Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [3]
- Immunohistochemistry [2]
- Flow cytometry [4]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN439384 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Solute Carrier Family 40 (Iron-Regulated Transporter), Member 1 (SLC40A1) (AA 250-300), (Internal Region) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 250-300, Internal Region
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes.
Type 4B hereditary hemochromatosis associated with a novel mutation in the SLC40A1 gene: A case report and a review of the literature.
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types.
Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Iron addiction: a novel therapeutic target in ovarian cancer.
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells.
Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.
Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression.
Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation.
In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.
Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.
Local iron homeostasis in the breast ductal carcinoma microenvironment.
Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis.
Hepcidin regulation in prostate and its disruption in prostate cancer.
β-Carotene can reverse dysregulation of iron protein in an in vitro model of inflammation.
Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.
Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron.
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice.
Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats.
Proposing a Caco-2/HepG2 cell model for in vitro iron absorption studies.
Iron transport through ferroportin is induced by intracellular ascorbate and involves IRP2 and HIF2α.
Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis.
Effects of excess dietary iron and fat on glucose and lipid metabolism.
Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice.
mTOR regulates cellular iron homeostasis through tristetraprolin.
Intestinal ferritin H is required for an accurate control of iron absorption.
Baba Y, Higa JK, Shimada BK, Horiuchi KM, Suhara T, Kobayashi M, Woo JD, Aoyagi H, Marh KS, Kitaoka H, Matsui T
American journal of physiology. Heart and circulatory physiology 2018 Mar 1;314(3):H659-H668
American journal of physiology. Heart and circulatory physiology 2018 Mar 1;314(3):H659-H668
Type 4B hereditary hemochromatosis associated with a novel mutation in the SLC40A1 gene: A case report and a review of the literature.
Zhang W, Lv T, Huang J, Ou X
Medicine 2017 Sep;96(38):e8064
Medicine 2017 Sep;96(38):e8064
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H
Nature communications 2017 Sep 1;8(1):403
Nature communications 2017 Sep 1;8(1):403
Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types.
Neves JV, Ramos MF, Moreira AC, Silva T, Gomes MS, Rodrigues PNS
Scientific reports 2017 Nov 1;7(1):14793
Scientific reports 2017 Nov 1;7(1):14793
Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Dietrich P, Johnson IM, Alli S, Dragatsis I
PLoS genetics 2017 Jul;13(7):e1006846
PLoS genetics 2017 Jul;13(7):e1006846
Iron addiction: a novel therapeutic target in ovarian cancer.
Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV
Oncogene 2017 Jul 20;36(29):4089-4099
Oncogene 2017 Jul 20;36(29):4089-4099
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells.
Raggi C, Gammella E, Correnti M, Buratti P, Forti E, Andersen JB, Alpini G, Glaser S, Alvaro D, Invernizzi P, Cairo G, Recalcati S
Scientific reports 2017 Dec 15;7(1):17667
Scientific reports 2017 Dec 15;7(1):17667
Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.
Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR
Toxicology and applied pharmacology 2017 Apr 15;321:1-17
Toxicology and applied pharmacology 2017 Apr 15;321:1-17
Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression.
Mertens C, Akam EA, Rehwald C, Brüne B, Tomat E, Jung M
PloS one 2016;11(11):e0166164
PloS one 2016;11(11):e0166164
Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation.
Asperti M, Stuemler T, Poli M, Gryzik M, Lifshitz L, Meyron-Holtz EG, Vlodavsky I, Arosio P
PloS one 2016;11(10):e0164183
PloS one 2016;11(10):e0164183
In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.
Gasperini L, Meneghetti E, Legname G, Benetti F
Frontiers in neuroscience 2016;10:437
Frontiers in neuroscience 2016;10:437
Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.
Kim DK, Kim YH, Jung YS, Kim KS, Jeong JH, Lee YS, Yuk JM, Oh BC, Choy HE, Dooley S, Muckenthaler MU, Lee CH, Choi HS
Scientific reports 2016 Sep 30;6:34630
Scientific reports 2016 Sep 30;6:34630
Local iron homeostasis in the breast ductal carcinoma microenvironment.
Marques O, Porto G, Rêma A, Faria F, Cruz Paula A, Gomez-Lazaro M, Silva P, Martins da Silva B, Lopes C
BMC cancer 2016 Mar 5;16:187
BMC cancer 2016 Mar 5;16:187
Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Feb;30(2):813-23
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Feb;30(2):813-23
(Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells.
Zhang YT, Li FM, Guo YZ, Jiang LR, Ma J, Ke Y, Qian ZM
European journal of pharmacology 2016 Dec 5;792:48-53
European journal of pharmacology 2016 Dec 5;792:48-53
Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis.
Bose C, Megyesi JK, Shah SV, Hiatt KM, Hall KA, Karaduta O, Swaminathan S
PloS one 2015;10(8):e0136563
PloS one 2015;10(8):e0136563
Hepcidin regulation in prostate and its disruption in prostate cancer.
Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV
Cancer research 2015 Jun 1;75(11):2254-63
Cancer research 2015 Jun 1;75(11):2254-63
β-Carotene can reverse dysregulation of iron protein in an in vitro model of inflammation.
Katz O, Reifen R, Lerner A
Immunologic research 2015 Feb;61(1-2):70-8
Immunologic research 2015 Feb;61(1-2):70-8
Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.
Gammella E, Diaz V, Recalcati S, Buratti P, Samaja M, Dey S, Noguchi CT, Gassmann M, Cairo G
American journal of physiology. Regulatory, integrative and comparative physiology 2015 Feb 15;308(4):R330-5
American journal of physiology. Regulatory, integrative and comparative physiology 2015 Feb 15;308(4):R330-5
Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron.
Mori M, Ito F, Shi L, Wang Y, Ishida C, Hattori Y, Niwa M, Hirayama T, Nagasawa H, Iwase A, Kikkawa F, Toyokuni S
Redox biology 2015 Dec;6:578-86
Redox biology 2015 Dec;6:578-86
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC
Oncogene 2015 Apr 16;34(16):2115-24
Oncogene 2015 Apr 16;34(16):2115-24
H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice.
Vercellotti GM, Khan FB, Nguyen J, Chen C, Bruzzone CM, Bechtel H, Brown G, Nath KA, Steer CJ, Hebbel RP, Belcher JD
Frontiers in pharmacology 2014;5:79
Frontiers in pharmacology 2014;5:79
Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats.
Theurl M, Nairz M, Schroll A, Sonnweber T, Asshoff M, Haschka D, Seifert M, Willenbacher W, Wilflingseder D, Posch W, Murphy AT, Witcher DR, Theurl I, Weiss G
Haematologica 2014 Sep;99(9):1516-24
Haematologica 2014 Sep;99(9):1516-24
Proposing a Caco-2/HepG2 cell model for in vitro iron absorption studies.
Scheers NM, Almgren AB, Sandberg AS
The Journal of nutritional biochemistry 2014 Jul;25(7):710-5
The Journal of nutritional biochemistry 2014 Jul;25(7):710-5
Iron transport through ferroportin is induced by intracellular ascorbate and involves IRP2 and HIF2α.
Scheers N, Sandberg AS
Nutrients 2014 Jan 3;6(1):249-60
Nutrients 2014 Jan 3;6(1):249-60
Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis.
Kim DK, Jeong JH, Lee JM, Kim KS, Park SH, Kim YD, Koh M, Shin M, Jung YS, Kim HS, Lee TH, Oh BC, Kim JI, Park HT, Jeong WI, Lee CH, Park SB, Min JJ, Jung SI, Choi SY, Choy HE, Choi HS
Nature medicine 2014 Apr;20(4):419-24
Nature medicine 2014 Apr;20(4):419-24
Effects of excess dietary iron and fat on glucose and lipid metabolism.
Choi JS, Koh IU, Lee HJ, Kim WH, Song J
The Journal of nutritional biochemistry 2013 Sep;24(9):1634-44
The Journal of nutritional biochemistry 2013 Sep;24(9):1634-44
Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice.
Díaz V, Gammella E, Recalcati S, Santambrogio P, Naldi AM, Vogel J, Gassmann M, Cairo G
Hepatology (Baltimore, Md.) 2013 Dec;58(6):2122-32
Hepatology (Baltimore, Md.) 2013 Dec;58(6):2122-32
mTOR regulates cellular iron homeostasis through tristetraprolin.
Bayeva M, Khechaduri A, Puig S, Chang HC, Patial S, Blackshear PJ, Ardehali H
Cell metabolism 2012 Nov 7;16(5):645-57
Cell metabolism 2012 Nov 7;16(5):645-57
Intestinal ferritin H is required for an accurate control of iron absorption.
Vanoaica L, Darshan D, Richman L, Schümann K, Kühn LC
Cell metabolism 2010 Sep 8;12(3):273-82
Cell metabolism 2010 Sep 8;12(3):273-82
No comments: Submit comment
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FACS
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FACS
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FACS
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FACS