66583-1-Ig

antibody from Proteintech Group

Targeting: OPA1 FLJ12460, KIAA0567, MGM1, NPG, NTG

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

66583-1-Ig

Provider

Proteintech Group

Product name

OPA1 antibody

Antibody type

Monoclonal

Description

KD/KO validated OPA1 antibody (Cat. #66583-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, pig, rat and has been validated for the following applications: WB, ELISA.

Reactivity

Human, Mouse, Rat, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1B2D8

Vial size

20ul, 150ul

References

Submitted references

Pre-Stress Trait Anxiety Levels Shape Hippocampal Responses to Acute Stress in High Anxiety Male Mice.

Papageorgiou MP, Nussbaumer M, Samiotaki M, Filiou MD
Journal of neurochemistry 2026 Mar;170(3):e70362

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Decreased OPA1 expression increases neuronal vulnerability to ischaemic stroke during ageing: Role of Timm8b as a therapeutic target.

Li H, Li X, Xu Z, Li L, Sun E, Cao C, Lu J, Bai L, Chen G, Sun Q, Li H
Free radical biology & medicine 2026 Feb 16;244:529-545

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HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.

Li H, Cai S, Mu H, Chang T, Wang X, Tang T, Dong T, Zhang Y, Zhang L, Li H, Zhou L, Xiang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828

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Niclosamide suppresses gastric cancer progression through YTHDF2 inhibition-affected lactate metabolic reprogramming.

Tang M, Hu Y, Zhu X, Dai J, Li R, Feng X, Chi K, Li X, Zhang Q, Chen K, Cao R, Zhu H, Huang H, Wu H, Sun L, Chen T, Wu J, Wang H, Gui Z
iScience 2025 Nov 21;28(11):113868

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circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes.

Yu Z, Xu W, Teng Y, Li T, Guo R, Li J, Li X, Li Y, Hao Y
European journal of histochemistry : EJH 2025 Jun 17;69(3)

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SENP1 prevents high fat diet-induced non-alcoholic fatty liver diseases by regulating mitochondrial dynamics.

Zeng W, Wang L, Wang C, Xiong X, Huang Q, Chen S, Liu C, Liu W, Wang Y, Huang Q
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167527

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TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis.

Qiu C, Cheng L, Di D, Xiang Z, Wang C, Li J, Xiong Y, Li M, Liu J, Zhou J, Liu T, Wang X, Luo D, Wang X, Li S, Wang H, Wang X, Zhao Y, Liu X, Wang L
Genes & diseases 2025 Jan;12(1):101251

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Cytochrome P450 2E1 aggravates DXR-induced myocardial injury through imbalanced mitochondrial OPA1.

Ma J, Wang Y, Lv H, Lei Y, Guan F, Dong W, Wang H, Zhang L, Lu D
Cell communication and signaling : CCS 2025 Apr 30;23(1):208

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Pyrroloquinoline Quinone Alleviates Mitochondria Damage in Radiation-Induced Lung Injury in a MOTS-c-Dependent Manner.

Zhang Y, Huang J, Li S, Jiang J, Sun J, Chen D, Pang Q, Wu Y
Journal of agricultural and food chemistry 2024 Sep 25;72(38):20944-20958

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Su X, Li Q, Yang M, Zhang W, Liu X, Ba Y, Deng Q, Zhang Y, Han L, Huang H
Experimental neurology 2024 Oct;380:114899

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MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury.

Zhuang K, Wang W, Zheng X, Guo X, Xu C, Ren X, Shen W, Han Q, Feng Z, Chen X, Cai G
Stem cell research & therapy 2024 Nov 19;15(1):438

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The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism.

Zhang Y, Huang J, Zhang Y, Jiang F, Li S, He S, Sun J, Chen D, Tong Y, Pang Q, Wu Y
Antioxidants (Basel, Switzerland) 2024 May 17;13(5)

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Human periodontal ligament stem cell sheets activated by graphene oxide quantum dots repair periodontal bone defects by promoting mitochondrial dynamics dependent osteogenic differentiation.

An N, Yan X, Qiu Q, Zhang Z, Zhang X, Zheng B, Zhao Z, Guo J, Liu Y
Journal of nanobiotechnology 2024 Mar 27;22(1):133

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Electroacupuncture pretreatment maintains mitochondrial quality control via HO-1/MIC60 signaling pathway to alleviate endotoxin-induced acute lung injury.

Shi J, Piao M, Liu C, Yang J, Guan X, Liu H, Li Q, Zhang Y, Yu J
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167480

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Renaud CCN, Trillet K, Jardine J, Merlet L, Renoult O, Laurent-Blond M, Catinaud Z, Pecqueur C, Gavard J, Bidère N
Communications biology 2023 Dec 15;6(1):1271

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Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling.

Zhang K, Zheng Y, Bao G, Ma W, Han B, Shi H, Zhao Z
Antioxidants (Basel, Switzerland) 2023 Aug 22;12(9)

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Effect of Physical Exercise on Mitochondrial Dysfunction and Purkinje Cell Survival in the Cerebellum of 3xTg-AD Mice.

Jin Y, Kim T, Kim T
Journal of integrative neuroscience 2023 Aug 14;22(5):117

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Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.

Jiang XL, Tai H, Xiao XS, Zhang SY, Cui SC, Qi SB, Hu DD, Zhang LN, Kuang JS, Meng XS, Li SM
Frontiers in endocrinology 2022;13:962154

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Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

Jiang XL, Tai H, Kuang JS, Zhang JY, Cui SC, Lu YX, Qi SB, Zhang SY, Li SM, Chen JP, Meng XS
Aging 2022 Oct 27;14(20):8321-8345

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Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway.

Xu J, Zhang Y, Yu Z, Guan Y, Lv Y, Zhang M, Zhang M, Chen L, Lv X, Guan F
Acta biochimica et biophysica Sinica 2022 Oct 25;54(10):1464-1475

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Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy.

Yi L, Shang XJ, Lv L, Wang Y, Zhang J, Quan C, Shi Y, Liu Y, Zhang L
Cell death & disease 2022 Nov 5;13(11):928

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Dihydromyricetin contributes to weight loss via pro-browning mediated by mitochondrial fission in white adipose.

Xiong X, Xia M, Niu A, Zhang Y, Yin T, Huang Q
European journal of pharmacology 2022 Nov 15;935:175345

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Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing.

Guan G, Zhang Q, Jiang Z, Liu J, Wan J, Jin P, Lv Q
Small (Weinheim an der Bergstrasse, Germany) 2022 Dec;18(51):e2203064

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Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart.

Chen Z, Zhou Z, Peng X, Sun C, Yang D, Li C, Zhu R, Zhang P, Zheng L, Tang C
The journal of physiological sciences : JPS 2021 Nov 8;71(1):33

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ChREBP-β regulates thermogenesis in brown adipose tissue.

Wei C, Ma X, Su K, Qi S, Zhu Y, Lin J, Wang C, Yang R, Chen X, Wang W, Zhang WJ
The Journal of endocrinology 2020 Jun;245(3):343-356

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Protective effect of exercise training against the progression of Alzheimer's disease in 3xTg-AD mice.

Kim D, Cho J, Kang H
Behavioural brain research 2019 Nov 18;374:112105