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Learn15857-1-AP
antibody from Proteintech Group
Targeting: H2BC21
H2B, H2B.1, H2B/q, H2BE, H2BFQ, HIST2H2BE
Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Immunohistochemistry [2]
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- Product number
- 15857-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15857-1-AP, RRID:AB_10664929
- Product name
- Histone H2B antibody
- Antibody type
- Polyclonal
- Description
- Histone H2B antibody (Cat. #15857-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues.
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.
Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation.
Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells.
Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia.
USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment.
RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration.
In the human sperm nucleus, nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning.
Function of RAD6B and RNF8 in spermatogenesis.
HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.
Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells.
Highly Selective and Large Scale Mass Spectrometric Analysis of 4-Hydroxynonenal Modification via Fluorous Derivatization and Fluorous Solid-Phase Extraction.
Regulation of the RhoA/ROCK/AKT/β-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma.
Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.
Heo SJ, Thakur S, Chen X, Loebel C, Xia B, McBeath R, Burdick JA, Shenoy VB, Mauck RL, Lakadamyali M
Nature biomedical engineering 2023 Feb;7(2):177-191
Nature biomedical engineering 2023 Feb;7(2):177-191
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.
Kay EJ, Paterson K, Riera-Domingo C, Sumpton D, Däbritz JHM, Tardito S, Boldrini C, Hernandez-Fernaud JR, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson LJ, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson RM, Park M, Kirschner K, Miller C, Kamphorst JJ, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S
Nature metabolism 2022 Jun;4(6):693-710
Nature metabolism 2022 Jun;4(6):693-710
Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation.
Xu B, Zhang C, Jiang A, Zhang X, Liang F, Wang X, Li D, Liu C, Liu X, Xia J, Li Y, Wang Y, Yang Z, Chen J, Zhou Y, Chen L, Sun H
The Journal of biological chemistry 2022 Jul;298(7):102115
The Journal of biological chemistry 2022 Jul;298(7):102115
Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells.
Saha T, Dash C, Jayabalan R, Khiste S, Kulkarni A, Kurmi K, Mondal J, Majumder PK, Bardia A, Jang HL, Sengupta S
Nature nanotechnology 2022 Jan;17(1):98-106
Nature nanotechnology 2022 Jan;17(1):98-106
Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia.
Richter WF, Shah RN, Ruthenburg AJ
eLife 2021 Jul 15;10
eLife 2021 Jul 15;10
USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment.
Li J, Wang R, Jin J, Han M, Chen Z, Gao Y, Hu X, Zhu H, Gao H, Lu K, Shao Y, Lyu C, Lai W, Li P, Hu G, Li J, Li D, Wang H, Wu Q, Wong J
Cell discovery 2020;6:58
Cell discovery 2020;6:58
RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration.
Guo Z, Tian Y, Guo Y, Li B, Liu X, Xie K, Song Y, Wang D
Frontiers in cellular neuroscience 2019;13:392
Frontiers in cellular neuroscience 2019;13:392
In the human sperm nucleus, nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning.
Zhang MZ, Cao XM, Xu FQ, Liang XW, Fu LL, Li B, Liu WG, Li SG, Sun FZ, Huang XY, Huang WH
Biology open 2019 Jul 10;8(7)
Biology open 2019 Jul 10;8(7)
Function of RAD6B and RNF8 in spermatogenesis.
Guo Y, Song Y, Guo Z, Hu M, Liu B, Duan H, Wang L, Yuan T, Wang D
Cell cycle (Georgetown, Tex.) 2018;17(2):162-173
Cell cycle (Georgetown, Tex.) 2018;17(2):162-173
HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.
Monteonofrio L, Valente D, Ferrara M, Camerini S, Miscione R, Crescenzi M, Rinaldo C, Soddu S
Oncogene 2018 Jun;37(26):3562-3574
Oncogene 2018 Jun;37(26):3562-3574
Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells.
Sun R, Fu L, Liu K, Tian C, Yang Y, Tallman KA, Porter NA, Liebler DC, Yang J
Molecular & cellular proteomics : MCP 2017 Oct;16(10):1789-1800
Molecular & cellular proteomics : MCP 2017 Oct;16(10):1789-1800
Highly Selective and Large Scale Mass Spectrometric Analysis of 4-Hydroxynonenal Modification via Fluorous Derivatization and Fluorous Solid-Phase Extraction.
Yuan W, Zhang Y, Xiong Y, Tao T, Wang Y, Yao J, Zhang L, Yan G, Bao H, Lu H
Analytical chemistry 2017 Mar 7;89(5):3093-3100
Analytical chemistry 2017 Mar 7;89(5):3093-3100
Regulation of the RhoA/ROCK/AKT/β-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma.
Song GL, Jin CC, Zhao W, Tang Y, Wang YL, Li M, Xiao M, Li X, Li QS, Lin X, Chen WW, Kuang J
International journal of oncology 2016 Aug;49(2):646-56
International journal of oncology 2016 Aug;49(2):646-56
Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.
Whitcomb SJ, Fierz B, McGinty RK, Holt M, Ito T, Muir TW, Allis CD
The Journal of biological chemistry 2012 Jul 6;287(28):23718-25
The Journal of biological chemistry 2012 Jul 6;287(28):23718-25
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas using 15857-1-AP(HIST2H2BE antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Histone H2B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Histone H2B. This antibody recognizes human antigen. The Histone H2B antibody has been validated for the following applications: ELISA, IHC analysis.
