Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-L3217 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse Anti-Mouse Fibroblast Activation Protein monoclonal antibody, clone 84.4
- Antibody type
- Monoclonal
- Description
- Fibroblast activation protein (FAP), also known as seprase, is a cell surface, type II integral transmembrane serine protease encoded by the Fap gene. It displays in vitro gelatinase, endopeptidase, and potentially collagenase activity. FAP has been detected on pericytes, bone marrow-derived mesenchymal stem cells, and a small population of macrophages. FAP is highly expressed on mesenchymal cells during embryogenesis and is repressed shortly after birth. FAP expression is up-regulated on activated fibroblasts in conditions associated with matrix remodeling, such as sites of inflammation in disease including wound healing, fibrosis, rheumatoid arthritis and osteoarthritis, liver disease, inflammatory bowel diseases, and several types of cancer.
- Reactivity
- Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 84.4
- Vial size
- 100 ug
- Storage
- Long time storage is recommended at -20°C.
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