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- References [3]
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- Product number
- MA1-10865 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- INSR Monoclonal Antibody (18-44)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- MA1-10865 detects Insulin Receptor from human samples. Low cross-reactivity with bovine and rabbit samples.
- Antibody clone number
- 18-44
- Concentration
- 0.41 mg/mL
Submitted references Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway.
The beta secretase BACE1 regulates the expression of insulin receptor in the liver.
A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.
Kowalczuk A, Bourebaba N, Kornicka-Garbowska K, Turlej E, Marycz K, Bourebaba L
Cell communication and signaling : CCS 2021 May 25;19(1):61
Cell communication and signaling : CCS 2021 May 25;19(1):61
The beta secretase BACE1 regulates the expression of insulin receptor in the liver.
Meakin PJ, Mezzapesa A, Benabou E, Haas ME, Bonardo B, Grino M, Brunel JM, Desbois-Mouthon C, Biddinger SB, Govers R, Ashford MLJ, Peiretti F
Nature communications 2018 Apr 3;9(1):1306
Nature communications 2018 Apr 3;9(1):1306
A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.
Burtrum D, Zhu Z, Lu D, Anderson DM, Prewett M, Pereira DS, Bassi R, Abdullah R, Hooper AT, Koo H, Jimenez X, Johnson D, Apblett R, Kussie P, Bohlen P, Witte L, Hicklin DJ, Ludwig DL
Cancer research 2003 Dec 15;63(24):8912-21
Cancer research 2003 Dec 15;63(24):8912-21
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- Invitrogen Antibodies (provider)
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- Fig. 7 Effect of total calystegines on collapsed insulin signalling pathway in HI/HG HepG2 cells. a Quantitative analysis of insulin signalling-related proteins expression using western blot. b Representative blots images of insulin signalling-related proteins profiling. c Relative genes expression of key insulin signalling regulators. Representative data from three independent experiments are shown +- SD (n = 3). An asterisk (*) indicates a comparison of IR group to untreated healthy cells. A hashtag (#) indicates a comparison of IR group pre-treated with calystegines to IR untreated healthy cells. */# p < 0.05, **/## p < 0.01, ***/### p < 0.001. HepG2_HE: HepG2 healthy untreated cells; HepG2_IR: Insulin resistant HepG2 cells exposed to high concentrations of insulin and glucose. HepG2_IR- H. albus _Caly: Insulin resistant HepG2 cells exposed to high concentrations of insulin and glucose and pre-treated with 250 mug/ml calystegines extracted from Hyoscyamus albus seeds
