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- References [16]
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- Product number
- 12080-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- VTCN1 antibody
- Antibody type
- Polyclonal
- Description
- VTCN1 antibody (Cat. #12080-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Abnormal Expression of B7-H4 Is Associated With the Pathogenesis of Autoimmune Thyroid Diseases.
Downregulation of B7-H4 contributes to the synergistic effect of USP2a-targeted/anti-PD-1 combination therapy in EGFR mutant lung cancer.
HSP90AA1 restrains clear cell renal cell carcinoma progression by promoting CADM1 expression and suppressing the PI3K-AKT pathway through interaction with FBXO7.
Spliceosomal GTPase EFTUD2 mediates DDX41 intron retention to promote the malignant progression of ovarian cancer.
The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level.
Expression of B7-H3 and B7-H4 in Gastric Gastrointestinal Stromal Tumors.
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.
Histone lactylation dynamics: Unlocking the triad of metabolism, epigenetics, and immune regulation in metastatic cascade of pancreatic cancer.
The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.
A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma.
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
B7-H4 is increased in lung adenocarcinoma harboring EGFR-activating mutations and contributes to immunosuppression.
Alpha-Fetoprotein Regulates the Expression of Immune-Related Proteins through the NF-κB (P65) Pathway in Hepatocellular Carcinoma Cells.
Overexpression of B7-H4 promotes renal cell carcinoma progression by recruiting tumor-associated neutrophils via upregulation of CXCL8.
Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7-H4 expression through the MEK/ERK signaling pathway.
RNA-Seq Analysis of Differentiated Keratinocytes Reveals a Massive Response to Late Events during Human Papillomavirus 16 Infection, Including Loss of Epithelial Barrier Function.
Wu Y, Xu J, Cai T, Fang Y, Huang Z, Zhang X, Li G, Xu W, Zhang J
Journal of immunology research 2026;2026(1):e5529891
Journal of immunology research 2026;2026(1):e5529891
Downregulation of B7-H4 contributes to the synergistic effect of USP2a-targeted/anti-PD-1 combination therapy in EGFR mutant lung cancer.
Sun B, Kong M, Jiang X, Zhu L, Zhang J, Tan L, Wang C, Yuan Z, Chen S, Wang C, Jiang Y, Zhang L
Cancer immunology, immunotherapy : CII 2026 Mar 26;75(4)
Cancer immunology, immunotherapy : CII 2026 Mar 26;75(4)
HSP90AA1 restrains clear cell renal cell carcinoma progression by promoting CADM1 expression and suppressing the PI3K-AKT pathway through interaction with FBXO7.
Yang W, Li Y, Li Z, Jiang C, Deng X, Peng D
Cell death discovery 2026 Jan 8;12(1):6
Cell death discovery 2026 Jan 8;12(1):6
Spliceosomal GTPase EFTUD2 mediates DDX41 intron retention to promote the malignant progression of ovarian cancer.
Liu Y, Chen Z, Duan Y, Shao Z, Chen Y, Yang N, Xiao H, Li Y, Song K
British journal of cancer 2025 Sep;133(4):508-523
British journal of cancer 2025 Sep;133(4):508-523
The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level.
Liu B, Wu Y, Xiang A, Yu Y, Song S, Zhang Y, Gu J, Lu H, Xu P, Liu F, Ruan Y
Cell reports 2025 Sep 23;44(9):116249
Cell reports 2025 Sep 23;44(9):116249
Expression of B7-H3 and B7-H4 in Gastric Gastrointestinal Stromal Tumors.
Mochizuki K, Oishi N, Tahara I, Inoue T, Kondo T
Applied immunohistochemistry & molecular morphology : AIMM 2024 Nov-Dec 01;32(10):484-487
Applied immunohistochemistry & molecular morphology : AIMM 2024 Nov-Dec 01;32(10):484-487
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.
Jing ZL, Liu GL, Zhou N, Xu DY, Feng N, Lei Y, Ma LL, Tang MS, Tong GH, Tang N, Deng YJ
Scientific reports 2024 Mar 13;14(1):6053
Scientific reports 2024 Mar 13;14(1):6053
Histone lactylation dynamics: Unlocking the triad of metabolism, epigenetics, and immune regulation in metastatic cascade of pancreatic cancer.
Wang X, Liu X, Xiao R, Fang Y, Zhou F, Gu M, Luo X, Jiang D, Tang Y, You L, Zhao Y
Cancer letters 2024 Aug 28;598:217117
Cancer letters 2024 Aug 28;598:217117
The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants.
Lu Y, Sun Y, Zhang J, Kong M, Zhao Z, Sun B, Wang Y, Jiang Y, Chen S, Wang C, Tong Y, Wen L, Huang M, Wu F, Zhang L
Cancer letters 2024 Aug 1;596:217020
Cancer letters 2024 Aug 1;596:217020
A Novel Gene Pair CSTF2/DPE2A Impacts Prognosis and Cell Cycle of Hepatocellular Carcinoma.
Huang Y, Xu J, Xie C, Liao Y, Lin R, Zeng Y, Yu F
Journal of hepatocellular carcinoma 2023;10:1639-1657
Journal of hepatocellular carcinoma 2023;10:1639-1657
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Yang J, Han F, Wu G, Dong Y, Su H, Xu J, Li J
Digestive diseases and sciences 2023 Feb;68(2):478-486
Digestive diseases and sciences 2023 Feb;68(2):478-486
B7-H4 is increased in lung adenocarcinoma harboring EGFR-activating mutations and contributes to immunosuppression.
Lu Y, Wu F, Cao Q, Sun Y, Huang M, Xiao J, Zhou B, Zhang L
Oncogene 2022 Jan;41(5):704-717
Oncogene 2022 Jan;41(5):704-717
Alpha-Fetoprotein Regulates the Expression of Immune-Related Proteins through the NF-κB (P65) Pathway in Hepatocellular Carcinoma Cells.
Li QT, Qiu MJ, Yang SL, Fang X, He XX, Wang MM, Li YN, Xiong ZF, Huang S
Journal of oncology 2020;2020:9327512
Journal of oncology 2020;2020:9327512
Overexpression of B7-H4 promotes renal cell carcinoma progression by recruiting tumor-associated neutrophils via upregulation of CXCL8.
Li A, Zhang N, Zhao Z, Chen Y, Zhang L
Oncology letters 2020 Aug;20(2):1535-1544
Oncology letters 2020 Aug;20(2):1535-1544
Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7-H4 expression through the MEK/ERK signaling pathway.
Zhao Z, Zhang N, Li A, Zhou B, Chen Y, Chen S, Huang M, Wu F, Zhang L
Cancer letters 2020 Aug 10;485:14-26
Cancer letters 2020 Aug 10;485:14-26
RNA-Seq Analysis of Differentiated Keratinocytes Reveals a Massive Response to Late Events during Human Papillomavirus 16 Infection, Including Loss of Epithelial Barrier Function.
Klymenko T, Gu Q, Herbert I, Stevenson A, Iliev V, Watkins G, Pollock C, Bhatia R, Cuschieri K, Herzyk P, Gatherer D, Graham SV
Journal of virology 2017 Dec 15;91(24)
Journal of virology 2017 Dec 15;91(24)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The VTCN1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VTCN1. This antibody recognizes human,mouse,rat antigen. The VTCN1 antibody has been validated for the following applications: ELISA, WB analysis.
