GRB14

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Description

Growth factor receptor bound protein 14

Tissue specificity

Tissue enhanced (liver, tongue)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (164492417 - 164621482)

Ensembl ID

ENSG00000115290  (ver. 103.38)

Orthologs

Mouse Grb14: ENSMUSG00000026888

UniProt

Q14449

neXtProt

NX_Q14449

Human splice variants
Mouse splice variants

Protein structure