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- Antigen structure
- References [21]
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- Product number
- 13917-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13917-1-AP, RRID:AB_2120844
- Product name
- HORMAD1 antibody
- Antibody type
- Polyclonal
- Description
- HORMAD1 antibody (Cat. #13917-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells.
Bi-allelic MEI1 variants cause meiosis arrest and non-obstructive azoospermia.
Co-transplantation of autologous T(reg) cells in a cell therapy for Parkinson's disease.
Structural and biochemical insights into the interaction mechanism underlying HORMAD1 and its partner proteins.
TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.
NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells.
Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis.
SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.
ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression.
UHRF1 is indispensable for meiotic sex chromosome inactivation and interacts with the DNA damage response pathway in mice†.
FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis.
Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis.
EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8.
Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.
SKP1 drives the prophase I to metaphase I transition during male meiosis.
Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells.
Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes.
A study of meiomitosis and novel pathways of genomic instability in cutaneous T-cell lymphomas (CTCL).
Structured illumination microscopy imaging reveals localization of replication protein A between chromosome lateral elements during mammalian meiosis.
Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives.
Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.
Feng HW, Zhao Y, Gao YL, Liu DT, Huo LJ
Asian journal of andrology 2024 Mar 1;26(2):165-174
Asian journal of andrology 2024 Mar 1;26(2):165-174
Bi-allelic MEI1 variants cause meiosis arrest and non-obstructive azoospermia.
Zhang Y, Li N, Ji Z, Bai H, Ou N, Tian R, Li P, Zhi E, Huang Y, Zhao J, Han Y, Zhang J, Zhou Y, Li Z, Yao C
Journal of human genetics 2023 Jun;68(6):383-392
Journal of human genetics 2023 Jun;68(6):383-392
Co-transplantation of autologous T(reg) cells in a cell therapy for Parkinson's disease.
Park TY, Jeon J, Lee N, Kim J, Song B, Kim JH, Lee SK, Liu D, Cha Y, Kim M, Leblanc P, Herrington TM, Carter BS, Schweitzer JS, Kim KS
Nature 2023 Jul;619(7970):606-615
Nature 2023 Jul;619(7970):606-615
Structural and biochemical insights into the interaction mechanism underlying HORMAD1 and its partner proteins.
Wang H, Xie R, Niu F, Yang Q, An L, Wu C, Liu X, Yang X
Structure (London, England : 1993) 2023 Dec 7;31(12):1578-1588.e3
Structure (London, England : 1993) 2023 Dec 7;31(12):1578-1588.e3
TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis.
Chotiner JY, Leu NA, Yang F, Cossu IG, Guan Y, Lin H, Wang PJ
bioRxiv : the preprint server for biology 2023 Dec 15;
bioRxiv : the preprint server for biology 2023 Dec 15;
NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells.
Chen L, Wang WJ, Liu Q, Wu YK, Wu YW, Jiang Y, Liao XQ, Huang F, Li Y, Shen L, Yu C, Zhang SY, Yan LY, Qiao J, Sha QQ, Fan HY
Nucleic acids research 2022 Oct 28;50(19):10896-10913
Nucleic acids research 2022 Oct 28;50(19):10896-10913
Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis.
Hirano K, Nonami Y, Nakamura Y, Sato T, Sato T, Ishiguro KI, Ogawa T, Yoshida S
Communications biology 2022 May 26;5(1):504
Communications biology 2022 May 26;5(1):504
SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.
Guan Y, Lin H, Leu NA, Ruthel G, Fuchs SY, Busino L, Luo M, Wang PJ
Nucleic acids research 2022 May 20;50(9):5129-5144
Nucleic acids research 2022 May 20;50(9):5129-5144
ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression.
Xu J, Gao J, Liu J, Huang X, Zhang H, Ma A, Ye J, Zhang X, Li Y, Yang G, Yin H, Khan R, Li T, Fan S, Jiang X, Zhang Y, Jiang H, Ma H, Shi Q
Cell reports 2022 Mar 22;38(12):110540
Cell reports 2022 Mar 22;38(12):110540
UHRF1 is indispensable for meiotic sex chromosome inactivation and interacts with the DNA damage response pathway in mice†.
Xiong M, Zhou S, Feng S, Gui Y, Li J, Wu Y, Dong J, Yuan S
Biology of reproduction 2022 Jul 25;107(1):168-182
Biology of reproduction 2022 Jul 25;107(1):168-182
FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis.
Tanno N, Takemoto K, Takada-Horisawa Y, Shimada R, Fujimura S, Tani N, Takeda N, Araki K, Ishiguro KI
iScience 2022 Apr 15;25(4):104008
iScience 2022 Apr 15;25(4):104008
Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis.
Tian H, Petkov PM
Development (Cambridge, England) 2021 Jun 1;148(11)
Development (Cambridge, England) 2021 Jun 1;148(11)
EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8.
Tian H, Billings T, Petkov PM
Molecular biology of the cell 2021 Jan 1;32(1):1-14
Molecular biology of the cell 2021 Jan 1;32(1):1-14
Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.
Fujiwara Y, Horisawa-Takada Y, Inoue E, Tani N, Shibuya H, Fujimura S, Kariyazono R, Sakata T, Ohta K, Araki K, Okada Y, Ishiguro KI
PLoS genetics 2020 Sep;16(9):e1009048
PLoS genetics 2020 Sep;16(9):e1009048
SKP1 drives the prophase I to metaphase I transition during male meiosis.
Guan Y, Leu NA, Ma J, Chmátal L, Ruthel G, Bloom JC, Lampson MA, Schimenti JC, Luo M, Wang PJ
Science advances 2020 Mar;6(13):eaaz2129
Science advances 2020 Mar;6(13):eaaz2129
Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells.
Liu K, Wang Y, Zhu Q, Li P, Chen J, Tang Z, Shen Y, Cheng X, Lu LY, Liu Y
Cell death & disease 2020 Jul 9;11(7):519
Cell death & disease 2020 Jul 9;11(7):519
Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes.
Bhattacharyya T, Walker M, Powers NR, Brunton C, Fine AD, Petkov PM, Handel MA
Current biology : CB 2019 Mar 18;29(6):1002-1018.e7
Current biology : CB 2019 Mar 18;29(6):1002-1018.e7
A study of meiomitosis and novel pathways of genomic instability in cutaneous T-cell lymphomas (CTCL).
Tsang M, Gantchev J, Netchiporouk E, Moreau L, Ghazawi FM, Glassman S, Sasseville D, Litvinov IV
Oncotarget 2018 Dec 28;9(102):37647-37661
Oncotarget 2018 Dec 28;9(102):37647-37661
Structured illumination microscopy imaging reveals localization of replication protein A between chromosome lateral elements during mammalian meiosis.
Yoon S, Choi EH, Kim JW, Kim KP
Experimental & molecular medicine 2018 Aug 28;50(8):1-12
Experimental & molecular medicine 2018 Aug 28;50(8):1-12
Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives.
Awe JP, Gschweng EH, Vega-Crespo A, Voutila J, Williamson MH, Truong B, Kohn DB, Kasahara N, Byrne JA
Stem cells translational medicine 2015 Feb;4(2):136-45
Stem cells translational medicine 2015 Feb;4(2):136-45
Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.
Fukuda T, Pratto F, Schimenti JC, Turner JM, Camerini-Otero RD, Höög C
PLoS genetics 2012 Feb;8(2):e1002485
PLoS genetics 2012 Feb;8(2):e1002485
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HORMAD1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HORMAD1. This antibody recognizes human, mouse, rat antigen. The HORMAD1 antibody has been validated for the following applications: ELISA, WB analysis.
