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- References [124]
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- Product number
- 11239-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11239-1-AP, RRID:AB_2245581
- Product name
- Cathepsin K antibody
- Antibody type
- Polyclonal
- Description
- Cathepsin K antibody (Cat. #11239-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibitory Effect of Allium cepa L.-Derived Extracellular Vesicles Loaded with Celecoxib on Osteoclast Differentiation in Periodontitis.
Plasma Proteomics Identifies Thousand-and-One-Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target.
Molybdenum nanodots reprogram inflammatory-driven osteolysis via bone immune remodeling.
Inflammatory cytokines secreted from senescent periodontal ligament cells influence the osteocyte network in alveolar bone.
Rosa roxburghii Tratt Juice Inhibits Fluoride Exposure-Induced Bone Damage in Male Rats by Regulating the Homeostasis of the ROS/TNF-α/NF-κB Pathway.
Structural alterations in osteocyte dendrites and lacunar-canalicular networks of the mandible of ovariectomized mice.
Stigmasterol upregulates Akt/mTOR/p70S6K signaling through SYVN1 to alleviate osteoporosis in ovariectomized rats.
Calcium-Polyphenol Functionalized Black Phosphorus Nanosheet System for Osteoporosis Therapy via Macrophage Reprogramming and Bone Microenvironment Remodeling.
Engineering Smart Bimetallic Ionic-Site MOF Nanozyme Nanocomposites for Microenvironment-Responsive Dynamic Therapy of Periapical Periodontitis.
Pathological Evidence From an Experimental Rat Model Demonstrates That Aortic Hypoperfusion Contributes to the Development of Medial Arterial Calcification.
Polyethylene terephthalate microplastics exposure enhances the risk of ulcerative colitis: insights from multiomics integration, machine learning, and molecular docking reveal intestinal toxicity mechanisms.
EBV promotes alveolar trabecula resorption via extracellular vesicle remodeling by group IIA secreted phospholipase A(2).
An alkaline nanosized platelet vesicle-based hydrogel for the treatment of osteoporotic bone defects.
Design, synthesis and bioactivity of indobufen derivatives.
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
Lang-chuang-ding restores bone homeostasis in systemic lupus erythematosus associated osteoporosis by targeting NF-κB signaling: a network pharmacology and experimental study.
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
Zingerone treats postmenopausal osteoporosis via increased ferroptosis sensitivity by p53-mediated regulation of SAT1 and GPX4 expression.
Kurarinone Mitigates LPS-Induced Inflammatory Osteolysis by Inhibiting Osteoclastogenesis Through the Reduction of ROS Levels and Suppression of the PI3K/AKT Signaling Pathway.
Therapeutic targeting of STING-IL6/STAT3 axis to inhibit osteoclastic niche formation and breast cancer bone metastasis.
Orally administered degradable nanoarmor-assisted probiotics for remodeling the gut microenvironment and treating osteoporosis.
BRG1 Ablation in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm: Mechanism and Translational Potential.
Neuro-skeletal crosstalk: Brain-derived 5-HT mediates the bone-protective effects of β-Sitosterol against postmenopausal osteoporosis.
PKM2 regulates osteoclastogenesis by affecting osteoclast precursor cell fusion via downregulation of OC-STAMP and DC-STAMP.
A sinomenine derivative alleviates bone destruction in collagen-induced arthritis mice by suppressing mitochondrial dysfunction and oxidative stress via the NRF2/HO-1/NQO1 signaling pathway.
Norwogonin Attenuates Inflammatory Osteolysis and Collagen-Induced Arthritis via Modulating Redox Signalling and Calcium Oscillations.
LncRNA H19 promotes osteoclast differentiation by sponging miR-29c-3p to increase expression of cathepsin K.
Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis.
Extracellular pH is a critical regulator of osteoclast fusion, size and activation.
Single-cell analysis links DCUN1D5 to immune remodeling and cisplatin resistance in recurrent osteosarcoma.
CD8a + GZMK + T Cells Inhibit Osteoclastogenesis in Postmenopausal Osteoporosis via the p38-MAPK Pathway.
Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation.
Porphyromonas gingivalis LPS-stimulated BMSC-derived exosome promotes osteoclastogenesis via miR-151-3p/PAFAH1B1.
The therapeutic potential of Osmundacetone for rheumatoid arthritis: Effects and mechanisms on osteoclastogenesis.
Fraxin inhibits ovariectomized-induced bone loss and osteoclastogenesis by suppressing ROS activity.
Divergent Requirements for Glutathione Biosynthesis During Osteoclast Differentiation In Vitro and In Vivo.
Mapping cell diversity and dynamics in inflammatory temporomandibular joint osteoarthritis with pain at single-cell resolution.
Hyperhomocysteinaemia aggravates periodontitis by suppressing the Nrf2/HO-1 signalling pathway.
Interaction Between Activating Transcription Factor 4 and Interleukin 6 Dictates Osteoclast Differentiation and Activity.
Sofalcone inhibits osteoclastogenesis through Keap1/Nrf2 signaling activation and mitigates ovariectomy-induced bone loss.
CTSK as a Collagen Degradation Marker Induces Gingival Recession During High-Force Orthodontic Tooth Movement.
Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity.
CD81(+) senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis.
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway.
CHD7 regulates craniofacial cartilage development via controlling HTR2B expression.
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis.
A Synthetic Small Molecule, LGM2605: A Promising Modulator of Increased Pro-Inflammatory Cytokine and Osteoclast Differentiation by Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin.
MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo.
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
Three Birds, One Stone: An Osteo-Microenvironment Stage-Regulative Scaffold for Bone Defect Repair through Modulating Early Osteo-Immunomodulation, Middle Neovascularization, and Later Osteogenesis.
Nel-like Molecule Type 1 Combined with Gold Nanoparticles Modulates Macrophage Polarization, Osteoclastogenesis, and Oral Microbiota in Periodontitis.
Outer Membrane Vesicles Derived From Fusobacterium nucleatum Trigger Periodontitis Through Host Overimmunity.
A 0.2 T-0.4 T Static Magnetic Field Improves the Bone Quality of Mice Subjected to Hindlimb Unloading and Reloading Through the Dual Regulation of BMSCs via Iron Metabolism.
Bone-protective effects of neutralizing angiopoietin-like protein 4 monoclonal antibody in rheumatoid arthritis.
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis.
Cathepsin B Nuclear Flux in a DNA-Guided "Antinuclear Missile" Cancer Therapy.
Toll-like receptor 4 deficiency affects the balance of osteoclastogenesis and osteoblastogenesis in periodontitis.
Yunnan Baiyao Inhibits Periodontitis by Suppressing the Autophagic Flux.
A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration.
S-nitrosoglutathione reductase-dependent p65 denitrosation promotes osteoclastogenesis by facilitating recruitment of p65 to NFATc1 promoter.
Isopsoralen suppresses receptor activator of nuclear factor kappa-β ligand-induced osteoclastogenesis by inhibiting the NF-κB signaling.
The genetic background determines material-induced bone formation through the macrophage-osteoclast axis.
Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts.
Hypoxia Drives Material-Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid-Loaded Macrophage Axis.
Effect of mitophagy in the formation of osteomorphs derived from osteoclasts.
Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis.
Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.
The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing.
Single-cell multi-omics analysis of human testicular germ cell tumor reveals its molecular features and microenvironment.
Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription.
The Dibenzyl Isoquinoline Alkaloid Berbamine Ameliorates Osteoporosis by Inhibiting Bone Resorption.
Extracellular Vesicles Derived From Murine Cementoblasts Possess the Potential to Increase Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclastogenesis.
Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption.
Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase : a novel approach in the prevention of osteoclastogenesis.
Effects of urolithin A on osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand via bone morphogenic protein 2.
Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice.
Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles.
Farnesoid X receptor agonist attenuates subchondral bone osteoclast fusion and osteochondral pathologies of osteoarthritis via suppressing JNK1/2/NFATc1 pathway.
BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.
Mechanical loading attenuates breast cancer-associated bone metastasis in obese mice by regulating the bone marrow microenvironment.
Andrographolide prevents bone loss via targeting estrogen-related receptor-α-regulated metabolic adaption of osteoclastogenesis.
Interleukin-1 induces receptor activator of nuclear factor-κB ligand-independent osteoclast differentiation in RAW264.7 cells.
BMP2 immune complexes promote new bone formation by facilitating the direct contact between osteoclasts and osteoblasts.
4-Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF-κB signaling pathway and reverses bone loss in ovariectomized mice.
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis.
Schisandrin A restrains osteoclastogenesis by inhibiting reactive oxygen species and activating Nrf2 signalling.
PERK controls bone homeostasis through the regulation of osteoclast differentiation and function.
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
Circadian control of the secretory pathway maintains collagen homeostasis.
Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway.
Cysteine cathepsins are altered by flow within an engineered in vitro microvascular niche.
ClC-7 Regulates the Pattern and Early Development of Craniofacial Bone and Tooth.
Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis.
Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis.
miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN/PI3K/AKT/FoxO1 pathway.
Ankle loading ameliorates bone loss from breast cancer-associated bone metastasis.
Treadmill Running in Established Phase Arthritis Inhibits Joint Destruction in Rat Rheumatoid Arthritis Models.
Low‑frequency pulsed electromagnetic field inhibits RANKL‑induced osteoclastic differentiation in RAW264.7 cells by scavenging reactive oxygen species.
Silencing of Aberrant Secretory Protein Expression by Disease-Associated Mutations.
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis.
Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.
Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice.
Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity.
YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism.
SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.
Pulsed electromagnetic field inhibits RANKL-dependent osteoclastic differentiation in RAW264.7 cells through the Ca(2+)-calcineurin-NFATc1 signaling pathway.
Cathepsin K in Lymphangioleiomyomatosis: LAM Cell-Fibroblast Interactions Enhance Protease Activity by Extracellular Acidification.
Role of endoplasmic reticulum stress in disuse osteoporosis.
Increased expression and activation of cathepsin K in human osteoarthritic cartilage and synovial tissues.
Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.
Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity.
Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis.
Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations.
Bone histomorphometry in a long-term hemodialysis patient with hypoparathyroidism and sarcoidosis.
Lentiviral small hairpin RNA knockdown of macrophage inflammatory protein-1γ ameliorates experimentally induced osteoarthritis in mice.
Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts.
Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis.
Cholesteatoma growth and proliferation: relevance with serpin B3.
Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts.
Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice.
Gao H, Yin S, Yan Y, Jin Y, Jiang M, Liu Y, Lu L, Ge Z, Cai Y, Wang H, Li C, Pan Y, Lin L
International journal of nanomedicine 2026;21:580087
International journal of nanomedicine 2026;21:580087
Plasma Proteomics Identifies Thousand-and-One-Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target.
Xin P, Li W, A X, Shen J, Meng X, Bian Y, Han H, Xiang Z, Ran L, Sun S, Xie J, Yue T, Zhu Q, Zhang X, Xie L, Xiao L
Arthritis & rheumatology (Hoboken, N.J.) 2026 May;78(5):1045-1061
Arthritis & rheumatology (Hoboken, N.J.) 2026 May;78(5):1045-1061
Molybdenum nanodots reprogram inflammatory-driven osteolysis via bone immune remodeling.
Fu Z, Hao W, Qin X, Wang H, Xie D, Zhang M, Ni D
Biomaterials 2026 May;328:123871
Biomaterials 2026 May;328:123871
Inflammatory cytokines secreted from senescent periodontal ligament cells influence the osteocyte network in alveolar bone.
Yamashita A, Tenshin H, Matsuki S, Nishino G, Ser-Od S, Saito FM, Hiasa M, Tanaka E
JBMR plus 2026 Mar;10(3):ziag014
JBMR plus 2026 Mar;10(3):ziag014
Rosa roxburghii Tratt Juice Inhibits Fluoride Exposure-Induced Bone Damage in Male Rats by Regulating the Homeostasis of the ROS/TNF-α/NF-κB Pathway.
Yang W, Ma L, Hu T, Zhang L, Wu K, Chen H, Zhang D, Luo P
Biological trace element research 2026 Mar 3;
Biological trace element research 2026 Mar 3;
Structural alterations in osteocyte dendrites and lacunar-canalicular networks of the mandible of ovariectomized mice.
Gao B, Bai J, Xiao R, Li J, Wang M, Wang Z, Feng Z, Shi J, Liu Z
Journal of periodontology 2026 Mar 28;
Journal of periodontology 2026 Mar 28;
Stigmasterol upregulates Akt/mTOR/p70S6K signaling through SYVN1 to alleviate osteoporosis in ovariectomized rats.
Zhu F, Li W, Cao Y, Dai B, Wu H, Zhu Y, Liu H
European journal of nutrition 2026 Mar 26;65(3)
European journal of nutrition 2026 Mar 26;65(3)
Calcium-Polyphenol Functionalized Black Phosphorus Nanosheet System for Osteoporosis Therapy via Macrophage Reprogramming and Bone Microenvironment Remodeling.
Deng X, Li Z, Yi X, Ruan D, Chen X, Luo J
Advanced healthcare materials 2026 Mar 13;:e04217
Advanced healthcare materials 2026 Mar 13;:e04217
Engineering Smart Bimetallic Ionic-Site MOF Nanozyme Nanocomposites for Microenvironment-Responsive Dynamic Therapy of Periapical Periodontitis.
Pan MM, Ye WH, Zhang RZ, Hu JX, Xie Y, Wang M, Xia H, Chen H, Yang Y, Xu L, Yu X, Chen LW
ACS nano 2026 Mar 10;20(9):7652-7669
ACS nano 2026 Mar 10;20(9):7652-7669
Pathological Evidence From an Experimental Rat Model Demonstrates That Aortic Hypoperfusion Contributes to the Development of Medial Arterial Calcification.
Sumi T, Higashihara M, Takeda T, Imai T, Tamura Y, Moriyama T, Zaima N
Pathology international 2026 Jan;76(1):e70077
Pathology international 2026 Jan;76(1):e70077
Polyethylene terephthalate microplastics exposure enhances the risk of ulcerative colitis: insights from multiomics integration, machine learning, and molecular docking reveal intestinal toxicity mechanisms.
Yang X, Yan B, Zhao Y, Zhou L, Liu M, Chen G, Shen L, Deng T
International journal of surgery (London, England) 2026 Jan 1;112(1):735-750
International journal of surgery (London, England) 2026 Jan 1;112(1):735-750
EBV promotes alveolar trabecula resorption via extracellular vesicle remodeling by group IIA secreted phospholipase A(2).
Kanamori A, Hasuike A, Kudo K, Carreras J, Shimizu T, Nakayama S, Yanagiya R, Koike R, Ogata Y, Takeichi O, Sato S, Ando K, Nakamura N, Murakami M, Imai K, Kotani A
Journal of lipid research 2026 Apr;67(4):101014
Journal of lipid research 2026 Apr;67(4):101014
An alkaline nanosized platelet vesicle-based hydrogel for the treatment of osteoporotic bone defects.
Yang K, Yang Y, Xia C, Chen Y, Dai Z, Wang Z, Hu L, Li Y, Wang Y, Wang Y, Li W, Wang Q, Li N, Jiang S, Zu S, Hao F, Shen Q, Fan S, Chen P, Shangguan L, Ning L
Materials today. Bio 2026 Apr;37:103000
Materials today. Bio 2026 Apr;37:103000
Design, synthesis and bioactivity of indobufen derivatives.
Yuan D, Chen L, Huang X, Zhang J, Meng Z
RSC advances 2026 Apr 24;16(24):21510-21518
RSC advances 2026 Apr 24;16(24):21510-21518
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
Wei J, Xie J, He Z, Feng X
Frontiers in pharmacology 2025;16:1742401
Frontiers in pharmacology 2025;16:1742401
Lang-chuang-ding restores bone homeostasis in systemic lupus erythematosus associated osteoporosis by targeting NF-κB signaling: a network pharmacology and experimental study.
Luo H, Zhou H, Shen S, Zeng L, Ruan H
Frontiers in endocrinology 2025;16:1639261
Frontiers in endocrinology 2025;16:1639261
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
Yao Z, He J, Hu M, Yan P, Xu Q, Zhang Q, Lin Y, Liao J, Cai X, Liu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
Zingerone treats postmenopausal osteoporosis via increased ferroptosis sensitivity by p53-mediated regulation of SAT1 and GPX4 expression.
Li H, Cao F, Liu D, Tao L
Communications biology 2025 Sep 26;8(1):1367
Communications biology 2025 Sep 26;8(1):1367
Kurarinone Mitigates LPS-Induced Inflammatory Osteolysis by Inhibiting Osteoclastogenesis Through the Reduction of ROS Levels and Suppression of the PI3K/AKT Signaling Pathway.
Lv H, Luo H, Tan W, Zhong J, Xiong J, Liu Z, Wu Q, Lin S, Cao K
Inflammation 2025 Oct;48(5):2986-3005
Inflammation 2025 Oct;48(5):2986-3005
Therapeutic targeting of STING-IL6/STAT3 axis to inhibit osteoclastic niche formation and breast cancer bone metastasis.
Zhao C, Liu P, Kong K, Chen X, Wu J, Wu W, Wang X, Wang L
Cell death discovery 2025 Oct 24;11(1):483
Cell death discovery 2025 Oct 24;11(1):483
Orally administered degradable nanoarmor-assisted probiotics for remodeling the gut microenvironment and treating osteoporosis.
Li Z, Deng X, Qiu C, Wang Z, Tang F, Pi Y, He Z, Zheng C, Luo J
Journal of nanobiotechnology 2025 Oct 11;23(1):660
Journal of nanobiotechnology 2025 Oct 11;23(1):660
BRG1 Ablation in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm: Mechanism and Translational Potential.
Li N, Xue Y, Zhang Q, Xu Y, Xu H, Yang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71199
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71199
Neuro-skeletal crosstalk: Brain-derived 5-HT mediates the bone-protective effects of β-Sitosterol against postmenopausal osteoporosis.
Wang K, Wang L, Zhou S, Chen X, Qian L, Zhang T, Sun X, Li M, Liu M, Guo Y, Hu Y, Ma Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157248
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157248
PKM2 regulates osteoclastogenesis by affecting osteoclast precursor cell fusion via downregulation of OC-STAMP and DC-STAMP.
Cai C, Jiang J, Li S, Gao C, Pu H, Zhao L, Xiao J
The Journal of biological chemistry 2025 May;301(5):108439
The Journal of biological chemistry 2025 May;301(5):108439
A sinomenine derivative alleviates bone destruction in collagen-induced arthritis mice by suppressing mitochondrial dysfunction and oxidative stress via the NRF2/HO-1/NQO1 signaling pathway.
Guo WY, Wu QM, Zeng HF, Chen YL, Xu J, Yu ZY, Shu YK, Yang XN, Zhang CH, He XZ, Mi JN, Chen S, Chen XM, Wu JQ, Yao HQ, Liu L, Pan HD
Pharmacological research 2025 May;215:107686
Pharmacological research 2025 May;215:107686
Norwogonin Attenuates Inflammatory Osteolysis and Collagen-Induced Arthritis via Modulating Redox Signalling and Calcium Oscillations.
Wang H, Yuan T, Yu X, Wang Y, Liu C, Li Z, Sun S
Journal of cellular and molecular medicine 2025 Mar;29(6):e70492
Journal of cellular and molecular medicine 2025 Mar;29(6):e70492
LncRNA H19 promotes osteoclast differentiation by sponging miR-29c-3p to increase expression of cathepsin K.
Li H, Zheng F, Tao A, Wu T, Zhan X, Tang H, Cui X, Ma Z, Li C, Jiang J, Wang Y
Bone 2025 Mar;192:117340
Bone 2025 Mar;192:117340
Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis.
Wang H, Yuan T, Wang J, Li D, Lee WY, Li Z, Sun S
Arthritis research & therapy 2025 Mar 8;27(1):54
Arthritis research & therapy 2025 Mar 8;27(1):54
Extracellular pH is a critical regulator of osteoclast fusion, size and activation.
Davies BK, Skelton AJ, Hopkinson M, Lumb S, Holdsworth G, Arnett TR, Orriss IR
Bone 2025 Jun;195:117466
Bone 2025 Jun;195:117466
Single-cell analysis links DCUN1D5 to immune remodeling and cisplatin resistance in recurrent osteosarcoma.
Wu X, Deng W, Zhao Q, Xiong J
Communications biology 2025 Jul 8;8(1):1019
Communications biology 2025 Jul 8;8(1):1019
CD8a + GZMK + T Cells Inhibit Osteoclastogenesis in Postmenopausal Osteoporosis via the p38-MAPK Pathway.
He X, Wang J, Liu M, Jiang Z, Yuan H
Calcified tissue international 2025 Jul 7;116(1):95
Calcified tissue international 2025 Jul 7;116(1):95
Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation.
Zhen C, Wang S, Yang J, Zhang G, Cai C, Wang J, Wang A, Xu Y, Fang Y, Wei M, Yin D, Luo X, Gong M, Zhang H, Shang P
Journal of orthopaedic translation 2025 Jan;50:144-157
Journal of orthopaedic translation 2025 Jan;50:144-157
Porphyromonas gingivalis LPS-stimulated BMSC-derived exosome promotes osteoclastogenesis via miR-151-3p/PAFAH1B1.
Dong JC, Liao Y, Zhou W, Sun MJ, Zhang HY, Li Y, Song ZC
Oral diseases 2025 Jan;31(1):206-216
Oral diseases 2025 Jan;31(1):206-216
The therapeutic potential of Osmundacetone for rheumatoid arthritis: Effects and mechanisms on osteoclastogenesis.
Wang Z, Liu Y, Feng C, Li T, Xu H, Ding Y, Liu W, Pu L, Li R, Ai C, Chen Z, Wang X
European journal of pharmacology 2025 Jan 15;987:177135
European journal of pharmacology 2025 Jan 15;987:177135
Fraxin inhibits ovariectomized-induced bone loss and osteoclastogenesis by suppressing ROS activity.
Zhou H, Chen P, Zhao C, Zou S, Wu H, Huang C, Hu H, Wu Q, Zhang C, Weng W
International immunopharmacology 2025 Feb 6;147:113871
International immunopharmacology 2025 Feb 6;147:113871
Divergent Requirements for Glutathione Biosynthesis During Osteoclast Differentiation In Vitro and In Vivo.
Hu G, Whitaker AL, Zhang GF, Karner CM
Antioxidants (Basel, Switzerland) 2025 Feb 10;14(2)
Antioxidants (Basel, Switzerland) 2025 Feb 10;14(2)
Mapping cell diversity and dynamics in inflammatory temporomandibular joint osteoarthritis with pain at single-cell resolution.
Jariyasakulroj S, Shu Y, Lin Z, Chen J, Chang Q, Ko PF, Chen JF
JCI insight 2025 Feb 10;10(3)
JCI insight 2025 Feb 10;10(3)
Hyperhomocysteinaemia aggravates periodontitis by suppressing the Nrf2/HO-1 signalling pathway.
Yang K, Yang Y, Long T, Wang X, Chen Y, He C, Li L, Yang X, Jiang M, Hu Y, Dai F, Song L
Redox report : communications in free radical research 2025 Dec;30(1):2475691
Redox report : communications in free radical research 2025 Dec;30(1):2475691
Interaction Between Activating Transcription Factor 4 and Interleukin 6 Dictates Osteoclast Differentiation and Activity.
Tu S, Liu S, Duan M, Li J, Zhang L, Ren J, Zhao T, Xie J, Liu X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71372
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71372
Sofalcone inhibits osteoclastogenesis through Keap1/Nrf2 signaling activation and mitigates ovariectomy-induced bone loss.
Liang H, Wu Q, Hua T, Chen Y, Luo J, Miao J, Su H, Yang S, Xu J, Wang X, Jin H
International immunopharmacology 2025 Dec 3;166:115589
International immunopharmacology 2025 Dec 3;166:115589
CTSK as a Collagen Degradation Marker Induces Gingival Recession During High-Force Orthodontic Tooth Movement.
Wang Y, Xu Y, Lu Y, Su X, Lei Y
International dental journal 2025 Aug;75(4):100810
International dental journal 2025 Aug;75(4):100810
Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity.
Suzuki N, Kuroda K, Ikegame M, Takino H, Tsunoda K, Izumi R, Tabuchi Y, Furusawa Y, Yachiguchi K, Endo M, Matsubara H, Yano S, Shimazu T, Honda M, Maruyama Y, Watanabe K, Takahashi A, Hirayama J, Hattori A
Life sciences in space research 2025 Aug;46:128-136
Life sciences in space research 2025 Aug;46:128-136
CD81(+) senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis.
Fu L, Yin C, Zhao Q, Guo S, Shao W, Xia T, Sun Q, Chen L, Li J, Wang M, Xia H
eLife 2025 Aug 13;13
eLife 2025 Aug 13;13
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway.
Song C, Yan Q, Ma Y, Li P, Yang Y, Wang Y, Li W, Wan X, Li Y, Zhu R, Liu H, Zhang Z
Drug design, development and therapy 2024;18:6359-6377
Drug design, development and therapy 2024;18:6359-6377
CHD7 regulates craniofacial cartilage development via controlling HTR2B expression.
Breuer M, Rummler M, Singh J, Maher S, Zaouter C, Jamadagni P, Pilon N, Willie BM, Patten SA
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 May 2;39(4):498-512
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 May 2;39(4):498-512
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis.
Zhao Y, Ning J, Teng H, Deng Y, Sheldon M, Shi L, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L
Nature communications 2024 Mar 16;15(1):2384
Nature communications 2024 Mar 16;15(1):2384
A Synthetic Small Molecule, LGM2605: A Promising Modulator of Increased Pro-Inflammatory Cytokine and Osteoclast Differentiation by Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin.
Kim TJ, MacElroy AS, Defreitas A, Shenker BJ, Boesze-Battaglia K
Dentistry journal 2024 Jun 26;12(7)
Dentistry journal 2024 Jun 26;12(7)
MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo.
Liu H, Chang Z, Liu S, Zhu R, Ma J, Lu X, Li L, Zhang Z
Heliyon 2024 Jan 15;10(1):e24241
Heliyon 2024 Jan 15;10(1):e24241
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Wu DZ, Zhu GZ, Zhao K, Gao JW, Cai GX, Li HZ, Huang YS, Tu C, Zhuang JS, Huang ZW, Zhong ZM
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
Liu Y, Li TQ, Bai J, Liu WL, Wang ZR, Feng C, Pu LL, Wang XX, Liu H
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166977
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166977
Three Birds, One Stone: An Osteo-Microenvironment Stage-Regulative Scaffold for Bone Defect Repair through Modulating Early Osteo-Immunomodulation, Middle Neovascularization, and Later Osteogenesis.
Yuan Y, Xu Y, Mao Y, Liu H, Ou M, Lin Z, Zhao R, Long H, Cheng L, Sun B, Zhao S, Zeng M, Lu B, Lu H, Zhu Y, Chen C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2306428
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2306428
Nel-like Molecule Type 1 Combined with Gold Nanoparticles Modulates Macrophage Polarization, Osteoclastogenesis, and Oral Microbiota in Periodontitis.
Liao W, Ni C, Ge R, Li Y, Jiang S, Yang W, Yan F
ACS applied materials & interfaces 2024 Feb 21;16(7):8442-8458
ACS applied materials & interfaces 2024 Feb 21;16(7):8442-8458
Outer Membrane Vesicles Derived From Fusobacterium nucleatum Trigger Periodontitis Through Host Overimmunity.
Zhang L, Zhang D, Liu C, Tang B, Cui Y, Guo D, Duan M, Tu Y, Zheng H, Ning X, Liu Y, Chen H, Huang M, Niu Z, Zhao Y, Liu X, Xie J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2400882
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2400882
A 0.2 T-0.4 T Static Magnetic Field Improves the Bone Quality of Mice Subjected to Hindlimb Unloading and Reloading Through the Dual Regulation of BMSCs via Iron Metabolism.
Wang J, Zhen C, Zhang G, Yang Z, Shang P
International journal of molecular sciences 2024 Dec 6;25(23)
International journal of molecular sciences 2024 Dec 6;25(23)
Bone-protective effects of neutralizing angiopoietin-like protein 4 monoclonal antibody in rheumatoid arthritis.
Ke L, He Q, Qu J, Wang X, Li K, Gong X, Li L, Xu J, Yu Q, Yu H, Lin X, Li J, Tan NS, Sun W, Li L, Zhang P, Cheng W
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4497-4513
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Dec 4;32(12):4497-4513
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis.
Ruan B, Dong J, Wei F, Huang Z, Yang B, Zhang L, Li C, Dong H, Cao W, Wang H, Wang Y
Bone research 2024 Dec 2;12(1):68
Bone research 2024 Dec 2;12(1):68
Cathepsin B Nuclear Flux in a DNA-Guided "Antinuclear Missile" Cancer Therapy.
Cao F, Tang C, Chen X, Tu Z, Jin Y, Turk OM, Nishimura RN, Ebens A, Dubljevic V, Campbell JA, Zhou J, Hansen JE
ACS central science 2024 Aug 28;10(8):1562-1572
ACS central science 2024 Aug 28;10(8):1562-1572
Toll-like receptor 4 deficiency affects the balance of osteoclastogenesis and osteoblastogenesis in periodontitis.
Pan L, She H, Hu Y, Liu L, Wang H, Zhu L
International immunopharmacology 2024 Aug 20;137:112500
International immunopharmacology 2024 Aug 20;137:112500
Yunnan Baiyao Inhibits Periodontitis by Suppressing the Autophagic Flux.
Li Y, Liu W, Zhao R, An Y, Zhang M, Ren X, He H
International dental journal 2024 Apr;74(2):284-293
International dental journal 2024 Apr;74(2):284-293
A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration.
Hao Z, Feng Q, Wang Y, Wang Y, Li H, Hu Y, Chen T, Wang J, Chen R, Lv X, Yang Z, Chen J, Guo X, Li J
Bioactive materials 2024 Apr;34:181-203
Bioactive materials 2024 Apr;34:181-203
S-nitrosoglutathione reductase-dependent p65 denitrosation promotes osteoclastogenesis by facilitating recruitment of p65 to NFATc1 promoter.
Liu S, Lu Q, Wang M, Guo H, Wang Y, Nong J, Wang S, Xia H, Xia T, Sun H
Bone 2024 Apr;181:117036
Bone 2024 Apr;181:117036
Isopsoralen suppresses receptor activator of nuclear factor kappa-β ligand-induced osteoclastogenesis by inhibiting the NF-κB signaling.
Zhan W, Ruan B, Dong H, Wang C, Wu S, Yu H, Xu X, Sun H, Cai J
PeerJ 2023;11:e14560
PeerJ 2023;11:e14560
The genetic background determines material-induced bone formation through the macrophage-osteoclast axis.
Li M, Li D, Jiang Y, He P, Li Y, Wu Y, Lei W, de Bruijn JD, Cannon RD, Mei L, Zhang H, Ji P, Zhang H, Yuan H
Biomaterials 2023 Nov;302:122356
Biomaterials 2023 Nov;302:122356
Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts.
Bourne LE, Davies BK, Millan JL, Arnett TR, Wheeler-Jones CPD, Keen JAC, Roberts SJ, Orriss IR
Bone 2023 Nov;176:116868
Bone 2023 Nov;176:116868
Hypoxia Drives Material-Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid-Loaded Macrophage Axis.
Li D, Jiang Y, He P, Li Y, Wu Y, Lei W, Liu N, de Bruijn JD, Zhang H, Zhang H, Ji P, Yuan H, Li M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(15):e2207224
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(15):e2207224
Effect of mitophagy in the formation of osteomorphs derived from osteoclasts.
Huang T, Wang Y, Yu Z, Miao X, Jiang Z, Yu K, Fu M, Lai K, Wang Y, Yang G
iScience 2023 May 19;26(5):106682
iScience 2023 May 19;26(5):106682
Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis.
Zhao Y, Teng H, Deng Y, Sheldon M, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L
Research square 2023 Mar 20;
Research square 2023 Mar 20;
Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.
Zhang C, Liu Z, Wang X, Zhang B, Cui L, Hu Q, Hu B, Cao K, Shan W, Shi H, Wang R
iScience 2023 Jun 16;26(6):106852
iScience 2023 Jun 16;26(6):106852
The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing.
Liu Q, Yu M, Liao M, Ran Z, Tang X, Hu J, Su B, Fu G, Wu Q
Journal of molecular histology 2023 Dec;54(6):689-702
Journal of molecular histology 2023 Dec;54(6):689-702
Single-cell multi-omics analysis of human testicular germ cell tumor reveals its molecular features and microenvironment.
Lu X, Luo Y, Nie X, Zhang B, Wang X, Li R, Liu G, Zhou Q, Liu Z, Fan L, Hotaling JM, Zhang Z, Bo H, Guo J
Nature communications 2023 Dec 20;14(1):8462
Nature communications 2023 Dec 20;14(1):8462
Babam2 negatively regulates osteoclastogenesis by interacting with Hey1 to inhibit Nfatc1 transcription.
Jin F, Zhu Y, Liu M, Wang R, Cui Y, Wu Y, Liu G, Wang Y, Wang X, Ren Z
International journal of biological sciences 2022;18(11):4482-4496
International journal of biological sciences 2022;18(11):4482-4496
The Dibenzyl Isoquinoline Alkaloid Berbamine Ameliorates Osteoporosis by Inhibiting Bone Resorption.
Zhang C, Zhong Z, Sang W, Ghorbani F, Ghalandari B, Mohamadali M, Irani S, Qian Z, Yi C, Yu B
Frontiers in endocrinology 2022;13:885507
Frontiers in endocrinology 2022;13:885507
Extracellular Vesicles Derived From Murine Cementoblasts Possess the Potential to Increase Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclastogenesis.
Sato R, Maruyama K, Nemoto E, Sakisaka Y, Suzuki S, Li J, Numazaki K, Tada H, Yamada S
Frontiers in physiology 2022;13:825596
Frontiers in physiology 2022;13:825596
Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption.
Li M, Yang D, Yan H, Tang Z, Jiang D, Zhang J, Chi Z, Nie W, Zhen W, Yu W, Chen S, Wang Z, Yu Q, Zhang X, Yang F, Fan S, Lin X, Wang D
Developmental cell 2022 Oct 24;57(20):2365-2380.e8
Developmental cell 2022 Oct 24;57(20):2365-2380.e8
Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase : a novel approach in the prevention of osteoclastogenesis.
Zhang Y, Jiang B, Zhang P, Chiu SK, Lee MH
Bone & joint research 2022 Nov;11(11):763-776
Bone & joint research 2022 Nov;11(11):763-776
Effects of urolithin A on osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand via bone morphogenic protein 2.
Wang Z, Qi G, Li Z, Cui X, Guo S, Zhang Y, Cai P, Wang X
Bioengineered 2022 Mar;13(3):5064-5078
Bioengineered 2022 Mar;13(3):5064-5078
Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice.
Selma J, Song H, Rivera C, Douglas S, Akella A, Bollavaram K, Thompson N, Platt MO, Botchwey EA
Blood advances 2022 Mar 8;6(5):1381-1393
Blood advances 2022 Mar 8;6(5):1381-1393
Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles.
Wu YL, Zhang CH, Teng Y, Pan Y, Liu NC, Liu PX, Zhu X, Su XL, Lin J
Military Medical Research 2022 Aug 23;9(1):46
Military Medical Research 2022 Aug 23;9(1):46
Farnesoid X receptor agonist attenuates subchondral bone osteoclast fusion and osteochondral pathologies of osteoarthritis via suppressing JNK1/2/NFATc1 pathway.
Hu W, Cai C, Li Y, Kang F, Chu T, Dong S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Apr;36(4):e22243
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Apr;36(4):e22243
BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.
Cai C, Hu W, Zhang Y, Hu X, Yang S, Qiu H, Wang R, Ma M, Qiu Y, Chu T
Frontiers in pharmacology 2021;12:772540
Frontiers in pharmacology 2021;12:772540
Mechanical loading attenuates breast cancer-associated bone metastasis in obese mice by regulating the bone marrow microenvironment.
Huang M, Liu H, Zhu L, Li X, Li J, Yang S, Liu D, Song X, Yokota H, Zhang P
Journal of cellular physiology 2021 Sep;236(9):6391-6406
Journal of cellular physiology 2021 Sep;236(9):6391-6406
Andrographolide prevents bone loss via targeting estrogen-related receptor-α-regulated metabolic adaption of osteoclastogenesis.
Huang T, Fu X, Wang N, Yang M, Zhang M, Wang B, Chen T, Majaz S, Wang H, Wong CW, Liu J, Guan M
British journal of pharmacology 2021 Nov;178(21):4352-4367
British journal of pharmacology 2021 Nov;178(21):4352-4367
Interleukin-1 induces receptor activator of nuclear factor-κB ligand-independent osteoclast differentiation in RAW264.7 cells.
Liao R, Feng Z, Li W, Liu R, Xu X, Yao S, Tian J
Experimental and therapeutic medicine 2021 Jun;21(6):640
Experimental and therapeutic medicine 2021 Jun;21(6):640
BMP2 immune complexes promote new bone formation by facilitating the direct contact between osteoclasts and osteoblasts.
Xu Y, Yang Y, Hua Z, Li S, Yang Z, Liu Q, Fu G, Ji P, Wu Q
Biomaterials 2021 Aug;275:120890
Biomaterials 2021 Aug;275:120890
4-Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF-κB signaling pathway and reverses bone loss in ovariectomized mice.
Yi W, Liu T, Gao X, Xie Y, Liu M
Experimental and therapeutic medicine 2021 Apr;21(4):354
Experimental and therapeutic medicine 2021 Apr;21(4):354
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Qi D, Liu H, Sun X, Luo D, Zhu M, Tao T, Gao C, Zhou C, Zhou W, Xiao J
Frontiers in pharmacology 2020;11:621110
Frontiers in pharmacology 2020;11:621110
Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis.
Qian Z, Zhong Z, Ni S, Li D, Zhang F, Zhou Y, Kang Z, Qian J, Yu B
Journal of cellular and molecular medicine 2020 Sep;24(17):10112-10127
Journal of cellular and molecular medicine 2020 Sep;24(17):10112-10127
Schisandrin A restrains osteoclastogenesis by inhibiting reactive oxygen species and activating Nrf2 signalling.
Ni S, Qian Z, Yuan Y, Li D, Zhong Z, Ghorbani F, Zhang X, Zhang F, Zhang Z, Liu Z, Yu B
Cell proliferation 2020 Oct;53(10):e12882
Cell proliferation 2020 Oct;53(10):e12882
PERK controls bone homeostasis through the regulation of osteoclast differentiation and function.
Guo J, Ren R, Sun K, Yao X, Lin J, Wang G, Guo Z, Xu T, Guo F
Cell death & disease 2020 Oct 13;11(10):847
Cell death & disease 2020 Oct 13;11(10):847
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
Zhu M, Liu H, Sun K, Liu J, Mou Y, Qi D, Zhou C, Abudunaibi M, Tasiken B, Li J, Cheng H, Huang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
Circadian control of the secretory pathway maintains collagen homeostasis.
Chang J, Garva R, Pickard A, Yeung CC, Mallikarjun V, Swift J, Holmes DF, Calverley B, Lu Y, Adamson A, Raymond-Hayling H, Jensen O, Shearer T, Meng QJ, Kadler KE
Nature cell biology 2020 Jan;22(1):74-86
Nature cell biology 2020 Jan;22(1):74-86
Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway.
Ma C, Geng B, Zhang X, Li R, Yang X, Xia Y
Medical science monitor : international medical journal of experimental and clinical research 2020 Jan 8;26:e918370
Medical science monitor : international medical journal of experimental and clinical research 2020 Jan 8;26:e918370
Cysteine cathepsins are altered by flow within an engineered in vitro microvascular niche.
Douglas SA, Haase K, Kamm RD, Platt MO
APL bioengineering 2020 Dec;4(4):046102
APL bioengineering 2020 Dec;4(4):046102
ClC-7 Regulates the Pattern and Early Development of Craniofacial Bone and Tooth.
Zhang Y, Ji D, Li L, Yang S, Zhang H, Duan X
Theranostics 2019;9(5):1387-1400
Theranostics 2019;9(5):1387-1400
Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis.
Zhong Z, Qian Z, Zhang X, Chen F, Ni S, Kang Z, Zhang F, Li D, Yu B
Frontiers in pharmacology 2019;10:1530
Frontiers in pharmacology 2019;10:1530
Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis.
Dong L, Wu J, Chen K, Xie J, Wang Y, Li D, Liu Y, Yin A, Zhao Y, Han Y, Zhou J, Zhang L, Chen Z, Zuo D
Frontiers in immunology 2019;10:1239
Frontiers in immunology 2019;10:1239
miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN/PI3K/AKT/FoxO1 pathway.
Lou Z, Peng Z, Wang B, Li X, Li X, Zhang X
Journal of bone and mineral metabolism 2019 Sep;37(5):815-824
Journal of bone and mineral metabolism 2019 Sep;37(5):815-824
Ankle loading ameliorates bone loss from breast cancer-associated bone metastasis.
Yang S, Liu H, Zhu L, Li X, Liu D, Song X, Yokota H, Zhang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Oct;33(10):10742-10752
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Oct;33(10):10742-10752
Treadmill Running in Established Phase Arthritis Inhibits Joint Destruction in Rat Rheumatoid Arthritis Models.
Fujii Y, Inoue H, Arai Y, Shimomura S, Nakagawa S, Kishida T, Tsuchida S, Kamada Y, Kaihara K, Shirai T, Terauchi R, Toyama S, Ikoma K, Mazda O, Mikami Y
International journal of molecular sciences 2019 Oct 15;20(20)
International journal of molecular sciences 2019 Oct 15;20(20)
Low‑frequency pulsed electromagnetic field inhibits RANKL‑induced osteoclastic differentiation in RAW264.7 cells by scavenging reactive oxygen species.
Pi Y, Liang H, Yu Q, Yin Y, Xu H, Lei Y, Han Z, Tian J
Molecular medicine reports 2019 May;19(5):4129-4136
Molecular medicine reports 2019 May;19(5):4129-4136
Silencing of Aberrant Secretory Protein Expression by Disease-Associated Mutations.
Tikhonova EB, Karamysheva ZN, von Heijne G, Karamyshev AL
Journal of molecular biology 2019 Jun 28;431(14):2567-2580
Journal of molecular biology 2019 Jun 28;431(14):2567-2580
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, Zhu M, Zhao L, Liu C, Guo F, Xiao J, Huang H
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis.
Parks AN, Nahata J, Edouard NE, Temenoff JS, Platt MO
Scientific reports 2019 Apr 1;9(1):5399
Scientific reports 2019 Apr 1;9(1):5399
Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo.
Cai C, Liu C, Zhao L, Liu H, Li W, Guan H, Zhao L, Xiao J
Frontiers in pharmacology 2018;9:1286
Frontiers in pharmacology 2018;9:1286
Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice.
Sui X, Deng S, Liu M, Fan L, Wang Y, Xu H, Sun Y, Kishen A, Zhang Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):2091-2102
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):2091-2102
Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity.
Xu R, Shi G, Xu L, Gu Q, Fu Y, Zhang P, Cheng J, Jiang H
Journal of tissue engineering and regenerative medicine 2018 May;12(5):1209-1219
Journal of tissue engineering and regenerative medicine 2018 May;12(5):1209-1219
YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism.
Zhao L, Guan H, Song C, Wang Y, Liu C, Cai C, Zhu H, Liu H, Zhao L, Xiao J
Bone 2018 May;110:177-186
Bone 2018 May;110:177-186
SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.
Sun JX, Chang TF, Li MH, Sun LJ, Yan XC, Yang ZY, Liu Y, Xu WQ, Lv Y, Su JB, Liang L, Han H, Dou GR, Wang YS
Angiogenesis 2018 Aug;21(3):635-652
Angiogenesis 2018 Aug;21(3):635-652
Pulsed electromagnetic field inhibits RANKL-dependent osteoclastic differentiation in RAW264.7 cells through the Ca(2+)-calcineurin-NFATc1 signaling pathway.
Zhang J, Xu H, Han Z, Chen P, Yu Q, Lei Y, Li Z, Zhao M, Tian J
Biochemical and biophysical research communications 2017 Jan 8;482(2):289-295
Biochemical and biophysical research communications 2017 Jan 8;482(2):289-295
Cathepsin K in Lymphangioleiomyomatosis: LAM Cell-Fibroblast Interactions Enhance Protease Activity by Extracellular Acidification.
Dongre A, Clements D, Fisher AJ, Johnson SR
The American journal of pathology 2017 Aug;187(8):1750-1762
The American journal of pathology 2017 Aug;187(8):1750-1762
Role of endoplasmic reticulum stress in disuse osteoporosis.
Li J, Yang S, Li X, Liu D, Wang Z, Guo J, Tan N, Gao Z, Zhao X, Zhang J, Gou F, Yokota H, Zhang P
Bone 2017 Apr;97:2-14
Bone 2017 Apr;97:2-14
Increased expression and activation of cathepsin K in human osteoarthritic cartilage and synovial tissues.
Kozawa E, Cheng XW, Urakawa H, Arai E, Yamada Y, Kitamura S, Sato K, Kuzuya M, Ishiguro N, Nishida Y
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016 Jan;34(1):127-34
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016 Jan;34(1):127-34
Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.
Sun T, Jiang D, Zhang L, Su Q, Mao W, Jiang C
Oncology letters 2016 Jan;11(1):575-583
Oncology letters 2016 Jan;11(1):575-583
Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity.
Haque M, Song J, Fino K, Sandhu P, Song X, Lei F, Zheng S, Ni B, Fang D, Song J
Scientific reports 2016 Feb 5;6:20588
Scientific reports 2016 Feb 5;6:20588
Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis.
Li X, Yang J, Liu D, Li J, Niu K, Feng S, Yokota H, Zhang P
Scientific reports 2016 Apr 18;6:24668
Scientific reports 2016 Apr 18;6:24668
Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations.
Xue Y, Wang L, Xia D, Li Q, Gao S, Dong M, Cai T, Shi S, He L, Hu K, Mao T, Duan X
Journal of dental research 2015 May;94(5):674-81
Journal of dental research 2015 May;94(5):674-81
Bone histomorphometry in a long-term hemodialysis patient with hypoparathyroidism and sarcoidosis.
Sumida K, Ubara Y, Hoshino J, Hayami N, Suwabe T, Hiramatsu R, Hasegawa E, Yamanouchi M, Sawa N, Fujii T, Takaichi K
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2015 Apr;26(4):1435-41
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2015 Apr;26(4):1435-41
Lentiviral small hairpin RNA knockdown of macrophage inflammatory protein-1γ ameliorates experimentally induced osteoarthritis in mice.
Shen PC, Lu CS, Shiau AL, Lee CH, Jou IM, Hsieh JL
Human gene therapy 2013 Oct;24(10):871-82
Human gene therapy 2013 Oct;24(10):871-82
Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts.
Hirabara S, Kojima T, Takahashi N, Hanabayashi M, Ishiguro N
Biochemical and biophysical research communications 2013 Jan 11;430(2):519-22
Biochemical and biophysical research communications 2013 Jan 11;430(2):519-22
Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis.
Kozawa E, Nishida Y, Cheng XW, Urakawa H, Arai E, Futamura N, Shi GP, Kuzuya M, Hu L, Sasaki T, Ishiguro N
Arthritis and rheumatism 2012 Feb;64(2):454-64
Arthritis and rheumatism 2012 Feb;64(2):454-64
Cholesteatoma growth and proliferation: relevance with serpin B3.
Ho KY, Huang HH, Hung KF, Chen JC, Chai CY, Chen WT, Tsai SM, Chien CY, Wang HM, Wu YJ
The Laryngoscope 2012 Dec;122(12):2818-23
The Laryngoscope 2012 Dec;122(12):2818-23
Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts.
Zhang D, Huang C, Yang C, Liu RJ, Wang J, Niu J, Brömme D
Respiratory research 2011 Nov 29;12(1):154
Respiratory research 2011 Nov 29;12(1):154
Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice.
MacLellan LM, Montgomery J, Sugiyama F, Kitson SM, Thümmler K, Silverman GJ, Beers SA, Nibbs RJ, McInnes IB, Goodyear CS
Arthritis and rheumatism 2011 Dec;63(12):3897-907
Arthritis and rheumatism 2011 Dec;63(12):3897-907
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- ROS1728 cells were subjected to SDS PAGE followed by western blot with 11239-1-AP( CTSK Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Cathepsin K antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Cathepsin K. This antibody recognizes human, mouse, rat antigen. The Cathepsin K antibody has been validated for the following applications: ELISA, IHC, WB analysis.
