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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 12096-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12096-1-AP, RRID:AB_2094914
- Product name
- DNAJC19 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DNAJC19 antibody (Cat. #12096-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting prohibitins activates the ISR through DELE1-HRI by impairing protein import into the mitochondrial matrix.
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization.
Generation of a homozygous DNAJC19 knockout human embryonic stem cell line by CRISPR/Cas9 system.
OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase.
LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport.
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation.
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
Defining functional classes of Barth syndrome mutation in humans.
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.
Sánchez-Vera I, Cosialls AM, Maritorena-Hualde N, Schuler MH, Lavilla R, Pons G, Jae LT, Iglesias-Serret D, Gil J
Cell death and differentiation 2026 May;33(5):1081-1095
Cell death and differentiation 2026 May;33(5):1081-1095
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
Thayer JA, Petersen JD, Huang X, Gruel Budet LM, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
The EMBO journal 2026 Jan;45(1):64-105
The EMBO journal 2026 Jan;45(1):64-105
OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization.
Krakowczyk M, Lenkiewicz AM, Sitarz T, Malinska D, Borrero M, Mussulini BHM, Linke V, Szczepankiewicz AA, Biazik JM, Wydrych A, Nieznanska H, Serwa RA, Chacinska A, Bragoszewski P
The Journal of cell biology 2024 May 6;223(5)
The Journal of cell biology 2024 May 6;223(5)
Generation of a homozygous DNAJC19 knockout human embryonic stem cell line by CRISPR/Cas9 system.
Chen G, Bai R, Huang P, Liu X, Ni J, Chen L
Stem cell research 2024 Jun;77:103427
Stem cell research 2024 Jun;77:103427
OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase.
Elancheliyan P, Maruszczak KK, Serwa RA, Stephan T, Gulgec AS, Borrero-Landazabal MA, Ngati S, Gosk A, Jakobs S, Wasilewski M, Chacinska A
Cell reports 2024 Dec 24;43(12):115038
Cell reports 2024 Dec 24;43(12):115038
LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport.
Sun H, Zhang J, Ye Q, Jiang T, Liu X, Zhang X, Zeng F, Li J, Zheng Y, Han X, Su C, Shi Y
Cell reports 2023 Nov 28;42(11):113214
Cell reports 2023 Nov 28;42(11):113214
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Acoba MG, Alpergin ESS, Renuse S, Fernández-Del-Río L, Lu YW, Khalimonchuk O, Clarke CF, Pandey A, Wolfgang MJ, Claypool SM
Cell reports 2021 Mar 16;34(11):108869
Cell reports 2021 Mar 16;34(11):108869
Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation.
Janz A, Chen R, Regensburger M, Ueda Y, Rost S, Klopocki E, Günther K, Edenhofer F, Duff HJ, Ergün S, Gerull B
Stem cell research 2020 Jul;46:101856
Stem cell research 2020 Jul;46:101856
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T
Nature cell biology 2017 Apr;19(4):318-328
Nature cell biology 2017 Apr;19(4):318-328
Defining functional classes of Barth syndrome mutation in humans.
Lu YW, Galbraith L, Herndon JD, Lu YL, Pras-Raves M, Vervaart M, Van Kampen A, Luyf A, Koehler CM, McCaffery JM, Gottlieb E, Vaz FM, Claypool SM
Human molecular genetics 2016 May 1;25(9):1754-70
Human molecular genetics 2016 May 1;25(9):1754-70
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.
Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, Langer T
Cell metabolism 2014 Jul 1;20(1):158-71
Cell metabolism 2014 Jul 1;20(1):158-71
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 12096-1-AP(DNAJC19 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using DNAJC19 antibody 12096-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
