orb2643947

antibody from Biorbyt
Targeting: VTCN1 B7-H4, B7H4, B7S1, B7x, FLJ22418
Provider product page for orb2643947
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
orb2643947 - Provider product page
Provider
Biorbyt
Product name
VTCN1 Antibody / B7H4
Antibody type
Monoclonal
Description
T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
B7H4/1788
Vial size
100 ug
Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
VTCN1 protein structure - orb2643947 shown in red.