10-4172-25

antibody from ABEOMICS Inc.
Targeting: VTCN1 B7-H4, B7H4, B7S1, B7x, FLJ22418
Provider product page for 10-4172-25

Antibody data

Product number
10-4172-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-B7-H4 Antibody
Antibody type
Monoclonal
Description
B7-H4, a member of B7 family, is a transmembrane protein that has been shown to inhibit T cell responses and neutrophil expansion during bacterial infections. B7-H4 mRNA is widely distributed in mouse and human peripheral tissues and can be induced in monocytes, macrophages, and dendritic cells upon IL-6 and IL-10 stimulation. However, in a variety of tumor cells, B7-H4 is predominantly present in intracellular compartments with unknown mechanism and functions. Cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. The overexpression of B7-H4 has been found in various types of human tumors, such as breast cancer, renal cell carcinoma (RCC), ovarian cancer, esophageal squamous cell carcinoma, gastric cancer, pancreatic cancer and melanoma etc, where its expression level is positively correlated with disease progression. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant protei
n (a.a 23-220) of B7-H4 was used a
s the immunogen for this antibody.
Isotype
IgG
Antibody clone number
ABM53A6
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
VTCN1 protein structure - 10-4172-25 shown in red.