21393-1-AP

antibody from Proteintech Group

Targeting: RNF168 FLJ35794

Provider product page for 21393-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [16]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 21393-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21393-1-AP, RRID:AB_10733883
Product name: RNF168 antibody
Antibody type: Polyclonal
Description: RNF168 antibody (Cat. #21393-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RNF168 protein structure - 21393-1-AP shown in red.

Submitted references Stress granules promote DNA damage repair through the G3BP1/NAT10/ATF3 axis to facilitate nasopharyngeal carcinoma progression.

Yue T, Yin H, Yuan L, Xie X, Xie H, Gong M, Xu X, Sun C, Zhang K, Liu J
Oncogene 2026 Apr 24;

TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer.

Yao X, Shen X, Fan Y, Wang H
NPJ breast cancer 2025 Oct 1;11(1):108

ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.

Xu F, Xia Q, Chen B, Wang R, Zhang J, Zhao X, Zhang Z, Yao Z, Zhang J, Zhou S, Li X, Chen B, Xu A, Wu L, Zhao G
Cell death and differentiation 2025 Jul;32(7):1303-1316

UHRF1-mediated ubiquitination of nonhomologous end joining factor XLF promotes DNA repair in human tumor cells.

Deng Z, Long C, Han S, Xu Z, Hou T, Li W, Wang X, Liu X
The Journal of biological chemistry 2024 Nov;300(11):107823

DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response.

Arends T, Tsuchida H, Adeyemi RO, Tapscott SJ
The Journal of cell biology 2024 May 6;223(5)

LOC730101 improves ovarian cancer drug sensitivity by inhibiting autophagy-mediated DNA damage repair via BECN1.

Zhong Y, Shuai Y, Yang J, Zhang M, He T, Zheng L, Yang S, Peng S
Cell death & disease 2024 Dec 18;15(12):893

A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.

Bao K, Ma Y, Li Y, Shen X, Zhao J, Tian S, Zhang C, Liang C, Zhao Z, Yang Y, Zhang K, Yang N, Meng FL, Hao J, Yang J, Liu T, Yao Z, Ai D, Shi L
Molecular cell 2024 Apr 4;84(7):1206-1223.e15

The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.

Qiu L, Xu W, Lu X, Chen F, Chen Y, Tian Y, Zhu Q, Liu X, Wang Y, Pei XH, Xu X, Zhang J, Zhu WG
Nucleic acids research 2023 Sep 22;51(17):9166-9182

SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer.

Wei M, Huang X, Liao L, Tian Y, Zheng X
Cancer research 2023 Sep 1;83(17):2908-2923

A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62.

Wang FC, Peng B, Ren TT, Liu SP, Du JR, Chen ZH, Zhang TT, Gu X, Li M, Cao SL, Xu X
Journal of medicinal chemistry 2022 Nov 24;65(22):15028-15047

Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance.

Hang Q, Zeng L, Wang L, Nie L, Yao F, Teng H, Deng Y, Yap S, Sun Y, Frank SJ, Chen J, Ma L
Nature communications 2021 Jun 29;12(1):4033

RNF8-ubiquitinated KMT5A is required for RNF168-induced H2A ubiquitination in response to DNA damage.

Lu X, Xu M, Zhu Q, Zhang J, Liu G, Bao Y, Gu L, Tian Y, Wen H, Zhu WG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21326

A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis.

Zhang Q, Cao C, Gong W, Bao K, Wang Q, Wang Y, Bi L, Ma S, Zhao J, Liu L, Tian S, Zhang K, Yang J, Yao Z, Song N, Shi L
Theranostics 2020;10(23):10769-10790

An LTR retrotransposon-derived lncRNA interacts with RNF169 to promote homologous recombination.

Deng B, Xu W, Wang Z, Liu C, Lin P, Li B, Huang Q, Yang J, Zhou H, Qu L
EMBO reports 2019 Nov 5;20(11):e47650

GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival.

Lu X, Tang M, Zhu Q, Yang Q, Li Z, Bao Y, Liu G, Hou T, Lv Y, Zhao Y, Wang H, Yang Y, Cheng Z, Wen H, Liu B, Xu X, Gu L, Zhu WG
Nucleic acids research 2019 Dec 2;47(21):10977-10993

p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress.

Wang L, Howell MEA, Sparks-Wallace A, Hawkins C, Nicksic CA, Kohne C, Hall KH, Moorman JP, Yao ZQ, Ning S
PLoS pathogens 2019 Apr;15(4):e1007541

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 21393-1-AP(RNF168 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using RNF168 antibody 21393-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line