11601-1-AP

antibody from Proteintech Group

Targeting: IGF2BP2 IMP-2

Provider product page for 11601-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [126]
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Western blot [1]
Immunohistochemistry [1]

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Product number: 11601-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11601-1-AP, RRID:AB_2122672
Product name: IGF2BP2 antibody
Antibody type: Polyclonal
Description: KD/KO validated IGF2BP2 antibody (Cat. #11601-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IGF2BP2 protein structure - 11601-1-AP shown in red.

Submitted references The FTO Mediated N6-Methyladenosine Modification of DDIT4 Regulation with Tumorigenesis and Metastasis in Prostate Cancer.

Zhao Y, Hu X, Yu H, Sun H, Zhang L, Shao C
Research (Washington, D.C.) 2024;7:0313

TRIM25 predominately associates with anti-viral stress granules.

Shang Z, Zhang S, Wang J, Zhou L, Zhang X, Billadeau DD, Yang P, Zhang L, Zhou F, Bai P, Jia D
Nature communications 2024 May 15;15(1):4127

NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m(6) A methylation through upregulation of METTL3 transcription.

Gong X, Huang M, Chen L
CNS neuroscience & therapeutics 2024 Mar;30(3):e14441

The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750.

Hu XT, Wu XF, Sui LM, Ao LQ, Pu CX, Yuan M, Xing W, Xu X
Journal of dermatological science 2024 Mar;113(3):93-102

KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.

Cai H, Liang J, Jiang Y, Wang Z, Li H, Wang W, Wang C, Hou J
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):69

The m(6)A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis.

Zhou Y, Yan J, Huang H, Liu L, Ren L, Hu J, Jiang X, Zheng Y, Xu L, Zhong F, Li X
Cell death & disease 2024 Mar 5;15(3):189

HMGA2 overexpression activates IGF2BP2 to stabilize APLP2 via m6A modification and promote pancreatic cancer progression.

Liu K, Wei C, Yu H, Zhang Q, Du Z
Heliyon 2024 Mar 15;10(5):e27268

Ubiquitin ligase TRIM15 promotes the progression of pancreatic cancer via the upregulation of the IGF2BP2-TLR4 axis.

Cai H, Zhao J, Zhang Q, Wu H, Sun Y, Guo F, Zhou Y, Qin G, Xia W, Zhao Y, Liang X, Yin S, Qin Y, Li D, Wu H, Ren D
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167183

The m(6)A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia.

Wu X, Liu H, Wang J, Zhang S, Hu Q, Wang T, Cui W, Shi Y, Bai H, Zhou J, Han L, Li L, Zhao T, Wu Y, Luo J, Feng D, Guo W, Ge S, Qu Y
Cell death and differentiation 2024 Jun 20;

Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.

Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435

m6A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB.

Shu F, Liu H, Chen X, Liu Y, Zhou J, Tang L, Cao W, Yang S, Long Y, Li R, Wang H, Wang H, Jiang G
Cancer research 2024 Jun 14;84(12):1947-1962

Systematic analysis of IGF2BP family members in non-small-cell lung cancer.

Gong L, Liu Q, Jia M, Sun X
Human genomics 2024 Jun 12;18(1):63

Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner.

Wu Y, Chen Y, Yan X, Dai X, Liao Y, Yuan J, Wang L, Liu D, Niu D, Sun L, Chen L, Zhang Y, Xiang L, Chen A, Li S, Xiang W, Ni Z, Chen M, He F, Yang M, Lian J
Autophagy 2024 Jul;20(7):1651-1672

Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging.

Li M, Guo H, Carey M, Huang C
Nature aging 2024 Jan;4(1):62-79

BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer.

Fan Y, Pan Y, Jia L, Gu S, Liu B, Mei Z, Lv C, Huang H, Zhu G, Deng Q
Cancer medicine 2024 Jan;13(1):e6811

FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.

Zhou Z, Zhang B, Deng Y, Deng S, Li J, Wei W, Wang Y, Wang J, Feng Z, Che M, Yang X, Meng J, Li Y, Hu Y, Sun Y, Wen L, Huang F, Sheng Y, Wan C, Yang K
Journal of experimental & clinical cancer research : CR 2024 Jan 29;43(1):34

METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.

Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie J
The Journal of clinical investigation 2024 Feb 6;134(6)

Single-cell and whole-transcriptome sequencing of lymph node metastasis-related gene signature: A large-scale pan-cancer cohort, machine learning and experimental study.

Lai J, He Y, Cai X, Cao Y, Long Y, Luo Z, Deng K, Lin Y, Teng R, Huang H, Zhu C, Cai DQ, Liao N
International journal of surgery (London, England) 2024 Feb 19;

IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway.

Shi R, Zhao R, Shen Y, Wei S, Zhang T, Zhang J, Shu W, Cheng S, Teng H, Wang H
Cancer gene therapy 2024 Aug;31(8):1221-1236

Phytic acid promotes high glucose-mediated bone marrow mesenchymal stem cells osteogenesis via modulating circEIF4B that sponges miR-186-5p and complexes with IGF2BP3.

Wu J, Li X, Nie H, Shen Y, Guo Z, Huihan Chu C, Cai K, Tang C
Biochemical pharmacology 2024 Apr;222:116118

CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease.

Lin Z, Lv D, Liao X, Peng R, Liu H, Wu T, Wu K, Sun Y, Zhang Z
Frontiers in immunology 2023;14:1226962

Mettl3 synergistically regulates TGF-β/SMAD2/3 to promote proliferation and metastasis of gastric cancer.

Yuan XN, Liu Q, Shao YC, Guan XQ, Yang ZL, Chu MF, Zhang JW, Tian YH, Wei L
American journal of cancer research 2023;13(7):3185-3202

IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer.

Guan XQ, Yuan XN, Feng KX, Shao YC, Liu Q, Yang ZL, Chen YY, Deng J, Hu MS, Li J, Tian YH, Chu MF, Zhang JW, Wei L
American journal of cancer research 2023;13(7):2948-2968

Rna M(6) a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis.

Li Y, Zhang Y, Zhang T, Ping X, Wang D, Chen Y, Yu J, Liu C, Liu Z, Zheng Y, Yang Y, Ruan C, Li D, Du Z, Wang J, Xu L, Ma X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300436

The predictive significance of a 5-m6A RNA methylation regulator signature in colorectal cancer.

Zhang D, Wu G, Yang L, Wu Q, Yuan L
Heliyon 2023 Oct;9(10):e20172

AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.

Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181

IGF2BP2 promotes ovarian cancer growth and metastasis by upregulating CKAP2L protein expression in an m(6) A-dependent manner.

Shi Y, Xiong X, Sun Y, Geng Z, Chen X, Cui X, Lv J, Ge L, Jia X, Xu J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23183

IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification.

Wu T, Liao L, Wu T, Chen S, Yi Q, Xu M
Cell cycle (Georgetown, Tex.) 2023 Oct;22(20):2245-2263

Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer.

Sun X, Ye G, Li J, Shou H, Bai G, Zhang J
Clinical and translational medicine 2023 Oct;13(10):e1457

The role of m6A RNA methylation regulator in meningioma.

Yang Y, Luo L, Zhou Z
Aging 2023 Oct 31;15(21):12068-12084

IGF2BP2-meidated m(6)A modification of CSF2 reprograms MSC to promote gastric cancer progression.

Ji R, Wu C, Yao J, Xu J, Lin J, Gu H, Fu M, Zhang X, Li Y, Zhang X
Cell death & disease 2023 Oct 21;14(10):693

METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.

Yi J, Peng F, Zhao J, Gong X
Scientific reports 2023 Oct 12;13(1):17292

Mammary Epithelial Cell-Derived Exosomal miR-221-3p Regulates Macrophage Polarization by Targeting Igf2bp2 during Mastitis.

Ji ZH, Gao F, Xie WY, Wu HY, Ren WZ, Yuan B
Journal of agricultural and food chemistry 2023 Oct 11;71(40):14742-14757

HOXD-AS2-STAT3 feedback loop attenuates sensitivity to temozolomide in glioblastoma.

Zhang ZX, Ren P, Cao YY, Wang TT, Huang GH, Li Y, Zhou S, Yang W, Yang L, Liu GL, Xiang Y, Pei YC, Chen QZ, Chen JX, Lv SQ
CNS neuroscience & therapeutics 2023 Nov;29(11):3430-3445

HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification.

Wang J, Zhu M, Zhu J, Li J, Zhu X, Wang K, Shen K, Yang K, Ni X, Liu X, Zhang G, Xi Q, Shi T, Chen W
Cell death discovery 2023 Nov 13;9(1):411

Decreased DANCR contributes to high glucose-induced extracellular matrix accumulation in human renal mesangial cell via regulating the TGF-β/Smad signaling.

Liu F, Cao Y, Zhang C, Su H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22926

N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness.

Dong H, Zeng L, Chen W, Zhang Q, Wang F, Wu Y, Cui B, Qi J, Zhang X, Liu C, Deng J, Yu Y, Schmitt CA, Du J
Cell death discovery 2023 May 6;9(1):149

The cancer-testis lncRNA LINC01977 promotes HCC progression by interacting with RBM39 to prevent Notch2 ubiquitination.

Xia A, Yue Q, Zhu M, Xu J, Liu S, Wu Y, Wang Z, Xu Z, An H, Wang Q, Wang S, Sun B
Cell death discovery 2023 May 18;9(1):169

Methyltransferase-like 3 promotes cervical cancer metastasis by enhancing cathepsin L mRNA stability in an N6-methyladenosine-dependent manner.

Liu P, Ju M, Zheng X, Jiang Y, Yu X, Pan B, Luo R, Jia W, Zheng M
Cancer science 2023 Mar;114(3):837-854

USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m(6)A Modification of YAP1 mRNA.

Ge X, Ye W, Zhu Y, Cui M, Zhou J, Xiao C, Jiang D, Tang P, Wang J, Wang Z, Ji C, Zhou X, Cao X, Liu W, Cai W
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Mar 1;43(9):1456-1474

FLOT1, stabilized by WTAP/IGF2BP2 mediated N6-methyladenosine modification, predicts poor prognosis and promotes growth and invasion in gliomas.

Song T, Hu Z, Zeng C, Luo H, Liu J
Heliyon 2023 Jun;9(6):e16280

m(6)A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma.

Fang H, Sun Q, Zhou J, Zhang H, Song Q, Zhang H, Yu G, Guo Y, Huang C, Mou Y, Jia C, Song Y, Liu A, Song K, Lu C, Tian R, Wei S, Yang D, Chen Y, Li T, Wang K, Yu Y, Lv Y, Mo K, Sun P, Yu X, Song X
Molecular cancer 2023 Jun 23;22(1):99

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.

Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151

Long non-coding RNA HOXC-AS1 exerts its oncogenic effects in esophageal squamous cell carcinoma by interaction with IGF2BP2 to stabilize SIRT1 expression.

Yang Z, Wan J, Ma L, Li Z, Yang R, Yang H, Li J, Zhou F, Ming L
Journal of clinical laboratory analysis 2023 Jan;37(1):e24801

Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer.

Gao Y, Zou T, Xu P, Wang Y, Jiang Y, Chen YX, Chen H, Hong J, Fang JY
Neoplasia (New York, N.Y.) 2023 Jan;35:100850

Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance.

Cheng Y, Gao Z, Zhang T, Wang Y, Xie X, Han G, Li Y, Yin R, Chen Y, Wang P, Hu J, Zhang T, Guo C, Chai J, Wang J, Cui M, Gao K, Liu W, Yao S, Lu P, Cao Z, Zheng Y, Chang J, Liu Z, Song Q, Li W, Zhou F, Zhang H
Cell stem cell 2023 Jan 5;30(1):69-85.e7

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116

Characterization of circSCL38A1 as a novel oncogene in bladder cancer via targeting ILF3/TGF-β2 signaling axis.

Li P, Mi Q, Yan S, Xie Y, Cui Z, Zhang S, Wang Y, Gao H, Wang Y, Li J, Du L, Wang C
Cell death & disease 2023 Jan 25;14(1):59

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246

F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner.

Zhou H, Zeng C, Liu J, Luo H, Huang W
Cancers 2023 Feb 2;15(3)

m(6)A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m(6)A/PD-L1 manner.

Guan H, Tian K, Luo W, Li M
Cell death & disease 2023 Feb 14;14(2):120

HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21 expression in metabolic syndrome-related liver injury.

Chen Y, Cai K, Du Y, Liu Z, Gong Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2023 Feb 1;101(1):52-63

Insulin-like growth factor 2 mRNA-binding protein 2 is a therapeutic target in ovarian cancer.

Yuan J, Li X, Wang F, Liu H, Guan W, Xu G
Experimental biology and medicine (Maywood, N.J.) 2023 Dec;248(23):2198-2209

m(6)A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3.

Shan T, Liu F, Wen M, Chen Z, Li S, Wang Y, Cheng H, Zhou Y
Molecular cell 2023 Dec 21;83(24):4494-4508.e6

Circular RNA circEYA3 promotes the radiation resistance of hepatocellular carcinoma via the IGF2BP2/DTX3L axis.

Hu P, Lin L, Huang T, Li Z, Xiao M, Guo H, Chen G, Liu D, Ke M, Shan H, Zhang F, Zhang Y
Cancer cell international 2023 Dec 2;23(1):308

LncRNA AK142643 promotes hepatic lipid accumulation by upregulating CD36 via interacting with IGF2BP2.

Wang P, Wang X, He D, Zhuang C
Gene 2023 Dec 15;887:147747

TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis.

Yang R, Wan J, Ma L, Zhou F, Yang Z, Li Z, Zhang M, Ming L
Cell death discovery 2023 Dec 1;9(1):431

Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.

Ni WJ, Zhou H, Lu H, Ma NN, Hou BB, Li W, Kong FX, Yu JT, Hou R, Jin J, Wen JG, Zhang T, Meng XM
Clinical and translational medicine 2023 Aug;13(8):e1359

A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.

Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui XL, Zou Z, Yue Z, Emch MJ, Hawse JR, Wang L, He HH, Xia S, Han B, He C, Huang H
Molecular cell 2023 Aug 3;83(15):2692-2708.e7

Interference of a mammalian circRNA regulates lipid metabolism reprogramming by targeting miR-24-3p/Igf2/PI3K-AKT-mTOR and Igf2bp2/Ucp1 axis.

Shao J, Wang M, Zhang A, Liu Z, Jiang G, Tang T, Wang J, Jia X, Lai S
Cellular and molecular life sciences : CMLS 2023 Aug 17;80(9):252

ACSM3 suppresses proliferation and induces apoptosis and cell cycle arrest in acute myeloid leukemia cells via the regulation of IGF2BP2.

Zheng X, Wu J, Song L, Huang B
Experimental and therapeutic medicine 2023 Apr;25(4):177

Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.

Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120

IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism.

Liu TY, Hu CC, Han CY, Mao SY, Zhang WX, Xu YM, Sun YJ, Jiang DB, Zhang XY, Zhang JX, Wang J, Qiao XP, Pan JY, Yang SY, Yang K
Biology direct 2023 Apr 23;18(1):19

N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer.

Yang J, Xu P, Chen Z, Zhang X, Xia Y, Fang L, Xie L, Li B, Xu Z
Cancer letters 2023 Apr 1;558:216092

Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease.

Liu F, Huang J, Zhang C, Xie Y, Cao Y, Tao L, Tang H, Lin J, Hammes HP, Huang K, Yi F, Su H, Zhang C
International journal of biological sciences 2022;18(15):5624-5640

Exploitation of tumor antigens and construction of immune subtype classifier for mRNA vaccine development in bladder cancer.

Zhang X, Zhang Y, Zhao L, Wang J, Li J, Wang X, Zhang M, Hu X
Frontiers in immunology 2022;13:1014638

Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer.

Zeng H, Hou Y, Zhou X, Lang L, Luo H, Sun Y, Wan X, Yuan T, Wang R, Liu Y, Tang R, Cheng S, Xu M, Liu M
Theranostics 2022;12(17):7351-7370

A pan-cancer landscape of IGF2BPs and their association with prognosis, stemness and tumor immune microenvironment.

Shao W, Zhao H, Zhang S, Ding Q, Guo Y, Hou K, Kan Y, Deng F, Xu Q
Frontiers in oncology 2022;12:1049183

Reply to the Comment on "The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ".

Wang X, Xu S, Chen D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Sep;9(25):e2201452

rtcisE2F promotes the self-renewal and metastasis of liver tumor-initiating cells via N(6)-methyladenosine-dependent E2F3/E2F6 mRNA stability.

Chen Z, Huang L, Wang K, Zhang L, Zhong X, Yan Z, Liu B, Zhu P
Science China. Life sciences 2022 Sep;65(9):1840-1854

m(6)A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization.

Bian Y, Wang Y, Xu S, Gao Z, Li C, Fan Z, Ding J, Wang K
Cells 2022 Sep 27;11(19)

WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma.

Qin Y, Wang CJ, Ye HL, Ye GX, Wang S, Pan DB, Wang J, Shen HJ, Xu SQ
Cell biology international 2022 Oct;46(10):1682-1692

The "m6A writer" METTL3 and the "m6A reader" IGF2BP2 regulate cutaneous T-cell lymphomas progression via CDKN2A.

Wang X, Hu M, Yu L, Wang X, Jiang X, Zhang G, Ding K
Hematological oncology 2022 Oct;40(4):567-576

m(6)A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer.

Tsuchiya K, Yoshimura K, Iwashita Y, Inoue Y, Ohta T, Watanabe H, Yamada H, Kawase A, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H
Cancer gene therapy 2022 Oct;29(10):1355-1372

IGF2BP2 Promotes Epithelial to Mesenchymal Transition and Metastasis through Stabilizing HMGA1 mRNA in Gastric Cancer.

Ouyang J, Li J, Li D, Jiang J, Hao T, Xia Y, Lu X, Zhang C, He Y
Cancers 2022 Oct 31;14(21)

Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation.

Ou B, Liu Y, Gao Z, Xu J, Yan Y, Li Y, Zhang J
Cell death & disease 2022 Oct 27;13(10):905

FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2.

Sun M, Zhang X, Bi F, Wang D, Zhou X, Li X, Yang Q
Cancers 2022 Oct 25;14(21)

RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.

Jiang T, He X, Zhao Z, Zhang X, Wang T, Jia L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554

Identification of an IGF2BP2-Targeted Peptide for Near-Infrared Imaging of Esophageal Squamous Cell Carcinoma.

Shu W, Xiao Y, Wang L, Liang M, Li Z, Wu X, Cao Q
Molecules (Basel, Switzerland) 2022 Nov 6;27(21)

N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.

Zhang X, Yin H, Zhang X, Jiang X, Liu Y, Zhang H, Peng Y, Li D, Yu Y, Zhang J, Cheng S, Yang A, Zhang R
Nature communications 2022 Nov 17;13(1):7038

m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling.

Liu X, He H, Zhang F, Hu X, Bi F, Li K, Yu H, Zhao Y, Teng X, Li J, Wang L, Zhang Y, Wu Q
Cell death & disease 2022 May 21;13(5):483

CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.

Song X, Chen B, Liang Y, Li Y, Zhang H, Han D, Wang Y, Ye F, Wang L, Zhao W, Yang Q
Cell death discovery 2022 May 14;8(1):261

N(6)-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition.

Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B, Gao Y, Gao S
Nature cell biology 2022 Jun;24(6):917-927

CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA.

Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, Bai B, Gu S, Zhao W, Zhan Q
Molecular cancer 2022 Jun 30;21(1):140

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019

Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma.

Wang Y, Zhao X, Li J, Wang X, Hu W, Zhang X
Technology in cancer research & treatment 2022 Jan-Dec;21:15330338221085373

FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner.

Huang J, Sun W, Wang Z, Lv C, Zhang T, Zhang D, Dong W, Shao L, He L, Ji X, Zhang P, Zhang H
Journal of experimental & clinical cancer research : CR 2022 Jan 28;41(1):42

Methyltransferase-like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1.

Liu T, Wang H, Fu Z, Wang Z, Wang J, Gan X, Wang A, Wang L
Cancer science 2022 Feb;113(2):446-458

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176

N(6)-methyladenosine (m(6)A) reader IGF2BP2 stabilizes HK2 stability to accelerate the Warburg effect of oral squamous cell carcinoma progression.

Xu K, Dai X, Wu J, Wen K
Journal of cancer research and clinical oncology 2022 Dec;148(12):3375-3384

IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis.

Wang C, Zhou M, Zhu P, Ju C, Sheng J, Du D, Wan J, Yin H, Xing Y, Li H, He J, He F
Journal of experimental & clinical cancer research : CR 2022 Dec 15;41(1):347

METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.

Li HB, Huang G, Tu J, Lv DM, Jin QL, Chen JK, Zou YT, Lee DF, Shen JN, Xie XB
EBioMedicine 2022 Aug;82:104142

METTL3-mediated m(6)A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy.

Jiang L, Liu X, Hu X, Gao L, Zeng H, Wang X, Huang Y, Zhu W, Wang J, Wen J, Meng X, Wu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1721-1740

IGF2BP2 Induces U251 Glioblastoma Cell Chemoresistance by Inhibiting FOXO1-Mediated PID1 Expression Through Stabilizing lncRNA DANCR.

Han J, Yu X, Wang S, Wang Y, Liu Q, Xu H, Wang X
Frontiers in cell and developmental biology 2021;9:659228

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Tan L, Tang Y, Li H, Li P, Ye Y, Cen J, Gui C, Luo J, Cao J, Wei J
Frontiers in oncology 2021;11:641833

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Gu J, Dai B, Shi X, He Z, Xu Y, Meng X, Zhu J
Aging 2021 Sep 13;13(17):21743-21757

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Ruan H, Yang F, Deng L, Yang D, Zhang X, Li X, Pang L
Scientific reports 2021 Oct 14;11(1):20478

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Jiang Y, Peng J, Song J, He J, Jiang M, Wang J, Ma L, Wang Y, Lin M, Wu H, Zhang Z, Gao D, Zhao Y
Nature metabolism 2021 Nov;3(11):1569-1584

N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer.

Lu S, Han L, Hu X, Sun T, Xu D, Li Y, Chen Q, Yao W, He M, Wang Z, Wu H, Wei M
Journal of hematology & oncology 2021 Nov 7;14(1):188

An in vitro system to silence mitochondrial gene expression.

Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P
Cell 2021 Nov 11;184(23):5824-5837.e15

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Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361

IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.

Wang J, Yuan X, Ding N
Experimental and therapeutic medicine 2021 Jun;21(6):593

m(6) A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2-mediated IGF1R mRNA stabilization.

Lang C, Yin C, Lin K, Li Y, Yang Q, Wu Z, Du H, Ren D, Dai Y, Peng X
Clinical and translational medicine 2021 Jun;11(6):e426

m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2.

Qian B, Wang P, Zhang D, Wu L
Cell death discovery 2021 Jun 26;7(1):157

The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ.

Wang X, Ji Y, Feng P, Liu R, Li G, Zheng J, Xue Y, Wei Y, Ji C, Chen D, Li J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jul;8(13):2100209

linc01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize HTR3A mRNA.

Huang GW, Chen QQ, Ma CC, Xie LH, Gu J
The international journal of biochemistry & cell biology 2021 Jul;136:106015

EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization.

Ying Y, Ma X, Fang J, Chen S, Wang W, Li J, Xie H, Wu J, Xie B, Liu B, Wang X, Zheng X, Xie L
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LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification.

Hou P, Meng S, Li M, Lin T, Chu S, Li Z, Zheng J, Gu Y, Bai J
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MNSFβ regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness.

Yang Q, Ma Y, Liu Y, Shao X, Jia W, Yu X, Li YX, Yang L, Gu W, Wang H, Wang J, Wang YL
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Chen R, Liu Y, Zhuang H, Yang B, Hei K, Xiao M, Hou C, Gao H, Zhang X, Jia C, Li L, Li Y, Zhang N
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Clinical Significance of an m6A Reader Gene, IGF2BP2, in Head and Neck Squamous Cell Carcinoma.

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Tumor Suppressor microRNA-138 Suppresses Low-Grade Glioma Development and Metastasis via Regulating IGF2BP2.

Yang Y, Liu X, Cheng L, Li L, Wei Z, Wang Z, Han G, Wan X, Wang Z, Zhang J, Chen C
OncoTargets and therapy 2020;13:2247-2260

Multiomics integrative analysis for gene signatures and prognostic values of m(6)A regulators in pancreatic adenocarcinoma: a retrospective study in The Cancer Genome Atlas project.

Gao W, Cheng L, He S, Li W, Zhou C, Zhou B, Liu J, Xu J, Yu X, Zhu H
Aging 2020 Oct 20;12(20):20587-20610

Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation.

Wang LJ, Xue Y, Li H, Huo R, Yan Z, Wang J, Xu H, Wang J, Cao Y, Zhao JZ
Journal of cellular and molecular medicine 2020 May;24(9):4981-4991

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader.

Hu X, Peng WX, Zhou H, Jiang J, Zhou X, Huang D, Mo YY, Yang L
Cell death and differentiation 2020 Jun;27(6):1782-1794

Functional characterization of the long noncoding RNA MIR22HG as a tumour suppressor in cervical cancer by targeting IGF2BP2.

Shu J, Wang D
European review for medical and pharmacological sciences 2020 Aug;24(15):7953-7962

N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.

Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, Wang F, Ma NF, Guan X, Yun JP, Wang FW, Xu RH, Dan Xie
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Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 mRNA.

Huang S, Wu Z, Cheng Y, Wei W, Hao L
Acta biochimica et biophysica Sinica 2019 Jul 10;51(7):743-752

Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway.

Xu X, Yu Y, Zong K, Lv P, Gu Y
Journal of experimental & clinical cancer research : CR 2019 Dec 18;38(1):497

The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome.

Li M, Zhao H, Zhao SG, Wei DM, Zhao YR, Huang T, Muhammad T, Yan L, Gao F, Li L, Lu G, Chan WY, Leung PCK, Dunaif A, Liu HB, Chen ZJ
The Journal of clinical endocrinology and metabolism 2019 Apr 1;104(4):1049-1059

Airn Regulates Igf2bp2 Translation in Cardiomyocytes.

Hosen MR, Militello G, Weirick T, Ponomareva Y, Dassanayaka S, Moore JB 4th, Döring C, Wysoczynski M, Jones SP, Dimmeler S, Uchida S
Circulation research 2018 May 11;122(10):1347-1353

Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.

Chen R, Liu Y, Zhuang H, Yang B, Hei K, Xiao M, Hou C, Gao H, Zhang X, Jia C, Li L, Li Y, Zhang N
Nucleic acids research 2017 Sep 29;45(17):9947-9959

Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation.

D'Armiento J, Shiomi T, Marks S, Geraghty P, Sankarasharma D, Chada K
Cancer research 2016 Feb 15;76(4):844-54

IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories.

Preitner N, Quan J, Li X, Nielsen FC, Flanagan JG
Development (Cambridge, England) 2016 Aug 1;143(15):2753-9

Role of IGF2BP3 in trophoblast cell invasion and migration.

Li W, Liu D, Chang W, Lu X, Wang YL, Wang H, Zhu C, Lin HY, Zhang Y, Zhou J, Wang H
Cell death & disease 2014 Jan 23;5(1):e1025

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human kidney tissue were subjected to SDS PAGE followed by western blot with 11601-1-AP(IGF2BP2 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IGF2BP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IGF2BP2. This antibody recognizes human,mouse,rat antigen. The IGF2BP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11601-1-AP.pdf

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