Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 15417-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15417-1-AP, RRID:AB_2274683
- Product name
- BDH1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BDH1 antibody (Cat. #15417-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references β-hydroxybutyrate restrains colitis-associated tumorigenesis by inhibiting HIF-1α-mediated angiogenesis.
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding.
Ketolysis drives CD8(+) T cell effector function through effects on histone acetylation.
Ketogenic diet modulates cardiac metabolic dysregulation in streptozocin-induced diabetic rats.
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Overcome Prostate Cancer Resistance to Immune Checkpoint Therapy with Ketogenic Diet-Induced Epigenetic Reprogramming.
Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.
Ketogenic diet uncovers differential metabolic plasticity of brain cells.
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Maternal use of methamphetamine induces sex-dependent changes in myocardial gene expression in adult offspring.
β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-α β-hydroxybutyrylation.
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
Ketone body oxidation increases cardiac endothelial cell proliferation.
Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway.
Deficiency of 3-hydroxybutyrate dehydrogenase (BDH1) in mice causes low ketone body levels and fatty liver during fasting.
Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.
Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina.
Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo.
Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments.
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice.
Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.
Huang C, Tan H, Wang J, Huang L, Liu H, Shi Y, Zhong C, Weng S, Chen C, Zhao W, Lin Z, Li J, Zhi F, Zhang B
Cancer letters 2024 Jul 1;593:216940
Cancer letters 2024 Jul 1;593:216940
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding.
Williams AS, Crown SB, Lyons SP, Koves TR, Wilson RJ, Johnson JM, Slentz DH, Kelly DP, Grimsrud PA, Zhang GF, Muoio DM
Cell metabolism 2024 Feb 6;36(2):422-437.e8
Cell metabolism 2024 Feb 6;36(2):422-437.e8
Ketolysis drives CD8(+) T cell effector function through effects on histone acetylation.
Luda KM, Longo J, Kitchen-Goosen SM, Duimstra LR, Ma EH, Watson MJ, Oswald BM, Fu Z, Madaj Z, Kupai A, Dickson BM, DeCamp LM, Dahabieh MS, Compton SE, Teis R, Kaymak I, Lau KH, Kelly DP, Puchalska P, Williams KS, Krawczyk CM, Lévesque D, Boisvert FM, Sheldon RD, Rothbart SB, Crawford PA, Jones RG
Immunity 2023 Sep 12;56(9):2021-2035.e8
Immunity 2023 Sep 12;56(9):2021-2035.e8
Ketogenic diet modulates cardiac metabolic dysregulation in streptozocin-induced diabetic rats.
Trang NN, Lee TW, Kao YH, Chao TF, Lee TI, Chen YJ
The Journal of nutritional biochemistry 2023 Jan;111:109161
The Journal of nutritional biochemistry 2023 Jan;111:109161
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Rome FI, Shobert GL, Voigt WC, Stagg DB, Puchalska P, Burgess SC, Crawford PA, Hughey CC
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
Overcome Prostate Cancer Resistance to Immune Checkpoint Therapy with Ketogenic Diet-Induced Epigenetic Reprogramming.
Murphy S, Rahmy S, Gan D, Zhu Y, Manyak M, Li J, Lu X, Lu X
bioRxiv : the preprint server for biology 2023 Aug 8;
bioRxiv : the preprint server for biology 2023 Aug 8;
Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.
Ye T, Lin L, Cao L, Huang W, Wei S, Shan Y, Zhang Z
Frontiers in oncology 2022;12:863266
Frontiers in oncology 2022;12:863266
Ketogenic diet uncovers differential metabolic plasticity of brain cells.
Düking T, Spieth L, Berghoff SA, Piepkorn L, Schmidke AM, Mitkovski M, Kannaiyan N, Hosang L, Scholz P, Shaib AH, Schneider LV, Hesse D, Ruhwedel T, Sun T, Linhoff L, Trevisiol A, Köhler S, Pastor AM, Misgeld T, Sereda M, Hassouna I, Rossner MJ, Odoardi F, Ischebeck T, de Hoz L, Hirrlinger J, Jahn O, Saher G
Science advances 2022 Sep 16;8(37):eabo7639
Science advances 2022 Sep 16;8(37):eabo7639
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Tang M, Xu H, Huang H, Kuang H, Wang C, Li Q, Zhang X, Ge Y, Song M, Zhang X, Wang Z, Ma C, Kang J, Zhang W, Wang Y, Zhang B, Zhang X, Chen Y, Cong M, Melino G, Wang X, Zhou F, Sun Q, Shi H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Maternal use of methamphetamine induces sex-dependent changes in myocardial gene expression in adult offspring.
Dague A, Chavva H, Brazeau DA, Denvir J, Rorabaugh BR
Physiological reports 2022 Nov;10(22):e15509
Physiological reports 2022 Nov;10(22):e15509
β-hydroxybutyrate reduces reinstatement of cocaine conditioned place preference through hippocampal CaMKII-α β-hydroxybutyrylation.
Li H, Wan X, Wu Z, Zhou Y, Chen R, Xu W, Zhang J, Yang Z, Bai L, Zhang J, Qin F, Wang L, Chen Y, Jiang L, He Y, Wang X, Wei Q, Li S, Dai Y, Chen Y, Wang Y, Wang H, Tian J, Zhao Y, Cen X
Cell reports 2022 Nov 29;41(9):111724
Cell reports 2022 Nov 29;41(9):111724
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
Rome FI, Hughey CC
Molecular metabolism 2022 Apr;58:101452
Molecular metabolism 2022 Apr;58:101452
Ketone body oxidation increases cardiac endothelial cell proliferation.
Weis EM, Puchalska P, Nelson AB, Taylor J, Moll I, Hasan SS, Dewenter M, Hagenmüller M, Fleming T, Poschet G, Hotz-Wagenblatt A, Backs J, Crawford PA, Fischer A
EMBO molecular medicine 2022 Apr 7;14(4):e14753
EMBO molecular medicine 2022 Apr 7;14(4):e14753
Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway.
Huang C, Wang J, Liu H, Huang R, Yan X, Song M, Tan G, Zhi F
BMC medicine 2022 Apr 15;20(1):148
BMC medicine 2022 Apr 15;20(1):148
Deficiency of 3-hydroxybutyrate dehydrogenase (BDH1) in mice causes low ketone body levels and fatty liver during fasting.
Otsuka H, Kimura T, Ago Y, Nakama M, Aoyama Y, Abdelkreem E, Matsumoto H, Ohnishi H, Sasai H, Osawa M, Yamaguchi S, Mitchell GA, Fukao T
Journal of inherited metabolic disease 2020 Sep;43(5):960-968
Journal of inherited metabolic disease 2020 Sep;43(5):960-968
Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.
Puchalska P, Martin SE, Huang X, Lengfeld JE, Daniel B, Graham MJ, Han X, Nagy L, Patti GJ, Crawford PA
Cell metabolism 2019 Feb 5;29(2):383-398.e7
Cell metabolism 2019 Feb 5;29(2):383-398.e7
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.
Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP
JCI insight 2019 Feb 21;4(4)
JCI insight 2019 Feb 21;4(4)
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.
Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC
Proceedings of the National Academy of Sciences of the United States of America 2018 Jan 23;115(4):E743-E752
Proceedings of the National Academy of Sciences of the United States of America 2018 Jan 23;115(4):E743-E752
Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina.
Izuta Y, Imada T, Hisamura R, Oonishi E, Nakamura S, Inagaki E, Ito M, Soga T, Tsubota K
Aging cell 2018 Feb;17(1)
Aging cell 2018 Feb;17(1)
Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo.
Zhang J, Jia PP, Liu QL, Cong MH, Gao Y, Shi HP, Yu WN, Miao MY
Journal of lipid research 2018 Apr;59(4):625-634
Journal of lipid research 2018 Apr;59(4):625-634
Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments.
Brownlow ML, Jung SH, Moore RJ, Bechmann N, Jankord R
Frontiers in molecular neuroscience 2017;10:129
Frontiers in molecular neuroscience 2017;10:129
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology 2017 Mar 6;216(3):675-693
The Journal of cell biology 2017 Mar 6;216(3):675-693
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Huang D, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin SC, Dang CV, Song L, Gao P, Zhang H
Cell research 2016 Oct;26(10):1112-1130
Cell research 2016 Oct;26(10):1112-1130
Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice.
Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA
American journal of physiology. Endocrinology and metabolism 2014 Jul 15;307(2):E176-85
American journal of physiology. Endocrinology and metabolism 2014 Jul 15;307(2):E176-85
Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.
Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA
The Journal of biological chemistry 2013 Jul 5;288(27):19739-49
The Journal of biological chemistry 2013 Jul 5;288(27):19739-49
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 15417-1-AP(BDH1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 15417-1-AP(BDH1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BDH1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BDH1. This antibody recognizes human,mouse,rat antigen. The BDH1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
