26601-1-AP

antibody from Proteintech Group

Targeting: SLC40A1 FPN1, HFE4, IREG1, MTP1, SLC11A3

Provider product page for 26601-1-AP

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Antigen structure
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Product number: 26601-1-AP - Provider product page
Provider: Proteintech Group
Product name: SLC40A1/FPN1 antibody
Antibody type: Polyclonal
Description: SLC40A1/FPN1 antibody (Cat. #26601-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC40A1 protein structure - 26601-1-AP shown in red.

Submitted references Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.

Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Drug design, development and therapy 2024;18:1349-1368

Water extract of moschus alleviates erastin-induced ferroptosis by regulating the Keap1/Nrf2 pathway in HT22 cells.

Song C, Chu Z, Dai J, Xie D, Qin T, Xie L, Zhai Z, Huang S, Xu Y, Sun T
Journal of ethnopharmacology 2024 May 23;326:117937

Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.

Yuan Q, Fang Y, Guo J, Zhang Z, Liao J, Kuang J
Toxicology and applied pharmacology 2024 Mar;484:116845

Mitochondrial ferritin alleviates ferroptosis in a kainic acid-induced mouse epilepsy model by regulating iron homeostasis: Involvement of nuclear factor erythroid 2-related factor 2.

Song Y, Gao M, Wei B, Huang X, Yang Z, Zou J, Guo Y
CNS neuroscience & therapeutics 2024 Mar;30(3):e14663

Hinokitiol protects gastric injury from ethanol exposure via its iron sequestration capacity.

Zhao M, Qiao C, Yang S, Tang Y, Sun W, Sun S, Guo Q, Du F, Zhang N, Ning T, Wu J, Xu J, Li P
European journal of pharmacology 2024 Mar 5;966:176340

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.

Xiang Z, Zhang P, Jia C, Xu R, Cao D, Xu Z, Lu T, Liu J, Wang X, Qiu C, Fu W, Li W, Cheng L, Yang Q, Feng S, Wang L, Zhao Y, Liu X
Bone research 2024 Mar 29;12(1):20

Effects of chronic low-level lead (Pb) exposure on cognitive function and hippocampal neuronal ferroptosis: An integrative approach using bioinformatics analysis, machine learning, and experimental validation.

Cao Y, Zhao W, Zhong Y, Jiang X, Mei H, Chang Y, Wu D, Dou J, Vasquez E, Shi X, Yang J, Jia Z, Tan X, Li Q, Dong Y, Xie R, Gao J, Wu Y, Liu Y
The Science of the total environment 2024 Mar 20;917:170317

Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway.

Lu JS, Wang JH, Han K, Li N
Inflammation 2024 Jun;47(3):975-988

YTHDF2 Promotes Cardiac Ferroptosis via Degradation of SLC7A11 in Cardiac Ischemia-Reperfusion Injury.

Pang P, Si W, Wu H, Ju J, Liu K, Wang C, Jia Y, Diao H, Zeng L, Jiang W, Yang Y, Xiong Y, Kong X, Zhang Z, Zhang F, Song J, Wang N, Yang B, Bian Y
Antioxidants & redox signaling 2024 Jun;40(16-18):889-905

Mitochondrial GCN5L1 acts as a novel regulator for iron homeostasis to promote sorafenib sensitivity in hepatocellular carcinoma.

Hu X, Zhang P, Li S, Zhang J, Wang D, Wang Z, Zhu L, Wang L
Journal of translational medicine 2024 Jun 25;22(1):593

Rocaglamide regulates iron homeostasis by suppressing hepcidin expression.

Zhu X, Zuo Q, Xie X, Chen Z, Wang L, Chang L, Liu Y, Luo J, Fang C, Che L, Zhou X, Yao C, Gong C, Hu D, Zhao W, Zhou Y, Zhu S
Free radical biology & medicine 2024 Jul;219:153-162

Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma.

Liu Y, Pang Z, Wang Y, Liu J, Wang G, Du J
Chemico-biological interactions 2024 Jan 5;387:110794

Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis.

Liu Y, Luo X, Chen Y, Dang J, Zeng D, Guo X, Weng W, Zhao J, Shi X, Chen J, Dong B, Zhong S, Ren J, Li Y, Wang J, Zhang J, Sun J, Xu H, Lu Y, Brand D, Zheng SG, Pan Y
Redox biology 2024 Feb;69:103008

Gemfibrozil Alleviates Cognitive Impairment by Inhibiting Ferroptosis of Astrocytes via Restoring the Iron Metabolism and Promoting Antioxidant Capacity in Type 2 Diabetes.

Wang N, Zhao Y, Wu M, Li N, Yan C, Guo H, Li Q, Li Q, Wang Q
Molecular neurobiology 2024 Feb;61(2):1187-1201

Identification of SLC40A1, LCN2, CREB5, and SLC7A11 as ferroptosis-related biomarkers in alopecia areata through machine learning.

Xu W, Wei D, Song X
Scientific reports 2024 Feb 15;14(1):3800

Preventive effects of lactoferrin on acute alcohol-induced liver injury via iron chelation and regulation of iron metabolism.

Guan S, Zhang S, Liu M, Guo J, Chen Y, Shen X, Deng X, Lu J
Journal of dairy science 2024 Aug;107(8):5316-5329

Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells.

Dai W, Xu B, Ding L, Zhang Z, Yang H, He T, Liu L, Pei X, Fu X
Free radical biology & medicine 2024 Aug 1;220:1-14

Excess iron accumulation mediated senescence in diabetic kidney injury.

Cheng X, Li Y, Chen L, Jiang C, Peng S, Yao P, Tang Y
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23683

PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.

Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429

Non-targeted metabolomics strategy reveals the role of Geng-Nian-Shu in regulating ferroptosis in perimenopausal syndrome.

Lv X, Bi A, Zhang Z, Li J, Wei Y, Wan M, Wang J, Yan T, Jia Y
Journal of pharmaceutical and biomedical analysis 2024 Apr 15;241:115980

Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity.

Chen J, Xiao F, Chen L, Zhou Z, Wei Y, Zhong Y, Li L, Xie Y
Frontiers in pharmacology 2023;14:1121280

Moderate Intensity of Treadmill Exercise Rescues TBI-Induced Ferroptosis, Neurodegeneration, and Cognitive Impairments via Suppressing STING Pathway.

Chen J, Zhu T, Yu D, Yan B, Zhang Y, Jin J, Yang Z, Zhang B, Hao X, Chen Z, Yan C, Yu J
Molecular neurobiology 2023 Sep;60(9):4872-4896

Trastuzumab-induced cardiomyopathy via ferroptosis-mediated mitochondrial dysfunction.

Ye T, Yang W, Gao T, Yu X, Chen T, Yang Y, Guo J, Li Q, Li H, Yang L
Free radical biology & medicine 2023 Sep;206:143-161

PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons.

Li T, Zhao L, Li Y, Dang M, Lu J, Lu Z, Huang Q, Yang Y, Feng Y, Wang X, Jian Y, Wang H, Guo Y, Zhang L, Jiang Y, Fan S, Wu S, Fan H, Kuang F, Zhang G
Cell death & disease 2023 Sep 26;14(9):634

Blocked erythroid differentiation and delayed enucleation of erythroblasts may contribute to murine embryonic toxicity upon exposure to low dose of cadmium.

Wang Q, Li J, Ma W, Sun L, Zhang B, Zhao Y, Zhang S
Toxicology letters 2023 Sep 15;387:28-34

Resveratrol inhibits ferroptosis via activating NRF2/GPX4 pathway in mice with spinal cord injury.

Ni C, Ye Q, Mi X, Jiao D, Zhang S, Cheng R, Fang Z, Fang M, Ye X
Microscopy research and technique 2023 Oct;86(10):1378-1390

Enriched environment attenuates ferroptosis after cerebral ischemia/reperfusion injury by regulating iron metabolism.

Luo Q, Zheng J, Fan B, Liu J, Liao W, Zhang X
Brain research bulletin 2023 Oct 15;203:110778

Neuroprotective Effect of Hydrogen Sulfide Subchronic Treatment Against TBI-Induced Ferroptosis and Cognitive Deficits Mediated Through Wnt Signaling Pathway.

Chen J, Chen Z, Yu D, Yan Y, Hao X, Zhang M, Zhu T
Cellular and molecular neurobiology 2023 Nov;43(8):4117-4140

Hepcidin as a key regulator of iron homeostasis triggers inflammatory features in the normal endometrium.

Izumi Y, Kataoka H, Koshiba A, Ito F, Tanaka Y, Takaoka O, Maeda E, Okimura H, Sugahara T, Tarumi Y, Shimura K, Khan KN, Kusuki I, Mori T
Free radical biology & medicine 2023 Nov 20;209(Pt 2):191-201

Quercetin alleviates subarachnoid hemorrhage-induced early brain injury via inhibiting ferroptosis in the rat model.

Jiao D, Xu J, Lou C, Luo Y, Ni C, Shen G, Fang M, Gong X
Anatomical record (Hoboken, N.J. : 2007) 2023 Mar;306(3):638-650

Thorium(IV) triggers ferroptosis through disrupting iron homeostasis and heme metabolism in the liver following oral ingestion.

Ma M, Wang R, Xu M
Journal of hazardous materials 2023 Jun 15;452:131217

Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells.

Kuang H, Sun X, Liu Y, Tang M, Wei Y, Shi Y, Li R, Xiao G, Kang J, Wang F, Peng J, Xu H, Zhou F
The FEBS journal 2023 Jul;290(14):3664-3687

ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.

Wu H, Liu Q, Shan X, Gao W, Chen Q
Autophagy 2023 Jul;19(7):2062-2077

Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.

Wang Y, Ying X, Wang Y, Zou Z, Yuan A, Xiao Z, Geng N, Qiao Z, Li W, Lu X, Pu J
Cellular signalling 2023 Jul;107:110655

Super-enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcoma.

Guo W, Wang X, Lu B, Yu J, Xu M, Huang R, Cheng M, Yang M, Zhao W, Zou C
Cell death & disease 2023 Jul 17;14(7):439

cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.

Li B, Wang W, Li Y, Wang S, Liu H, Xia Z, Gao W, Zhao B
Experimental neurology 2023 Jan;359:114269

TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway.

Cheng Y, Gao Y, Li J, Rui T, Li Q, Chen H, Jia B, Song Y, Gu Z, Wang T, Gao C, Wang Y, Wang Z, Wang F, Tao L, Luo C
Free radical biology & medicine 2023 Jan;194:184-198

Sphingosine 1-phosphate alleviates radiation-induced ferroptosis in ovarian granulosa cells by upregulating glutathione peroxidase 4.

Zhao J, Tang M, Tang H, Wang M, Guan H, Tang L, Zhang H
Reproductive toxicology (Elmsford, N.Y.) 2023 Jan;115:49-55

Organic extracts in PM2.5 are the major triggers to induce ferroptosis in SH-SY5Y cells.

Guo C, Lyu Y, Xia S, Ren X, Li Z, Tian F, Zheng J
Ecotoxicology and environmental safety 2023 Jan 1;249:114350

Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.

Ding J, Lu B, Liu L, Zhong Z, Wang N, Li B, Sheng W, He Q
Pharmaceutical biology 2023 Dec;61(1):213-227

Sculponeatin A promotes the ETS1-SYVN1 interaction to induce SLC7A11/xCT-dependent ferroptosis in breast cancer.

Peng P, Ren Y, Wan F, Tan M, Wu H, Shen J, Qian C, Liu X, Xiang Y, Yu Q, Zhang L, Si Y, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154921

IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2.

Lan Y, Yang T, Yue Q, Wang Z, Zhong X, Luo X, Zuo B, Zhang M, Zeng T, Liu B, Guo H
iScience 2023 Aug 18;26(8):107377

Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.

Dong C, Song C, He Z, Song Q, Song T, Liu J, Xiong Y, Su X, Zhou J, Yang S, Liao W
International immunopharmacology 2023 Apr;117:110042

Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction.

Liu J, Chen H, Lin H, Peng S, Chen L, Cheng X, Yao P, Tang Y
The Journal of nutritional biochemistry 2023 Apr;114:109258

Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.

Liang Z, Miao Y, Teng X, Xiao L, Guo Q, Xue H, Tian D, Jin S, Wu Y
Frontiers in molecular biosciences 2022;9:947778

Low Level of Dietary Organic Trace Elements Improve the Eggshell Strength, Trace Element Utilization, and Intestinal Function in Late-Phase Laying Hens.

Chen X, Ma XM, Yang CW, Jiang SZ, Huang LB, Li Y, Zhang F, Jiao N, Yang WR
Frontiers in veterinary science 2022;9:903615

Atorvastatin Inhibits Ferroptosis of H9C2 Cells by regulatingSMAD7/Hepcidin Expression to Improve Ischemia-Reperfusion Injury.

Peng Y, Liao B, Zhou Y, Zeng W, Zeng ZY
Cardiology research and practice 2022;2022:3972829

HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.

Han S, Lin F, Qi Y, Liu C, Zhou L, Xia Y, Chen K, Xing J, Liu Z, Yu W, Zhang Y, Zhou X, Rao T, Cheng F
Oxidative medicine and cellular longevity 2022;2022:3846217

NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells.

Zhou H, Zhou YL, Mao JA, Tang LF, Xu J, Wang ZX, He Y, Li M
Redox biology 2022 Sep;55:102413

Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice.

Han P, Wang X, Zhou T, Cheng J, Wang C, Sun F, Zhao X
Free radical biology & medicine 2022 Nov 20;193(Pt 1):421-429

Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting Ferroptosis.

Yang S, Pei T, Wang L, Zeng Y, Li W, Yan S, Xiao W, Cheng W
Molecules (Basel, Switzerland) 2022 Nov 19;27(22)

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.

Wu J, Liu Q, Zhang X, Tan M, Li X, Liu P, Wu L, Jiao F, Lin Z, Wu X, Wang X, Zhao Y, Ren J
Cell death & disease 2022 Jul 28;13(7):653

Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation.

Li L, Li WJ, Zheng XR, Liu QL, Du Q, Lai YJ, Liu SQ
Molecular medicine (Cambridge, Mass.) 2022 Jan 29;28(1):11

3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis.

Shao C, Liu Y, Chen Z, Qin Y, Wang X, Wang X, Yan C, Zhu HL, Zhao J, Qian Y
Cell chemical biology 2022 Jan 20;29(1):43-56.e12

Electroacupuncture Preconditioning Reduces Oxidative Stress in the Acute Phase of Cerebral Ischemia-Reperfusion in Rats by Regulating Iron Metabolism Pathways.

Liang R, Tang Q, Song W, Zhang M, Teng L, Kang Y, Zhu L
Evidence-based complementary and alternative medicine : eCAM 2021;2021:3056963

Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer.

Zhang Z, Lu M, Chen C, Tong X, Li Y, Yang K, Lv H, Xu J, Qin L
Theranostics 2021;11(7):3167-3182

N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.

Peng W, Zhu Z, Yang Y, Hou J, Lu J, Chen C, Liu F, Pi R
Brain research bulletin 2021 Sep;174:250-259

Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion.

Zeng L, Zhou J, Wang X, Zhang Y, Wang M, Su P
Free radical biology & medicine 2021 Nov 20;176:176-188

Activation of NRF2/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis.

Tian H, Xiong Y, Zhang Y, Leng Y, Tao J, Li L, Qiu Z, Xia Z
Cell stress & chaperones 2021 Mar;27(2):149-164

Tolerable upper intake level of iron damages the liver of weaned piglets.

Ding H, Zhao Y, Yu X, Chen L, Han J, Feng J
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677

Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis.

Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z
Experimental and molecular pathology 2021 Feb;118:104570

Tolerable upper intake level of iron damages the intestine and alters the intestinal flora in weaned piglets.

Ding H, Yu X, Chen L, Han J, Zhao Y, Feng J
Metallomics : integrated biometal science 2020 Sep 23;12(9):1356-1369

miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia.

Zhang H, He Y, Wang JX, Chen MH, Xu JJ, Jiang MH, Feng YL, Gu YF
Redox biology 2020 Jan;29:101402

Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.

Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329

Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells.

Yu X, Chen L, Ding H, Zhao Y, Feng J
Nutrients 2019 Feb 26;11(3)

Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.

Wang J, Wang S, Sun P, Cao F, Li H, Sun J, Peng M, Liu W, Shi P
Metallomics : integrated biometal science 2018 Sep 19;10(9):1307-1314

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