67494-1-Ig

antibody from Proteintech Group

Targeting: PYCARD ASC, CARD5, TMS-1

Provider product page for 67494-1-Ig

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Antigen structure
References [28]
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Product number: 67494-1-Ig - Provider product page
Provider: Proteintech Group
Product name: ASC/TMS1 antibody
Antibody type: Monoclonal
Description: ASC/TMS1 antibody (Cat. #67494-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: WB, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2G12E6
Vial size: 20ul, 150ul

PYCARD protein structure - 67494-1-Ig shown in red.

Submitted references Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis.

Li H, Ni H, Li Y, Zhou A, Qin X, Li Y, Che L, Mo H, Qin C, Li J
Cell death discovery 2024 May 13;10(1):227

Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis.

Wang R, Wang Y, Liu H, Zhu J, Fang C, Xu W, Lu Z, Yan Y, He W, Ruan Y, Zhou M
Chinese medicine 2024 Mar 4;19(1):40

Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice.

Wang R, Wang Y, Yang Q, Liu J, Lu Z, Xu W, Zhu J, Liu H, He W, Yan Y, Ruan Y, Zhou M
Journal of ethnopharmacology 2024 Mar 1;321:117490

Study on the therapeutic mechanism of HJ granules in a rat model of urinary tract infection caused by Escherichia coli.

Cao S, Gao S, Ni C, Xu Y, Pang B, Zhang J, Zhang Y, Wang Y, Geng Z, Li S, Zhao R, Han B, Cui X, Bao Y
Journal of ethnopharmacology 2024 Jun 28;328:118056

Overexpression of SESN1 improves mitochondrial damage and mitophagy, a potential therapeutic strategy for cognitive dysfunction after anaesthesia.

Sun L, Hong X, Wang D, Li Y
The European journal of neuroscience 2024 Jan;59(2):208-219

Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.

Tong T, Hao C, Shen J, Liu S, Yan S, Aslam MS, Chen Y, Chen W, Li J, Li Y, Zeng J, Li M, You Z, Gulizhaerkezi T, Wei S, Zhu A, Meng X
Brain research bulletin 2024 Jan;206:110838

IP3R2-mediated Ca(2+) release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway.

Wu QR, Yang H, Zhang HD, Cai YJ, Zheng YX, Fang H, Wang ZF, Kuang SJ, Rao F, Huang HL, Deng CY, Chen CB
Cell death discovery 2024 Feb 20;10(1):91

Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.

Wang C, Chen Q, Chen S, Fan L, Gan Z, Zhao M, Shi L, Bin P, Yang G, Zhou X, Ren W
Molecular cell 2024 Feb 15;84(4):744-759.e6

Isofraxidin attenuates dextran sulfate sodium-induced ulcerative colitis through inhibiting pyroptosis by upregulating Nrf2 and reducing reactive oxidative species.

He S, Zhang T, Wang YY, Yuan W, Li L, Li J, Yang YY, Wu DM, Xu Y
International immunopharmacology 2024 Feb 15;128:111570

Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice.

Zhou Q, Zhang L, Lin Q, Liu H, Ye G, Liu X, Jiao S, Li J, Tang Y, Shi D, Huang L, Weng C
Journal of virology 2023 Mar 30;97(3):e0000323

An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.

Yiu SPT, Zerbe C, Vanderwall D, Huttlin EL, Weekes MP, Gewurz BE
Molecular cell 2023 Jul 6;83(13):2367-2386.e15

Disulfiram protects against abdominal aortic aneurysm by ameliorating vascular smooth muscle cells pyroptosis.

Liao F, Wang L, Wu Z, Luo G, Qian Y, He X, Ding S, Pu J
Cardiovascular drugs and therapy 2023 Dec;37(6):1-14

SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis.

Mao X, Wu W, Nan Y, Sun W, Wang Y
Arthritis research & therapy 2023 Aug 9;25(1):144

PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway.

Li Z, Liu T, Feng Y, Tong Y, Jia Y, Wang C, Cui R, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2022;2022:1269747

Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway.

Huo XY, Lei LR, Guo WX, Hu YJ, Kuang QX, Liu MD, Peng W, Dai YF, Wang D, Gu YC, Guo DL, Deng Y
Frontiers in microbiology 2022;13:999996

Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway.

Li L, Deng S, Liu M, Yang M, Li J, Liu T, Zhang T, Zhao Y, He M, Wu D, Xu Y
Frontiers in pharmacology 2022;13:956402

H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion.

Zhang X, Li C, Chen D, He X, Zhao Y, Bao L, Wang Q, Zhou J, Xie Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Jan;71(1):141-155

Crosstalk Between RPE Cells and Choroidal Endothelial Cells via the ANXA1/FPR2/SHP2/NLRP3 Inflammasome/Pyroptosis Axis Promotes Choroidal Neovascularization.

Zhu M, Wang Y, Zhu L, Du S, Wang Z, Zhang Y, Guo Y, Tu Y, Song E
Inflammation 2022 Feb;45(1):414-427

Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway.

Liu B, Wang Z, He R, Xiong R, Li G, Zhang L, Fu T, Li C, Li N, Geng Q
Clinical science (London, England : 1979) 2022 Feb 25;136(4):273-289

Restoring myocardial infarction-induced long-term memory impairment by targeting the cystic fibrosis transmembrane regulator.

Vanherle L, Lidington D, Uhl FE, Steiner S, Vassallo S, Skoug C, Duarte JMN, Ramu S, Uller L, Desjardins JF, Connelly KA, Bolz SS, Meissner A
EBioMedicine 2022 Dec;86:104384

GABA regulates IL-1β production in macrophages.

Fu J, Han Z, Wu Z, Xia Y, Yang G, Yin Y, Ren W
Cell reports 2022 Dec 6;41(10):111770

SP1 transcriptionally activates NLRP6 inflammasome and induces immune evasion and radioresistance in glioma cells.

Yu Y, Cao F, Xiong Y, Zhou H
International immunopharmacology 2021 Sep;98:107858

Hypoxia-preconditioned mesenchymal stem cells attenuate microglial pyroptosis after intracerebral hemorrhage.

Liu J, He J, Huang Y, Ge L, Xiao H, Zeng L, Jiang Z, Lu M, Hu Z
Annals of translational medicine 2021 Sep;9(17):1362

Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.

Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558

Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.

Huo S, Ren J, Ma Y, Ozathaley A, Yuan W, Ni H, Li D, Liu Z
Journal of neuroinflammation 2021 Nov 26;18(1):275

Resveratrol affects the expression of uric acid transporter by improving inflammation.

Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)

Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.

Gu Y, Zhu Y, Deng G, Liu S, Sun Y, Lv W
International immunopharmacology 2021 Apr;93:107375

HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.

Leng Y, Chen R, Chen R, He S, Shi X, Zhou X, Zhang Z, Chen AF
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646

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