Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 15417-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15417-1-AP, RRID:AB_2274683
- Product name
- BDH1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BDH1 antibody (Cat. #15417-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deficiency of 3-hydroxybutyrate dehydrogenase (BDH1) in mice causes low ketone body levels and fatty liver during fasting.
Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.
Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina.
Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo.
Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments.
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Impairments of hepatic gluconeogenesis and ketogenesis in PPARĪ±-deficient neonatal mice.
Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.
Otsuka H, Kimura T, Ago Y, Nakama M, Aoyama Y, Abdelkreem E, Matsumoto H, Ohnishi H, Sasai H, Osawa M, Yamaguchi S, Mitchell GA, Fukao T
Journal of inherited metabolic disease 2020 Sep;43(5):960-968
Journal of inherited metabolic disease 2020 Sep;43(5):960-968
Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.
Puchalska P, Martin SE, Huang X, Lengfeld JE, Daniel B, Graham MJ, Han X, Nagy L, Patti GJ, Crawford PA
Cell metabolism 2019 Feb 5;29(2):383-398.e7
Cell metabolism 2019 Feb 5;29(2):383-398.e7
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.
Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP
JCI insight 2019 Feb 21;4(4)
JCI insight 2019 Feb 21;4(4)
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.
Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC
Proceedings of the National Academy of Sciences of the United States of America 2018 Jan 23;115(4):E743-E752
Proceedings of the National Academy of Sciences of the United States of America 2018 Jan 23;115(4):E743-E752
Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina.
Izuta Y, Imada T, Hisamura R, Oonishi E, Nakamura S, Inagaki E, Ito M, Soga T, Tsubota K
Aging cell 2018 Feb;17(1)
Aging cell 2018 Feb;17(1)
Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo.
Zhang J, Jia PP, Liu QL, Cong MH, Gao Y, Shi HP, Yu WN, Miao MY
Journal of lipid research 2018 Apr;59(4):625-634
Journal of lipid research 2018 Apr;59(4):625-634
Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments.
Brownlow ML, Jung SH, Moore RJ, Bechmann N, Jankord R
Frontiers in molecular neuroscience 2017;10:129
Frontiers in molecular neuroscience 2017;10:129
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology 2017 Mar 6;216(3):675-693
The Journal of cell biology 2017 Mar 6;216(3):675-693
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Huang, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin SC, Dang CV, Song L, Gao P, Zhang H
Cell research 2016 Oct;26(10):1112-1130
Cell research 2016 Oct;26(10):1112-1130
Impairments of hepatic gluconeogenesis and ketogenesis in PPARĪ±-deficient neonatal mice.
Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA
American journal of physiology. Endocrinology and metabolism 2014 Jul 15;307(2):E176-85
American journal of physiology. Endocrinology and metabolism 2014 Jul 15;307(2):E176-85
Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.
Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA
The Journal of biological chemistry 2013 Jul 5;288(27):19739-49
The Journal of biological chemistry 2013 Jul 5;288(27):19739-49
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 15417-1-AP(BDH1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 15417-1-AP(BDH1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BDH1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BDH1. This antibody recognizes human,mouse,rat antigen. The BDH1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.