Tissue expression
Cell line expression
Protein structure
KDELR1
KDEL endoplasmic reticulum protein retention receptor 1ERD2, ERD2.1, HDEL
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Boster Biological Technology | M07617-1 | 2 references | Monoclonal |
WB
ICC
IHC
FC |
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antibodies-online | ABIN2481596 | 1 references | Monoclonal |
WB
ICC
IP
IHC |
|
Novus Biologicals | NBP2-12873-100ug | Monoclonal |
WB
ICC
IP
IHC |
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Affinity Biosciences | DF2933 | Polyclonal |
WB
EL
ICC
IHC |
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HUABIO Research | ET7107-86 | Monoclonal |
WB
ICC
IHC
FC |
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