67494-1-Ig

antibody from Proteintech Group

Targeting: PYCARD ASC, CARD5, TMS-1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

67494-1-Ig

Provider

Proteintech Group

Product name

ASC/TMS1 antibody

Antibody type

Monoclonal

Description

ASC/TMS1 antibody (Cat. #67494-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: WB, ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2G12E6

Vial size

20ul, 150ul

References

Submitted references

Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model.

Wu X, You Z, Zhang T, Zeng J, Li M, Yan S, Li J, Li P, Shen J, Liu S, Aslam MS, Li J, Ning L, Fang H, Li Y, Yao D, Hao C, Meng X
Metabolic brain disease 2026 Jan 16;41(1):20

---

Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.

Duan R, Wang X, Wang Q, Zhou X, Gao S, Sun Y, Feng Q, Li Z, Yang Z, Ding J, Chen Z, Duan J, Yang Y
Cell reports 2026 Feb 24;45(2):116942

---

The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.

Zhang H, Fu J, Guo Y, Liu S, Mei X, Zeng X, Ren W
Cell chemical biology 2026 Feb 19;33(2):169-182.e5

---

Erxian Decoction Ameliorates Myocardial Damage in Ovariectomized Rats by Regulating the Gut Microbiota and TMAO-Mediated NLRP3 Inflammatory Pathway.

Hu J, Yang Y, Jiang Y, Wang Y, Zhu R, Zhang Z, Liu H, Chen Y
Journal of microbiology and biotechnology 2026 Feb 11;36:e2512005

---

Fruit-Derived Citri Reticulatae Semen Extract Attenuates Alzheimer's Disease Neuroinflammation and Cognitive Impairment via Modulation of the PI3K/Akt/FoxO1 Pathway.

Li S, Zhang X, Zhang P, Wang X, Yang Y, Qin D, Law BY, Pan Y, Tang Y
Molecular nutrition & food research 2026 Apr;70(7):e70452

---

Fingolimod Suppresses NLRP3 Inflammasome Activation and Alleviates Oxidative Stress in Traumatic Brain Injury-Induced Acute Lung Injury.

Shi Q, Hu T, Xu L, Fu J, Fang Y, Lan Y, Fan W, Wu Q, Tong X, Yan H
Journal of inflammation research 2025;18:2229-2245

---

Investigating the mechanisms of Sini San in alleviating inflammatory responses via multi-omics and the BDNF/TrkB/PI3K/AKT signaling pathway in depressive model rats.

Zeng JW, Han ZJ, He XT, Liu XJ, Wang HY, Yang SS, Bai J, Duan YJ, Lin L
Frontiers in psychiatry 2025;16:1628634

---

Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.

Zhang M, Liu S, Wu Z, Wang C, Zhang H, Yang J, Guo C, Dai M, Wang X, Ren W
Science China. Life sciences 2025 Oct;68(10):3037-3050

---

Streptococcus pyogenes EVs induce the alternative inflammasome via caspase-4/-5 in human monocytes.

Krause K, Franch Arroyo S, Ugolini M, Kueck T, Sullivan TJ, Gálvez EJC, Muenzner M, Goosmann C, Brinkmann V, Frese CK, Alagesan K, Vierbuchen T, Heine H, Resch U, Sander LE, Charpentier E
EMBO reports 2025 Oct;26(19):4847-4885

---

Ellagic acid mediated pyroptosis in hepatocellular carcinoma via the ESR1/G6PD pathway.

Wang S, Cai Y, Zhou F, Zhang M, Li J, Shang L, Huang J, Chen L, Yang S
Biochemical pharmacology 2025 Nov;241:117178

---

Hippocampal NLRP1 inflammasome mediates anxiety-like behavior in mice with hypothyroidism.

Cheng YW, Zou ZH, Lou CL, Tong MR, Li JK, Zhu WH, Lu YL, Zhu DF, Xu Q, Xu YX
Scientific reports 2025 May 9;15(1):16176

---

Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation.

Liu XJ, Ye-Er-Tai YL, Jia YB, Wu CH, Wang XX, Yang KM, Yao X, Ling JH
World journal of gastroenterology 2025 Mar 7;31(9):102256

---

PGAM5 promotes RIPK1-PANoptosome activity by phosphorylating and activating RIPK1 to mediate PANoptosis after subarachnoid hemorrhage in rats.

Jiajia D, Wen Y, Enyan J, Xiaojian Z, Zhen F, Jia Z, Jikai W, Xiaoxin Y, Aihua L, Fangen K, Fei L
Experimental neurology 2025 Feb;384:115072

---

Long non-coding RNA NRIR inhibits osteogenesis in peri-implantitis by promoting NLRP3 inflammasome-mediated macrophage pyroptosis.

Wang L, Zhao R, Xiao K, Zhou Y, Liu Q, Yu K
International immunopharmacology 2025 Feb 20;148:114180

---

Calycosin attenuates mitochondrial damage and pyroptosis in heart failure via the Nrf2/ROS/TXNIP pathway.

Yuan HJ, Han QC, Yu YD, Yu H, Liu XJ, Xue YT, Li Y
International journal of molecular medicine 2025 Dec;56(6)

---

Neutrophil CD11b is a pivotal PANoptosis marker correlated with disease activity in antineutrophil cytoplasmic antibody-associated vasculitis.

Han XY, Zhao YY, Chen SF, Li ZY, Zhao MH, Chen M
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3115-3128

---

Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy.

Gu X, Li L, Duan T, Jin L, Sheng Q, Gao Q, Chen M, Sui X
Experimental hematology & oncology 2025 Dec 31;15(1):2

---

Loss of Trim31 Worsens Cardiac Remodeling in a Mouse Model of Heart Failure by Enhancing the Activation of the NLRP3 Inflammasome.

Duan F, Li H, Lu B, Wang X, Xu X
Inflammation 2025 Aug;48(4):2650-2662

---

Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome.

Yu F, Meng Y, Wang X, Chen J, He J, Yi X, He Y, Chen K
Cell reports 2025 Aug 26;44(8):116084

---

Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism.

Ji J, An ZY, Khan A, Peng L, Kulshreshtha S, Salama ES, Yun H, Liu P, Jin WL, Li X
NPJ science of food 2025 Aug 23;9(1):183

---

Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.

Ma L, Sun H, Xiang N, Xu Q
Scientific reports 2025 Apr 25;15(1):14516

---

Asparagine transporter supports macrophage inflammation via histone phosphorylation.

Wang C, Ye Y, Zhao M, Chen Q, Liu B, Ren W
Science advances 2025 Apr 11;11(15):eads3506

---

(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation.

Zhang X, Huo Z, Jia X, Xiong Y, Li B, Zhang L, Li X, Li X, Fang Y, Dong X, Chen G
Food & function 2024 May 20;15(10):5450-5465

---

Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis.

Li H, Ni H, Li Y, Zhou A, Qin X, Li Y, Che L, Mo H, Qin C, Li J
Cell death discovery 2024 May 13;10(1):227

---

Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis.

Wang R, Wang Y, Liu H, Zhu J, Fang C, Xu W, Lu Z, Yan Y, He W, Ruan Y, Zhou M
Chinese medicine 2024 Mar 4;19(1):40

---

Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice.

Wang R, Wang Y, Yang Q, Liu J, Lu Z, Xu W, Zhu J, Liu H, He W, Yan Y, Ruan Y, Zhou M
Journal of ethnopharmacology 2024 Mar 1;321:117490

---

Study on the therapeutic mechanism of HJ granules in a rat model of urinary tract infection caused by Escherichia coli.

Cao S, Gao S, Ni C, Xu Y, Pang B, Zhang J, Zhang Y, Wang Y, Geng Z, Li S, Zhao R, Han B, Cui X, Bao Y
Journal of ethnopharmacology 2024 Jun 28;328:118056

---

Overexpression of SESN1 improves mitochondrial damage and mitophagy, a potential therapeutic strategy for cognitive dysfunction after anaesthesia.

Sun L, Hong X, Wang D, Li Y
The European journal of neuroscience 2024 Jan;59(2):208-219

---

Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.

Tong T, Hao C, Shen J, Liu S, Yan S, Aslam MS, Chen Y, Chen W, Li J, Li Y, Zeng J, Li M, You Z, Gulizhaerkezi T, Wei S, Zhu A, Meng X
Brain research bulletin 2024 Jan;206:110838

---

IP3R2-mediated Ca(2+) release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway.

Wu QR, Yang H, Zhang HD, Cai YJ, Zheng YX, Fang H, Wang ZF, Kuang SJ, Rao F, Huang HL, Deng CY, Chen CB
Cell death discovery 2024 Feb 20;10(1):91

---

Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.

Wang C, Chen Q, Chen S, Fan L, Gan Z, Zhao M, Shi L, Bin P, Yang G, Zhou X, Ren W
Molecular cell 2024 Feb 15;84(4):744-759.e6

---

Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species.

He S, Zhang T, Wang YY, Yuan W, Li L, Li J, Yang YY, Wu DM, Xu Y
International immunopharmacology 2024 Feb 15;128:111570

---

Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice.

Zhou Q, Zhang L, Lin Q, Liu H, Ye G, Liu X, Jiao S, Li J, Tang Y, Shi D, Huang L, Weng C
Journal of virology 2023 Mar 30;97(3):e0000323

---

An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.

Yiu SPT, Zerbe C, Vanderwall D, Huttlin EL, Weekes MP, Gewurz BE
Molecular cell 2023 Jul 6;83(13):2367-2386.e15

---

Disulfiram protects against abdominal aortic aneurysm by ameliorating vascular smooth muscle cells pyroptosis.

Liao F, Wang L, Wu Z, Luo G, Qian Y, He X, Ding S, Pu J
Cardiovascular drugs and therapy 2023 Dec;37(6):1-14

---

Zerumbone attenuates the excessive proliferation of keratinocytes in psoriasis mice through regulating NLRP3/NF-κB pathway.

Lin J, Fang Y, Cao Y, Ma L, Tao M, Wang X, Li Y, Qing L
Toxicology research 2023 Aug;12(4):658-664

---

SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis.

Mao X, Wu W, Nan Y, Sun W, Wang Y
Arthritis research & therapy 2023 Aug 9;25(1):144

---

PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway.

Li Z, Liu T, Feng Y, Tong Y, Jia Y, Wang C, Cui R, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2022;2022:1269747

---

Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway.

Huo XY, Lei LR, Guo WX, Hu YJ, Kuang QX, Liu MD, Peng W, Dai YF, Wang D, Gu YC, Guo DL, Deng Y
Frontiers in microbiology 2022;13:999996

---

Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway.

Li L, Deng S, Liu M, Yang M, Li J, Liu T, Zhang T, Zhao Y, He M, Wu D, Xu Y
Frontiers in pharmacology 2022;13:956402

---

H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.

Zhang X, Li C, Chen D, He X, Zhao Y, Bao L, Wang Q, Zhou J, Xie Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Jan;71(1):141-155

---

Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.

Zhu M, Wang Y, Zhu L, Du S, Wang Z, Zhang Y, Guo Y, Tu Y, Song E
Inflammation 2022 Feb;45(1):414-427

---

Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway.

Liu B, Wang Z, He R, Xiong R, Li G, Zhang L, Fu T, Li C, Li N, Geng Q
Clinical science (London, England : 1979) 2022 Feb 25;136(4):273-289

---

Restoring myocardial infarction-induced long-term memory impairment by targeting the cystic fibrosis transmembrane regulator.

Vanherle L, Lidington D, Uhl FE, Steiner S, Vassallo S, Skoug C, Duarte JMN, Ramu S, Uller L, Desjardins JF, Connelly KA, Bolz SS, Meissner A
EBioMedicine 2022 Dec;86:104384

---

GABA regulates IL-1β production in macrophages.

Fu J, Han Z, Wu Z, Xia Y, Yang G, Yin Y, Ren W
Cell reports 2022 Dec 6;41(10):111770

---

SP1 transcriptionally activates NLRP6 inflammasome and induces immune evasion and radioresistance in glioma cells.

Yu Y, Cao F, Xiong Y, Zhou H
International immunopharmacology 2021 Sep;98:107858

---

Hypoxia-preconditioned mesenchymal stem cells attenuate microglial pyroptosis after intracerebral hemorrhage.

Liu J, He J, Huang Y, Ge L, Xiao H, Zeng L, Jiang Z, Lu M, Hu Z
Annals of translational medicine 2021 Sep;9(17):1362

---

Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.

Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558

---

Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.

Huo S, Ren J, Ma Y, Ozathaley A, Yuan W, Ni H, Li D, Liu Z
Journal of neuroinflammation 2021 Nov 26;18(1):275

---

Resveratrol affects the expression of uric acid transporter by improving inflammation.

Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)

---

Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.

Gu Y, Zhu Y, Deng G, Liu S, Sun Y, Lv W
International immunopharmacology 2021 Apr;93:107375

---

HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.

Leng Y, Chen R, Chen R, He S, Shi X, Zhou X, Zhang Z, Chen AF
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646