Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Immunocytochemistry [2]
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- Product number
- ADI-905-173-100 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ADI-905-173-100, RRID:AB_2038839
- Product name
- ASC polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- Peptide affinity purified.
- Reactivity
- Human
- Host
- Rabbit
- Vial size
- 100 μg
- Storage
- -20°C
Submitted references Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages.
Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing.
Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2.
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular.
Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.
Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome.
Anti-inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation.
Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.
Varicella-zoster virus infection triggers formation of an interleukin-1β (IL-1β)-processing inflammasome complex.
Aflaki E, Moaven N, Borger DK, Lopez G, Westbroek W, Chae JJ, Marugan J, Patnaik S, Maniwang E, Gonzalez AN, Sidransky E
Aging cell 2016 Feb;15(1):77-88
Aging cell 2016 Feb;15(1):77-88
Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing.
Karasawa T, Kawashima A, Usui F, Kimura H, Shirasuna K, Inoue Y, Komada T, Kobayashi M, Mizushina Y, Sagara J, Takahashi M
FEBS open bio 2015;5:348-56
FEBS open bio 2015;5:348-56
Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2.
Rajanbabu V, Galam L, Fukumoto J, Enciso J, Tadikonda P, Lane TN, Bandyopadhyay S, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N
Cellular immunology 2015 Sep;297(1):40-5
Cellular immunology 2015 Sep;297(1):40-5
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD
Nature medicine 2015 Mar;21(3):263-9
Nature medicine 2015 Mar;21(3):263-9
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA
Nature medicine 2015 Mar;21(3):248-55
Nature medicine 2015 Mar;21(3):248-55
Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular.
Melehani JH, James DB, DuMont AL, Torres VJ, Duncan JA
PLoS pathogens 2015 Jun;11(6):e1004970
PLoS pathogens 2015 Jun;11(6):e1004970
Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.
Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M
Scientific reports 2015 Jun 5;5:10901
Scientific reports 2015 Jun 5;5:10901
Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome.
Wei Q, Guo P, Mu K, Zhang Y, Zhao W, Huai W, Qiu Y, Li T, Ma X, Liu Y, Chen X, Han L
Laboratory investigation; a journal of technical methods and pathology 2015 Jul;95(7):804-16
Laboratory investigation; a journal of technical methods and pathology 2015 Jul;95(7):804-16
Anti-inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation.
Han JW, Shim DW, Shin WY, Heo KH, Kwak SB, Sim EJ, Jeong JH, Kang TB, Lee KH
International journal of molecular sciences 2015 Apr 10;16(4):8102-9
International journal of molecular sciences 2015 Apr 10;16(4):8102-9
Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.
Vajjhala PR, Mirams RE, Hill JM
The Journal of biological chemistry 2012 Dec 7;287(50):41732-43
The Journal of biological chemistry 2012 Dec 7;287(50):41732-43
Varicella-zoster virus infection triggers formation of an interleukin-1β (IL-1β)-processing inflammasome complex.
Nour AM, Reichelt M, Ku CC, Ho MY, Heineman TC, Arvin AM
The Journal of biological chemistry 2011 May 20;286(20):17921-33
The Journal of biological chemistry 2011 May 20;286(20):17921-33
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Supportive validation
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Western blot analysis of ASC in HL60 whole cell lysate in the absence (A) or presence (B) of blocking peptide (2287P) with ASC antibody at 1µg/ml.
- Submitted by
- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Immunocytochemistry analysis of ASC in HL60 cells with ASC antibody at 5µg/ml.