Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN359886 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Insulin Receptor (INSR) (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- N-Term
- Vial size
- 0.4 mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject.
An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
Genotype-phenotype correlation in inherited severe insulin resistance.
Identification of novel C253Y missense and Y864X nonsense mutations in the insulin receptor gene in type A insulin-resistant patients.
Identification of three novel mutations in the insulin receptor gene in type A insulin resistant patients.
George S, Johansen A, Soos MA, Mortensen H, Gammeltoft S, Saudek V, Siddle K, Hansen L, O'Rahilly S
Endocrinology 2003 Feb;144(2):631-7
Endocrinology 2003 Feb;144(2):631-7
An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
Hamer I, Foti M, Emkey R, Cordier-Bussat M, Philippe J, De Meyts P, Maeder C, Kahn CR, Carpentier JL
Diabetologia 2002 May;45(5):657-67
Diabetologia 2002 May;45(5):657-67
Genotype-phenotype correlation in inherited severe insulin resistance.
Longo N, Wang Y, Smith SA, Langley SD, DiMeglio LA, Giannella-Neto D
Human molecular genetics 2002 Jun 1;11(12):1465-75
Human molecular genetics 2002 Jun 1;11(12):1465-75
Identification of novel C253Y missense and Y864X nonsense mutations in the insulin receptor gene in type A insulin-resistant patients.
Osawa H, Nishimiya T, Ochi M, Niiya T, Onuma H, Kitamuro F, Kaino Y, Kida K, Makino H
Clinical genetics 2001 Mar;59(3):194-7
Clinical genetics 2001 Mar;59(3):194-7
Identification of three novel mutations in the insulin receptor gene in type A insulin resistant patients.
Riqué S, Nogués C, Ibàñez L, Marcos MV, Ferragut J, Carrascosa A, Potau N
Clinical genetics 2000 Jan;57(1):67-9
Clinical genetics 2000 Jan;57(1):67-9
No comments: Submit comment
No validations: Submit validation data