20433-1-AP

antibody from Proteintech Group

Targeting: INSR CD220

Provider product page for 20433-1-AP

Western blot

ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [39]
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Validations
Western blot [1]

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Product number: 20433-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20433-1-AP, RRID:AB_10646469
Product name: INSR antibody
Antibody type: Polyclonal
Description: INSR antibody (Cat. #20433-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

INSR protein structure - 20433-1-AP shown in red.

Submitted references Insulin-like growth factor 2 alleviates metabolic inflammation and associated cognitive impairment in diet-induced obesity mice.

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In vitro anti-diabetic activities of phytochemicals isolated from Cornus officinalis fruits.

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Liu Z, Wang P, Hu Y, Zhang N, Xu L, Kang T, Zhao S, Zhao D, Chan C, Li J
Cell reports 2026 Feb 24;45(2):116974

Genome-wide mapping of RNA-protein associations through sequencing.

Qi Z, Xue S, Chen J, Zhao W, Johnson K, Wen X, Charles Richard JL, Lin P, Zhong S
Nature biotechnology 2025 Sep 9;

Effect of rumen-protected guanidinoacetic acid provision as a dietary supplement on the growth, slaughter performance, and meat quality in simmental bulls.

Zhang J, Xue C, Lang J, Pei C, Liu Q
Meat science 2025 Oct;228:109889

Investigation of the biomarkers and mechanism based on endoplasmic reticulum stress in irritable bowel syndrome.

Fan Z, Yao J, Zeng X, Zuo J, Qu J
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2025 Nov;26(4):337-346

Reynoutrin targets EphB4 to ameliorate hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus.

Lyu D, Xiao H, Shao Z, Li S, Li M, Pan L, Li Z, Huang H
Biochemical pharmacology 2025 Nov;241:117132

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Lai H, Zhu C, Li X, He L, Deng C, Guo L, Wang X
Scientific reports 2025 Nov 25;15(1):45324

Lycium barbarum polysaccharide mitigates high-fat-diet-induced skeletal muscle atrophy by promoting AMPK/PINK1/Parkin-mediated mitophagy.

Ren Y, Wang K, Wu Y, Li J, Ma J, Wang L, Zhang C, Li J, Wei Y, Yang Y
International journal of biological macromolecules 2025 Apr;301:140488

High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.

Amer J, Amleh A, Salhab A, Kolodny Y, Yochelis S, Saffouri B, Paltiel Y, Safadi R
Frontiers in nutrition 2024;11:1469952

Growth hormone improves insulin resistance in visceral adipose tissue after duodenal-jejunal bypass by regulating adiponectin secretion.

Liu ZT, Yang GW, Zhao X, Dong SH, Jiao Y, Ge Z, Yu A, Zhang XQ, Xu XZ, Cheng ZQ, Zhang X, Wang KX
World journal of diabetes 2024 Jun 15;15(6):1340-1352

Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway.

Zhang S, Liu B, Huang L, Zhang R, An L, Liu Z
Journal of molecular medicine (Berlin, Germany) 2024 Jan;102(1):113-128

Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice.

Liu T, Zhu C, Duan Z, Ma P, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Aug 21;72(33):18537-18551

Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.

Li J, Zhang S, Sun Y, Li J, Feng Z, Li H, Zhang M, Yan T, Han J, Duan Y
EMBO reports 2024 Apr;25(4):2097-2117

Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth-retarded suckling piglets associated with activation of FGF21-AMPKα pathway.

Bai G, Chen J, Liu Y, Chen J, Yan H, You J, Zou T
Journal of the science of food and agriculture 2024 Apr;104(6):3719-3728

Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus.

Zhao Y, Liu Y, Deng J, Zhu C, Ma X, Jiang M, Fan D
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14263-14275

Exploring the targets and molecular mechanism of glycyrrhetinic acid against diabetic nephropathy based on network pharmacology and molecular docking.

Meng FD, Yuan L, Xu DJ, Che MY, Hou SZ, Lu DD, Liu WJ, Nan Y
World journal of diabetes 2023 Nov 15;14(11):1672-1692

High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia (Oreochromis niloticus).

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Marine life science & technology 2023 Feb;5(1):56-74

IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced ulcerative colitis.

Chen L, Zhong XL, Cao WY, Mao ML, Liu DD, Liu WJ, Zu XY, Liu JH
European journal of pharmacology 2023 Dec 5;960:176122

The effect of PINK1/Parkin pathway on glucose homeostasis imbalance induced by tacrolimus in mouse livers.

Li Z, Xiang J, Mei S, Wu Y, Xu Y
Heliyon 2023 Apr;9(4):e15536

Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice.

Hara T, Toyama H, Ohata Y, Ikeuchi T, Nakamura S, Joh T, Ohtsubo K
Bioscience, biotechnology, and biochemistry 2022 Oct 20;86(11):1570-1575

Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.

Huang H, Chen J, Hu X, Chen Y, Xie J, Ao T, Wang H, Xie J, Yu Q
Food & function 2022 Mar 7;13(5):2710-2728

Dependence of glucose transport on autophagy and GAPDH activity.

Craven RJ, Frazier HN, Thibault O
Brain research 2022 Feb 1;1776:147747

Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism.

Bai Y, Mo K, Wang G, Chen W, Zhang W, Guo Y, Sun Z
Frontiers in pharmacology 2021;12:710722

Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease.

Wang H, Lv JJ, Zhao Y, Wei HL, Zhang TJ, Yang HJ, Chen ZN, Jiang JL
CNS neuroscience & therapeutics 2021 Sep;27(9):1048-1063

Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.

Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)

Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.

Raber J, Perez R, Torres ERS, Krenik D, Boutros S, Patel E, Chlebowski AC, Torres ER, Perveen Z, Penn A, Paulsen DB, Bartlett MG, Jia E, Holden S, Hall R, Morré J, Wong C, Ho E, Choi J, Stevens JF, Noël A, Bobe G, Kisby G
Environmental health perspectives 2021 May;129(5):57009

Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.

Huang F, Zhu P, Wang J, Chen J, Lin W
Pediatric research 2021 Jan;89(1):143-149

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Han SL, Liu Y, Limbu SM, Chen LQ, Zhang ML, Du ZY
Fish physiology and biochemistry 2021 Feb;47(1):173-188

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Huang Q, Zhang F, Liu S, Jiang Y, Ouyang D
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Huang G, Song C, Wang N, Qin T, Sui S, Obr A, Zeng L, Wood TL, Leroith D, Li M, Wu Y
Carcinogenesis 2020 Sep 24;41(9):1294-1305

Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish.

Li LY, Lv HB, Jiang ZY, Qiao F, Chen LQ, Zhang ML, Du ZY
The Journal of physiology 2020 Oct;598(20):4537-4553

Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.

Xu T, Xu L, Meng P, Ma X, Yang X, Zhou Y, Feng M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13548-13560

Acid Loading Unmasks Glucose Homeostatic Instability in Proximal-Tubule-Targeted Insulin/Insulin-Like-Growth-Factor-1 Receptor Dual Knockout Mice.

Aljaylani A, Fluitt M, Piselli A, Shepard BD, Tiwari S, Ecelbarger CM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2020 Jul 18;54(4):682-695

l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.

Lin L, Zeng L, Liu A, Peng Y, Yuan D, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Food & function 2020 Feb 26;11(2):1798-1809

Inhibited autophagy impairs systemic nutrient metabolism in Nile tilapia.

Han SL, Wang J, Zhang YX, Qiao F, Chen LQ, Zhang ML, Du ZY
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2019 Oct;236:110521

NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.

Yang S, Liu M, Chen Y, Ma C, Liu L, Zhao B, Wang Y, Li X, Zhu Y, Gao X, Kong D, Duan Y, Han J, Yang X
Scientific reports 2018 Jun 14;8(1):9158

MiR-128 regulation of glucose metabolism and cell proliferation in triple-negative breast cancer.

Xiao M, Lou C, Xiao H, Yang Y, Cai X, Li C, Jia S, Huang Y
The British journal of surgery 2018 Jan;105(1):75-85

Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ.

Zhang W, Shen XY, Zhang WW, Chen H, Xu WP, Wei W
Toxicology and applied pharmacology 2017 Feb 1;316:17-26

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The INSR antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human INSR. This antibody recognizes human antigen. The INSR antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 20433-1-AP.pdf

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