M00422

antibody from Boster Biological Technology

Targeting: FAP DPPIV

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

M00422

Provider

Boster Biological Technology

Product name

Anti-FAP1 Rabbit Monoclonal Antibody

Antibody type

Monoclonal

Description

Monoclonal antibody for Fibroblast Activation Protein alpha/FAP detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC, WB. Reactive species: Human Fibroblast Activation Protein alpha/FAP information: Molecular Weight: 87713 MW; Subcellular Localization: Prolyl endopeptidase FAP: Cell surface . Cell membrane ; Single- pass type II membrane protein . Cell projection, lamellipodium membrane ; Single-pass type II membrane protein . Cell projection, invadopodium membrane ; Single-pass type II membrane protein . Cell projection, ruffle membrane ; Single-pass type II membrane protein . Membrane ; Single-pass type II membrane protein . Localized on cell surface with lamellipodia and invadopodia membranes and on shed vesicles. Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Anchored and enriched preferentially by integrin alpha-3/beta-1 at invadopodia, plasma membrane protrusions that correspond to sites of cell invasion, in

Reactivity

Human

Host

Rabbit

Antibody clone number

AbF22

Vial size

100ug/vial

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage

At -20°C for one year. Avoid repeated freezing and thawing.

References

Submitted references

Down-regulation of COL1A1 inhibits tumor-associated fibroblast activation and mediates matrix remodeling in the tumor microenvironment of breast cancer.

Ma B, Li F, Ma B
Open life sciences 2023;18(1):20220776

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Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma.

Cai Z, Chen L, Chen S, Fang R, Chen X, Lei W
Cell communication and signaling : CCS 2023 Oct 18;21(1):292

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Small Leucine-Rich Proteoglycan PODNL1 Identified as a Potential Tumor Matrix-Mediated Biomarker for Prognosis and Immunotherapy in a Pan-Cancer Setting.

Dai G, Sun Y, Wei R, Xi L
Current issues in molecular biology 2023 Jul 22;45(7):6116-6139

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Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses.

Wei C, Sun W, Shen K, Zhong J, Liu W, Gao Z, Xu Y, Wang L, Hu T, Ren M, Li Y, Zhu Y, Zheng S, Zhu M, Luo R, Yang Y, Hou Y, Qi F, Zhou Y, Chen Y, Gu J
Nature communications 2023 Dec 8;14(1):8119

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The Expression of FAP in Hepatocellular Carcinoma Cells is Induced by Hypoxia and Correlates with Poor Clinical Outcomes.

Zou B, Liu X, Zhang B, Gong Y, Cai C, Li P, Chen J, Xing S, Chen J, Peng S, Pokhrel B, Ding L, Zeng L, Li J
Journal of Cancer 2018;9(18):3278-3286