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- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS4426 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- Insulin Receptor (phospho Y1361) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1361.
- Description
- The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular ÉÇ subunit and an extracellular Ï« subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of p-Insulin Receptor (Y1361) pAb in extracts from THP1 cells.
