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Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [72]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [2]
- Flow cytometry [5]
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- Product number
- NBP1-21502 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-21502, RRID:AB_1660490
- Product name
- Rabbit Polyclonal Ferroportin/SLC40A1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Bovine, Porcine
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Cyclophosphamide induces a significant increase in iron content in the liver and spleen of mice.
Local synthesis of hepcidin in the anterior segment of the eye: A novel observation with physiological and pathological implications.
A role for hepcidin in the anemia caused by Trypanosoma brucei infection.
African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.
Angiotensin II down-regulates transferrin receptor 1 and ferroportin 1 expression in Neuro-2a cells via activation of type-1 receptor.
Effects of Heterozygous TfR1 (Transferrin Receptor 1) Deletion in Pathogenesis of Renal Fibrosis in Mice.
Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex.
The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth.
H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron.
Role of microRNA-122 in microcystin-leucine arginine-induced dysregulation of hepatic iron homeostasis in mice.
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels.
Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury.
Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.
Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia.
Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells.
Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.
Iron Oversupplementation Causes Hippocampal Iron Overloading and Impairs Social Novelty Recognition in Nursing Piglets.
Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2.
Novel reprogramming of neutrophils modulates inflammation resolution during atherosclerosis.
Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression.
A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness.
ZIP14 is degraded in response to manganese exposure.
Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology.
Repression of ferritin light chain translation by human eIF3.
Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2(+ve) breast cancer metastasis.
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment.
MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin.
Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia.
Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission.
The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages.
Inflammation-induced iron transport and metabolism by brain microglia.
TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.
Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes.
Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer.
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease.
Different Characteristics of Hepcidin Expression in IL-6+/+ and IL-6-/- Neurons and Astrocytes Treated with Lipopolysaccharides.
The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells.
Conventional and electronic cigarettes dysregulate the expression of iron transporters and detoxifying enzymes at the brain vascular endothelium: In vivo evidence of a gender-specific cellular response to chronic cigarette smoke exposure.
In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity.
Impairment of Hepcidin Upregulation by Lipopolysaccharide in the Interleukin-6 Knockout Mouse Brain.
Type 4B hereditary hemochromatosis associated with a novel mutation in the SLC40A1 gene: A case report and a review of the literature.
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types.
Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Iron addiction: a novel therapeutic target in ovarian cancer.
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells.
Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.
Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression.
Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation.
In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.
Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.
Local iron homeostasis in the breast ductal carcinoma microenvironment.
Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis.
Hepcidin regulation in prostate and its disruption in prostate cancer.
β-Carotene can reverse dysregulation of iron protein in an in vitro model of inflammation.
Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.
Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron.
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice.
Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats.
Proposing a Caco-2/HepG2 cell model for in vitro iron absorption studies.
Iron transport through ferroportin is induced by intracellular ascorbate and involves IRP2 and HIF2α.
Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis.
Effects of excess dietary iron and fat on glucose and lipid metabolism.
Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice.
mTOR regulates cellular iron homeostasis through tristetraprolin.
Intestinal ferritin H is required for an accurate control of iron absorption.
Sheng Y, Chen YJ, Qian ZM, Zheng J, Liu Y
Human & experimental toxicology 2020 Jul;39(7):973-983
Human & experimental toxicology 2020 Jul;39(7):973-983
Local synthesis of hepcidin in the anterior segment of the eye: A novel observation with physiological and pathological implications.
Ashok A, Chaudhary S, McDonald D, Kritikos A, Bhargava D, Singh N
Experimental eye research 2020 Jan;190:107890
Experimental eye research 2020 Jan;190:107890
A role for hepcidin in the anemia caused by Trypanosoma brucei infection.
Neves JV, Gomes AC, Costa DM, Barroso C, Vaulont S, Cordeiro da Silva A, Tavares J, Rodrigues PNS
Haematologica 2020 Jan 9;
Haematologica 2020 Jan 9;
African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.
Singh KS, Leu JI, Barnoud T, Vonteddu P, Gnanapradeepan K, Lin C, Liu Q, Barton JC, Kossenkov AV, George DL, Murphy ME, Dotiwala F
Nature communications 2020 Jan 24;11(1):473
Nature communications 2020 Jan 24;11(1):473
Angiotensin II down-regulates transferrin receptor 1 and ferroportin 1 expression in Neuro-2a cells via activation of type-1 receptor.
Chen YJ, Qian ZM, Sheng Y, Zheng J, Liu Y
Neuroscience letters 2020 Jan 18;716:134684
Neuroscience letters 2020 Jan 18;716:134684
Effects of Heterozygous TfR1 (Transferrin Receptor 1) Deletion in Pathogenesis of Renal Fibrosis in Mice.
Yasumura S, Naito Y, Okuno K, Sawada H, Asakura M, Masuyama T, Ishihara M
Hypertension (Dallas, Tex. : 1979) 2020 Feb;75(2):413-421
Hypertension (Dallas, Tex. : 1979) 2020 Feb;75(2):413-421
Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex.
Chen X, Li D, Sun HY, Wang WW, Wu H, Kong W, Kong WJ
The FEBS journal 2020 Feb 28;
The FEBS journal 2020 Feb 28;
The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth.
Schnetz M, Meier JK, Rehwald C, Mertens C, Urbschat A, Tomat E, Akam EA, Baer P, Roos FC, Brüne B, Jung M
Cancers 2020 Feb 25;12(3)
Cancers 2020 Feb 25;12(3)
H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron.
Mesquita G, Silva T, Gomes AC, Oliveira PF, Alves MG, Fernandes R, Almeida AA, Moreira AC, Gomes MS
Scientific reports 2020 Feb 20;10(1):3061
Scientific reports 2020 Feb 20;10(1):3061
Role of microRNA-122 in microcystin-leucine arginine-induced dysregulation of hepatic iron homeostasis in mice.
Wang R, Liu X, Wu J, Liu H, Wang W, Chen X, Yuan L, Wang Y, Du X, Ma Y, Losiewicz MD, Zhang X, Zhang H
Environmental toxicology 2020 Aug;35(8):822-830
Environmental toxicology 2020 Aug;35(8):822-830
Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron.
Li S, Qian ZM, Xu G, Zheng J, Wu Y
Bioscience reports 2020 Apr 30;40(4)
Bioscience reports 2020 Apr 30;40(4)
Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels.
Villalpando-Rodriguez GE, Blankstein AR, Konzelman C, Gibson SB
Oxidative medicine and cellular longevity 2019;2019:9561281
Oxidative medicine and cellular longevity 2019;2019:9561281
Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury.
Scindia Y, Wlazlo E, Leeds J, Loi V, Ledesma J, Cechova S, Ghias E, Swaminathan S
Frontiers in pharmacology 2019;10:615
Frontiers in pharmacology 2019;10:615
Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.
Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD
The Journal of biological chemistry 2019 Sep 6;294(36):13292-13303
The Journal of biological chemistry 2019 Sep 6;294(36):13292-13303
Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia.
Okuno K, Naito Y, Yasumura S, Sawada H, Asakura M, Masuyama T, Ishihara M
Scientific reports 2019 Sep 20;9(1):13658
Scientific reports 2019 Sep 20;9(1):13658
Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells.
Pandur E, Tamási K, Pap R, Varga E, Miseta A, Sipos K
Cellular and molecular neurobiology 2019 Oct;39(7):985-1001
Cellular and molecular neurobiology 2019 Oct;39(7):985-1001
Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.
Nobuta H, Yang N, Ng YH, Marro SG, Sabeur K, Chavali M, Stockley JH, Killilea DW, Walter PB, Zhao C, Huie P Jr, Goldman SA, Kriegstein AR, Franklin RJM, Rowitch DH, Wernig M
Cell stem cell 2019 Oct 3;25(4):531-541.e6
Cell stem cell 2019 Oct 3;25(4):531-541.e6
Iron Oversupplementation Causes Hippocampal Iron Overloading and Impairs Social Novelty Recognition in Nursing Piglets.
Ji P, Lönnerdal B, Kim K, Jinno CN
The Journal of nutrition 2019 Mar 1;149(3):398-405
The Journal of nutrition 2019 Mar 1;149(3):398-405
Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2.
Miyazawa M, Bogdan AR, Tsuji Y
Cell chemical biology 2019 Jan 17;26(1):85-97.e4
Cell chemical biology 2019 Jan 17;26(1):85-97.e4
Novel reprogramming of neutrophils modulates inflammation resolution during atherosclerosis.
Geng S, Zhang Y, Lee C, Li L
Science advances 2019 Feb;5(2):eaav2309
Science advances 2019 Feb;5(2):eaav2309
Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression.
Kalainayakan SP, Ghosh P, Dey S, Fitzgerald KE, Sohoni S, Konduri PC, Garrossian M, Liu L, Zhang L
Scientific reports 2019 Feb 5;9(1):1405
Scientific reports 2019 Feb 5;9(1):1405
A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness.
Katsura Y, Ohara T, Noma K, Ninomiya T, Kashima H, Kato T, Sato H, Komoto S, Narusaka T, Tomono Y, Xing B, Chen Y, Tazawa H, Kagawa S, Shirakawa Y, Kasai T, Seno M, Matsukawa A, Fujiwara T
Cancers 2019 Feb 3;11(2)
Cancers 2019 Feb 3;11(2)
ZIP14 is degraded in response to manganese exposure.
Thompson KJ, Wessling-Resnick M
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2019 Dec;32(6):829-843
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2019 Dec;32(6):829-843
Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology.
Silva JM, Rodrigues S, Sampaio-Marques B, Gomes P, Neves-Carvalho A, Dioli C, Soares-Cunha C, Mazuik BF, Takashima A, Ludovico P, Wolozin B, Sousa N, Sotiropoulos I
Cell death and differentiation 2019 Aug;26(8):1411-1427
Cell death and differentiation 2019 Aug;26(8):1411-1427
Repression of ferritin light chain translation by human eIF3.
Pulos-Holmes MC, Srole DN, Juarez MG, Lee AS, McSwiggen DT, Ingolia NT, Cate JH
eLife 2019 Aug 15;8
eLife 2019 Aug 15;8
Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2(+ve) breast cancer metastasis.
Nagpal A, Redvers RP, Ling X, Ayton S, Fuentes M, Tavancheh E, Diala I, Lalani A, Loi S, David S, Anderson RL, Smith Y, Merino D, Denoyer D, Pouliot N
Breast cancer research : BCR 2019 Aug 13;21(1):94
Breast cancer research : BCR 2019 Aug 13;21(1):94
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment.
Mertens C, Mora J, Ören B, Grein S, Winslow S, Scholich K, Weigert A, Malmström P, Forsare C, Fernö M, Schmid T, Brüne B, Jung M
Oncoimmunology 2018;7(3):e1408751
Oncoimmunology 2018;7(3):e1408751
MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin.
Samba-Mondonga M, Calvé A, Mallette FA, Santos MM
Frontiers in cell and developmental biology 2018;6:105
Frontiers in cell and developmental biology 2018;6:105
Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia.
Broide E, Reifen R, Matalon S, Berkovich Z, Shirin H, Moshe M
Journal of diabetes research 2018;2018:7494821
Journal of diabetes research 2018;2018:7494821
Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission.
Ashok A, Karmakar S, Chandel R, Ravikumar R, Dalal S, Kong Q, Singh N
Experimental eye research 2018 Oct;175:1-13
Experimental eye research 2018 Oct;175:1-13
The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages.
Lim D, Kim KS, Jeong JH, Marques O, Kim HJ, Song M, Lee TH, Kim JI, Choi HS, Min JJ, Bumann D, Muckenthaler MU, Choy HE
Nature communications 2018 May 29;9(1):2091
Nature communications 2018 May 29;9(1):2091
Inflammation-induced iron transport and metabolism by brain microglia.
McCarthy RC, Sosa JC, Gardeck AM, Baez AS, Lee CH, Wessling-Resnick M
The Journal of biological chemistry 2018 May 18;293(20):7853-7863
The Journal of biological chemistry 2018 May 18;293(20):7853-7863
TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.
Zhabyeyev P, Das SK, Basu R, Shen M, Patel VB, Kassiri Z, Oudit GY
American journal of physiology. Heart and circulatory physiology 2018 May 1;314(5):H978-H990
American journal of physiology. Heart and circulatory physiology 2018 May 1;314(5):H978-H990
Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes.
Baba Y, Higa JK, Shimada BK, Horiuchi KM, Suhara T, Kobayashi M, Woo JD, Aoyagi H, Marh KS, Kitaoka H, Matsui T
American journal of physiology. Heart and circulatory physiology 2018 Mar 1;314(3):H659-H668
American journal of physiology. Heart and circulatory physiology 2018 Mar 1;314(3):H659-H668
Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer.
Blanchette-Farra N, Kita D, Konstorum A, Tesfay L, Lemler D, Hegde P, Claffey KP, Torti FM, Torti SV
Oncogene 2018 Jul;37(29):4013-4032
Oncogene 2018 Jul;37(29):4013-4032
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Shin D, Kim EH, Lee J, Roh JL
Free radical biology & medicine 2018 Dec;129:454-462
Free radical biology & medicine 2018 Dec;129:454-462
Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice.
Zhang MW, Zhao P, Yung WH, Sheng Y, Ke Y, Qian ZM
Aging 2018 Dec 16;10(12):3834-3850
Aging 2018 Dec 16;10(12):3834-3850
Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease.
Puy V, Darwiche W, Trudel S, Gomila C, Lony C, Puy L, Lefebvre T, Vitry S, Boullier A, Karim Z, Ausseil J
Glia 2018 Aug;66(8):1709-1723
Glia 2018 Aug;66(8):1709-1723
Different Characteristics of Hepcidin Expression in IL-6+/+ and IL-6-/- Neurons and Astrocytes Treated with Lipopolysaccharides.
Ma J, Zhang FL, Zhou G, Bao YX, Shen Y, Qian ZM
Neurochemical research 2018 Aug;43(8):1624-1630
Neurochemical research 2018 Aug;43(8):1624-1630
The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells.
Ramakrishnan L, Pedersen SL, Toe QK, West LE, Mumby S, Casbolt H, Issitt T, Garfield B, Lawrie A, Wort SJ, Quinlan GJ
Scientific reports 2018 Aug 28;8(1):12972
Scientific reports 2018 Aug 28;8(1):12972
Conventional and electronic cigarettes dysregulate the expression of iron transporters and detoxifying enzymes at the brain vascular endothelium: In vivo evidence of a gender-specific cellular response to chronic cigarette smoke exposure.
Kaisar MA, Sivandzade F, Bhalerao A, Cucullo L
Neuroscience letters 2018 Aug 24;682:1-9
Neuroscience letters 2018 Aug 24;682:1-9
In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity.
Sajja RK, Kaisar MA, Vijay V, Desai VG, Prasad S, Cucullo L
Scientific reports 2018 Aug 23;8(1):12708
Scientific reports 2018 Aug 23;8(1):12708
Impairment of Hepcidin Upregulation by Lipopolysaccharide in the Interleukin-6 Knockout Mouse Brain.
Zhang FL, Hou HM, Yin ZN, Chang L, Li FM, Chen YJ, Ke Y, Qian ZM
Frontiers in molecular neuroscience 2017;10:367
Frontiers in molecular neuroscience 2017;10:367
Type 4B hereditary hemochromatosis associated with a novel mutation in the SLC40A1 gene: A case report and a review of the literature.
Zhang W, Lv T, Huang J, Ou X
Medicine 2017 Sep;96(38):e8064
Medicine 2017 Sep;96(38):e8064
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H
Nature communications 2017 Sep 1;8(1):403
Nature communications 2017 Sep 1;8(1):403
Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types.
Neves JV, Ramos MF, Moreira AC, Silva T, Gomes MS, Rodrigues PNS
Scientific reports 2017 Nov 1;7(1):14793
Scientific reports 2017 Nov 1;7(1):14793
Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Dietrich P, Johnson IM, Alli S, Dragatsis I
PLoS genetics 2017 Jul;13(7):e1006846
PLoS genetics 2017 Jul;13(7):e1006846
Iron addiction: a novel therapeutic target in ovarian cancer.
Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV
Oncogene 2017 Jul 20;36(29):4089-4099
Oncogene 2017 Jul 20;36(29):4089-4099
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells.
Raggi C, Gammella E, Correnti M, Buratti P, Forti E, Andersen JB, Alpini G, Glaser S, Alvaro D, Invernizzi P, Cairo G, Recalcati S
Scientific reports 2017 Dec 15;7(1):17667
Scientific reports 2017 Dec 15;7(1):17667
Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.
Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR
Toxicology and applied pharmacology 2017 Apr 15;321:1-17
Toxicology and applied pharmacology 2017 Apr 15;321:1-17
Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression.
Mertens C, Akam EA, Rehwald C, Brüne B, Tomat E, Jung M
PloS one 2016;11(11):e0166164
PloS one 2016;11(11):e0166164
Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation.
Asperti M, Stuemler T, Poli M, Gryzik M, Lifshitz L, Meyron-Holtz EG, Vlodavsky I, Arosio P
PloS one 2016;11(10):e0164183
PloS one 2016;11(10):e0164183
In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.
Gasperini L, Meneghetti E, Legname G, Benetti F
Frontiers in neuroscience 2016;10:437
Frontiers in neuroscience 2016;10:437
Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.
Kim DK, Kim YH, Jung YS, Kim KS, Jeong JH, Lee YS, Yuk JM, Oh BC, Choy HE, Dooley S, Muckenthaler MU, Lee CH, Choi HS
Scientific reports 2016 Sep 30;6:34630
Scientific reports 2016 Sep 30;6:34630
Local iron homeostasis in the breast ductal carcinoma microenvironment.
Marques O, Porto G, Rêma A, Faria F, Cruz Paula A, Gomez-Lazaro M, Silva P, Martins da Silva B, Lopes C
BMC cancer 2016 Mar 5;16:187
BMC cancer 2016 Mar 5;16:187
Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Feb;30(2):813-23
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Feb;30(2):813-23
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Zhang YT, Li FM, Guo YZ, Jiang LR, Ma J, Ke Y, Qian ZM
European journal of pharmacology 2016 Dec 5;792:48-53
European journal of pharmacology 2016 Dec 5;792:48-53
Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis.
Bose C, Megyesi JK, Shah SV, Hiatt KM, Hall KA, Karaduta O, Swaminathan S
PloS one 2015;10(8):e0136563
PloS one 2015;10(8):e0136563
Hepcidin regulation in prostate and its disruption in prostate cancer.
Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV
Cancer research 2015 Jun 1;75(11):2254-63
Cancer research 2015 Jun 1;75(11):2254-63
β-Carotene can reverse dysregulation of iron protein in an in vitro model of inflammation.
Katz O, Reifen R, Lerner A
Immunologic research 2015 Feb;61(1-2):70-8
Immunologic research 2015 Feb;61(1-2):70-8
Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.
Gammella E, Diaz V, Recalcati S, Buratti P, Samaja M, Dey S, Noguchi CT, Gassmann M, Cairo G
American journal of physiology. Regulatory, integrative and comparative physiology 2015 Feb 15;308(4):R330-5
American journal of physiology. Regulatory, integrative and comparative physiology 2015 Feb 15;308(4):R330-5
Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron.
Mori M, Ito F, Shi L, Wang Y, Ishida C, Hattori Y, Niwa M, Hirayama T, Nagasawa H, Iwase A, Kikkawa F, Toyokuni S
Redox biology 2015 Dec;6:578-586
Redox biology 2015 Dec;6:578-586
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC
Oncogene 2015 Apr 16;34(16):2115-24
Oncogene 2015 Apr 16;34(16):2115-24
H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice.
Vercellotti GM, Khan FB, Nguyen J, Chen C, Bruzzone CM, Bechtel H, Brown G, Nath KA, Steer CJ, Hebbel RP, Belcher JD
Frontiers in pharmacology 2014;5:79
Frontiers in pharmacology 2014;5:79
Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats.
Theurl M, Nairz M, Schroll A, Sonnweber T, Asshoff M, Haschka D, Seifert M, Willenbacher W, Wilflingseder D, Posch W, Murphy AT, Witcher DR, Theurl I, Weiss G
Haematologica 2014 Sep;99(9):1516-24
Haematologica 2014 Sep;99(9):1516-24
Proposing a Caco-2/HepG2 cell model for in vitro iron absorption studies.
Scheers NM, Almgren AB, Sandberg AS
The Journal of nutritional biochemistry 2014 Jul;25(7):710-5
The Journal of nutritional biochemistry 2014 Jul;25(7):710-5
Iron transport through ferroportin is induced by intracellular ascorbate and involves IRP2 and HIF2α.
Scheers N, Sandberg AS
Nutrients 2014 Jan 3;6(1):249-60
Nutrients 2014 Jan 3;6(1):249-60
Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis.
Kim DK, Jeong JH, Lee JM, Kim KS, Park SH, Kim YD, Koh M, Shin M, Jung YS, Kim HS, Lee TH, Oh BC, Kim JI, Park HT, Jeong WI, Lee CH, Park SB, Min JJ, Jung SI, Choi SY, Choy HE, Choi HS
Nature medicine 2014 Apr;20(4):419-24
Nature medicine 2014 Apr;20(4):419-24
Effects of excess dietary iron and fat on glucose and lipid metabolism.
Choi JS, Koh IU, Lee HJ, Kim WH, Song J
The Journal of nutritional biochemistry 2013 Sep;24(9):1634-44
The Journal of nutritional biochemistry 2013 Sep;24(9):1634-44
Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice.
Díaz V, Gammella E, Recalcati S, Santambrogio P, Naldi AM, Vogel J, Gassmann M, Cairo G
Hepatology (Baltimore, Md.) 2013 Dec;58(6):2122-32
Hepatology (Baltimore, Md.) 2013 Dec;58(6):2122-32
mTOR regulates cellular iron homeostasis through tristetraprolin.
Bayeva M, Khechaduri A, Puig S, Chang HC, Patial S, Blackshear PJ, Ardehali H
Cell metabolism 2012 Nov 7;16(5):645-57
Cell metabolism 2012 Nov 7;16(5):645-57
Intestinal ferritin H is required for an accurate control of iron absorption.
Vanoaica L, Darshan D, Richman L, Schümann K, Kühn LC
Cell metabolism 2010 Sep 8;12(3):273-82
Cell metabolism 2010 Sep 8;12(3):273-82
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Supportive validation
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- Western Blot: Ferroportin/SLC40A1 Antibody [NBP1-21502] - Western blot of human intestine lysate (Molecular weight: 62.5 KDa) using Ferroportin/SLC40A1 Antibody.
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- Western Blot: Ferroportin/SLC40A1 Antibody [NBP1-21502] - Western blot of bovine adult eye using Ferroportin/SLC40A1 Antibody. Image from verified customer review.
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- Western Blot: Ferroportin/SLC40A1 Antibody [NBP1-21502] - Duodenal mucosa samples from weanling pigs with iron replete or iron deficient status were probed using Ferroportin/SLC40A1 Antibody(NBP1-21502; 1:1000 dilution) and GAPDH (loading control). Image from verified customer review.
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- Western Blot: Ferroportin/SLC40A1 Antibody [NBP1-21502] - Mouse Ferroportin/SLC40A1, 5-aminolevulinic acid synthase (ALAS), and ferritin light chain (FLC) proteins are increased in sickle mice overexpressing human wt-FHC. Proteins of subcellular fractions isolated from livers of wt-, ms-, and LRS-treated mice (n = 4) were run on a western blot (30 ug protein/lane) and immunostained for microsomal ferroportin. Image collected and cropped by CiteAb from the following publication (http://journal.frontiersin.org/article/10.3389/fphar.2014.00079/abstract), licensed under a CC-BY licence.
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- Western Blot: Ferroportin/SLC40A1 Antibody [NBP1-21502] - HepG2 clones overexpressing heparanase showed a reduction of hepcidin expression and indices of iron loading. Two stable clones of HepG2 cells transfected with pcDNA3.1-HPA (HPA3 and HPA6) were analyzed for hepcidin expression, BMP/SMAD signaling and indices of iron status. Western blot of Ferroportin/SLC40A1 and its densitometry. The values are expressed as-dCt (for HPA mRNA) or as fold change over the control (MOCK) (for hepcidin and Id1 mRNA). The images are representative from three different analyses. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371:journal.pone.0164183), licensed under a CC-BY licence.
Supportive validation
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- Immunohistochemistry-Paraffin: Ferroportin/SLC40A1 Antibody [NBP1-21502] - Detection of Ferroportin/SLC40A1 protein in murine liver section using Ferroportin/SLC40A1 Antibody at a dilution of 1:200. The representative image shows intense staining in the cellular membranes, whereas, a relatively milder postivity was observed in the cytoplasm of hepatocytes.
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- Immunohistochemistry-Paraffin: Ferroportin/SLC40A1 Antibody [NBP1-21502] - Detection of Ferroportin/SLC40A1 protein in murine small intestinal section using Ferroportin/SLC40A1 Antibody at a dilution of 1:200. The antibody primarily developed a membranous staining pattern in the intestinal epithelial cells.
Supportive validation
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- Flow Cytometry: Ferroportin/SLC40A1 Antibody [NBP1-21502] - An intracellular stain was performed on HepG2 cells with NBP1-21502AF647 (blue) and a matched isotype control (orange, NBP2-24893AF647). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 647.
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- Flow Cytometry: Ferroportin/SLC40A1 Antibody [NBP1-21502] - Histogram of Ferroportin staining of human spleen macrophages using Alexa Fluor 700 conjugated Ferroportin antibody (red, NBP1-21502AF700) and isotype control (grey) as a negative control. Image from verified customer review.
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- Flow Cytometry: Ferroportin/SLC40A1 Antibody [NBP1-21502] - Analysis using the PE conjugate of Ferroportin/SLC40A1 Antibody. Staining of Ferroportin in human B lymphocytes in peripheral blood using PE conjugated anti-Ferroportin/SLC40A1 antibody. Image from verified customer review.
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- Flow (Intracellular): Ferroportin/SLC40A1 Antibody [NBP1-21502] - An intracellular stain was performed on HepG2 cells with Ferroportin/SLC40A1 antibody NBP1-21502AF700 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 10 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 700.
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- Main image
- Experimental details
- Flow Cytometry: Ferroportin/SLC40A1 Antibody [NBP1-21502] - An intracellular stain was performed on HepG2 cells with Ferroportin/SLC40A1 Antibody and a matched isotype control. Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody.
