11601-1-AP

antibody from Proteintech Group

Targeting: IGF2BP2 IMP-2

Provider product page for 11601-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [226]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 11601-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11601-1-AP, RRID:AB_2122672
Product name: IGF2BP2 antibody
Antibody type: Polyclonal
Description: KD/KO validated IGF2BP2 antibody (Cat. #11601-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IGF2BP2 protein structure - 11601-1-AP shown in red.

Submitted references IGF2BP2 Drives Thyroid Cancer Dedifferentiation Through m6A-Dependent STAT1 mRNA Destabilization.

Chen R, Li YX, Lu WL, Wu KF, Wang YX, Wang ZW, Li YH, Yang HY, Zhang X, Shi L, Zhou D, Wang Y, Ding Q
International journal of biological sciences 2026;22(2):622-640

Redox-triggered USP18 confers cisplatin resistance in ovarian cancer by selectively activating a non-canonical FSP1-dependent ferroptosis escape pathway.

Zhao Z, Ge G, Gong M, Liu Y, Ma L, Zhang D, Sun L, Song Y
Redox biology 2026 Jun;93:104179

N(6)-methyladenosine attenuates tumor-associated macrophages M2 polarization via suppressing the translation of Snail.

Tian Y, Peng J, Zhou J, Yang W, Peng Y, Li J, Rui Y, Zhang H, Xie G, Wang H, Wang J, Li J, Huang Z, Ma X, Wang H, He J
Science China. Life sciences 2026 Jan;69(1):119-135

Novel N(6)-methyladenosine (m(6)A) writer METTL16 promotes the cervical cancer tumorigenesis by targeting FTH1-dependent ferroptosis.

Huang Z, Luo Y, Gao Q, Wang L, Li C
Discover oncology 2026 Jan 20;17(1):304

METTL3-mediated m(6)A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca(2+) signaling.

Chen C, Xiong K, Liang F, Zhong Y, Qin X, Huang N, Fang Y, Zhu B, Cheng J, Wei Q, Zheng L, Zhao J
Molecular cancer 2026 Jan 19;25(1)

The regulatory role of circGDI2 in hepatocellular carcinoma proliferation and glycolysis with the involvement of m6A modification.

Chen S, Xia H, Chen S
Non-coding RNA research 2026 Apr;17:21-31

N(6)-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4.

Zhang J, Zhang M, Qiu A, Li C, Chen Q, Li J, Zeng Y, Zhu J, Huang JA, Zhang X, Liu Z
International journal of biological sciences 2025;21(4):1391-1409

WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.

Xu Q, Zhang J, Zou Y, Chen L, Sun F, Luo X, Wang T, Li Y, Zhang S, Xiong F, Yu Q, Yang P, Gong Q, Liu SW, Wang CY
International journal of biological sciences 2025;21(12):5428-5443

METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.

Li J, Luo Q, Lu M, Lu C, Xu C, Ding J, Zhan T, Zhu J, Qian M, Lin S, Chang L, Li J, Wang K
International journal of biological sciences 2025;21(11):4782-4797

Integration of bioinformatics and identification of the role of m6A genes in NAFLD.

Ma J, Xu R, Li R, Fu Y, Xu J, Zhou L, Qi Y
PloS one 2025;20(5):e0321757

IGF2BP2 contributes to thyroid cancer progression by enhancing the stability of m6A-modified CTSH mRNA.

Dong L, Chen L, Qi X, Lu Q, Li Y, Hou M
PloS one 2025;20(10):e0332061

METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification.

He D, Jiang X, Guo G, Ma J, Chen J, Zhang Y, Zhuang J, Xie P, Zhang Z
Frontiers in immunology 2025;16:1717319

ZFAS1/STAT3 axis modulates imatinib resistance of chronic myeloid leukemia cells through glucose metabolism reprogramming.

Yang L, Han Y
Frontiers in oncology 2025;15:1603060

IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis.

Zhang Q, Liu X, Chen Y, Wang R, Zhao S, Tian Y, Li S, Liu X
Frontiers in oncology 2025;15:1512177

DANCR promotes septic cardiomyopathy by enhancing macrophage glycolytic reprogramming via the IGF2BP2/HK2 axis.

Ma C, Liu S, Zhao Y, Liu H, Zhang X
Frontiers in cell and developmental biology 2025;13:1628915

Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction.

Li CM, Zheng XJ, Xie SS, Lin DY, Liu ZT
The Kaohsiung journal of medical sciences 2025 Sep;41(9):e70047

Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism.

Tang R, Zhang Z, Liu X, Liao Y, Chen Y, Xiao M, Li Y, Zhou C, Tan Z, Zhang C, Chen C, Rong Z, Liu Y, Li P, Du Q, He Q, Lei Y, Wu Z, Lu S, Xu J, Wang W, Shi S, Yu X
Gastroenterology 2025 Sep;169(4):615-631.e32

H3K36me3-Guided m(6)A Modification of Oncogenic L1CAM-AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma.

Wang T, Han L, Huo Y, Zhang L, Huang Y, Zhang N, Yang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e14909

WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.

Pang H, Fu B, Wang P, Meng Y, Xie P, Hu X, Ma Q
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244

Ouabain-mediated IGF2BP2-GLS/NOS3 axis affects arginine metabolism in diffuse large B-cell lymphoma.

Hong Y, Ma H, Zhao Z, Song W, Li J
European journal of medical research 2025 Oct 9;30(1):945

ADAP-METTL3 modulates the inflammatory responses of macrophages via m(6)A modification of Spry1.

Dong A, Zhang P, Yang F, Wang Y, Liu H
Cell death & disease 2025 Oct 7;16(1):708

P4HA2 interacted with ATAD3A to modulate PINK1/parkin-dependent mitophagy and (125)I brachytherapy sensitization in esophageal carcinoma.

Yao X, Feng C, Huang X, Wu S, Lu S, Gao Y, Sun T, Bai X, Li C, Jia K, Han X, Wang Z, Chen B, Wang X, Guo J, Lu J
Cell death & disease 2025 Oct 6;16(1):685

Acupuncture alleviates the progression of knee osteoarthritis by inhibiting X-inactive specific transcript-mediated activation of the mechanosensitive ion channel Piezo1 signaling.

Liu M, Zhang B, Wang Z, Gou H, Zhao J, Ye M, Song C, Lu X, Ji Y, Meng J, Wu T, Wu H
Nagoya journal of medical science 2025 Nov;87(4):644-663

METTL3/IGF2BP2 stabilizes IQGAP3 via m6A modification to drive HCC metastasis through TGF-β/Smad signaling and EMT.

Pan D, Zhang H, Zhou J, He S, Yuan G
Pathology, research and practice 2025 Nov;275:156228

Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.

Wang J, Deng J, Sun B, Qiao G, Yang J, Gao Z, Zhang Q, Dong M, Qu P, Wang Z
Cellular signalling 2025 Nov;135:112024

IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation.

Xiong X, Wang X, Wang Z, Chen F, Shi Y, Chen X, Gong W, Jia X, Xu J
Cell reports 2025 Nov 25;44(11):116511

MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction.

Zhou H, Gong H, Zeng X, Zeng C, Liu D, Liu J, Zhang Y
International journal of molecular medicine 2025 May;55(5)

SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis.

Sheng Z, Luo S, Huang L, Deng YN, Zhang N, Luo Y, Zhao X, Chen Y, Li Q, Dai R, Liang S
Oncogene 2025 May;44(19):1361-1374

The Impact of METTL3 on MDM2 Promotes Podocytes Injury During Diabetic Kidney Disease.

Wu H, Yu Z, Yang Y, Han Z, Pan Q, Chen Y, Yu H, Shen S, Xu L
Journal of cellular and molecular medicine 2025 May;29(10):e70627

Heat stress enhances the expression of METTL3 to mediate N6-methyladenosine modification of SOS2 and NLRP3 inflammasome activation in boar Sertoli cells.

Zhang X, Tang Y, Wang J, Yang M, Jiang J, Xue H, Wang Y, Zhang J, Wang X
Journal of hazardous materials 2025 May 5;488:137432

Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.

Miller C, Ealy A, Gregory A, Janarthanam C, Albers W, Richardson G, Jin H, Zenitsky G, Anantharam V, Kanthasamy A, Kanthasamy AG
Cell reports 2025 May 27;44(5):115618

SNORD9 promotes ovarian cancer tumorigenesis via METTL3/IGF2BP2-mediated NFYA m6A modification and is a potential target for antisense oligonucleotide therapy.

Chen S, Wen JT, Zhang S, Wang JL, Yuan J, Bao HJ, Chen X, Zhao Y
Life sciences 2025 May 1;368:123527

Monosome Stalls the Translation Process Mediated by IGF2BP in Arcuate Nucleus for Puberty Onset Delay.

Shen Y, Zhang L, Yang T, Li X, Liu C, Li H, Hu Y, Shen H, Li H, Orlov YL, Zhou S, Shen Y
Molecular neurobiology 2025 Mar;62(3):3167-3181

Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1.

Du SM, Li N, Xu WJ, Liu K
Oncology reports 2025 Mar;53(3)

METTL3-Mediated m6A Methylation Stabilizes IFI27 to Drive Esophageal Squamous Cell Carcinoma Progression Through an IGF2BP2-Dependent Mechanism.

Zhang X, Bai Y, Shang L, Wang Y, Yao W, Wu S
Journal of biochemical and molecular toxicology 2025 Mar;39(3):e70167

Inhibition of METTL3 Attenuates Renal Fibrosis by Upregulating ABCG2 m6A Modifications via IGF2BP2-Dependent Mechanisms in Hyperuricemic Nephropathy.

Zu T, Yang H, Wang J, Li S, Yu Y, Zhang K, Song X, Ying J, Yang Y, Wang X, Jin J
Journal of cellular and molecular medicine 2025 Mar;29(6):e70468

Replication factor C4, which is regulated by insulin-like growth factor 2 mRNA binding protein 2, enhances the radioresistance of breast cancer by promoting the stemness of tumor cells.

Zhu XY, Li PS, Qu H, Ai X, Zhao ZT, He JB
Human cell 2025 Mar 7;38(3):65

Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.

Guo D, Pang Y, Wang W, Feng Y, Wang L, Sun Y, Hao J, Li F, Zhao S
Cells 2025 Mar 1;14(5)

LINC02154 Promotes Esophageal Squamous Cell Carcinoma Progression via the PI3K-AKT-mTOR Signaling Pathway by Interacting With IGF2BP2.

Zhang M, Zhang C, Zhou F, Yang R, Feng Y, Ji Y, Ren H, Ming L
Molecular carcinogenesis 2025 Jun;64(6):985-996

The Long Noncoding RNA LINC02820 Promotes Tumor Growth and Metastasis Through Regulating MYH9 Expression in Esophageal Squamous Cell Carcinoma.

Xu X, Mao X, Liu W, Ming Y, Zhang T, Yang Y, Gu-Ha AL, Lin YD, Peng Y
MedComm 2025 Jun;6(6):e70218

Inhibition of METTL3 promotes mesangial cell mitophagy and attenuates glomerular damage by alleviating FOSL1 m6A modifications via IGF2BP2-dependent mechanisms.

Liu T, Zhuang XX, Li Zhu X, Wu X, Juan Qin X, Bing Wei L, Chen Gao Y, Rong Gao J
Biochemical pharmacology 2025 Jun;236:116867

The IGF2BP2-circ-DAPK1 axis promotes high-glucose-induced ferroptosis of HUVECs by decreasing NQO1 expression.

Qiu C, Zheng X, Zhou X, Wang B, Chen T, Xu Y, Yu X, Lu W, Wu Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167797

USP14-IMP2-CXCL2 axis in tumor-associated macrophages facilitates resistance to anti-PD-1 therapy in gastric cancer by recruiting myeloid-derived suppressor cells.

You L, Wang Q, Zhang T, Xiao H, Lv M, Lv H, Deng L, Zhang X, Zhang Y
Oncogene 2025 Jul;44(28):2413-2426

FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.

Wang H, Peng H, Zhang Z, Abulimiti Y, Hu J, Zhou Y, Ji P, Li D
Clinical and translational medicine 2025 Jul;15(7):e70392

IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.

Luo X, Wei Q, Xie L, Chen N, Gu B, Xu J, Jiang X, Zuo X, Zhao H, Liu X, Yang Y, Liu T, Zhu Y, Yi P, Xu J
Clinical and translational medicine 2025 Jul;15(7):e70388

M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression.

Ling L, Hu T, Zhou C, Dai Y, Hu L, Chen Y, Hu Z, Huang K, Chen J, Wang Y
Molecular cancer 2025 Jul 8;24(1):192

A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC.

Guo J, Li K, Ming Y, Pan Y, Tan S, Ma H, Chen S, Duan Y, Peng Y
Proceedings of the National Academy of Sciences of the United States of America 2025 Jul 8;122(27):e2504320122

circFTO binding with IGF2BP2 regulates trophoblast cells proliferation, migration, and invasion while mediating m6A modification of CCAR1 mRNA in spontaneous abortion.

Zhang Y, Wu M, Lin X, Lu B, Chen X, Li Q, Jiang Y, Li B, Zhou D, Sheng X
BMC molecular and cell biology 2025 Jul 2;26(1):21

LncRNA USP2-AS1 facilitates colorectal cancer development through the PHLDA2/PI3K/AKT axis.

Zhu J, Lin S, Chang L, Luo Q, Qian M, Ding J, Li J, Pu J, Wang K
Experimental cell research 2025 Jul 15;450(2):114649

ALKBH5 regulates intrauterine adhesion progression through m6A dependent FABP4 mRNA stabilization and serum lipid metabolism.

Yang X, Feng Q
Communications biology 2025 Jul 1;8(1):973

N6-methyladenosine-modified circQKI inhibits prostate cancer docetaxel-sensitivity via miR-188-3p/Beclin-1 pathway.

Zhao T, Li K, Zhang Y, Dong Y, Li Y, Pang M, Wei Y, Yao B, Zhu Q
Life sciences 2025 Jul 1;372:123646

The m(6)A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia.

Wu X, Liu H, Wang J, Zhang S, Hu Q, Wang T, Cui W, Shi Y, Bai H, Zhou J, Han L, Li L, Zhao T, Wu Y, Luo J, Feng D, Guo W, Ge S, Qu Y
Cell death and differentiation 2025 Jan;32(1):100-117

METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression.

Zhang C, Yang T, Chen H, Ding X, Chen H, Liang Z, Zhao Y, Ma S, Liu X
Cell death & disease 2025 Jan 11;16(1):9

METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.

Liu Z, Sun T, Zhang Z, Piao C, Kong C, Zhang X
Clinical and translational medicine 2025 Feb;15(2):e70232

SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.

Xin W, Zhou J, Peng Y, Gong S, Liao W, Wang Y, Huang X, Mao Y, Yao M, Qin S, Xiong J, Li Y, Lan Q, Huang Y, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233

Circ-Sirt6 promotes the stability and expression of m(6)A modified Sirt6 mRNA by recruiting IGF2BP2.

Zhang C, Wang J, Kong P, Sun G, Sun H, Yu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 28;39(4):e70405

Targeting the ALKBH5-NLRP3 positive feedback loop alleviates cardiomyocyte pyroptosis after myocardial infarction.

Cui LG, Zhai MM, Yin JJ, Wang ZM, Wang SH, Zhou YJ, Li PP, Wang Y, Xia L, Wang P, Cha XX, Zhang LR, Han SN
European journal of pharmacology 2025 Feb 15;989:177247

m6A reader IGF2BP2 mediates paclitaxel resistance in esophageal squamous cell carcinoma via FOXM1 mRNA stabilization.

Ren S, Wu J, Zhang L, Guan G, Jiang W
Oncology reports 2025 Dec;54(6)

The ELF1/IGF2BP2/FAM111B Cascade Drives Colorectal Cancer Progression and Ferroptosis Resistance.

Yin D, Cao L, Hua M, Chen Y
Clinical and experimental pharmacology & physiology 2025 Dec;52(12):e70090

METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.

Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455

Hsa_circ_0020491 promotes polycystic ovary syndrome by interacting with IGF2BP2 through regulation of granular cell autophagy and mitochondrial dysfunction.

Huang X, Yu F
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2025 Dec;41(1):2536579

CircATP5C1 promotes triple-negative breast cancer progression by binding IGF2BP2 to modulate CSF-1 secretion.

Liu H, Wang H, Gao W, Yuan Y, Tang T, Sang M, Liu F, Geng C
Cancer biology & therapy 2025 Dec;26(1):2479926

Targeting IQGAP3 skews macrophages polarization towards M1 phenotype and promotes antitumor immune response.

Li X, An X, Zhang Y, Zhang S, Zeng L, Shi J, Wu S, Wang Y, Xu Y, Lv X, Yang S, Yuan B
Cellular and molecular life sciences : CMLS 2025 Dec 30;83(1):53

TNF-α-driven m6A modification disrupts the immunoregulatory function of MSCs by regulating HDAC5-dependent super-enhancers.

Zhang W, Lin J, Zhou Y, Wu C, Li Q, Chen J, Zeng Y, Xiao Z, Shen H, Wu Y, Su Z, Yu W, Xie Z
Cell death & disease 2025 Dec 23;16(1):902

m6A-mediated regulation of ECA39 promotes renal fibrosis in chronic kidney disease by enhancing glycolysis and epithelial-mesenchymal transition.

Tong Z, Zhao H, Cui C, Hong M, Ma Y, Sui L, Wang J, Yuan Q, Sun L
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119981

ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.

Xie X, Zhao Y, Liu J, Li H, Zhu X, Liu Y, Sang Y, Xu K, Du F, Ren H, Cui X, Cai B, Chen H, Wu N, Hou G, Jing C, Chong W, Li L, Shang L
Cell death & disease 2025 Aug 7;16(1):596

FTO-mediated the destabilization of RASGRF1 mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization.

Li Z, Ma J, Guan H, Lai J, Xu F, Cao G
Cell biology and toxicology 2025 Aug 4;41(1):123

IGF2BP2 regulates inflammation in ulcerative colitis through N6-methyladenosine-dependent modulation of CBR1.

Wu W, Zhou Z, Pang C, Wen X, Ye S, Quan JH, Li H, He H, Wu B, Tan W
International immunopharmacology 2025 Aug 28;161:115072

IGF2BPs-regulated TIN2 confers the malignant biological behaviors of gastric cancer cells.

Li F, Zhou Y, Liao Z, Huang D, Zhang Z, Chen G
Tissue & cell 2025 Apr;93:102716

N6-methyladenosine-mediated EIF3H promotes anaplastic thyroid cancer progression and ferroptosis resistance by stabilizing β-catenin.

Zhang Z, Zhou D, Qiu X, Xia F, Li X
Free radical biology & medicine 2025 Apr;231:38-47

Synonymous mutations promote tumorigenesis by disrupting m(6)A-dependent mRNA metabolism.

Lan Y, Xia Z, Shao Q, Lin P, Lu J, Xiao X, Zheng M, Chen D, Dou Y, Xie Q
Cell 2025 Apr 3;188(7):1828-1841.e15

Dual Disruption of EGFR/PI3K Signaling: IGF2BP2 Targeting Reverses Anti-EGFR Resistance in CAFs-Infiltrated Oral Squamous Cell Carcinoma.

Hu Y, Zhu T, Nong S, Sun Y, Li Y, Pan J, Ma J, Zhang J
International journal of molecular sciences 2025 Apr 22;26(9)

The FTO Mediated N6-Methyladenosine Modification of DDIT4 Regulation with Tumorigenesis and Metastasis in Prostate Cancer.

Zhao Y, Hu X, Yu H, Sun H, Zhang L, Shao C
Research (Washington, D.C.) 2024;7:0313

HULC-IGF2BP2 Interaction Drives Proliferation and Metastasis in Colorectal Cancer.

Pang Q, Huang S, Wang H, Cao J
Journal of Cancer 2024;15(20):6686-6697

N(6)-methyladenosine-modified circ_0006168 promotes epithelial mesenchymal transition via miR-384/STAT3/Snail axis in esophageal squamous cell carcinoma.

Wu G, Hou Q, Liu Z, Pu Z, Wu L
Journal of Cancer 2024;15(15):4939-4954

RNA m(6)A modification regulates cell fate transition between pluripotent stem cells and 2-cell-like cells.

Su Z, Dong Y, Sun J, Wu Y, Wei Q, Liang Y, Lin Z, Li Y, Shen L, Xi C, Wu L, Xu Y, Liu Y, Yin J, Wang H, Shi K, Le R, Gao S, Xu X
Cell proliferation 2024 Sep;57(9):e13696

N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.

Cai Y, Zhou J, Xu A, Huang J, Zhang H, Xie G, Zhong K, Wu Y, Ye P, Wang H, Niu H
The Journal of biological chemistry 2024 Sep;300(9):107598

LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis.

Zhang C, Shen S, Xu L, Li M, Tian B, Yao L, Zhu X
Journal of cellular and molecular medicine 2024 Sep;28(17):e70090

Downregulation of the (pro)renin receptor alleviates ferroptosis-associated cardiac pathological changes via the NCOA 4-mediated ferritinophagy pathway in diabetic cardiomyopathy.

Zhang X, Dong X, Jie H, Li S, Li H, Su Y, Li L, Kang L, Dong B, Zhang Y
International immunopharmacology 2024 Sep 10;138:112605

Methyltransferase-Like 3-Mediated N6-Methyladenosine RNA Methylation Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Pyroptosis by Targeting PTEN.

Jiang Y, Liu H, Shi R, Hao Y, Zhang J, Xin W, Li Y, Ma C, Zheng X, Zhang L, Zhao X, Zhu D
Journal of the American Heart Association 2024 Oct;13(19):e034470

FTO/IGF2BP2-mediated N6 methyladenosine modification in invasion and metastasis of thyroid carcinoma via CDH12.

Chen Z, Zhong X, Xia M, Liu C, Tang W, Liu G, Yi Y, Guo Y, Jiang Q, Zu X, Zhong J
Cell death & disease 2024 Oct 8;15(10):733

m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma.

Xu X, Wu S, Zhang Y, Fan W, Lin X, Chen K, Lin X
Molecular carcinogenesis 2024 Nov;63(11):2174-2189

Zhao F, Xie H, Guan Y, Teng J, Li Z, Gao F, Luo X, Ma C, Ai X
Scientific reports 2024 Nov 16;14(1):28323

The m6A reader IGF2BP2 promotes esophageal cell carcinoma progression by enhancing EIF4A1 translation.

Li Y, Xiao Z, Wang Y, Zhang D, Chen Z
Cancer cell international 2024 May 9;24(1):162

Exosome-derived circUPF2 enhances resistance to targeted therapy by redeploying ferroptosis sensitivity in hepatocellular carcinoma.

Dong FL, Xu ZZ, Wang YQ, Li T, Wang X, Li J
Journal of nanobiotechnology 2024 May 30;22(1):298

IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis.

Nan Y, Chen M, Wu W, Huang R, Sun W, Lu Q, Gu Z, Mao X, Xu H, Wang Y
Cell death discovery 2024 May 3;10(1):215

TRIM25 predominately associates with anti-viral stress granules.

Shang Z, Zhang S, Wang J, Zhou L, Zhang X, Billadeau DD, Yang P, Zhang L, Zhou F, Bai P, Jia D
Nature communications 2024 May 15;15(1):4127

NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m(6) A methylation through upregulation of METTL3 transcription.

Gong X, Huang M, Chen L
CNS neuroscience & therapeutics 2024 Mar;30(3):e14441

The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750.

Hu XT, Wu XF, Sui LM, Ao LQ, Pu CX, Yuan M, Xing W, Xu X
Journal of dermatological science 2024 Mar;113(3):93-102

KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.

Cai H, Liang J, Jiang Y, Wang Z, Li H, Wang W, Wang C, Hou J
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):69

The m(6)A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis.

Zhou Y, Yan J, Huang H, Liu L, Ren L, Hu J, Jiang X, Zheng Y, Xu L, Zhong F, Li X
Cell death & disease 2024 Mar 5;15(3):189

HMGA2 overexpression activates IGF2BP2 to stabilize APLP2 via m6A modification and promote pancreatic cancer progression.

Liu K, Wei C, Yu H, Zhang Q, Du Z
Heliyon 2024 Mar 15;10(5):e27268

Inhibition of METTL3 in macrophages provides protection against intestinal inflammation.

Yin H, Ju Z, Zhang X, Zuo W, Yang Y, Zheng M, Zhang X, Liu Y, Peng Y, Xing Y, Yang A, Zhang R
Cellular & molecular immunology 2024 Jun;21(6):589-603

Ubiquitin ligase TRIM15 promotes the progression of pancreatic cancer via the upregulation of the IGF2BP2-TLR4 axis.

Cai H, Zhao J, Zhang Q, Wu H, Sun Y, Guo F, Zhou Y, Qin G, Xia W, Zhao Y, Liang X, Yin S, Qin Y, Li D, Wu H, Ren D
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167183

m6A-methylated Lonp1 drives mitochondrial proteostasis stress to induce testicular pyroptosis upon environmental cadmium exposure.

Ouyang KW, Wang TT, Wang H, Luo YX, Hu YF, Zheng XM, Ling Q, Wang KW, Xiong YW, Zhang J, Chang W, Zhang YF, Yuan Z, Li H, Gao L, Xu DX, Zhu HL, Yang L, Wang H
The Science of the total environment 2024 Jun 25;931:172938

Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.

Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435

m6A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB.

Shu F, Liu H, Chen X, Liu Y, Zhou J, Tang L, Cao W, Yang S, Long Y, Li R, Wang H, Wang H, Jiang G
Cancer research 2024 Jun 14;84(12):1947-1962

Systematic analysis of IGF2BP family members in non-small-cell lung cancer.

Gong L, Liu Q, Jia M, Sun X
Human genomics 2024 Jun 12;18(1):63

Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner.

Wu Y, Chen Y, Yan X, Dai X, Liao Y, Yuan J, Wang L, Liu D, Niu D, Sun L, Chen L, Zhang Y, Xiang L, Chen A, Li S, Xiang W, Ni Z, Chen M, He F, Yang M, Lian J
Autophagy 2024 Jul;20(7):1651-1672

m6A reader IGF2BP2 promotes M2 macrophage polarization and malignant biological behavior of bladder cancer by stabilizing NRP1 mRNA expression.

Fu D, Shi X, Yi X, Wu D, He H, Zhou W, Cheng W
BMC urology 2024 Jul 16;24(1):147

N(6)-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor.

Shu G, Zhao Z, Zhao T, Deng C, Zhu J, Han Y, Chen M, Jing J, Bai G, Li D, Li F, He J, Fu W, Liu G
Journal of experimental & clinical cancer research : CR 2024 Jul 11;43(1):191

Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging.

Li M, Guo H, Carey M, Huang C
Nature aging 2024 Jan;4(1):62-79

BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.

Fan Y, Pan Y, Jia L, Gu S, Liu B, Mei Z, Lv C, Huang H, Zhu G, Deng Q
Cancer medicine 2024 Jan;13(1):e6811

FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.

Zhou Z, Zhang B, Deng Y, Deng S, Li J, Wei W, Wang Y, Wang J, Feng Z, Che M, Yang X, Meng J, Li Y, Hu Y, Sun Y, Wen L, Huang F, Sheng Y, Wan C, Yang K
Journal of experimental & clinical cancer research : CR 2024 Jan 29;43(1):34

METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner.

Cao F, Chen G, Xu Y, Wang X, Tang X, Zhang W, Song X, Yang X, Zeng W, Xie J
Cell death & disease 2024 Jan 13;15(1):43

METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.

Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie J
The Journal of clinical investigation 2024 Feb 6;134(6)

Single-cell and whole-transcriptome sequencing of lymph node metastasis-related gene signature: A large-scale pan-cancer cohort, machine learning and experimental study: [RETRACTED].

International journal of surgery (London, England) 2024 Feb 19;

HNRNPH1 stabilizes FLOT2 mRNA in a non-canonical m6A-dependent manner to promote malignant progression in nasopharyngeal carcinoma.

Li Q, Liu J, Zeng C, Qin D, Zhang Z, Lv Q, Li J, Huang W
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2279-2295

m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.

Li F, Wang F, Wang L, Wang J, Wei S, Meng J, Li Y, Feng L, Jiang P
Epigenetics 2024 Dec;19(1):2326868

IGF2BP2 Shapes the Tumor Microenvironment by Regulating Monocyte and Macrophage Recruitment in Bladder Cancer.

Li J, Jiang Y, Ma M, Wang L, Jing M, Yang Z, Wang L, Qiu Q, Song R, Pu Y, Zhang Y, Mei N, Zhang M, Fan J
Cancer medicine 2024 Dec;13(24):e70506

IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils.

Qian L, Ji Z, Mei L, Zhao J
Immunologic research 2024 Dec 17;73(1):16

N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer.

Ding P, Wu H, Wu J, Li T, He J, Ju Y, Liu Y, Li F, Deng H, Gu R, Zhang L, Guo H, Tian Y, Yang P, Meng N, Li X, Guo Z, Meng L, Zhao Q
Oncogene 2024 Aug;43(34):2548-2563

IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway.

Shi R, Zhao R, Shen Y, Wei S, Zhang T, Zhang J, Shu W, Cheng S, Teng H, Wang H
Cancer gene therapy 2024 Aug;31(8):1221-1236

Long noncoding RNA H19 knockdown promotes angiogenesis via IMP2 after ischemic stroke.

Zhong L, Fan J, Yan F, Yang Z, Hu Y, Li L, Wang R, Zheng Y, Luo Y, Liu P
CNS neuroscience & therapeutics 2024 Aug;30(8):e70000

N(6)-methyladenosine-modified SRPK1 promotes aerobic glycolysis of lung adenocarcinoma via PKM splicing.

Wang A, Zeng Y, Zhang W, Zhao J, Gao L, Li J, Zhu J, Liu Z, Huang JA
Cellular & molecular biology letters 2024 Aug 2;29(1):106

CircEZH2 promotes gallbladder cancer progression and lipid metabolism reprogramming through the miR-556-5p/SCD1 axis.

Tong H, Yu X, Zhou D, Shen Z, Chen J, Si Y, Zhang L, Lu B, Yu J, Wang S, Tang Z
iScience 2024 Aug 16;27(8):110428

Phytic acid promotes high glucose-mediated bone marrow mesenchymal stem cells osteogenesis via modulating circEIF4B that sponges miR-186-5p and complexes with IGF2BP3.

Wu J, Li X, Nie H, Shen Y, Guo Z, Huihan Chu C, Cai K, Tang C
Biochemical pharmacology 2024 Apr;222:116118

CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease.

Lin Z, Lv D, Liao X, Peng R, Liu H, Wu T, Wu K, Sun Y, Zhang Z
Frontiers in immunology 2023;14:1226962

Mettl3 synergistically regulates TGF-β/SMAD2/3 to promote proliferation and metastasis of gastric cancer.

Yuan XN, Liu Q, Shao YC, Guan XQ, Yang ZL, Chu MF, Zhang JW, Tian YH, Wei L
American journal of cancer research 2023;13(7):3185-3202

IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer.

Guan XQ, Yuan XN, Feng KX, Shao YC, Liu Q, Yang ZL, Chen YY, Deng J, Hu MS, Li J, Tian YH, Chu MF, Zhang JW, Wei L
American journal of cancer research 2023;13(7):2948-2968

Rna M(6) a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis.

Li Y, Zhang Y, Zhang T, Ping X, Wang D, Chen Y, Yu J, Liu C, Liu Z, Zheng Y, Yang Y, Ruan C, Li D, Du Z, Wang J, Xu L, Ma X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300436

The predictive significance of a 5-m6A RNA methylation regulator signature in colorectal cancer.

Zhang D, Wu G, Yang L, Wu Q, Yuan L
Heliyon 2023 Oct;9(10):e20172

AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.

Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181

IGF2BP2 promotes ovarian cancer growth and metastasis by upregulating CKAP2L protein expression in an m(6) A-dependent manner.

Shi Y, Xiong X, Sun Y, Geng Z, Chen X, Cui X, Lv J, Ge L, Jia X, Xu J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23183

IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification.

Wu T, Liao L, Wu T, Chen S, Yi Q, Xu M
Cell cycle (Georgetown, Tex.) 2023 Oct;22(20):2245-2263

Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer.

Sun X, Ye G, Li J, Shou H, Bai G, Zhang J
Clinical and translational medicine 2023 Oct;13(10):e1457

The role of m6A RNA methylation regulator in meningioma.

Yang Y, Luo L, Zhou Z
Aging 2023 Oct 31;15(21):12068-12084

IGF2BP2-meidated m(6)A modification of CSF2 reprograms MSC to promote gastric cancer progression.

Ji R, Wu C, Yao J, Xu J, Lin J, Gu H, Fu M, Zhang X, Li Y, Zhang X
Cell death & disease 2023 Oct 21;14(10):693

METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.

Yi J, Peng F, Zhao J, Gong X
Scientific reports 2023 Oct 12;13(1):17292

Mammary Epithelial Cell-Derived Exosomal miR-221-3p Regulates Macrophage Polarization by Targeting Igf2bp2 during Mastitis.

Ji ZH, Gao F, Xie WY, Wu HY, Ren WZ, Yuan B
Journal of agricultural and food chemistry 2023 Oct 11;71(40):14742-14757

HOXD-AS2-STAT3 feedback loop attenuates sensitivity to temozolomide in glioblastoma.

Zhang ZX, Ren P, Cao YY, Wang TT, Huang GH, Li Y, Zhou S, Yang W, Yang L, Liu GL, Xiang Y, Pei YC, Chen QZ, Chen JX, Lv SQ
CNS neuroscience & therapeutics 2023 Nov;29(11):3430-3445

HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification.

Wang J, Zhu M, Zhu J, Li J, Zhu X, Wang K, Shen K, Yang K, Ni X, Liu X, Zhang G, Xi Q, Shi T, Chen W
Cell death discovery 2023 Nov 13;9(1):411

Decreased DANCR contributes to high glucose-induced extracellular matrix accumulation in human renal mesangial cell via regulating the TGF-β/Smad signaling.

Liu F, Cao Y, Zhang C, Su H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22926

N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness.

Dong H, Zeng L, Chen W, Zhang Q, Wang F, Wu Y, Cui B, Qi J, Zhang X, Liu C, Deng J, Yu Y, Schmitt CA, Du J
Cell death discovery 2023 May 6;9(1):149

The cancer-testis lncRNA LINC01977 promotes HCC progression by interacting with RBM39 to prevent Notch2 ubiquitination.

Xia A, Yue Q, Zhu M, Xu J, Liu S, Wu Y, Wang Z, Xu Z, An H, Wang Q, Wang S, Sun B
Cell death discovery 2023 May 18;9(1):169

Methyltransferase-like 3 promotes cervical cancer metastasis by enhancing cathepsin L mRNA stability in an N6-methyladenosine-dependent manner.

Liu P, Ju M, Zheng X, Jiang Y, Yu X, Pan B, Luo R, Jia W, Zheng M
Cancer science 2023 Mar;114(3):837-854

USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m(6)A Modification of YAP1 mRNA.

Ge X, Ye W, Zhu Y, Cui M, Zhou J, Xiao C, Jiang D, Tang P, Wang J, Wang Z, Ji C, Zhou X, Cao X, Liu W, Cai W
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Mar 1;43(9):1456-1474

FLOT1, stabilized by WTAP/IGF2BP2 mediated N6-methyladenosine modification, predicts poor prognosis and promotes growth and invasion in gliomas.

Song T, Hu Z, Zeng C, Luo H, Liu J
Heliyon 2023 Jun;9(6):e16280

m(6)A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma.

Fang H, Sun Q, Zhou J, Zhang H, Song Q, Zhang H, Yu G, Guo Y, Huang C, Mou Y, Jia C, Song Y, Liu A, Song K, Lu C, Tian R, Wei S, Yang D, Chen Y, Li T, Wang K, Yu Y, Lv Y, Mo K, Sun P, Yu X, Song X
Molecular cancer 2023 Jun 23;22(1):99

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.

Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151

Long non-coding RNA HOXC-AS1 exerts its oncogenic effects in esophageal squamous cell carcinoma by interaction with IGF2BP2 to stabilize SIRT1 expression.

Yang Z, Wan J, Ma L, Li Z, Yang R, Yang H, Li J, Zhou F, Ming L
Journal of clinical laboratory analysis 2023 Jan;37(1):e24801

Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer.

Gao Y, Zou T, Xu P, Wang Y, Jiang Y, Chen YX, Chen H, Hong J, Fang JY
Neoplasia (New York, N.Y.) 2023 Jan;35:100850

Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance.

Cheng Y, Gao Z, Zhang T, Wang Y, Xie X, Han G, Li Y, Yin R, Chen Y, Wang P, Hu J, Zhang T, Guo C, Chai J, Wang J, Cui M, Gao K, Liu W, Yao S, Lu P, Cao Z, Zheng Y, Chang J, Liu Z, Song Q, Li W, Zhou F, Zhang H
Cell stem cell 2023 Jan 5;30(1):69-85.e7

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116

Characterization of circSCL38A1 as a novel oncogene in bladder cancer via targeting ILF3/TGF-β2 signaling axis.

Li P, Mi Q, Yan S, Xie Y, Cui Z, Zhang S, Wang Y, Gao H, Wang Y, Li J, Du L, Wang C
Cell death & disease 2023 Jan 25;14(1):59

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246

F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner.

Zhou H, Zeng C, Liu J, Luo H, Huang W
Cancers 2023 Feb 2;15(3)

m(6)A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m(6)A/PD-L1 manner.

Guan H, Tian K, Luo W, Li M
Cell death & disease 2023 Feb 14;14(2):120

HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21 expression in metabolic syndrome-related liver injury.

Chen Y, Cai K, Du Y, Liu Z, Gong Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Feb 1;101(1):52-63

Insulin-like growth factor 2 mRNA-binding protein 2 is a therapeutic target in ovarian cancer.

Yuan J, Li X, Wang F, Liu H, Guan W, Xu G
Experimental biology and medicine (Maywood, N.J.) 2023 Dec;248(23):2198-2209

m(6)A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3.

Shan T, Liu F, Wen M, Chen Z, Li S, Wang Y, Cheng H, Zhou Y
Molecular cell 2023 Dec 21;83(24):4494-4508.e6

Circular RNA circEYA3 promotes the radiation resistance of hepatocellular carcinoma via the IGF2BP2/DTX3L axis.

Hu P, Lin L, Huang T, Li Z, Xiao M, Guo H, Chen G, Liu D, Ke M, Shan H, Zhang F, Zhang Y
Cancer cell international 2023 Dec 2;23(1):308

LncRNA AK142643 promotes hepatic lipid accumulation by upregulating CD36 via interacting with IGF2BP2.

Wang P, Wang X, He D, Zhuang C
Gene 2023 Dec 15;887:147747

TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis.

Yang R, Wan J, Ma L, Zhou F, Yang Z, Li Z, Zhang M, Ming L
Cell death discovery 2023 Dec 1;9(1):431

Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.

Ni WJ, Zhou H, Lu H, Ma NN, Hou BB, Li W, Kong FX, Yu JT, Hou R, Jin J, Wen JG, Zhang T, Meng XM
Clinical and translational medicine 2023 Aug;13(8):e1359

A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.

Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui XL, Zou Z, Yue Z, Emch MJ, Hawse JR, Wang L, He HH, Xia S, Han B, He C, Huang H
Molecular cell 2023 Aug 3;83(15):2692-2708.e7

Interference of a mammalian circRNA regulates lipid metabolism reprogramming by targeting miR-24-3p/Igf2/PI3K-AKT-mTOR and Igf2bp2/Ucp1 axis.

Shao J, Wang M, Zhang A, Liu Z, Jiang G, Tang T, Wang J, Jia X, Lai S
Cellular and molecular life sciences : CMLS 2023 Aug 17;80(9):252

ACSM3 suppresses proliferation and induces apoptosis and cell cycle arrest in acute myeloid leukemia cells via the regulation of IGF2BP2.

Zheng X, Wu J, Song L, Huang B
Experimental and therapeutic medicine 2023 Apr;25(4):177

Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.

Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120

IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism.

Liu TY, Hu CC, Han CY, Mao SY, Zhang WX, Xu YM, Sun YJ, Jiang DB, Zhang XY, Zhang JX, Wang J, Qiao XP, Pan JY, Yang SY, Yang K
Biology direct 2023 Apr 23;18(1):19

N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer.

Yang J, Xu P, Chen Z, Zhang X, Xia Y, Fang L, Xie L, Li B, Xu Z
Cancer letters 2023 Apr 1;558:216092

Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease.

Liu F, Huang J, Zhang C, Xie Y, Cao Y, Tao L, Tang H, Lin J, Hammes HP, Huang K, Yi F, Su H, Zhang C
International journal of biological sciences 2022;18(15):5624-5640

Exploitation of tumor antigens and construction of immune subtype classifier for mRNA vaccine development in bladder cancer.

Zhang X, Zhang Y, Zhao L, Wang J, Li J, Wang X, Zhang M, Hu X
Frontiers in immunology 2022;13:1014638

Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer.

Zeng H, Hou Y, Zhou X, Lang L, Luo H, Sun Y, Wan X, Yuan T, Wang R, Liu Y, Tang R, Cheng S, Xu M, Liu M
Theranostics 2022;12(17):7351-7370

A pan-cancer landscape of IGF2BPs and their association with prognosis, stemness and tumor immune microenvironment.

Shao W, Zhao H, Zhang S, Ding Q, Guo Y, Hou K, Kan Y, Deng F, Xu Q
Frontiers in oncology 2022;12:1049183

Reply to the Comment on "The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ".

Wang X, Xu S, Chen D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Sep;9(25):e2201452

rtcisE2F promotes the self-renewal and metastasis of liver tumor-initiating cells via N(6)-methyladenosine-dependent E2F3/E2F6 mRNA stability.

Chen Z, Huang L, Wang K, Zhang L, Zhong X, Yan Z, Liu B, Zhu P
Science China. Life sciences 2022 Sep;65(9):1840-1854

m(6)A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization.

Bian Y, Wang Y, Xu S, Gao Z, Li C, Fan Z, Ding J, Wang K
Cells 2022 Sep 27;11(19)

WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma.

Qin Y, Wang CJ, Ye HL, Ye GX, Wang S, Pan DB, Wang J, Shen HJ, Xu SQ
Cell biology international 2022 Oct;46(10):1682-1692

The "m6A writer" METTL3 and the "m6A reader" IGF2BP2 regulate cutaneous T-cell lymphomas progression via CDKN2A.

Wang X, Hu M, Yu L, Wang X, Jiang X, Zhang G, Ding K
Hematological oncology 2022 Oct;40(4):567-576

m(6)A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer.

Tsuchiya K, Yoshimura K, Iwashita Y, Inoue Y, Ohta T, Watanabe H, Yamada H, Kawase A, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H
Cancer gene therapy 2022 Oct;29(10):1355-1372

Promotion of nonalcoholic steatohepatitis by RNA N(6)-methyladenosine reader IGF2BP2 in mice.

Zhou B, Luo Y, Ji N, Mao F, Xiang L, Bian H, Zheng MH, Hu C, Li Y, Lu Y
Life metabolism 2022 Oct;1(2):161-174

IGF2BP2 Promotes Epithelial to Mesenchymal Transition and Metastasis through Stabilizing HMGA1 mRNA in Gastric Cancer.

Ouyang J, Li J, Li D, Jiang J, Hao T, Xia Y, Lu X, Zhang C, He Y
Cancers 2022 Oct 31;14(21)

Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation.

Ou B, Liu Y, Gao Z, Xu J, Yan Y, Li Y, Zhang J
Cell death & disease 2022 Oct 27;13(10):905

FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2.

Sun M, Zhang X, Bi F, Wang D, Zhou X, Li X, Yang Q
Cancers 2022 Oct 25;14(21)

RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.

Jiang T, He X, Zhao Z, Zhang X, Wang T, Jia L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554

Identification of an IGF2BP2-Targeted Peptide for Near-Infrared Imaging of Esophageal Squamous Cell Carcinoma.

Shu W, Xiao Y, Wang L, Liang M, Li Z, Wu X, Cao Q
Molecules (Basel, Switzerland) 2022 Nov 6;27(21)

N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.

Zhang X, Yin H, Zhang X, Jiang X, Liu Y, Zhang H, Peng Y, Li D, Yu Y, Zhang J, Cheng S, Yang A, Zhang R
Nature communications 2022 Nov 17;13(1):7038

m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling.

Liu X, He H, Zhang F, Hu X, Bi F, Li K, Yu H, Zhao Y, Teng X, Li J, Wang L, Zhang Y, Wu Q
Cell death & disease 2022 May 21;13(5):483

CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.

Song X, Chen B, Liang Y, Li Y, Zhang H, Han D, Wang Y, Ye F, Wang L, Zhao W, Yang Q
Cell death discovery 2022 May 14;8(1):261

N(6)-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition.

Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B, Gao Y, Gao S
Nature cell biology 2022 Jun;24(6):917-927

CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA.

Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, Bai B, Gu S, Zhao W, Zhan Q
Molecular cancer 2022 Jun 30;21(1):140

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019

Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma.

Wang Y, Zhao X, Li J, Wang X, Hu W, Zhang X
Technology in cancer research & treatment 2022 Jan-Dec;21:15330338221085373

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner.

Huang J, Sun W, Wang Z, Lv C, Zhang T, Zhang D, Dong W, Shao L, He L, Ji X, Zhang P, Zhang H
Journal of experimental & clinical cancer research : CR 2022 Jan 28;41(1):42

Methyltransferase-like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1.

Liu T, Wang H, Fu Z, Wang Z, Wang J, Gan X, Wang A, Wang L
Cancer science 2022 Feb;113(2):446-458

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176

N(6)-methyladenosine (m(6)A) reader IGF2BP2 stabilizes HK2 stability to accelerate the Warburg effect of oral squamous cell carcinoma progression.

Xu K, Dai X, Wu J, Wen K
Journal of cancer research and clinical oncology 2022 Dec;148(12):3375-3384

IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis.

Wang C, Zhou M, Zhu P, Ju C, Sheng J, Du D, Wan J, Yin H, Xing Y, Li H, He J, He F
Journal of experimental & clinical cancer research : CR 2022 Dec 15;41(1):347

METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.

Li HB, Huang G, Tu J, Lv DM, Jin QL, Chen JK, Zou YT, Lee DF, Shen JN, Xie XB
EBioMedicine 2022 Aug;82:104142

METTL3-mediated m(6)A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy.

Jiang L, Liu X, Hu X, Gao L, Zeng H, Wang X, Huang Y, Zhu W, Wang J, Wen J, Meng X, Wu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1721-1740

IGF2BP2 Induces U251 Glioblastoma Cell Chemoresistance by Inhibiting FOXO1-Mediated PID1 Expression Through Stabilizing lncRNA DANCR.

Han J, Yu X, Wang S, Wang Y, Liu Q, Xu H, Wang X
Frontiers in cell and developmental biology 2021;9:659228

N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.

Tan L, Tang Y, Li H, Li P, Ye Y, Cen J, Gui C, Luo J, Cao J, Wei J
Frontiers in oncology 2021;11:641833

lncRNA HCG11 suppresses human osteosarcoma growth through upregulating p27 Kip1.

Gu J, Dai B, Shi X, He Z, Xu Y, Meng X, Zhu J
Aging 2021 Sep 13;13(17):21743-21757

Human m(6)A-mRNA and lncRNA epitranscriptomic microarray reveal function of RNA methylation in hemoglobin H-constant spring disease.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human kidney tissue were subjected to SDS PAGE followed by western blot with 11601-1-AP(IGF2BP2 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IGF2BP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IGF2BP2. This antibody recognizes human,mouse,rat antigen. The IGF2BP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11601-1-AP.pdf

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