C, Guo H, Wu X, Lu H, Qin J, Wang R, Liu H, Ye K, Lu X
Materials today. Bio 2026 Feb;36:102770
Materials today. Bio 2026 Feb;36:102770
Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Loaded with Emodin Alleviate Intestinal Injury in Acute Pancreatitis.
Liu S, Xu Z, Liu X, Huang X, Huang X, Pan M, Lin J
Biotechnology journal 2026 Feb;21(2):e70198
Biotechnology journal 2026 Feb;21(2):e70198
Sulfated Pelvetia siliquosa Polysaccharides Attenuate Pyroptosis via NF-κB Pathway Inhibition Against Calcium Oxalate Stone Formation.
Tong XY, Chen XW, Zhang JY, Ouyang JM
Marine drugs 2026 Feb 8;24(2)
Marine drugs 2026 Feb 8;24(2)
Targeting macrophage glycogen metabolism attenuates ulcerative colitis by suppressing IL-1β production through UDPG-P2Y(14) signaling.
Tong S, Zhu T, Liang S, Cui Y, Ma Y, Zhang X, Bian Y, Wei K, Wu S, Ma J
Molecular medicine (Cambridge, Mass.) 2026 Feb 4;32(1):15
Molecular medicine (Cambridge, Mass.) 2026 Feb 4;32(1):15
Shh-S100A10 axis curbs neuronal PANoptosis after ischemic stroke.
Wang L, Tang H, Wen J, Yang Q, Huang J, Zhao Y, Ren Y, Yang Q
Neural regeneration research 2026 Aug 1;21(8):3579-3587
Neural regeneration research 2026 Aug 1;21(8):3579-3587
Targeted delivery of nebivolol via lactoferrin-modified liposomes inhibits NEK7-mediated pyroptosis to ameliorate inflammatory bowel disease.
Yao H, Yang L, Zhang Y, Wu Q, Xie K, Liu H, Yao B, Jiang Z, Sun Q, Zeng Z, Yuan L
Free radical biology & medicine 2026 Apr 28;252:493-508
Free radical biology & medicine 2026 Apr 28;252:493-508
Dehydroepiandrosterone alleviates pulmonary fibrosis by modulating the TLR4/NF-κB/NLRP3 signaling cascade in macrophages.
Xie Q, Zhao X, Lu Y, Shuai S
The Journal of steroid biochemistry and molecular biology 2026 Apr 27;262:107028
The Journal of steroid biochemistry and molecular biology 2026 Apr 27;262:107028
Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis.
Huang T, Takashima Y, Kumar J, Morales J, Le K, Hu Z, Rubino S, Trousdale RT, Berry GJ, Goronzy JJ, Weyand CM
Immunity 2026 Apr 14;59(4):970-987.e6
Immunity 2026 Apr 14;59(4):970-987.e6
Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis.
Wang Y, Chen Y, Yang Y, Zhou Y, Yang Y, Zhu J
Journal of pain research 2025;18:4935-4945
Journal of pain research 2025;18:4935-4945
Deciphering the Therapeutic Mechanisms of Banxia Xiexin Decoction Against Ulcerative Colitis: Targeting Pyroptosis and Necroptosis.
Lu J, Liang K, Zhang L, Cui B, You L, An R, Hu C, Wang X
Journal of inflammation research 2025;18:17537-17560
Journal of inflammation research 2025;18:17537-17560
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.
Li J, Han L, Feng S, Lin G, Zou G, Huang T, Ran T, Zhao X
Journal of inflammation research 2025;18:15429-15440
Journal of inflammation research 2025;18:15429-15440
Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.
Li Z, Cao S, Yang J, Chen L, Jia L, Lu P, Liu J, Liu M, Liu Q
Journal of inflammation research 2025;18:11935-11950
Journal of inflammation research 2025;18:11935-11950
ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway.
Tong S, Li X, Wang F, Cheng Q, Zhang P, Chen M, Xie Y, Lu X, Wu H
Journal of inflammation research 2025;18:11095-11108
Journal of inflammation research 2025;18:11095-11108
Treadmill exercise alleviates Alzheimer's disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming.
Liang F, Sun F, Guo C, Zhong H
Frontiers in aging neuroscience 2025;17:1734837
Frontiers in aging neuroscience 2025;17:1734837
Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism.
Lei C, Zhao C, Li X, Wang K, Cen T, Liu Q, Xu X, Zhang J
Frontiers in immunology 2025;16:1709586
Frontiers in immunology 2025;16:1709586
Low-dose extracorporeal shock wave attenuates sepsis-related acute lung injury by targeting mitochondrial dysfunction and pyroptosis crosstalk in type II alveolar epithelial cells.
Guo J, Qu X, Ge R, Liu D, Liu J, Hui Q, Ye F, Chen Y, Wang C, Lv D, Tang L, Xia M, Zhang Q
Frontiers in immunology 2025;16:1637378
Frontiers in immunology 2025;16:1637378
Comprehensive multiomics analysis identifies PYCARD as a key pyroptosis-related gene in osteoarthritis synovial macrophages.
Yao Z, Li Y, Mai H, Wang Z, Zhang H, Cai D, Wang X
Frontiers in immunology 2025;16:1558139
Frontiers in immunology 2025;16:1558139
Acetylcholine in the gingival epithelium drives the pathogenesis of periodontitis.
Xu S, Guo J, Yang S, Cheng B, Xia J
Frontiers in cell and developmental biology 2025;13:1701252
Frontiers in cell and developmental biology 2025;13:1701252
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands.
Lv X, Long Q, Kang Y, Lin T, Jiang C
Frontiers in veterinary science 2025;12:1476302
Frontiers in veterinary science 2025;12:1476302
M2 Macrophages-Derived Exosomes Inhibited Podocyte Pyroptosis via lncRNA AFAP1-AS1/EZH2 Axis.
Zhan Q, Liu H, Zhao M, Huang H
Clinical and experimental pharmacology & physiology 2025 Sep;52(9):e70056
Clinical and experimental pharmacology & physiology 2025 Sep;52(9):e70056
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
Wang Z, Sun Y, Wang C, Yao J, Hao R, Wang Y, Sun H
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication.
Lan Q, Zhang X, Sun Y, Yang J, Li X, Kuang E
PLoS pathogens 2025 Sep;21(9):e1013509
PLoS pathogens 2025 Sep;21(9):e1013509
SPHK2 inhibition alleviates chronic intermittent hypoxia-induced inflammation in adipose tissue by decreasing endoplasmic reticulum stress.
Ran L, Wei C, Wang X, Zhao Y, Li P, Huang D, Gu W, Wu X, Liang Z, Wang X, Gong L
European journal of pharmacology 2025 Sep 5;1002:177841
European journal of pharmacology 2025 Sep 5;1002:177841
Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway.
Duan H, Zhang Y, Shen A, Ren J, Zhang F, Lu Y, Wei X, Yang C, Gong J, Wang X, Du Y, Pei Q, Zhang A
Veterinary research 2025 Sep 25;56(1):182
Veterinary research 2025 Sep 25;56(1):182
Caffeic acid ameliorates intestinal barrier injury to attenuate acute pancreatitis via inhibiting GSDMD-mediated pyroptotic pathway.
Zhang Y, Lin X, Shen B, Huang W, Zhou Q, Tan G, Zhi F, Liang E
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120261
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120261
Emodin enhances the therapeutic efficacy of human umbilical cord mesenchymal stem cell-derived extracellular vesicles in acute pancreatitis-induced lung injury.
Dong B, Liu X, Huang X, Liu S, Hu J, Huang X, Lin J
Toxicology and applied pharmacology 2025 Sep 14;505:117566
Toxicology and applied pharmacology 2025 Sep 14;505:117566
A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure.
Yin H, Jiang H, Zhao R, Zhang Y, Fan X, Zhai X, Yang X, Zhang Y
Ecotoxicology and environmental safety 2025 Sep 1;302:118752
Ecotoxicology and environmental safety 2025 Sep 1;302:118752
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
Pang H, Fu B, Wang P, Meng Y, Xie P, Hu X, Ma Q
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.
Li S, Wang J, Chen Y, Cheng Y, Wang Y, Xu N, Wang H, Wang L, Chi Y, Ye X, Shi Y, Fang J, Yao X, Huang J, Xia Q, Bai T, Zhu B
Inflammation 2025 Oct;48(5):3180-3193
Inflammation 2025 Oct;48(5):3180-3193
Baicalein Reduces Pyroptosis of Acinar Cells in Hyperlipidemic Acute Pancreatitis by Inhibiting M1 Polarization of Macrophages via the HMGB1/TLR4/NLRP3 Pathway.
Wang X, Zhou Y, Liu Y, Mo T, Chen Z, Zhang Y, Yang L, Liu P
Inflammation 2025 Oct;48(5):3130-3145
Inflammation 2025 Oct;48(5):3130-3145
NR4A1 mediates PRRSV-induced ileal injury in piglets by transcriptional regulation of NLRP3.
Meng F, Zhu C, Zhu C, Yuan L, Li C, Sun M, Cai D
Veterinary microbiology 2025 Oct;309:110677
Veterinary microbiology 2025 Oct;309:110677
AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure.
Lin Q, Cai H, Yu F, Gong C, Wu Y, Wu Q, Xie F, Xu W, Chen S, Yao X, Jin L, Peng R
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2340-2357
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2340-2357
Indole-3 propionate inhibits NF-κB/NLRP3-mediated osteoclastogenesis and improves bone quality in high-fat-diet induced obese mice.
Wu R, Kong Y, Li J, Chen H, Jiao Y, Sun C, Ju Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167952
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167952
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Li L, Zuo A, Yin R, Liu Q, Liu C, Li N, Xu D, Zhang S, Li J, Lei S, Ruan S, Li T, Guo Y
Cell death & disease 2025 Oct 7;16(1):710
Cell death & disease 2025 Oct 7;16(1):710
LncRNA MIR17HG accelerates the development of atherosclerosis by promoting macrophage pyroptosis through the miR-301a-3p/TXNIP pathway.
Wang YP, Liu X, Xu XD, Hui L, Xu GH, Ma MQ, Zhu L, Ren K
International immunopharmacology 2025 Oct 30;164:115407
International immunopharmacology 2025 Oct 30;164:115407
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
Zhou W, Liu Z, Qiu X, Tian M, He B, Tang C, Tang Q, Ye R, Zhong D, Liao Y
International immunopharmacology 2025 Oct 30;164:115400
International immunopharmacology 2025 Oct 30;164:115400
The effect of puerarin on the NLRP3 Inflammasome pathway and MMP-9 in aortic dissection of ApoE(-/-) mice.
Cai Z, Yan T, Zhang B, Cao X, Feng M, Zhang W, Zhang H, Wang X
International immunopharmacology 2025 Oct 10;163:115286
International immunopharmacology 2025 Oct 10;163:115286
Rv2647-Mediated NLRP3 Ubiquitination Inhibits Macrophage Pyroptosis and Promotes Mycobacterium tuberculosis Survival.
Jin X, Yan H, Chen X, Feng J, Li G, Yao J, Du X, Feng G
ACS infectious diseases 2025 Oct 10;11(10):2739-2753
ACS infectious diseases 2025 Oct 10;11(10):2739-2753
PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1/ROS pathway.
Dong J, Ma T, Qu Y, Ye R, Feng J, Bai G, Hong A, Ma Y
Molecular and cellular endocrinology 2025 Oct 1;608:112633
Molecular and cellular endocrinology 2025 Oct 1;608:112633
Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss.
Fang J, Li Z, Wang P, Zhang X, Mao S, Li Y, Yu D, Li X, Xing Y, Shi H, Yin S
Neural regeneration research 2025 Oct 1;20(10):3025-3039
Neural regeneration research 2025 Oct 1;20(10):3025-3039
CDK8 mediated inflammatory microenvironment aggravates osteoarthritis progression.
Lin Z, Xu Y, Jiang H, Zeng W, Wang Y, Zhu L, Lin C, Lou C, Shen H, Ye H, Gu Y, Yu H, Pan X, Zheng L
Journal of advanced research 2025 Nov;77:585-603
Journal of advanced research 2025 Nov;77:585-603
Cytopathic bovine viral diarrhea virus-induced NLRP3 inflammasome activation triggers GSDMD-mediated pyroptosis, amplifying the inflammatory response.
Yao X, Li Y, Wang J, Liu Z, Chen J, Feng Z, Wang Z, Xiang J, Xu R, Jia S, Qi Z, Xu Y
Veterinary microbiology 2025 Nov;310:110736
Veterinary microbiology 2025 Nov;310:110736
Ellagic acid mediated pyroptosis in hepatocellular carcinoma via the ESR1/G6PD pathway.
Wang S, Cai Y, Zhou F, Zhang M, Li J, Shang L, Huang J, Chen L, Yang S
Biochemical pharmacology 2025 Nov;241:117178
Biochemical pharmacology 2025 Nov;241:117178
Targeting ICAM1 through LIF-mediated NF-κB/JAK2-STAT3 crosstalk protects nucleus pulposus from IL-1β-driven pyroptosis to ameliorate intervertebral disc degeneration.
Wang Z, Liu J, Xu H, Sun Y, Xu S, He X
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Journal of orthopaedic surgery and research 2025 Nov 22;20(1):1096
Modulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen's Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats.
Wu L, Yang C, Ding Y, Liu X, Sun H, Li X, Lu Y, Liu L, Fu Q, Li M, Wang Y, Zhao Y, Han W, Lu G, Sun L
Molecular neurobiology 2025 Nov 20;63(1):100
Molecular neurobiology 2025 Nov 20;63(1):100
Curcumin Alleviates Bisphenol A-Induced Blood-Testis Barrier Disruption in Mice by Targeting Surfactant Protein B (SFTPB) to Suppress Oxidative Stress-Activated NLRP3 Inflammasome.
Duan H, Yang S, Xiao L, Yang S, Jiang B, Fang Z, Yan Z, Zeng J, Ma X, Dong W, Liu Y
Journal of agricultural and food chemistry 2025 Nov 19;73(46):29874-29885
Journal of agricultural and food chemistry 2025 Nov 19;73(46):29874-29885
PROM2 exacerbates CCl4-Induced liver fibrosis via NLRP3 inflammasome activation and hepatocyte pyroptosis.
Guo J, Lin Y, Gong X, Kuang G, Hu J, Du H, Liu H, Zhang J, Zhang L, Wan J, Wang T
Cellular and molecular life sciences : CMLS 2025 Nov 14;82(1):403
Cellular and molecular life sciences : CMLS 2025 Nov 14;82(1):403
MiR-193b-3p Regulates Gasdermin-D/NLRP3 by Targeting the Signaling Axis Inhibition of Pyroptosis Attenuates Myocardial Ischemia-Reperfusion Injury.
Yu C, Zhu QP, Xie W, Xu WS, Liu JL, Wang W, Zhang YF, Zhang T, Shao G
Journal of physiological investigation 2025 Nov 1;68(6):349-357
Journal of physiological investigation 2025 Nov 1;68(6):349-357
Repurposing of FDA-approved drugs by targeting SIRT2 to alleviate inflammatory response and kidney injury.
Huang HJ, Lin YC, Ho LJ, Su RY, Liu WC, Chiu HW
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025 Nov 1;214:107296
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025 Nov 1;214:107296
Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function.
Jiang C, Gong Y, Wu X, Chen J, Chen Y, Chen J, Tang F, Fang Z, Bao Y, Ye J, Wang Z, Hong Z
Journal of orthopaedic translation 2025 May;52:220-232
Journal of orthopaedic translation 2025 May;52:220-232
AdipoRon attenuates depression-like behavior in T2DM mice via inhibiting inflammation and regulating autophagy.
Zhao W, Li Y, Zhou Y, Zhao J, Lu Y, Xu Z
Brain research bulletin 2025 May;224:111308
Brain research bulletin 2025 May;224:111308
Deoxynivalenol-induced pyroptosis and autophagy inhibition collectively promote inflammatory injury in the glandular stomach of chicken embryos.
Chen F, Yang G, Qiu H, Gao S, Hou L, Dong J, Zhao P, Dong W
Poultry science 2025 May;104(5):105052
Poultry science 2025 May;104(5):105052
Terminalia chebula Retz. extract relieves gout arthritis by inhibiting xanthine oxidase, the uric acid transporter, and NLRP3 inflammasome activation.
He A, Wang J, Feng Y, Liao Z, Zheng Q, Zhang W, Chen H
Journal of ethnopharmacology 2025 May 28;348:119848
Journal of ethnopharmacology 2025 May 28;348:119848
Icariin alleviates cardiomyocyte pyroptosis through AMPK-NLRP3 pathway to ameliorates diabetic cardiomyopathy.
Cai Z, Sun F, Wang Q, Li S, Wang L, Li H, Su Y, Yang H, Dong B
International immunopharmacology 2025 May 27;156:114690
International immunopharmacology 2025 May 27;156:114690
Green tea epigallocatechin gallate attenuate metabolic dysfunction-associated steatotic liver disease by regulation of pyroptosis.
Zhang J, Wang S, Zhang T, Zi M, Wang S, Zhang Q
Lipids in health and disease 2025 May 17;24(1):180
Lipids in health and disease 2025 May 17;24(1):180
Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway.
Li HH, Liu X, Wang YP, Xu X, Zhu L, Zhang W, Ren K
Metabolites 2025 May 15;15(5)
Metabolites 2025 May 15;15(5)
Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.
Xiang Y, Kuang G, Gong X, Xie H, Lin Y, Zhang X, Chen Z, Wan J, Li Z
Phytotherapy research : PTR 2025 Mar;39(3):1531-1548
Phytotherapy research : PTR 2025 Mar;39(3):1531-1548
Glaesserella parasuis serotype 5 promotes pyroptosis via degrading Caveolin-1 in 3D4/21 cells.
Lin H, Zhang J, Wang Q, Zhou H, Fan H
Veterinary microbiology 2025 Mar;302:110393
Veterinary microbiology 2025 Mar;302:110393
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Liu Q, Wang F, Du Y, Liu Y, Zhang Z, Zhang X, Li J, Huang G, Liu F, Li B, Xiao W, Sui C, Bao N, Zhuang R, Gao C, Wang X, Gu X
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p.
Yang Q, Chen Q, Zhang KB, Liu Y, Zheng JC, Hu DX, Luo J
Acta neuropathologica communications 2025 Mar 5;13(1):48
Acta neuropathologica communications 2025 Mar 5;13(1):48
Coal dust particles can upregulate the expression of NLRP3 inflammasome components in rat alveolar macrophages through phagocytosis.
Zhang Y, Yan J, Ren Y, Cheng Y, Qin H, Hu Y, Zhao H
Scientific reports 2025 Mar 15;15(1):8989
Scientific reports 2025 Mar 15;15(1):8989
Citrinin-Induced Intestinal Onset of Pyroptosis via the IP3R1-GRP75-VDAC1 Complex-Mediated Mitochondrial Oxidative Stress.
Li Y, Zhang Q, Liu X, Wang Y, Yang C, Wu Y, Xiao B, Feng Y, Wu A, Yi J, Wu J, Liang Z, Yuan Z
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5803-5815
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5803-5815
Blocking GATA6 Alleviates Pyroptosis and Inhibits Abdominal Wall Endometriosis Lesion Growth Through Inactivating the PI3K/AKT Pathway.
Du X, Yang H, Kang X, Fu C, Yang T
Cell biochemistry and biophysics 2025 Jun;83(2):1757-1770
Cell biochemistry and biophysics 2025 Jun;83(2):1757-1770
Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells.
Cui Y, Lin H, Ma J, Zhao Y, Li J, Wang Y, Zhuang J, Yang Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167782
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167782
Probiotic Combination of Limosilactobacillus fermentum HF07 and Lactococcus lactis HF08 Targeting Gut Microbiota-Secondary Bile Acid Metabolism Ameliorates Inflammation and Intestinal Barrier Dysfunction in Aging Colitis.
Liu X, Guan K, Ma Y, Jiang L, Li Q, Liu Y, Mao K, Wang R
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13439-13454
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13439-13454
Nigericin Induces Paraptosis-Like Cell Death Instead of Pyroptosis in Corneal Keratocytes.
Mi X, Zhou X, Zhu S, Mateus A, Backman LJ, Danielson P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70740
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70740
Investigating the Mechanism of Emodin in Rheumatoid Arthritis Through the HIF-1α/NLRP3 Pathway and Mitochondrial Autophagy.
Du D, Zhou L, Tian J, Cheng L, Zhang H, Tang Y, Qiu Z, Zhang T, Rong X
Current issues in molecular biology 2025 Jun 25;47(7)
Current issues in molecular biology 2025 Jun 25;47(7)
Calycosin treats acute myocardial infarction via NLRP3 inflammasome: Bioinformatics, network pharmacology and experimental validation.
Yuan HJ, Han QC, Yu H, Yu YD, Liu XJ, Xue YT, Li Y
European journal of pharmacology 2025 Jun 15;997:177621
European journal of pharmacology 2025 Jun 15;997:177621
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis.
Zhang H, Jiang N, Xu M, Jing D, Dong T, Liu Q, Lv Q, Huo R, Chen P, Li L, Wang X
Life sciences 2025 Jun 1;370:123561
Life sciences 2025 Jun 1;370:123561
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
Wei X, Yu C, Wang J
Connective tissue research 2025 Jul;66(4):298-310
Connective tissue research 2025 Jul;66(4):298-310
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
Ma MQ, Yang C, Jin SY, Yang Y, Pan YY, Lin XH
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.
Tang H, Ning K, Wu B, Wang X, He J, Li P, Pan L, Zhang J, He Y, Bian S, Ma X, Zhang J, Liu C, Qin Z, Hu H
Biochemical pharmacology 2025 Jul;237:116932
Biochemical pharmacology 2025 Jul;237:116932
E2-Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells.
Shen S, Yin H
Nature chemical biology 2025 Jul;21(7):1089-1099
Nature chemical biology 2025 Jul;21(7):1089-1099
Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells.
Zhang HL, Chang J, Sun CP, Huo ZP, Feng YL, Li PY, Jia YX, Hui SW, Zhu QM, Cai JY, He Y, Qiu F, Zhang J
Molecular immunology 2025 Jul;183:313-320
Molecular immunology 2025 Jul;183:313-320
Koumine mediates the generation of mtROS through the IP3R1-GRP75-VDAC1 complex to improve Citrinin induced intestinal inflammation.
Li Y, Liu X, Zhang Q, Jiang Z, Zhang W, Yang C, Ni J, Deng S, Yi J, Wu J, Sun Z, Liang Z, Yuan Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156803
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156803
Xiongshao Zhitong granules alleviate nitroglycerin-induced migraine by regulating the TRPV1-mediated NLRP3 inflammatory pathway in rats.
Wang Y, Yang S, Liu X, Chen C, Li Q, Wang X, Xu W, Gao J, Wang Y, Wang W, Wang T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156754
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156754
Mechanism of hydroxychloroquine in the treatment of obstetric antiphospholipid syndrome by inhibiting NETs-induced trophoblast pyroptosis.
Liu J, Xu M, Shen D, Wang X
Molecular biology reports 2025 Jul 7;52(1):679
Molecular biology reports 2025 Jul 7;52(1):679
Ginsenoside Rg3 alleviates brain damage caused by chlorpyrifos exposure by targeting and regulating the microbial-gut-brain axis.
Liu S, Yang Y, Zong Y, Chen W, Geng J, Zhao Y, Du R, He Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156838
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Sun S, Qiu H, Wang C, Zhang K, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2025 Jul 24;351:120149
Journal of ethnopharmacology 2025 Jul 24;351:120149
Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells.
Li D, Li H, Wang Z, Huang Y, Zhao C, Zhang H, Zhao Y, Zhu N, Tang X, Jin Y, Zhou D
Veterinary research 2025 Jul 21;56(1):155
Veterinary research 2025 Jul 21;56(1):155
S-COS-Se mitigates cadmium-induced oxidative stress, inflammation, and immunotoxicity by restoring immune balance and inhibiting mitochondria-pyroptosis crosstalk.
Zheng H, Dong W, Qiu H, Gao S, Hou L, Dong J, Zhao P, Chen F
Ecotoxicology and environmental safety 2025 Jul 15;300:118462
Ecotoxicology and environmental safety 2025 Jul 15;300:118462
Defective RuO(2) Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.
Lv J, Muhammad F, Wang Z, Qiao C, Gu X, Liu Y, Li W, Gong W, Lv Z, Fei Y, Peng L, Lu Z, Xu N, Hu C, Zhang H, Wu R, Xu X, Wei H, Sun Z, Shi D
ACS nano 2025 Jul 1;19(25):23080-23095
ACS nano 2025 Jul 1;19(25):23080-23095
Ginsenoside Rg1 improves hypoxia-induced pulmonary vascular endothelial dysfunction through TXNIP/NLRP3 pathway-modulated mitophagy.
Zhang R, Lu M, Ran C, Niu L, Qi Q, Wang H
Journal of ginseng research 2025 Jan;49(1):80-91
Journal of ginseng research 2025 Jan;49(1):80-91
Highly BBB-permeable nanomedicine reverses neuroapoptosis and neuroinflammation to treat Alzheimer's disease.
Xie A, Cheng G, Wu J, Li Z, Yu G, Zhu X, Chen T
Biomaterials 2025 Jan;312:122749
Biomaterials 2025 Jan;312:122749
PRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation.
Zhang L, Gao Y, Zhou H, Liang X, Jiang X, Gong W, Sun Y, Zhang D, Wang X, Nauwynck H, Bai J, Jiang P
PLoS pathogens 2025 Jan;21(1):e1012915
PLoS pathogens 2025 Jan;21(1):e1012915
Chemerin-9 is neuroprotective in APP/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of Aβ.
Zhang J, Zhang Y, Liu L, Zhang M, Zhang X, Deng J, Zhao F, Lin Q, Zheng X, Fu B, Zhao Y, Wang X
Journal of neuroinflammation 2025 Jan 8;22(1):5
Journal of neuroinflammation 2025 Jan 8;22(1):5
Huashi baidu granule alleviates inflammation and lung edema by suppressing the NLRP3/caspase-1/GSDMD-N pathway and promoting fluid clearance in a porcine reproductive and respiratory syndrome (PRRS) model.
Zhang FL, Chen YL, Luo ZY, Song ZB, Chen Z, Zhang JX, Zheng ZZ, Tan XM
Journal of ethnopharmacology 2025 Jan 31;340:119207
Journal of ethnopharmacology 2025 Jan 31;340:119207
Tangzu granule alleviate neuroinflammation in diabetic peripheral neuropathy by suppressing pyroptosis through P2X7R /NLRP3 signaling pathway.
Feng H, Wu T, Chin J, Ding R, Long C, Wang G, Yan D, Ma X, Yue R
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118792
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118792
Novel Nanoliposomes Synergistically Modulated by Sitogluside and Dioscin: Stability, Bioavailability, and Capacity To Alleviate Hyperuricaemia.
Liu G, Liu J, Shao P, Kai D, Yang L, Sun P, Feng S
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2596-2612
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2596-2612
Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.
Cai Z, Liang C, Huang K, Luo J, Lu R, Lai Y, Zheng D, Lin Z, Zhong J, Dai J, Huang J, Zhang H, Chen J
International immunopharmacology 2025 Jan 27;146:113928
International immunopharmacology 2025 Jan 27;146:113928
Therapeutic effects of tripterygium glycosides on periodontitis: Exploring the role of ursolic acid and the RIPK3/NLRP3 signaling pathway.
Ren L, Gao Y, Chen L, Yang L
International immunopharmacology 2025 Jan 27;146:113903
International immunopharmacology 2025 Jan 27;146:113903
Pirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation.
Su Q, Feng Y, Guo J, Cui X, Zhu J, Yang J, Zhang S
Clinical and experimental immunology 2025 Jan 21;219(1)
Clinical and experimental immunology 2025 Jan 21;219(1)
Ganoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling.
Zhang L, Wang K, Huang L, Deng B, Chen C, Zhao K, Wang W
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1563-1579
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1563-1579
α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Wang H, Zhang H, Miao L, Wang C, Teng H, Li X, Zhang X, Yang G, Wang S, Zeng X
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
Ecotoxicology and environmental safety 2025 Jan 15;290:117749
Inhibition of tumor necrosis factor receptor-associated factor 6 alleviates secondary brain injury by reducing neuronal pyroptosis after intracerebral hemorrhage.
Hu Q, Zeng H, Feng C, Tian W, He Y, Li B
Experimental animals 2025 Jan 10;74(1):39-48
Experimental animals 2025 Jan 10;74(1):39-48
Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression.
Chen M, Zhang Y, Zhao Y, Cao K, Niu R, Guo D, Sun Z
Ecotoxicology and environmental safety 2025 Jan 1;289:117476
Ecotoxicology and environmental safety 2025 Jan 1;289:117476
Molecular insights of T-2 toxin exposure-induced neurotoxicity and the neuroprotective effect of dimethyl fumarate.
Pei X, Ma S, Hong L, Zuo Z, Xu G, Chen C, Shen Y, Liu D, Li C, Li D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115166
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115166
A Heparan Sulfate Mimetic RAFT Copolymer Inhibits SARS-CoV-2 Infection and Ameliorates Viral-Induced Inflammation.
Ling J, Lundkvist Å, Guerrini M, Ferro V, Li JP, Li J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2411737
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2411737
Structural Characterization and Anti-Gouty Nephropathy Potential of Polysaccharides from Atractylodes chinensis.
Chen X, Jia R, Zhang K, Sun S, Mei M, Zhao H, Shen Y, Wang Y, Zhang Y
Molecules (Basel, Switzerland) 2025 Feb 7;30(4)
Molecules (Basel, Switzerland) 2025 Feb 7;30(4)
The absence of IRG1 exacerbates bone loss in a mouse model of ovariectomy-induced osteoporosis by increasing osteoclastogenesis through the potentiation of NLRP3 inflammasome activation.
Wang F, Liu Y, Zhao Y, Zheng H, Zhang L
International immunopharmacology 2025 Feb 20;148:114099
International immunopharmacology 2025 Feb 20;148:114099
Dapagliflozin attenuates skeletal muscle atrophy in diabetic nephropathy mice through suppressing Gasdermin D-mediated pyroptosis.
Zhang S, Guo S, Wang P, Song Y, Yang L, Sun Q, Huang Q, Zhang Y
International immunopharmacology 2025 Feb 20;148:114088
International immunopharmacology 2025 Feb 20;148:114088
PCBP2 Promotes NRG4 mRNA Stability to Diminish Angiotensin II-Induced Hypertrophy, NLRP3 Inflammasome Activation, and Oxidative Stress of AC16 Cardiomyocytes.
Zhang Y, Liu Y, Wang Y
Cell biochemistry and biophysics 2025 Dec;83(4):4989-5001
Cell biochemistry and biophysics 2025 Dec;83(4):4989-5001
Anti-inflammatory Effects of Membrane Vesicles from Eubacterium rectale via the NLRP3 Signal Pathway.
Zhang H, Zhao Y, Li D, Li H, Wang Z, Zhang L, Niu H, Huang Y, Zhao C, Jin Y, Zhou D
Probiotics and antimicrobial proteins 2025 Dec;17(6):4841-4850
Probiotics and antimicrobial proteins 2025 Dec;17(6):4841-4850
Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.
Sun B, Wu J, Li Z, Zhang Y, Lu X, Wang J, Xu X
International immunopharmacology 2025 Dec 3;166:115639
International immunopharmacology 2025 Dec 3;166:115639
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling.
Ning P, Wu J, Long Q, Zheng Y, Gan J, Hu X, Song S, Li X, Jiang M, Ye H, Yu W, He Y, Zheng Y, Gao Z
Inflammation 2025 Dec 20;49(1):11
Inflammation 2025 Dec 20;49(1):11
Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.
Yu K, Liu M, Zhang T, Guo C, Du L, Li M, Wang Q, Han N, Chi Y, Li Y
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Diabetology & metabolic syndrome 2025 Dec 2;18(1):7
Metformin Nanodelivery System Alleviates Morphine-Induced Analgesic Tolerance via Inhibiting the TXNIP/NLRP3/GSDMD Axis.
Yao D, Zhao X, Wang Y, Xu X, Cao L, Sun T, Zhao A, Chen J
ACS applied bio materials 2025 Dec 15;8(12):11075-11088
ACS applied bio materials 2025 Dec 15;8(12):11075-11088
Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation.
Wang X, Jiang H, Wang H, Zhao C, Ba X
International immunopharmacology 2025 Dec 10;167:115682
International immunopharmacology 2025 Dec 10;167:115682
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Chen X, Zhang F, Zhou Z, Jiang D, Wen L
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
Fibroblast Growth Factor 21 Confers Protection Against Asthma Through Inhibition of NLRP3 Inflammasome Activation.
Liu Y, Li J, Wu Z, Wu S, Yang X
Inflammation 2025 Aug;48(4):2720-2731
Inflammation 2025 Aug;48(4):2720-2731
Colchicine Alleviates Interstitial Lung Disease in an Experimental Autoimmune Myositis Murine Model by Inhibiting the Formation of Neutrophil Extracellular Traps.
Li F, Zhao P, Zhao L, Bai L, Su Q, Feng Y, Ma W, Zhu J, Yang J, Zhang S
Inflammation 2025 Aug;48(4):2692-2703
Inflammation 2025 Aug;48(4):2692-2703
Atorvastatin Alleviates Age-Related Macular Degeneration via AIM2-Regulated Pyroptosis.
Lu J, He Y, Du Y, Zhao L, Wu P, Shu Q, Peng H, Wang X
Inflammation 2025 Aug;48(4):2122-2136
Inflammation 2025 Aug;48(4):2122-2136
GPR40 inhibits microglia-mediated neuroinflammation via the NLRP3/IL-1β/glutaminase pathway after subarachnoid hemorrhage.
Zou Y, Zhang B, Jiang K, Zhou X, Tang Q, Chen S, Wu Q, Zhao X, Zhang X
Biochemical pharmacology 2025 Aug;238:116971
Biochemical pharmacology 2025 Aug;238:116971
RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis.
Wang X, Zhang Y, Chen X, Fu K, Cui J, Wu J, Sun Y, Ren J, Xue F, Dai J, Tang F
Nature communications 2025 Aug 7;16(1):7309
Nature communications 2025 Aug 7;16(1):7309
Emodin-Enhanced hUC-MSC extracellular vesicles alleviate acute pancreatitis by targeting inflammation and pyroptosis.
Liu X, Huang X, Huang X, Liu S, Hu J, Lin J
Stem cell research & therapy 2025 Aug 6;16(1):434
Stem cell research & therapy 2025 Aug 6;16(1):434
Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners.
Sun HJ, Lu QB, Liu SJ, Fu X, Yu CL, Su JB, Meng XY, Guo X, Shao X, Li JH, Sun QY, Zhu XX, Shan JJ, Zhou W
Cell reports. Medicine 2025 Aug 19;6(8):102241
Cell reports. Medicine 2025 Aug 19;6(8):102241
The role of glutathione S-transferase mu 2 in mitigating fatty acid-induced hepatic inflammation in dairy cows.
Li J, Zhao C, Qi D, Kong F, Liu M, Gao J, Li E, Gao W, Du X, Song Y, Li X, Feng H, Lei L
Journal of dairy science 2025 Apr;108(4):4149-4162
Journal of dairy science 2025 Apr;108(4):4149-4162
Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40.
He Y, Lu J, Du Y, Zhao L, Gong L, Wu P, Shu Q, Peng H, Wang X
Scientific reports 2025 Apr 19;15(1):13514
Scientific reports 2025 Apr 19;15(1):13514
Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivation.
Wu X, Xin R, Zhang Y, Yang C, Sun F, Wang Y, Zheng F
Clinics (Sao Paulo, Brazil) 2024;79:100336
Clinics (Sao Paulo, Brazil) 2024;79:100336
Poly-(ADP-ribose) polymerases inhibition by olaparib attenuates activities of the NLRP3 inflammasome and of NF-κB in THP-1 monocytes.
Mustafa K, Han Y, He D, Wang Y, Niu N, Jose PA, Jiang Y, Kopp JB, Lee H, Qu P
PloS one 2024;19(2):e0295837
PloS one 2024;19(2):e0295837
Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-κB and NLRP3/Caspase-1/GSDMD Signaling Pathways.
Li J, Du X, Mu Z, Han X
Journal of inflammation research 2024;17:8009-8026
Journal of inflammation research 2024;17:8009-8026
Cynaroside: a potential therapeutic agent targeting arachidonate 15-lipoxygenase to mitigate cerebral ischemia/reperfusion injury.
Cao W, Hu Y, Yu X, Long T, Sun B, Lei S, Xie P, Yu W
Frontiers in neurology 2024;15:1490640
Frontiers in neurology 2024;15:1490640
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
Chen Y, Wu X, Jiang Z, Li X
Frontiers in pharmacology 2024;15:1461931
Frontiers in pharmacology 2024;15:1461931
Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation.
Li X, Dong X, Zhang L, Zhang S, Huang W, Wang C, Huo Z, Li X, Zhang X, Jia X, Chen G, Kuang B
Frontiers in pharmacology 2024;15:1285797
Frontiers in pharmacology 2024;15:1285797
Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation.
Zhang Q, Yang XR, Deng Y
Cell biochemistry and biophysics 2024 Sep;82(3):2275-2283
Cell biochemistry and biophysics 2024 Sep;82(3):2275-2283
Dexmedetomidine improves mitophagy and pyroptosis through the ALKBH5/FUNDC1 axis during epidural-related maternal fever.
Xiao F, Yao H, Qian J, Huang J, Xia G
Advances in medical sciences 2024 Sep;69(2):272-280
Advances in medical sciences 2024 Sep;69(2):272-280
Pseudorabies Virus UL4 protein promotes the ASC-dependent inflammasome activation and pyroptosis to exacerbate inflammation.
Zhang X, Chen G, Yin J, Nie L, Li L, Du Q, Tong D, Huang Y
PLoS pathogens 2024 Sep;20(9):e1012546
PLoS pathogens 2024 Sep;20(9):e1012546
Targeted-lung delivery of bardoxolone methyl using PECAM-1 antibody-conjugated nanostructure lipid carriers for the treatment of lung inflammation.
He JX, Zhu CQ, Liang GF, Mao HB, Shen WY, Hu JB
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:116992
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:116992
Attenuation of PM2.5-Induced Lung Injury by 4-Phenylbutyric Acid: Maintenance of [Ca(2+)]i Stability between Endoplasmic Reticulum and Mitochondria.
Ma Z, Du X, Sun Y, Jia Y, Liang X, Gao Y
Biomolecules 2024 Sep 8;14(9)
Biomolecules 2024 Sep 8;14(9)
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
Xue J, Jiang C, Chen X, Wang L
International immunopharmacology 2024 Sep 10;138:112591
International immunopharmacology 2024 Sep 10;138:112591
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
Peng S, Liu X, Chang L, Liu B, Zhang M, Mao Y, Shen X
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
piR112710 attenuates diabetic cardiomyopathy through inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
Jiao A, Liu H, Wang H, Yu J, Gong L, Zhang H, Fu L
Cellular signalling 2024 Oct;122:111333
Cellular signalling 2024 Oct;122:111333
Deleting fibroblast growth factor 2 in macrophages aggravates septic acute lung injury by increasing M1 polarization and inflammatory cytokine secretion.
Yi L, Chen Y, Zhang Y, Huang H, Li J, Qu Y, Weng T, Chai J
Molecular biomedicine 2024 Oct 22;5(1):50
Molecular biomedicine 2024 Oct 22;5(1):50
Acupuncture ameliorates depression-like behavior of poststroke depression model rats through the regulation of gut microbiota and NLRP3 inflammasome in the colon.
Cai W, Wei XF, Zhang JR, Tao L, Li D, Zhang K, Shen WD
Neuroreport 2024 Oct 2;35(14):883-894
Neuroreport 2024 Oct 2;35(14):883-894
miRNA-193a-mediated WT1 suppression triggers podocyte injury through activation of the EZH2/β-catenin/NLRP3 pathway in children with diabetic nephropathy.
Wang P, Yang J, Dai S, Gao P, Qi Y, Zhao X, Liu J, Wang Y, Gao Y
Experimental cell research 2024 Oct 1;442(2):114238
Experimental cell research 2024 Oct 1;442(2):114238
Gut microbiome and metabolites mediate the benefits of caloric restriction in mice after acute kidney injury.
Zhu XX, Fu X, Meng XY, Su JB, Zheng GL, Xu AJ, Chen G, Zhang Y, Liu Y, Hou XH, Qiu HB, Sun QY, Hu JY, Lv ZL, Wang Y, Jiang HB, Bao N, Han ZJ, Lu QB, Sun HJ
Redox biology 2024 Nov;77:103373
Redox biology 2024 Nov;77:103373
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
Gao Y, Li H, Que Y, Chen W, Huang SY, Liu W, Ye X
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway.
Ma X, Zhang W, Chen Y, Hu Q, Wang Z, Jiang T, Zeng Y, Efferth T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:156021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:156021
Salidroside promotes liver regeneration after partial hepatectomy in mice by modulating NLRP3 inflammasome-mediated pyroptosis pathway.
Zhang S, Yu M, Wang F, Li S, Li X, Hu H, Zhang Z, Zhu X, Tian W
Biochemical and biophysical research communications 2024 Nov 26;735:150678
Biochemical and biophysical research communications 2024 Nov 26;735:150678
Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy.
Yang S, Fang Z, Duan H, Dong W, Xiao L
Antioxidants (Basel, Switzerland) 2024 Nov 24;13(12)
Antioxidants (Basel, Switzerland) 2024 Nov 24;13(12)
Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1-NF-kB-NLRP3/Pyroptosis Pathway.
Wang X, Su L, Liu S, He Z, Li J, Zong Y, Chen W, Du R
International journal of molecular sciences 2024 Nov 22;25(23)
International journal of molecular sciences 2024 Nov 22;25(23)
UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis.
Huang B, Lin G, Chen F, Yang W, Zhang C, Yao Y, Zeng Q, Yang Y, Huang J
International immunopharmacology 2024 Nov 15;141:112935
International immunopharmacology 2024 Nov 15;141:112935
Bovine DDX3X Restrains Bovine SP110c-Mediated Activation of Inflammasome in Macrophages.
Li Z, Han J, Jing J, Fan A, Zhang Y, Gao Y
Animals : an open access journal from MDPI 2024 May 31;14(11)
Animals : an open access journal from MDPI 2024 May 31;14(11)
Exosomal long non-coding RNA AU020206 alleviates macrophage pyroptosis in atherosclerosis by suppressing CEBPB-mediated NLRP3 transcription.
Zhang N, Luo Y, Shao J, Sun H, Ma K, Gao X
Experimental cell research 2024 May 15;438(2):114054
Experimental cell research 2024 May 15;438(2):114054
Triclosan induces liver injury in long-life exposed mice via activation of TLR4/NF-κB/NLRP3 pathway.
Peng Y, Cui H, Shu C, Wei Z, Ni X, Liu J
Ecotoxicology and environmental safety 2024 Mar 15;273:116115
Ecotoxicology and environmental safety 2024 Mar 15;273:116115
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy.
Su L, Guo P, Guo X, He Z, Zhao Y, Zong Y, Li J, Chen W, DU R
Chinese journal of natural medicines 2024 Jun;22(6):515-529
Chinese journal of natural medicines 2024 Jun;22(6):515-529
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Qi W, Jin L, Huang S, Aikebaier A, Xue S, Wang Q, Chen Q, Lu Y, Ding C
Acta biomaterialia 2024 Jun;181:425-439
Acta biomaterialia 2024 Jun;181:425-439
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Feng S, Xie X, Li J, Xu X, Chen C, Zou G, Lin G, Huang T, Hu R, Ran T, Han L, Zhang Q, Li Y, Zhao X
Hepatology international 2024 Jun;18(3):1040-1052
Hepatology international 2024 Jun;18(3):1040-1052
Tmem30a protects against podocyte injury through suppression of pyroptosis.
Hou Y, Chen S, Peng L, Huang L, Zhang H, Zhang P, Yu M, Xiong L, Zhong X, Liu W, Zhu X, Wang L, Li Y, Li G
iScience 2024 Jun 21;27(6):109976
iScience 2024 Jun 21;27(6):109976
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome.
Zhao P, Zhu J, Bai L, Ma W, Li F, Zhang C, Zhao L, Wang L, Zhang S
Clinical and experimental immunology 2024 Jun 20;217(1):89-98
Clinical and experimental immunology 2024 Jun 20;217(1):89-98
Revealing the Mechanism of NLRP3 Inflammatory Pathway Activation through K(+) Efflux Induced by PLO via Signal Point Mutations.
Shan Q, Ma W, Li B, Li Q, Wang X, Li Y, Wang J, Zhu Y, Liu N
International journal of molecular sciences 2024 Jun 18;25(12)
International journal of molecular sciences 2024 Jun 18;25(12)
Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress.
Zhang JR, Shen SY, Zhai MY, Shen ZQ, Li W, Liang LF, Yin SY, Han QQ, Li B, Zhang YQ, Yu J
Nature communications 2024 Jun 18;15(1):5199
Nature communications 2024 Jun 18;15(1):5199
Asprosin promotes vascular inflammation via TLR4-NFκB-mediated NLRP3 inflammasome activation in hypertension.
Ge R, Chen JL, Zheng F, Yin SM, Dai M, Wang YM, Chen Q, Li YH, Zhu GQ, Chen AD
Heliyon 2024 Jun 15;10(11):e31659
Heliyon 2024 Jun 15;10(11):e31659
Mahuang Fuzi Xixin decoction alleviates allergic rhinitis by inhibiting NLRP3/Caspase-1/GSDMD-N-mediated pyroptosis.
Ding M, Wei X, Liu C, Tan X
Journal of ethnopharmacology 2024 Jun 12;327:118041
Journal of ethnopharmacology 2024 Jun 12;327:118041
P2Y6 Receptor Activation Aggravates NLRP3-dependent Microglial Pyroptosis via Downregulation of the PI3K/AKT Pathway in a Mouse Model of Intracerebral Hemorrhage.
Li Y, Tu H, Zhang S, Ding Z, Wu G, Piao J, Lv D, Hu L, Li F, Wang Q
Molecular neurobiology 2024 Jul;61(7):4259-4277
Molecular neurobiology 2024 Jul;61(7):4259-4277
Glaesserella parasuis serotype 5 induces pyroptosis via the RIG-I/MAVS/NLRP3 pathway in swine tracheal epithelial cells.
Li Y, Guo M, Wang Q, Zhou H, Wu W, Lin H, Fan H
Veterinary microbiology 2024 Jul;294:110127
Veterinary microbiology 2024 Jul;294:110127
Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties.
Hao Y, Wang H, Liu X, Gai W, Hu S, Liu W, Miao Z, Gan Y, Yu X, Shi R, Tan Y, Kang T, Hai A, Zhao Y, Fu Y, Tang Y, Ye L, Liu J, Liang X, Ke B
Acta pharmaceutica Sinica. B 2024 Jul;14(7):3086-3109
Acta pharmaceutica Sinica. B 2024 Jul;14(7):3086-3109
4-Octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders.
Li T, Li JW, Qin YH, Liu R, Xu XN, Li X, Li LM, Feng B, Yang L, Yang CS
Annals of clinical and translational neurology 2024 Jul;11(7):1732-1749
Annals of clinical and translational neurology 2024 Jul;11(7):1732-1749
Diallyl trisulfide induces pyroptosis and impairs lung CSC-like properties by activating the ROS/Caspase 1 signaling pathway.
Xie C, Zhou X, Chen W, Ren D, Li X, Jiang R, Zhong C, Zhu J
Chemico-biological interactions 2024 Jul 1;397:111083
Chemico-biological interactions 2024 Jul 1;397:111083
Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway.
Tong Z, Kong L, Zhang Y, Hu T, Dai R, Wang Y, Ji J, Huang Z, Hu L
Bioorganic chemistry 2024 Jan;142:106955
Bioorganic chemistry 2024 Jan;142:106955
ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
Liu L, Zhang J, Lu K, Zhang Y, Xu X, Deng J, Zhang X, Zhang H, Zhao Y, Wang X
Journal of translational medicine 2024 Jan 4;22(1):23
Journal of translational medicine 2024 Jan 4;22(1):23
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway.
Zhou Y, Yan J, Qiao L, Zeng J, Cao F, Sheng X, Qi X, Long C, Liu B, Wang X, Yao H, Xiao L
Antioxidants (Basel, Switzerland) 2024 Jan 31;13(2)
Antioxidants (Basel, Switzerland) 2024 Jan 31;13(2)
Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis.
Zhang J, Cai H, Sun W, Wu W, Nan Y, Ni Y, Wu X, Chen M, Xu H, Wang Y
Arthritis research & therapy 2024 Jan 25;26(1):36
Arthritis research & therapy 2024 Jan 25;26(1):36
Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2.
You G, Zheng L, Zhang Y, Zhang Y, Wang Y, Guo W, Liu H, Tatiana P, Vladimir K, Zan J
Inflammation 2024 Feb;47(1):145-158
Inflammation 2024 Feb;47(1):145-158
Colchicine ameliorates short-term abdominal aortic aneurysms by inhibiting the expression of NLRP3 inflammasome components in mice.
Hu J, Xu J, Zhao J, Liu Y, Huang R, Yao D, Xie J, Lei Y
European journal of pharmacology 2024 Feb 5;964:176297
European journal of pharmacology 2024 Feb 5;964:176297
ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis.
Cai H, Zhang J, Xu H, Sun W, Wu W, Dong C, Zhou P, Xue C, Nan Y, Ni Y, Wu X, Gu Z, Chen M, Wang Y
Science signaling 2024 Feb 27;17(825):eadh1178
Science signaling 2024 Feb 27;17(825):eadh1178
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Duan S, Li X, Han J, Yang Y, Luo R, Cai Y, Li X, Zheng Q, Guo J, Liu R
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome.
Zeng F, Lai Y, Huang Y, Zhu F, Gao J, Chen Z, Zeng L, Feng M, Qiu P, Yuan S, Deng G
Annals of medicine 2024 Dec;56(1):2394584
Annals of medicine 2024 Dec;56(1):2394584
LncRNA MALAT1 to Enhance Pyroptosis in Viral Myocarditis Through UPF1-Mediated SIRT6 mRNA Decay and Wnt-β-Catenin Signal Pathway.
Zeng M, Chen Z, Wang Y, Yang Z, Xiang J, Wang X, Wang X
Cardiovascular toxicology 2024 Dec;24(12):1439-1454
Cardiovascular toxicology 2024 Dec;24(12):1439-1454
Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway.
Zhou C, Li J, Wu X, Liu F
Experimental gerontology 2024 Dec;198:112626
Experimental gerontology 2024 Dec;198:112626
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
Fang H, Xu M, Zhang J, Qin H, Tang H, He Y, Guo W
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
Aminoadipic acid aggravates atherosclerotic vascular inflammation through ROS/TXNIP/NLRP3 pathway, a harmful microbial metabolite reduced by paeonol.
Wang T, Wu H, Shi X, Dai M, Liu Y
The international journal of biochemistry & cell biology 2024 Dec;177:106678
The international journal of biochemistry & cell biology 2024 Dec;177:106678
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
Li W, Zhong Y, Lin Z, Deng Z, Long D, Li M, Li C, Mao G, Kang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
Jianwei Shoutai Pills alleviates miscarriage by modulating gut microbial production of BAs and NLRP3-inflammasome at the maternal-fetal interface of rats.
Chen S, Xue X, Zhang H, Huang X, Lin X, He J, Chen L, Luo S, Gao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156000
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156000
Triggering receptor expressed on myeloid cells-1 aggravates obliterative bronchiolitis via enhancing the proinflammatory phenotype of macrophages.
Wan J, Yang F, Tong S, Zhou T, Wang S
International immunopharmacology 2024 Dec 25;143(Pt 1):113274
International immunopharmacology 2024 Dec 25;143(Pt 1):113274
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Zhao M, Xie J, Zhang J, Zhao B, Zhang Y, Xue J, Zhang R, Zhang R, Wang H, Li Y, Ge W, Zhou X
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
Wang XF, Xiang XH, Wei J, Zhang PB, Xu Q, Liu MH, Qu LQ, Wang XX, Yu L, Wu AG, Qing DL, Wu JM, Law BY, Yu CL, Yong-Tang
Neurochemical research 2024 Aug;49(8):2197-2214
Neurochemical research 2024 Aug;49(8):2197-2214
Hydrogen Attenuates Cognitive Impairment in Rat Models of Vascular Dementia by Inhibiting Oxidative Stress and NLRP3 Inflammasome Activation.
Yang C, He Y, Ren S, Ding Y, Liu X, Li X, Sun H, Jiao D, Zhang H, Wang Y, Sun L
Advanced healthcare materials 2024 Aug;13(20):e2400400
Advanced healthcare materials 2024 Aug;13(20):e2400400
Polygonatum sibiricum Polysaccharides Alleviate Depressive-like Symptoms in Chronic Restraint Stress-Induced Mice via Microglial Regulation in Prefrontal Cortex.
Yuan ZY, Zhang X, Yu ZZ, Wang XY, Zeng ZH, Wei MX, Qiu MT, Wang J, Cheng J, Yi LT
Polymers 2024 Aug 20;16(16)
Polymers 2024 Aug 20;16(16)
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
Crosstalk between autophagy and inflammasomes in ricin-induced inflammatory injury.
Zhang S, Zhao N, Song S, Wang Y, Wang Y, Sun C, Dong M, Huo M, Xu N, Liu W, Li G
Toxicology and applied pharmacology 2024 Apr;485:116890
Toxicology and applied pharmacology 2024 Apr;485:116890
Human Umbilical Cord Mesenchymal Stem Cells Repair Endothelial Injury and Dysfunction by Regulating NLRP3 to Inhibit Endothelial Cell Pyroptosis in Kawasaki Disease.
Xu T, Chen T, Fang H, Shen X, Shen X, Tang Z, Zhao J
Inflammation 2024 Apr;47(2):483-502
Inflammation 2024 Apr;47(2):483-502
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Xu Y, Sun D, Xiong L, Zhang Z, Li Y, Liu K, Li H, Chen L
Bioorganic chemistry 2024 Apr;145:107190
Bioorganic chemistry 2024 Apr;145:107190
Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects.
Hu H, Cai Y, Shi Y, Zhang S, Yu X, Ma T, Liao S
iScience 2024 Apr 19;27(4):109544
iScience 2024 Apr 19;27(4):109544
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells.
Xue L, Huang L, Tian Y, Cao X, Song Y
Journal of ophthalmology 2023;2023:8224752
Journal of ophthalmology 2023;2023:8224752
Molecular mechanism of miRNA-23a in sepsis-induced lung injury.
Zhang P, Huang Q, Liao P, Sun S, Yang J
American journal of translational research 2023;15(6):3900-3911
American journal of translational research 2023;15(6):3900-3911
Weight bearing training alleviates muscle atrophy and pyroptosis of middle-aged rats.
Fu P, Gong L, Yang L, Tang S, Ma F
Frontiers in endocrinology 2023;14:1202686
Frontiers in endocrinology 2023;14:1202686
Role of NLRP3 inflammasome activation in HCC cell progression.
Dai B, Cao H, Hu Y, Gong Z, Huang X, Chen Y, Liu F, Peng X, Zhang Y, Lei X
Heliyon 2023 Sep;9(9):e19542
Heliyon 2023 Sep;9(9):e19542
PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia.
Zhang M, Chen Y, Qiu Y, Sun J, He J, Liu Z, Shi J, Wei W, Wu G, Liang J
JACC. Basic to translational science 2023 Sep;8(9):1060-1077
JACC. Basic to translational science 2023 Sep;8(9):1060-1077
Protection of Oxygen Glucose Deprivation-Induced Human Brain Vascular Pericyte Injury: Beneficial Effects of Bellidifolin in Cellular Pyroptosis.
An D, Xu W, Ge Y, Ge Y, Zhang L, Zhu Y, Zhang Z, Fan J, Gao R, Jiang L, Huang P, Wang J, Chen X
Neurochemical research 2023 Sep;48(9):2794-2807
Neurochemical research 2023 Sep;48(9):2794-2807
Pseudorabies virus infection activates the NLRP3 and IFI16 inflammasomes to trigger pyroptosis.
Zhang X, Chen G, Yin J, Li L, Huang K, Du Q, Tong D, Huang Y
Veterinary microbiology 2023 Sep;284:109826
Veterinary microbiology 2023 Sep;284:109826
Maslinic acid alleviates LPS-induced mice mastitis by inhibiting inflammatory response, maintaining the integrity of the blood-milk barrier and regulating intestinal flora.
Li K, Ran X, Zeng Y, Li S, Hu G, Wang X, Li Y, Yang Z, Liu J, Fu S
International immunopharmacology 2023 Sep;122:110551
International immunopharmacology 2023 Sep;122:110551
Through regulation of the SIRT1 pathway plant sterol ester of α-linolenic acid inhibits pyroptosis thereby attenuating the development of NASH in mice.
Han H, Li J, Tian L, Pei L, Zheng M
The Journal of nutritional biochemistry 2023 Sep;119:109408
The Journal of nutritional biochemistry 2023 Sep;119:109408
Lunasin reduces the susceptibility of IL-10 deficient mice to inflammatory bowel disease and modulates the activation of the NLRP3 inflammasome.
Nieto-Veloza A, Hong S, Reeder M, Sula MJ, D'Souza DH, Zhong Q, Dia VP
The Journal of nutritional biochemistry 2023 Sep;119:109383
The Journal of nutritional biochemistry 2023 Sep;119:109383
Ursolic Acid Alleviates Neuroinflammation after Intracerebral Hemorrhage by Mediating Microglial Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway.
Lei P, Li Z, Hua Q, Song P, Gao L, Zhou L, Cai Q
International journal of molecular sciences 2023 Sep 30;24(19)
International journal of molecular sciences 2023 Sep 30;24(19)
Sodium thiosulfate ameliorates atopic dermatitis via inhibiting the activation of NLRP3 inflammasome.
Wang D, Liu Y, Zong X, Li X, Yang S, Zeng Y, Lu J
Biochemical and biophysical research communications 2023 Sep 17;673:160-168
Biochemical and biophysical research communications 2023 Sep 17;673:160-168
Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease.
Guo Y, Zhang L
In vitro cellular & developmental biology. Animal 2023 Oct;59(9):665-673
In vitro cellular & developmental biology. Animal 2023 Oct;59(9):665-673
VCAM-1(+) hUC-MSCs Exert Considerable Neuroprotection Against Cerebral Infarction in Rats by Suppression of NLRP3-Induced Pyroptosis.
Zhang X, Sang X, Chen Y, Yu H, Sun Y, Liang X, Zheng X, Wang X, Yang H, Bi J, Zhang L, Wang P
Neurochemical research 2023 Oct;48(10):3084-3098
Neurochemical research 2023 Oct;48(10):3084-3098
A novel pyroptosis-associated lncRNA LINC01133 promotes pancreatic adenocarcinoma development via miR-30b-5p/SIRT1 axis.
Li J, Lin J, Ji Y, Wang X, Fu D, Wang W, Shen B
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1381-1398
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1381-1398
Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model.
Dumbuya JS, Chen X, Du J, Li S, Liang L, Xie H, Zeng Q
International immunopharmacology 2023 Oct;123:110758
International immunopharmacology 2023 Oct;123:110758
Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway.
Zhao Y, Shao C, Zhou H, Yu L, Bao Y, Mao Q, Yang J, Wan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155002
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155002
RORα overexpression reduced interleukin-33 expression and prevented mast cell degranulation and inflammation by inducing autophagy in allergic rhinitis.
Yu W, Du J, Peng L, Zhang T
Immunity, inflammation and disease 2023 Oct;11(10):e1017
Immunity, inflammation and disease 2023 Oct;11(10):e1017
Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs/NF-kB and pyroptosis pathways.
Jiang Z, Zeng Z, He H, Li M, Lan Y, Hui J, Bie P, Chen Y, Liu H, Fan H, Xia H
Journal of translational medicine 2023 Oct 31;21(1):770
Journal of translational medicine 2023 Oct 31;21(1):770
CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis.
Zhang H, Deng Z, Wang Y, Zheng X, Zhou L, Yan S, Wang Y, Dai Y, Kanwar YS, Deng F
iScience 2023 Oct 20;26(10):107762
iScience 2023 Oct 20;26(10):107762
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
The Expression of High Mobility Group Box-1 (HMG1) in the Peripheral Blood and Its Relation with Systemic Vasculitis Patients.
Qin Y, Li X, Shi L, Liu Y, Wang Z, Guan Y
Iranian journal of public health 2023 Nov;52(11):2390-2401
Iranian journal of public health 2023 Nov;52(11):2390-2401
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells.
Zhuang C, Zhao J, Zhang S, Shahid M
Microbial pathogenesis 2023 Nov;184:106338
Microbial pathogenesis 2023 Nov;184:106338
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
Song D, Tao W, Liu F, Wu X, Bi H, Shu J, Wang D, Li X
Molecular immunology 2023 Nov;163:127-135
Molecular immunology 2023 Nov;163:127-135
The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice.
Liu M, Ling Y, Zhang Y, Liu L, Qiu Y, Liu Y, Yin Y
International immunopharmacology 2023 Nov;124(Pt B):111023
International immunopharmacology 2023 Nov;124(Pt B):111023
Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro.
She Y, Shao L, Jiao K, Sun R, Lang T, Long H, Tang Y, Zhang W, Ding C, Deng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155001
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155001
Identification of CRKL as an oncogenic biomarker for prognosis and immunotherapy in melanoma, and its potential molecular mechanism.
Li Z, Wu X, Chen S, Zhong J, Qiu X, Kpegah JKSK, Shi K, Can L, Zhang X, Yin M, Xie H, Su J, Zhou J
Genomics 2023 May;115(3):110634
Genomics 2023 May;115(3):110634
The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.
Chi S, Li S, Xu Z, Yang G, Song Y, Liao Z, Yang C, Wu X
Biochemical and biophysical research communications 2023 May 7;655:1-10
Biochemical and biophysical research communications 2023 May 7;655:1-10
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Chen Y, Liu Y, Jiang K, Wen Z, Cao X, Wu S
Journal of orthopaedic translation 2023 Mar;39:1-11
Journal of orthopaedic translation 2023 Mar;39:1-11
Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout.
Mirzaesmaeili A, Zangiabadi S, Raspanti J, Akram A, Inman RD, Abdul-Sater AA
Journal of immunology (Baltimore, Md. : 1950) 2023 Mar 1;210(5):531-535
Journal of immunology (Baltimore, Md. : 1950) 2023 Mar 1;210(5):531-535
LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis.
He W, Duan L, Zhang L
Korean circulation journal 2023 Jun;53(6):387-403
Korean circulation journal 2023 Jun;53(6):387-403
Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
Wang F, Fan X, Kong J, Wang C, Ma B, Sun W, Ye Z, Liu P, Wen J
Vascular 2023 Jun;31(3):533-543
Vascular 2023 Jun;31(3):533-543
The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS-14036/miR-1228-5p/PRKCDBP pathway.
Jiang R, Lu B, Feng F, Li Q, Chen X, Cao S, Pan Z, Deng Z, Zhou Y, Liu P, Xu J
Cell proliferation 2023 Jul;56(7):e13402
Cell proliferation 2023 Jul;56(7):e13402
Analgesic Effect of Perineural Injection of BoNT/A on Neuropathic Pain Induced by Chronic Constriction Injury of Sciatic Nerve in Rats.
He JJ, Wei XM, Wu ML, Song ZB, Jiang L, Zhang WX
Neurochemical research 2023 Jul;48(7):2161-2174
Neurochemical research 2023 Jul;48(7):2161-2174
Oxidative Stress Initiates Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Mediated Corneal Epithelial Necroptosis and Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Signaling during Fungal Keratitis.
Wang B, Yang X, Zuo X, Zeng H, Wang X, Huang H, He D, Wang L, Ouyang H, Yuan J
The American journal of pathology 2023 Jul;193(7):883-898
The American journal of pathology 2023 Jul;193(7):883-898
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Bai Y, Zhang L, Zheng B, Zhang X, Zhang H, Zhao A, Yu J, Yang Z, Wen J
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia.
Chen Q, He J, Liu H, Huang Q, Wang S, Yin A, Chen S, Shen X, Xiao Y, Hu H, Jiang J, Chen W, Wang S, Huang Z, Li J, Peng Y, Wang X, Yang X, Wang Z, Zhong M
Journal of translational medicine 2023 Jul 24;21(1):496
Journal of translational medicine 2023 Jul 24;21(1):496
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Liu J, Cao C, Jin Y, Wang Y, Ma X, Li J, Guo S, Yang J, Niu J, Liang X
iScience 2023 Jul 21;26(7):107022
iScience 2023 Jul 21;26(7):107022
Alternate-day fasting for the protection of cognitive impairment in c57BL/6J mice following whole-brain radiotherapy.
Wu Q, Yu M, Wang Z, Ai X, Liu Z, Zeng J, Li C, Yuan L, He J, Lin X, Wan W
Neurochemistry international 2023 Jan;162:105463
Neurochemistry international 2023 Jan;162:105463
Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3/GSDMD pathway.
Chi YN, Hai DM, Ma L, Cui YH, Hu HT, Liu N, Juan-Du, Lan XB, Yu JQ, Yang JM
International immunopharmacology 2023 Jan;114:109520
International immunopharmacology 2023 Jan;114:109520
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
Wu G, Su Q, Li J, Xue C, Zhu J, Cai Q, Huang J, Ji S, Cheng B, Ge H
Journal of nanobiotechnology 2023 Jan 5;21(1):7
Journal of nanobiotechnology 2023 Jan 5;21(1):7
Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury.
Rao X, Zhou D, Deng H, Chen Y, Wang J, Zhou X, Jie X, Xu Y, Wu Z, Wang G, Dong X, Zhang S, Meng R, Wu C, Xing S, Fan K, Wu G, Zhou R
Respiratory research 2023 Jan 24;24(1):25
Respiratory research 2023 Jan 24;24(1):25
MicroRNA-29b regulates pyroptosis involving calcific aortic valve disease through the STAT3/SOCS1 pathway.
Fang M, Li B, Li X, Wang Y, Zhuang Y
International journal of cardiology 2023 Jan 15;371:319-328
International journal of cardiology 2023 Jan 15;371:319-328
Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages.
Fu M, Chen N, Zhou Y, Chen S, Xu W, Gong S, Geng L
Vaccines 2023 Jan 12;11(1)
Vaccines 2023 Jan 12;11(1)
The combined effect of deoxynivalenol and Fumonisin B(1) on small intestinal inflammation mediated by pyroptosis in vivo and in vitro.
Mao X, Zhang P, Du H, Ge L, Liu S, Huang K, Chen X
Toxicology letters 2023 Jan 1;372:25-35
Toxicology letters 2023 Jan 1;372:25-35
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.
Zhu X, Hao W, Liu Z, Song Y, Hao C, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Jan 1;249:114373
Ecotoxicology and environmental safety 2023 Jan 1;249:114373
Renal NLRP3 Inflammasome activation is associated with disease activity in lupus nephritis.
Chen FF, Liu XT, Tao J, Mao ZM, Wang H, Tan Y, Qu Z, Yu F
Clinical immunology (Orlando, Fla.) 2023 Feb;247:109221
Clinical immunology (Orlando, Fla.) 2023 Feb;247:109221
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis.
Liu D, Tian Q, Liu K, Ren F, Liu G, Zhou J, Yuan L, Fang Z, Zou B, Wang S
Journal of agricultural and food chemistry 2023 Feb 8;
Journal of agricultural and food chemistry 2023 Feb 8;
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway.
Liu C, Yao K, Tian Q, Guo Y, Wang G, He P, Wang J, Wang J, Zhang Z, Li M
Redox biology 2023 Dec;68:102960
Redox biology 2023 Dec;68:102960
Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
Zhong B, Sun S, Tan KS, Ong HH, Du J, Liu F, Liu Y, Liu S, Ba L, Li J, Wang Y, Liu J
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
The Journal of allergy and clinical immunology 2023 Dec;152(6):1444-1459.e14
The Comparative Effects of Schwann Cells and Wharton's Jelly Mesenchymal Stem Cells on the AIM2 Inflammasome Activity in an Experimental Model of Spinal Cord Injury.
Kharazinejad E, Hassanzadeh G, Sahebkar A, Yousefi B, Reza Sameni H, Majidpoor J, Golchini E, Taghdiri Nooshabadi V, Mousavi M
Neuroscience 2023 Dec 15;535:1-12
Neuroscience 2023 Dec 15;535:1-12
Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3.
Song L, Wang L, Li X, Xiao L
Animals : an open access journal from MDPI 2023 Dec 1;13(23)
Animals : an open access journal from MDPI 2023 Dec 1;13(23)
USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.
Shi S, Pan X, Chen M, Zhang L, Zhang S, Wang X, Shi S, Chen Z, Lin W, Jiang Y
Hepatology communications 2023 Aug 1;7(8)
Hepatology communications 2023 Aug 1;7(8)
Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury.
Zhang F, Ke C, Zhou Z, Xu K, Wang Y, Liu Y, Tu J
Planta medica 2023 Apr;89(5):493-507
Planta medica 2023 Apr;89(5):493-507
PRRSV infection activates NLRP3 inflammasome through inducing cytosolic mitochondrial DNA stress.
Li H, Yang X, Song Y, Zhu Q, Liao Z, Liang Y, Guo J, Wan B, Bao D
Veterinary microbiology 2023 Apr;279:109673
Veterinary microbiology 2023 Apr;279:109673
Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome.
Zhang JR, Yin SY, Shen ZQ, Li B, Zhang YQ, Yu J
Brain research bulletin 2023 Apr;195:130-140
Brain research bulletin 2023 Apr;195:130-140
Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells.
Kang TH, Shin S, Park J, Lee BR, Lee SI
Toxins 2023 Apr 19;15(4)
Toxins 2023 Apr 19;15(4)
Detection of ASC Oligomerization by Western Blotting.
Zangiabadi S, Akram A, Abdul-Sater AA
Methods in molecular biology (Clifton, N.J.) 2022;2459:73-78
Methods in molecular biology (Clifton, N.J.) 2022;2459:73-78
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.
Liang G, Zeng M, Gao M, Xing W, Jin X, Wang Q, Deng L, Ou H, He Z
Oxidative medicine and cellular longevity 2022;2022:9369035
Oxidative medicine and cellular longevity 2022;2022:9369035
Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.
Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y
Journal of immunology research 2022;2022:2291877
Journal of immunology research 2022;2022:2291877
Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication.
Deng H, Zhu S, Zhu L, Sun J, Ding Y, Li F, Jian Z, Zhao J, Deng L, Deng J, Deng Y, Guo H, Sun X, Lai SY, Tang H, Cui H, Ge LP, Xu Z
Frontiers in immunology 2022;13:955671
Frontiers in immunology 2022;13:955671
Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization.
Su J, Yang F, Kang X, Liu J, Tao Y, Diao Q, Meng X, Liu D, Zhang Y
Frontiers in pharmacology 2022;13:932198
Frontiers in pharmacology 2022;13:932198
Dendrobium Nobile Lindl. Alkaloid Suppresses NLRP3-Mediated Pyroptosis to Alleviate LPS-Induced Neurotoxicity.
Li DD, Fan HX, Yang R, Li YY, Zhang F, Shi JS
Frontiers in pharmacology 2022;13:846541
Frontiers in pharmacology 2022;13:846541
Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway.
Chai Y, Cai Y, Fu Y, Wang Y, Zhang Y, Zhang X, Zhu L, Miao M, Yan T
Frontiers in pharmacology 2022;13:812362
Frontiers in pharmacology 2022;13:812362
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Li W, Yang K, Li B, Wang Y, Liu J, Chen D, Diao Y
Frontiers in pharmacology 2022;13:1060104
Frontiers in pharmacology 2022;13:1060104
Modified Baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis.
Wang X, Long H, Chen M, Zhou Z, Wu Q, Xu S, Li G, Lu Z
Frontiers in physiology 2022;13:1023453
Frontiers in physiology 2022;13:1023453
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
Yu J, Tang R, Li J
Frontiers in oncology 2022;12:991165
Frontiers in oncology 2022;12:991165
Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer.
Yu Z, Cao W, Han C, Wang Z, Qiu Y, Wang J, Wei M, Wang J, Zhang S, Liu S, Mo S, Chen J
Frontiers in bioengineering and biotechnology 2022;10:796820
Frontiers in bioengineering and biotechnology 2022;10:796820
Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway.
Li Q, Zuo Z, Pan Y, Zhang Q, Xu L, Jiang B
Cardiovascular toxicology 2022 Sep;22(9):842-857
Cardiovascular toxicology 2022 Sep;22(9):842-857
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
Long Q, Li L, Yang H, Lu Y, Yang H, Zhu Y, Tang Y, Liu C, Yuan J
International immunopharmacology 2022 Sep;110:109024
International immunopharmacology 2022 Sep;110:109024
Lactobacillus rhamnosus GR-1 attenuates foodborne Bacillus cereus-induced NLRP3 inflammasome activity in bovine mammary epithelial cells by protecting intercellular tight junctions.
Shan Q, Liu N, Wang X, Zhu Y, Yin J, Wang J
Journal of animal science and biotechnology 2022 Sep 9;13(1):101
Journal of animal science and biotechnology 2022 Sep 9;13(1):101
VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis.
Jia X, Bai X, Yang X, Wang L, Lu Y, Zhu L, Zhao Y, Cheng W, Shu M, Mei Q, Jin S
Metabolism: clinical and experimental 2022 Oct;135:155274
Metabolism: clinical and experimental 2022 Oct;135:155274
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
Zou Y, Wang X, Xu J, Wang S, Li S, Zhu Y, Wang J
International journal of molecular sciences 2022 Oct 31;23(21)
International journal of molecular sciences 2022 Oct 31;23(21)
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
Zhao AN, Yang Z, Wang DD, Shi B, Zhang H, Bai Y, Yan BW, Zhang Y, Wen JK, Wang XL, Qu CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602
Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway.
Sun H, Sun Z, Xu X, Lv Z, Li J, Wu R, Fei Y, Tan G, Liu Z, Liu Y, Shi D
Antioxidants (Basel, Switzerland) 2022 Nov 23;11(12)
Antioxidants (Basel, Switzerland) 2022 Nov 23;11(12)
Neutrophil Extracellular Traps Mediate Bovine Endometrial Epithelial Cell Pyroptosis in Dairy Cows with Endometritis.
Shen W, Ma X, Shao D, Wu X, Wang S, Zheng J, Lv Y, Ding X, Ma B, Yan Z
International journal of molecular sciences 2022 Nov 13;23(22)
International journal of molecular sciences 2022 Nov 13;23(22)
Leonurine inhibits the TXNIP/NLRP3 and NF-κB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.
Yan K, Hu J, Hou T, Ci X, Peng L
Phytotherapy research : PTR 2022 May;36(5):2161-2172
Phytotherapy research : PTR 2022 May;36(5):2161-2172
Enhanced autophagy alleviated corneal allograft rejection via inhibiting NLRP3 inflammasome activity.
Wei C, Ma L, Xiang D, Huang C, Wang H, Wang X, Zhang S, Qi X, Shi W, Gao H
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2022 May;22(5):1362-1371
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2022 May;22(5):1362-1371
Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk.
Zhou Y, Gao C, Vong CT, Tao H, Li H, Wang S, Wang Y
British journal of pharmacology 2022 May;179(9):1978-1997
British journal of pharmacology 2022 May;179(9):1978-1997
BtpB inhibits innate inflammatory responses in goat alveolar macrophages through the TLR/NF-κB pathway and NLRP3 inflammasome during Brucella infection.
Li J, Zhang G, Zhi F, Zhai Y, Zhou D, Chen H, Lin P, Tang K, Liu W, Jin Y, Wang A
Microbial pathogenesis 2022 May;166:105536
Microbial pathogenesis 2022 May;166:105536
Inhibition of the P2X7/NLRP3 Inflammasome Signaling Pathway by Deacetylgedunin from Toona sinensis.
Li Q, Tang P, Zhang P, Cui L, Li Y, Li J, Kong L, Luo J
Journal of natural products 2022 May 27;85(5):1388-1397
Journal of natural products 2022 May 27;85(5):1388-1397
GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.
Qin Z, Song J, Lin A, Yang W, Zhang W, Zhong F, Huang L, Lü Y, Yu W
Journal of neuroinflammation 2022 May 27;19(1):121
Journal of neuroinflammation 2022 May 27;19(1):121
Effect of NLRP3 repression on NLRP3 inflammasome activation in human corneal epithelial cells with black carbon exposure.
Xiao K, Shang J, Liu Y, Chen Z, Wang L, Long Q
Cutaneous and ocular toxicology 2022 Jun;41(2):107-112
Cutaneous and ocular toxicology 2022 Jun;41(2):107-112
Curcumin improves the function of umbilical vein endothelial cells by inhibiting H(2)O(2)‑induced pyroptosis.
Yuan Y, Zhang C, He Y, Yuan L, Zhao Q, Liu Y, Long S
Molecular medicine reports 2022 Jun;25(6)
Molecular medicine reports 2022 Jun;25(6)
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Han N, Wang Z, Luo H, Chi Y, Zhang T, Wang B, Li Y
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice.
Jiang J, Ding S, Zhang G, Dong Y
Ecotoxicology and environmental safety 2022 Jun 15;238:113571
Ecotoxicology and environmental safety 2022 Jun 15;238:113571
Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway.
Liu Y, Sun R, Lin X, Wu L, Chen H, Shen S, Li Y, Wei Y, Deng G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113078
Preconditioning with procyanidin B2 protects MAC-T cells against heat exposure-induced mitochondrial dysfunction and inflammation.
Wang H, Hao W, Yang L, Yan P, Wei S
Molecular immunology 2022 Jul;147:126-135
Molecular immunology 2022 Jul;147:126-135
Selenomethionine alleviated Ochratoxin A induced pyroptosis and renal fibrotic factors expressions in MDCK cells.
Mao X, Li H, Ge L, Liu S, Hou L, Yue D, Du H, Pan C, Gan F, Liu Y, Huang K, Chen X
Journal of biochemical and molecular toxicology 2022 Jan;36(1):e22933
Journal of biochemical and molecular toxicology 2022 Jan;36(1):e22933
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
Lactobacillus rhamnosus Ameliorates Multi-Drug-Resistant Bacillus cereus-Induced Cell Damage through Inhibition of NLRP3 Inflammasomes and Apoptosis in Bovine Endometritis.
Liu N, Wang X, Shan Q, Xu L, Li Y, Chu B, Yang L, Wang J, Zhu Y
Microorganisms 2022 Jan 10;10(1)
Microorganisms 2022 Jan 10;10(1)
Enhancement of anti-inflammatory effect of cattle bile by fermentation and its inhibition of neuroinflammation on microglia by inhibiting NLRP3 inflammasome.
Pei Y, Cheng F, Li W, Yu Q, Ma C, Zou Y, Xu T, Liu S, Zhang S, Wang Q
Journal of bioscience and bioengineering 2022 Feb;133(2):146-154
Journal of bioscience and bioengineering 2022 Feb;133(2):146-154
Staphylococcus aureus mediates pyroptosis in bovine mammary epithelial cell via activation of NLRP3 inflammasome.
Wang X, Liu M, Geng N, Du Y, Li Z, Gao X, Han B, Liu J, Liu Y
Veterinary research 2022 Feb 5;53(1):10
Veterinary research 2022 Feb 5;53(1):10
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Zhang L, Zhu XZ, Badamjav R, Zhang JZ, Kou JP, Yu BY, Li F
European journal of pharmacology 2022 Feb 15;917:174748
European journal of pharmacology 2022 Feb 15;917:174748
ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
Zhang J, Liu L, Zhang Y, Yuan Y, Miao Z, Lu K, Zhang X, Ni R, Zhang H, Zhao Y, Wang X
Redox biology 2022 Dec;58:102554
Redox biology 2022 Dec;58:102554
Identification of key proteins of cytopathic biotype bovine viral diarrhoea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response.
Fan W, Wang Y, Jiang S, Li Y, Yao X, Wang M, Zhao J, Sun X, Jiang X, Zhong L, Han Y, Song H, Xu Y
Virulence 2022 Dec;13(1):1884-1899
Virulence 2022 Dec;13(1):1884-1899
A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner.
Yang Q, Zhang J, Liu F, Chen H, Zhang W, Yang H, He N, Dong J, Zhao P
Virulence 2022 Dec;13(1):1486-1501
Virulence 2022 Dec;13(1):1486-1501
Demethyleneberberine blocked the maturation of IL-1β in inflammation by inhibiting TLR4-mitochondria signaling.
Zhao Y, Liu P, Zhang Y, Jiang H, Luan H, Xu Y, Zhang Y, Li R
International immunopharmacology 2022 Dec;113(Pt A):109319
International immunopharmacology 2022 Dec;113(Pt A):109319
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Zhou Z, Li C, Bao T, Zhao X, Xiong W, Luo C, Yin G, Fan J
Journal of neurotrauma 2022 Aug;39(15-16):1057-1074
Journal of neurotrauma 2022 Aug;39(15-16):1057-1074
Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model.
Xia B, Zhong R, Wu W, Luo C, Meng Q, Gao Q, Zhao Y, Chen L, Zhang S, Zhao X, Zhang H
Microbiome 2022 Aug 31;10(1):139
Microbiome 2022 Aug 31;10(1):139
N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways.
Huang L, Gong L, Huo X, Lei L, Zhang Q, Hu Y, Kuang Q, Gui Y, Dai Y, Gu Y, Deng Y, Wang D, Guo D
Acta biochimica et biophysica Sinica 2022 Aug 25;55(1):23-33
Acta biochimica et biophysica Sinica 2022 Aug 25;55(1):23-33
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
Yang G, Wang J, Wang S, Zhu Y
International journal of molecular sciences 2022 Aug 20;23(16)
International journal of molecular sciences 2022 Aug 20;23(16)
Immunohistochemical analysis of pyroptosis-related protein expression in IgG4-related sialadenitis.
Pu J, Jia M, Shi W, Hu L, Wang F, Niu Y, Tong Q, Gong Z
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2022 Apr;51(4):388-394
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2022 Apr;51(4):388-394
Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.
Diao M, Xu J, Wang J, Zhang M, Wu C, Hu X, Zhu Y, Zhang M, Hu W
Neurochemical research 2022 Apr;47(4):1097-1109
Neurochemical research 2022 Apr;47(4):1097-1109
Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4/Akt/HIF1a/NLRP3 pathway.
Wei Y, Hu Y, Qi K, Li Y, Chen J, Wang R
Behavioural brain research 2022 Apr 9;423:113775
Behavioural brain research 2022 Apr 9;423:113775
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Wang Z, Li C, He X, Xu K, Xue Z, Wang T, Xu Z, Liu X
Food & function 2022 Apr 4;13(7):3946-3956
Food & function 2022 Apr 4;13(7):3946-3956
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Liu H, Zhang Y, Song W, Sun Y, Jiang Y
Frontiers in cell and developmental biology 2021;9:681790
Frontiers in cell and developmental biology 2021;9:681790
Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration.
Li S, Liao Z, Luo R, Song Y, Wang K, Feng X, Ou Y, Wu X, Zhang Y, Gao Y, Yin H, Yang C
Frontiers in cell and developmental biology 2021;9:672847
Frontiers in cell and developmental biology 2021;9:672847
Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy.
Li C, Zhu Y, Wu Y, Fu M, Wu Y, Wu Y, Qiu Y, Zhang H, Ding M
Frontiers in medicine 2021;8:813047
Frontiers in medicine 2021;8:813047
Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia.
Zhang Y, Liu W, Zhong Y, Li Q, Wu M, Yang L, Liu X, Zou L
Oxidative medicine and cellular longevity 2021;2021:1806344
Oxidative medicine and cellular longevity 2021;2021:1806344
Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.
Cai Y, Chai Y, Fu Y, Wang Y, Zhang Y, Zhang X, Zhu L, Miao M, Yan T
Frontiers in aging neuroscience 2021;13:809433
Frontiers in aging neuroscience 2021;13:809433
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest.
Xu J, Zhang M, Liu F, Shi L, Jiang X, Chen C, Wang J, Diao M, Khan ZU, Zhang M
Frontiers in pharmacology 2021;12:793829
Frontiers in pharmacology 2021;12:793829
Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.
Feng B, Zhao X, Zhao W, Jiang H, Ren Z, Chen Y, Yuan Y, Du Z
Frontiers in pharmacology 2021;12:719822
Frontiers in pharmacology 2021;12:719822
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J
Frontiers in immunology 2021;12:715098
Frontiers in immunology 2021;12:715098
The Essential Oil of Artemisia argyi H.Lév. and Vaniot Attenuates NLRP3 Inflammasome Activation in THP-1 Cells.
Chen P, Bai Q, Wu Y, Zeng Q, Song X, Guo Y, Zhou P, Wang Y, Liao X, Wang Q, Ren Z, Wang Y
Frontiers in pharmacology 2021;12:712907
Frontiers in pharmacology 2021;12:712907
Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.
Li J, Dai X, Zhou L, Li X, Pan D
Frontiers in pharmacology 2021;12:691773
Frontiers in pharmacology 2021;12:691773
Inflammasome-Induced Osmotic Pressure and the Mechanical Mechanisms Underlying Astrocytic Swelling and Membrane Blebbing in Pyroptosis.
Zheng Z, Wang T, Chen J, Qiu H, Zhang C, Liu W, Qin S, Tian J, Guo J
Frontiers in immunology 2021;12:688674
Frontiers in immunology 2021;12:688674
LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.
Ma X, Li Y, Shen W, Oladejo AO, Yang J, Jiang W, Imam BH, Wu X, Ding X, Yang Y, Wang S, Yan Z
Frontiers in immunology 2021;12:676088
Frontiers in immunology 2021;12:676088
H(2)S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome.
Cui J, Xu G, Bian F
International journal of cardiology 2021 Sep 1;338:215-225
International journal of cardiology 2021 Sep 1;338:215-225
Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway.
Cheng J, Hao J, Jiang X, Ji J, Wu T, Chen X, Zhang F
International immunopharmacology 2021 Oct;99:108006
International immunopharmacology 2021 Oct;99:108006
Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
Xu M, Ye Z, Zhao X, Guo H, Gong X, Huang R
Cellular signalling 2021 Oct;86:110084
Cellular signalling 2021 Oct;86:110084
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
Wang Y, Song M, Zhou P, Wang J, Zheng J, Xu H
International immunopharmacology 2021 Nov;100:108067
International immunopharmacology 2021 Nov;100:108067
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Ge S, Yang W, Chen H, Yuan Q, Liu S, Zhao Y, Zhang J
International journal of molecular sciences 2021 Nov 17;22(22)
International journal of molecular sciences 2021 Nov 17;22(22)
Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma.
Koizumi M, Watanabe T, Masumoto J, Sunago K, Imamura Y, Kanemitsu K, Kumagi T, Hiasa Y
Scientific reports 2021 Nov 16;11(1):22351
Scientific reports 2021 Nov 16;11(1):22351
Deletion of inflammasome adaptor protein ASC enhances functional recovery after spinal cord injury in mice.
Shiraishi Y, Kimura A, Kimura H, Ohmori T, Takahashi M, Takeshita K
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2021 May;26(3):487-493
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2021 May;26(3):487-493
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Wei Z, Fei Y, Wang Q, Hou J, Cai X, Yang Y, Chen T, Xu Q, Wang Y, Li YG
Free radical biology & medicine 2021 May 1;167:243-257
Free radical biology & medicine 2021 May 1;167:243-257
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Stress increases blood beta-hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model.
Nishiguchi T, Iwata M, Kajitani N, Miura A, Matsuo R, Murakami S, Nakada Y, Pu S, Shimizu Y, Tsubakino T, Yamanashi T, Shinozaki G, Tsubota J, Shirayama Y, Watanabe K, Kaneko K
Neuropsychopharmacology reports 2021 Jun;41(2):159-167
Neuropsychopharmacology reports 2021 Jun;41(2):159-167
Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cells.
Zeng Y, Yan Wang C, Xu J, Le Xu X
Biochemical pharmacology 2021 Jun;188:114559
Biochemical pharmacology 2021 Jun;188:114559
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless of the macrophage polarization states.
Tang W, Yang Y, Yang L, Tang M, Chen Y, Li C
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470
Activation of Interleukin-1β Release and Pyroptosis by Transmissible Gastroenteritis Virus Is Dependent on the NOD-Like Receptor Protein 3 Inflammasome in Porcine Intestinal Epithelial Cell Line.
Wei G, Luo S, Wu W, Hu J, Zhou R
Viral immunology 2021 Jul-Aug;34(6):401-409
Viral immunology 2021 Jul-Aug;34(6):401-409
Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway.
Li R, Qu Y, Li X, Tao Y, Yang Q, Wang J, Diao Y, Li Q, Fang Y, Huang Y, Wang L
Investigative ophthalmology & visual science 2021 Jul 1;62(9):2
Investigative ophthalmology & visual science 2021 Jul 1;62(9):2
Microcystin-LR Induces NLRP3 Inflammasome Activation via FOXO1 Phosphorylation, Resulting in Interleukin-1β Secretion and Pyroptosis in Hepatocytes.
Zhang Y, Zhu P, Wu X, Yuan T, Su Z, Chen S, Zhou Y, Tao WA
Toxicological sciences : an official journal of the Society of Toxicology 2021 Jan 6;179(1):53-69
Toxicological sciences : an official journal of the Society of Toxicology 2021 Jan 6;179(1):53-69
Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures.
Zhao W, He F, Barkema HW, Xu S, Gao J, Liu G, Deng Z, Shahid M, Shi Y, Kastelic JP, Han B
Veterinary research 2021 Dec 11;52(1):144
Veterinary research 2021 Dec 11;52(1):144
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, Yang H
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.
Chen Q, Wang Y, Jiao F, Cao P, Shi C, Pei M, Wang L, Gong Z
Journal of cellular and molecular medicine 2021 Aug;25(15):7218-7228
Journal of cellular and molecular medicine 2021 Aug;25(15):7218-7228
Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway.
Li H, Yuan L, Li X, Luo Y, Zhang Z, Li J
Antioxidants (Basel, Switzerland) 2021 Aug 11;10(8)
Antioxidants (Basel, Switzerland) 2021 Aug 11;10(8)
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692
Inflammation 2021 Apr;44(2):682-692
The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.
Jiao Y, Wang L, Lu L, Liu J, Li X, Zhao H, Hou Z, Zheng B
Stem cells international 2020;2020:8867115
Stem cells international 2020;2020:8867115
Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-κB Pathway.
Zhang Q, Sun J, Fu Y, He W, Li Y, Tan H, Xu H, Jiang X
Mediators of inflammation 2020;2020:8528901
Mediators of inflammation 2020;2020:8528901
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Zhou B, Qiu Y, Wu N, Chen AD, Zhou H, Chen Q, Kang YM, Li YH, Zhu GQ
Oxidative medicine and cellular longevity 2020;2020:6384803
Oxidative medicine and cellular longevity 2020;2020:6384803
The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells.
Ming SL, Zeng L, Guo YK, Zhang S, Li GL, Ma YX, Zhai YY, Chang WR, Yang L, Wang J, Yang GY, Chu BB
Frontiers in immunology 2020;11:575818
Frontiers in immunology 2020;11:575818
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.
Ding PH, Yang MX, Wang NN, Jin LJ, Dong Y, Cai X, Chen LL
Frontiers in microbiology 2020;11:1881
Frontiers in microbiology 2020;11:1881
MiR-21-5p Induces Pyroptosis in Colorectal Cancer via TGFBI.
Jiang R, Chen X, Ge S, Wang Q, Liu Y, Chen H, Xu J, Wu J
Frontiers in oncology 2020;10:610545
Frontiers in oncology 2020;10:610545
A novel mechanism of protection against isoproterenol-induced cardiac inflammation via regulation of the SIRT1/NRF2 signaling pathway with a natural SIRT1 agonist.
Nie Q, Zhang J, He B, Wang F, Sun M, Wang C, Sun W, Guo J, Wen J, Liu P
European journal of pharmacology 2020 Nov 5;886:173398
European journal of pharmacology 2020 Nov 5;886:173398
hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis.
Xavier A, Al-Zeer MA, Meyer TF, Daumke O
Cell reports 2020 May 19;31(7):107667
Cell reports 2020 May 19;31(7):107667
Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice.
Huang M, Wang Q, Long F, Di Y, Wang J, Zhun Zhu Y, Liu X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4107-4119
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4107-4119
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Kai J, Yang X, Wang Z, Wang F, Jia Y, Wang S, Tan S, Chen A, Shao J, Zhang F, Zhang Z, Zheng S
Free radical biology & medicine 2020 Jun;153:89-102
Free radical biology & medicine 2020 Jun;153:89-102
RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.
Liu N, Wang Y, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Li Y, Sun H, Yang M, Sun J, Yang X
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151
Mechanism investigation on Bisphenol S-induced oxidative stress and inflammation in murine RAW264.7 cells: The role of NLRP3 inflammasome, TLR4, Nrf2 and MAPK.
Xie C, Ge M, Jin J, Xu H, Mao L, Geng S, Wu J, Zhu J, Li X, Zhong C
Journal of hazardous materials 2020 Jul 15;394:122549
Journal of hazardous materials 2020 Jul 15;394:122549
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Zhang Q, Zhao S, Zheng W, Fu H, Wu T, Hu F
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
Lam HYP, Chen TT, Chen CC, Yang TH, Cheng PC, Peng SY
Parasitology international 2020 Aug;77:102119
Parasitology international 2020 Aug;77:102119
Lactobacillus johnsonii L531 Ameliorates Escherichia coli-Induced Cell Damage via Inhibiting NLRP3 Inflammasome Activity and Promoting ATG5/ATG16L1-Mediated Autophagy in Porcine Mammary Epithelial Cells.
Zou YJ, Xu JJ, Wang X, Zhu YH, Wu Q, Wang JF
Veterinary sciences 2020 Aug 14;7(3)
Veterinary sciences 2020 Aug 14;7(3)
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Zhao Y, Wang Z, Feng D, Zhao H, Lin M, Hu Y, Zhang N, Lv L, Gao Z, Zhai X, Tian X, Yao J
Theranostics 2019;9(5):1510-1522
Theranostics 2019;9(5):1510-1522
Correlation Between the NLRP3 Inflammasome and the Prognosis of Patients With LSCC.
Xue Y, Du HD, Tang D, Zhang D, Zhou J, Zhai CW, Yuan CC, Hsueh CY, Li SJ, Heng Y, Tao L, Lu LM
Frontiers in oncology 2019;9:588
Frontiers in oncology 2019;9:588
Suppressive Effect of Huzhentongfeng on Experimental Gouty Arthritis: An In Vivo and In Vitro Study.
Wu ZC, Xue Q, Zhao ZL, Zhou PJ, Zhou Q, Zhang Z, Deng JP, Yang K, Fan H, Wang YF, Wang ZP
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2969364
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2969364
Weighted Gene Co-expression Network Analysis for RNA-Sequencing Data of the Varicose Veins Transcriptome.
Zhang J, Nie Q, Si C, Wang C, Chen Y, Sun W, Pan L, Guo J, Kong J, Cui Y, Wang F, Fan X, Ye Z, Wen J, Liu P
Frontiers in physiology 2019;10:278
Frontiers in physiology 2019;10:278
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Dia VP, Bradwell J, Pangloli P
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
Plant foods for human nutrition (Dordrecht, Netherlands) 2019 Sep;74(3):307-315
IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation.
Ai QD, Chen C, Chu S, Zhang Z, Luo Y, Guan F, Lin M, Liu D, Wang S, Chen N
Translational research : the journal of laboratory and clinical medicine 2019 Oct;212:36-53
Translational research : the journal of laboratory and clinical medicine 2019 Oct;212:36-53
Activation of P2X(7)R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH).
Zhang Y, Xu Y, Sun Q, Xue S, Guan H, Ji M
Experimental eye research 2019 Nov;188:107771
Experimental eye research 2019 Nov;188:107771
Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway.
Gao S, Xu T, Guo H, Deng Q, Xun C, Liang W, Sheng W
Life sciences 2019 Nov 15;237:116978
Life sciences 2019 Nov 15;237:116978
Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway.
Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L
International immunopharmacology 2019 May;70:28-36
International immunopharmacology 2019 May;70:28-36
NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis.
Wang J, Feng Y, Huo H, Zhang X, Yue J, Zhang W, Yan Z, Jiao X
Acta biochimica et biophysica Sinica 2019 May 23;51(5):501-508
Acta biochimica et biophysica Sinica 2019 May 23;51(5):501-508
TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice.
Wang Z, Zhou L, An D, Xu W, Wu C, Sha S, Li Y, Zhu Y, Chen A, Du Y, Chen L, Chen L
Cell death & disease 2019 May 16;10(6):386
Cell death & disease 2019 May 16;10(6):386
Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.
Tan J, Wan L, Chen X, Li X, Hao X, Li X, Li J, Ding H
Molecular nutrition & food research 2019 Jun;63(12):e1801402
Molecular nutrition & food research 2019 Jun;63(12):e1801402
Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine.
Gong W, Zhang S, Zong Y, Halim M, Ren Z, Wang Y, Ma Y, Li B, Ma L, Zhou G, Yu J, Zhang J, Liu Q
Journal of affective disorders 2019 Jul 1;254:15-25
Journal of affective disorders 2019 Jul 1;254:15-25
LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-κB/NLRP3 inflammasome pathway.
Ma M, Pei Y, Wang X, Feng J, Zhang Y, Gao MQ
Cell proliferation 2019 Jan;52(1):e12525
Cell proliferation 2019 Jan;52(1):e12525
Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.
Du L, Shen K, Bai Y, Chao J, Hu G, Zhang Y, Yao H
Toxicology letters 2019 Feb;301:53-63
Toxicology letters 2019 Feb;301:53-63
Schwann cell transplantation exerts neuroprotective roles in rat model of spinal cord injury by combating inflammasome activation and improving motor recovery and remyelination.
Mousavi M, Hedayatpour A, Mortezaee K, Mohamadi Y, Abolhassani F, Hassanzadeh G
Metabolic brain disease 2019 Aug;34(4):1117-1130
Metabolic brain disease 2019 Aug;34(4):1117-1130
Intrathecal transplantation of Wharton's jelly mesenchymal stem cells suppresses the NLRP1 inflammasome in the rat model of spinal cord injury.
Mohamadi Y, Noori Moghahi SMH, Mousavi M, Borhani-Haghighi M, Abolhassani F, Kashani IR, Hassanzadeh G
Journal of chemical neuroanatomy 2019 Apr;97:1-8
Journal of chemical neuroanatomy 2019 Apr;97:1-8
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.
Zhou F, Zhang Y, Chen J, Hu Y, Xu Y
Frontiers in endocrinology 2018;9:640
Frontiers in endocrinology 2018;9:640
Chronic Kidney Disease Increases Atrial Fibrillation Inducibility: Involvement of Inflammation, Atrial Fibrosis, and Connexins.
Qiu H, Ji C, Liu W, Wu Y, Lu Z, Lin Q, Xue Z, Liu X, Wu H, Jiang W, Zou C
Frontiers in physiology 2018;9:1726
Frontiers in physiology 2018;9:1726
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Wu Q, Zhu YH, Xu J, Liu X, Duan C, Wang MJ, Wang JF
Frontiers in microbiology 2018;9:1661
Frontiers in microbiology 2018;9:1661
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.
Song S, Qiu D, Luo F, Wei J, Wu M, Wu H, Du C, Du Y, Ren Y, Chen N, Duan H, Shi Y
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
He W, Ye S, Zeng C, Xue S, Hu X, Zhang X, Gao S, Xiong Y, He X, Vivalda S, Li L, Wang Y, Ye Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 5;:fj201800028RR
2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease.
Han M, Zhang T, Gu W, Yang X, Zhao R, Yu J
Experimental and therapeutic medicine 2018 Aug;16(2):1087-1094
Experimental and therapeutic medicine 2018 Aug;16(2):1087-1094
MCL Plays an Anti-Inflammatory Role in Mycobacterium tuberculosis-Induced Immune Response by Inhibiting NF-κB and NLRP3 Inflammasome Activation.
Zhang Q, Jiang X, He W, Wei K, Sun J, Qin X, Zheng Y, Jiang X
Mediators of inflammation 2017;2017:2432904
Mediators of inflammation 2017;2017:2432904
Anti-inflammatory capacity of Lactobacillus rhamnosus GG in monophasic variant Salmonella infected piglets is correlated with impeding NLRP6-mediated host inflammatory responses.
Yu J, Zhu YH, Yang GY, Zhang W, Zhou D, Su JH, Wang JF
Veterinary microbiology 2017 Oct;210:91-100
Veterinary microbiology 2017 Oct;210:91-100
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
Yin Y, Zhou Z, Liu W, Chang Q, Sun G, Dai Y
The international journal of biochemistry & cell biology 2017 Mar;84:22-34
The international journal of biochemistry & cell biology 2017 Mar;84:22-34
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.
Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O'Neill LAJ, Lynch MA
Brain, behavior, and immunity 2017 Mar;61:306-316
Brain, behavior, and immunity 2017 Mar;61:306-316
Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer's disease.
Xia Z, Peng W, Cheng S, Zhong B, Sheng C, Zhang C, Gong W, Cheng S, Li J, Wang Z
Oncotarget 2017 Jun 27;8(26):42648-42663
Oncotarget 2017 Jun 27;8(26):42648-42663
Pepsin-pancreatin hydrolysis reduced the ability of lunasin-enriched material to inhibit activation of the inflammasomes in THP-1 human macrophages.
Price SJ, Pangloli P, Dia VP
Food & function 2017 Dec 13;8(12):4449-4458
Food & function 2017 Dec 13;8(12):4449-4458
NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis.
Shen J, Wang L, Jiang N, Mou S, Zhang M, Gu L, Shao X, Wang Q, Qi C, Li S, Wang W, Che X, Ni Z
Scientific reports 2016 Oct 10;6:34682
Scientific reports 2016 Oct 10;6:34682
Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice.
Zhou F, Zhang Y, Chen J, Hu X, Xu Y
European journal of pharmacology 2016 Nov 15;791:735-740
European journal of pharmacology 2016 Nov 15;791:735-740
NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis.
Tervaniemi MH, Katayama S, Skoog T, Siitonen HA, Vuola J, Nuutila K, Sormunen R, Johnsson A, Linnarsson S, Suomela S, Kankuri E, Kere J, Elomaa O
Scientific reports 2016 Mar 15;6:22745
Scientific reports 2016 Mar 15;6:22745
New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.
Ding C, Zhao Y, Shi X, Zhang N, Zu G, Li Z, Zhou J, Gao D, Lv L, Tian X, Yao J
Scientific reports 2016 Jun 27;6:28734
Scientific reports 2016 Jun 27;6:28734
Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway.
Ma X, Guo P, Qiu Y, Mu K, Zhu L, Zhao W, Li T, Han L
Oncotarget 2016 Jun 14;7(24):36185-36197
Oncotarget 2016 Jun 14;7(24):36185-36197
Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome.
Deng Q, Wang Y, Zhang Y, Li M, Li D, Huang X, Wu Y, Pu J, Wu M
Infection and immunity 2016 Jan;84(1):56-66
Infection and immunity 2016 Jan;84(1):56-66
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.
Wu Q, Liu MC, Yang J, Wang JF, Zhu YH
Applied and environmental microbiology 2016 Feb 15;82(4):1173-1182
Applied and environmental microbiology 2016 Feb 15;82(4):1173-1182
A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing.
Kapoor-Vazirani P, Vertino PM
The Journal of biological chemistry 2014 Mar 14;289(11):7425-37
The Journal of biological chemistry 2014 Mar 14;289(11):7425-37
OxLDL-induced IL-1 beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation.
Liu W, Yin Y, Zhou Z, He M, Dai Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2014 Jan;63(1):33-43
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2014 Jan;63(1):33-43
Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury.
Zhang X, Ibrahim E, de Rivero Vaccari JP, Lotocki G, Aballa TC, Dietrich WD, Keane RW, Lynne CM, Brackett NL
Fertility and sterility 2013 Jan;99(1):118-124.e2
Fertility and sterility 2013 Jan;99(1):118-124.e2
Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma.
Liu W, Luo Y, Dunn JH, Norris DA, Dinarello CA, Fujita M
The Journal of investigative dermatology 2013 Feb;133(2):518-27
The Journal of investigative dermatology 2013 Feb;133(2):518-27
SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation.
Kapoor-Vazirani P, Kagey JD, Vertino PM
Molecular and cellular biology 2011 Apr;31(8):1594-609
Molecular and cellular biology 2011 Apr;31(8):1594-609
Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha.
Lucas ME, Crider KS, Powell DR, Kapoor-Vazirani P, Vertino PM
The Journal of biological chemistry 2009 May 29;284(22):14698-709
The Journal of biological chemistry 2009 May 29;284(22):14698-709
Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells.
Parsons MJ, Patel P, Brat DJ, Colbert L, Vertino PM
Cancer research 2009 Mar 1;69(5):1706-11
Cancer research 2009 Mar 1;69(5):1706-11
Expression of apoptotic tumour necrosis factor receptor-associated factor, caspase recruitment domain and cell death-inducing DFF-45 effector genes in therapy-treated renal cell carcinoma.
Rajandram R, Pat BK, Li J, Johnson DW, Gobe GC
Nephrology (Carlton, Vic.) 2009 Apr;14(2):205-12
Nephrology (Carlton, Vic.) 2009 Apr;14(2):205-12
Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.
Kapoor-Vazirani P, Kagey JD, Powell DR, Vertino PM
Cancer research 2008 Aug 15;68(16):6810-21
Cancer research 2008 Aug 15;68(16):6810-21
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HL-60 cells were subjected to SDS PAGE followed by western blot with 10500-1-AP(TMS1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TMS1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TMS1. This antibody recognizes human antigen. The TMS1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
