12855-1-AP

antibody from Proteintech Group

Targeting: GLS GLS1, KIAA0838

Provider product page for 12855-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [95]
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Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [1]

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Product number: 12855-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12855-1-AP, RRID:AB_2110381
Product name: KGA/GAC antibody
Antibody type: Polyclonal
Description: KD/KO validated KGA/GAC antibody (Cat. #12855-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GLS protein structure - 12855-1-AP shown in red.

Submitted references AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.

Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC
Cell research 2024 Oct;34(10):683-706

Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.

Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9

Augmented drug resistance of osteosarcoma cells within decalcified bone matrix scaffold: The role of glutamine metabolism.

Ren J, Zhao C, Sun R, Sun J, Lu L, Wu J, Li S, Cui L
International journal of cancer 2024 May 1;154(9):1626-1638

Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer.

Han X, Wang D, Yang L, Wang N, Shen J, Wang J, Zhang L, Chen L, Gao S, Zong WX, Wang Y
Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 26;121(13):e2319429121

ERK5 Interacts with Mitochondrial Glutaminase and Regulates Its Expression.

Guillén-Pérez YM, Ortiz-Ruiz MJ, Márquez J, Pandiella A, Esparís-Ogando A
International journal of molecular sciences 2024 Mar 14;25(6)

Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice.

Takahashi K, Kurokawa K, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M
Neuroscience letters 2024 Mar 10;825:137711

Removal of gemcitabine-induced senescent cancer cells by targeting glutaminase1 improves the therapeutic effect in pancreatic ductal adenocarcinoma.

Oyama K, Iwagami Y, Kobayashi S, Sasaki K, Yamada D, Tomimaru Y, Noda T, Asaoka T, Takahashi H, Tanemura M, Doki Y, Eguchi H
International journal of cancer 2024 Mar 1;154(5):912-925

ABCG2 and SLC1A5 functionally interact to rewire metabolism and confer a survival advantage to cancer cells under oxidative stress.

Shi J, Pabon K, Ding R, Scotto KW
The Journal of biological chemistry 2024 Jun;300(6):107299

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival.

Goswami MT, Weh E, Subramanya S, Weh KM, Durumutla HB, Hager H, Miller N, Chaudhury S, Andren A, Sajjakulnukit P, Zhang L, Besirli CG, Lyssiotis CA, Wubben TJ
bioRxiv : the preprint server for biology 2024 Jul 1;

Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells.

Bian Y, Yin G, Wang G, Liu T, Liang L, Yang X, Zhang W, Tang D
Cell biology and toxicology 2023 Oct;39(5):1957-1978

Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism.

Gan PXL, Liao W, Lim HF, Wong WSF
Pharmacological research 2023 Oct;196:106929

Mitochondrial transplantation ameliorates doxorubicin-induced cardiac dysfunction via activating glutamine metabolism.

Sun X, Chen H, Gao R, Huang Y, Qu Y, Yang H, Wei X, Hu S, Zhang J, Wang P, Zou Y, Hu K, Ge J, Sun A
iScience 2023 Oct 20;26(10):107790

Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage.

Tang L, Xu XH, Xu S, Liu Z, He Q, Li W, Sun J, Shuai W, Mao J, Zhao JY, Jin L
Cell reports. Medicine 2023 May 16;4(5):101026

Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis.

Park G, Haley JA, Le J, Jung SM, Fitzgibbons TP, Korobkina ED, Li H, Fluharty SM, Chen Q, Spinelli JB, Trivedi CM, Jang C, Guertin DA
Nature metabolism 2023 Jul;5(7):1204-1220

Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis.

Xiang Z, Bai L, Zhou JQ, Cevallos RR, Sanders JR, Liu G, Bernard K, Sanders YY
Molecular metabolism 2023 Jan;67:101655

Regulation of the Volume-Regulated Anion Channel Pore-Forming Subunit LRRC8A in the Intrahippocampal Kainic Acid Model of Mesial Temporal Lobe Epilepsy.

Ghouli MR, Jonak CR, Sah R, Fiacco TA, Binder DK
ASN neuro 2023 Jan-Dec;15:17590914231184072

MicroRNA-376b-3p Suppresses Choroidal Neovascularization by Regulating Glutaminolysis in Endothelial Cells.

Feng Y, Wang L, Dong C, Yang X, Wang J, Zhang X, Yuan Y, Dai J, Huang J, Yuan F
Investigative ophthalmology & visual science 2023 Jan 3;64(1):22

Exploiting metabolic vulnerabilities after anti-VEGF antibody therapy in ovarian cancer.

Glassman D, Kim MS, Spradlin M, Badal S, Taki M, Bhattacharya P, Dutta P, Kingsley CV, Foster KI, Animasahun O, Jeon JH, Achreja A, Jayaraman A, Kumar P, Nenwani M, Wuchu F, Bayraktar E, Wu Y, Stur E, Mangala L, Lee S, Yap TA, Westin SN, Eberlin LS, Nagrath D, Sood AK
iScience 2023 Feb 17;26(2):106020

Norovirus NS1/2 protein increases glutaminolysis for efficient viral replication.

Hafner A, Meurs N, Garner A, Azar E, Passalacqua KD, Nagrath D, Wobus CE
bioRxiv : the preprint server for biology 2023 Dec 19;

Caveolin-1 and Its Functional Peptide CSP7 Affect Silica-Induced Pulmonary Fibrosis by Regulating Fibroblast Glutaminolysis.

Li G, Xu Q, Cheng D, Sun W, Liu Y, Ma D, Wang Y, Zhou S, Ni C
Toxicological sciences : an official journal of the Society of Toxicology 2022 Oct 27;190(1):41-53

The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro.

Holzknecht M, Guerrero-Navarro L, Petit M, Albertini E, Damisch E, Simonini A, Schmitt F, Parson W, Fiegl H, Weiss A, Jansen-Duerr P
FEBS letters 2022 Nov;596(21):2781-2794

c-Abl tyrosine kinase inhibition attenuate oxidative stress-induced pancreatic β-Cell dysfunction via glutathione antioxidant system.

Karunakaran U, Elumalai S, Moon JS, Won KC
Translational research : the journal of laboratory and clinical medicine 2022 Nov;249:74-87

Inhibition of glutaminolysis ameliorates lupus by regulating T and B cell subsets and downregulating the mTOR/P70S6K/4EBP1 and NLRP3/caspase-1/IL-1β pathways in MRL/lpr mice.

Zhang X, Wang G, Bi Y, Jiang Z, Wang X
International immunopharmacology 2022 Nov;112:109133

Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells.

Choudhury D, Rong N, Ikhapoh I, Rajabian N, Tseropoulos G, Wu Y, Mehrotra P, Thiyagarajan R, Shahini A, Seldeen KL, Troen BR, Lei P, Andreadis ST
Cell reports 2022 Nov 29;41(9):111744

Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment.

Sponagel J, Jones JK, Frankfater C, Zhang S, Tung O, Cho K, Tinkum KL, Gass H, Nunez E, Spitz DR, Chinnaiyan P, Schaefer J, Patti GJ, Graham MS, Mauguen A, Grkovski M, Dunphy MP, Krebs S, Luo J, Rubin JB, Ippolito JE
Med (New York, N.Y.) 2022 Nov 11;3(11):792-811.e12

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690

Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma.

Zhang T, Cui Y, Wu Y, Meng J, Han L, Zhang J, Zhang C, Yang C, Chen L, Bai X, Zhang K, Wu K, Sack MN, Wang L, Zhu L
Clinical and translational medicine 2022 May;12(5):e852

Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer's disease.

Morrone CD, Lai AY, Bishay J, Hill ME, McLaurin J
Translational neurodegeneration 2022 May 3;11(1):26

Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling.

Yoshikawa S, Nagao M, Toh R, Shinohara M, Iino T, Irino Y, Nishimori M, Tanaka H, Satomi-Kobayashi S, Ishida T, Hirata KI
American journal of physiology. Heart and circulatory physiology 2022 May 1;322(5):H749-H761

Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.

Miao Y, Geng Y, Yang L, Zheng Y, Dai Y, Wei Z
The Journal of nutritional biochemistry 2022 Mar;101:108923

Loss of vascular endothelial glutaminase inhibits tumor growth and metastasis, and increases sensitivity to chemotherapy.

Ngwa VM, Edwards DN, Hwang Y, Karno B, Wang X, Yan C, Richmond A, Brantley-Sieders DM, Chen J
Cancer research communications 2022 Jul;2(7):694-705

The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells.

Fu X, Li K, Niu Y, Lin Q, Liang H, Luo X, Liu L, Li N
Microbiology spectrum 2022 Feb 23;10(1):e0231021

Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis.

Yang L, Zheng Y, Miao YM, Yan WX, Geng YZ, Dai Y, Wei ZF
Acta pharmacologica Sinica 2022 Apr;43(4):963-976

Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells.

Ye C, Liu S, Li N, Zuo S, Niu Y, Lin Q, Liang H, Luo X, Fu X
Microbiology spectrum 2022 Apr 27;10(2):e0272721

Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.

Karunakaran U, Elumalai S, Moon JS, Won KC
Redox biology 2021 Sep;45:102029

Andrographolide prevents bone loss via targeting estrogen-related receptor-α-regulated metabolic adaption of osteoclastogenesis.

Huang T, Fu X, Wang N, Yang M, Zhang M, Wang B, Chen T, Majaz S, Wang H, Wong CW, Liu J, Guan M
British journal of pharmacology 2021 Nov;178(21):4352-4367

Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.

Sulistomo HW, Nemoto T, Kage Y, Fujii H, Uchida T, Takamiya K, Sumimoto H, Kataoka H, Bito H, Takeya R
Cerebral cortex (New York, N.Y. : 1991) 2021 Mar 5;31(4):2205-2219

Maternal high sugar and fat diet benefits offspring brain function via targeting on the gut-brain axis.

Wang D, Zhang H, Zeng M, Tang X, Zhu X, Guo Y, Qi L, Xie Y, Zhang M, Chen D
Aging 2021 Mar 26;13(7):10240-10274

A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.

Wu X, Sheng H, Wang L, Xia P, Wang Y, Yu L, Lv W, Hu J
Aging 2021 Mar 26;13(7):10034-10057

Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure.

Jones B, Balasubramaniam M, Lebowitz JJ, Taylor A, Villalta F, Khoshbouei H, Grueter C, Grueter B, Dash C, Pandhare J
Scientific reports 2021 Jan 14;11(1):1422

Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase.

Beręsewicz-Haller M, Krupska O, Bochomulski P, Dudzik D, Chęcińska A, Hilgier W, Barbas C, Zablocki K, Zablocka B
International journal of molecular sciences 2021 Aug 7;22(16)

Compound 968 reverses adriamycin resistance in breast cancer MCF-7(ADR) cells via inhibiting P-glycoprotein function independently of glutaminase.

Yang R, Guo Z, Zhao Y, Ma L, Li B, Yang C
Cell death discovery 2021 Aug 5;7(1):204

Brain network reorganization after targeted attack at a hub region.

Tu W, Ma Z, Zhang N
NeuroImage 2021 Aug 15;237:118219

Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.

Ruiz-Rodado V, Lita A, Dowdy T, Celiku O, Saldana AC, Wang H, Yang CZ, Chari R, Li A, Zhang W, Song H, Zhang M, Ahn S, Davis D, Chen X, Zhuang Z, Herold-Mende C, Walters KJ, Gilbert MR, Larion M
Cancer & metabolism 2020;8:23

Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice.

Chen S, Lin Z, Tan KL, Chen R, Su W, Zhao H, Tan Q, Tan W
Frontiers in psychiatry 2020;11:564843

Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats.

Zhao X, Ding J, Pan H, Zhang S, Pan D, Yu H, Ye Z, Hua T
The Journal of physiology 2020 Sep;598(17):3727-3745

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer.

Jin H, Wang S, Zaal EA, Wang C, Wu H, Bosma A, Jochems F, Isima N, Jin G, Lieftink C, Beijersbergen R, Berkers CR, Qin W, Bernards R
eLife 2020 Oct 5;9

Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity.

Byun JK, Park M, Lee S, Yun JW, Lee J, Kim JS, Cho SJ, Jeon HJ, Lee IK, Choi YK, Park KG
Molecular cell 2020 Nov 19;80(4):592-606.e8

Upregulation of GLS1 Isoforms KGA and GAC Facilitates Mitochondrial Metabolism and Cell Proliferation in Epstein-Barr Virus Infected Cells.

Krishna G, Soman Pillai V, Valiya Veettil M
Viruses 2020 Jul 27;12(8)

The cross-talk between DDR1 and STAT3 promotes the development of hepatocellular carcinoma.

Lin Y, Jin H, Wu X, Jian Z, Zou X, Huang J, Guan R, Wei X
Aging 2020 Jul 27;12(14):14391-14405

Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis.

Henderson J, Duffy L, Stratton R, Ford D, O'Reilly S
Journal of cellular and molecular medicine 2020 Dec;24(23):14026-14038

In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.

Wong CC, Xu J, Bian X, Wu JL, Kang W, Qian Y, Li W, Chen H, Gou H, Liu D, Yat Luk ST, Zhou Q, Ji F, Chan LS, Shirasawa S, Sung JJ, Yu J
Gastroenterology 2020 Dec;159(6):2163-2180.e6

A New Therapeutic Strategy Targeting Protein Deacetylation for Spinal Cord Injury.

Liu X, Ma B, Zhang H, Chai R, Xiang L
Neuroscience 2020 Dec 15;451:197-206

BPTES inhibits anthrax lethal toxin-induced inflammatory response.

Wang J, Yang D, Shen X, Wang J, Liu X, Lin J, Zhong J, Zhao Y, Qi Z
International immunopharmacology 2020 Aug;85:106664

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.

Zhou H, Su J, Hu X, Zhou C, Li H, Chen Z, Xiao Q, Wang B, Wu W, Sun Y, Zhou Y, Tang C, Liu F, Wang L, Feng C, Liu M, Li S, Zhang Y, Xu H, Yao H, Shi L, Yang H
Cell 2020 Apr 30;181(3):590-603.e16

Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.

Zhang P, Wang Q, Lin Z, Yang P, Dou K, Zhang R
OncoTargets and therapy 2019;12:11751-11763

Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis.

Cui H, Xie N, Jiang D, Banerjee S, Ge J, Sanders YY, Liu G
American journal of respiratory cell and molecular biology 2019 Oct;61(4):492-500

Tissue-Resident Macrophages Promote Renal Cystic Disease.

Zimmerman KA, Song CJ, Li Z, Lever JM, Crossman DK, Rains A, Aloria EJ, Gonzalez NM, Bassler JR, Zhou J, Crowley MR, Revell DZ, Yan Z, Shan D, Benveniste EN, George JF, Mrug M, Yoder BK
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1841-1856

Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.

Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Gökalp GA, Meliton AY, Dulin NO, Mutlu GM
American journal of respiratory cell and molecular biology 2019 Nov;61(5):597-606

Blockade of lncRNA-ASLNCS5088-enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation.

Chen J, Zhou R, Liang Y, Fu X, Wang D, Wang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12200-12212

TNFα increases STAT3-mediated expression of glutaminase isoform KGA in cultured rat astrocytes.

Milewski K, Bogacińska-Karaś M, Hilgier W, Albrecht J, Zielińska M
Cytokine 2019 Nov;123:154774

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.

Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA Jr, Pollak M, Larsson O, Pelletier J, Chio IIC
Nature communications 2019 Nov 13;10(1):5151

Glutaminolysis Epigenetically Regulates Antiapoptotic Gene Expression in Idiopathic Pulmonary Fibrosis Fibroblasts.

Bai L, Bernard K, Tang X, Hu M, Horowitz JC, Thannickal VJ, Sanders YY
American journal of respiratory cell and molecular biology 2019 Jan;60(1):49-57

GLS1 promotes proliferation in hepatocellular carcinoma cells via AKT/GSK3β/CyclinD1 pathway.

Xi J, Sun Y, Zhang M, Fa Z, Wan Y, Min Z, Xu H, Xu C, Tang J
Experimental cell research 2019 Aug 1;381(1):1-9

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.

Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, Valsecchi F, Primiano G, Calder EL, Carelli V, Denton TT, Beal MF, Gross SS, Manfredi G, D'Aurelio M
Cell metabolism 2018 May 1;27(5):1007-1025.e5

Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.

Ge J, Cui H, Xie N, Banerjee S, Guo S, Dubey S, Barnes S, Liu G
American journal of respiratory cell and molecular biology 2018 Mar;58(3):378-390

Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.

Bernard K, Logsdon NJ, Benavides GA, Sanders Y, Zhang J, Darley-Usmar VM, Thannickal VJ
The Journal of biological chemistry 2018 Jan 26;293(4):1218-1228

Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.

Wang YQ, Wang HL, Xu J, Tan J, Fu LN, Wang JL, Zou TH, Sun DF, Gao QY, Chen YX, Fang JY
Nature communications 2018 Feb 7;9(1):545

Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.

Hu M, Liu L, Yao W
Gene 2018 Dec 15;678:261-269

Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.

Cai WF, Zhang C, Wu YQ, Zhuang G, Ye Z, Zhang CS, Lin SC
Cell research 2018 Aug;28(8):865-867

PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC.

Kim MJ, Choi YK, Park SY, Jang SY, Lee JY, Ham HJ, Kim BG, Jeon HJ, Kim JH, Kim JG, Lee IK, Park KG
Molecular cancer research : MCR 2017 Sep;15(9):1230-1242

HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma.

Li W, Chen C, Zhao X, Ye H, Zhao Y, Fu Z, Pan W, Zheng S, Wei L, Nong T, Li Z, Chen R
Journal of cellular and molecular medicine 2017 Nov;21(11):2896-2908

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells.

Munksgaard Thorén M, Vaapil M, Staaf J, Planck M, Johansson ME, Mohlin S, Påhlman S
Oncotarget 2017 Jul 25;8(30):48983-48995

Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing Glutamine Anaplerosis and Osteogenic Differentiation of Mesenchymal Stem Cells.

Huang T, Liu R, Fu X, Yao D, Yang M, Liu Q, Lu WW, Wu C, Guan M
Stem cells (Dayton, Ohio) 2017 Feb;35(2):411-424

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.

Pérez-Escuredo J, Dadhich RK, Dhup S, Cacace A, Van Hée VF, De Saedeleer CJ, Sboarina M, Rodriguez F, Fontenille MJ, Brisson L, Porporato PE, Sonveaux P
Cell cycle (Georgetown, Tex.) 2016;15(1):72-83

Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells.

Guo Y, Deng Y, Li X, Ning Y, Lin X, Guo S, Chen M, Han M
PloS one 2016;11(9):e0162658

Blocking glutamate carboxypeptidase II inhibits glutamate excitotoxicity and regulates immune responses in experimental autoimmune encephalomyelitis.

Ha D, Bing SJ, Ahn G, Kim J, Cho J, Kim A, Herath KH, Yu HS, Jo SA, Cho IH, Jee Y
The FEBS journal 2016 Sep;283(18):3438-56

Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.

Kahlert UD, Cheng M, Koch K, Marchionni L, Fan X, Raabe EH, Maciaczyk J, Glunde K, Eberhart CG
International journal of cancer 2016 Mar 1;138(5):1246-55

Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR
Toxicological sciences : an official journal of the Society of Toxicology 2016 Feb;149(2):358-71

Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.

Lee SY, Jeon HM, Ju MK, Jeong EK, Kim CH, Park HG, Han SI, Kang HS
Oncotarget 2016 Feb 16;7(7):7925-39

Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival.

Fuchsberger T, Martínez-Bellver S, Giraldo E, Teruel-Martí V, Lloret A, Viña J
Scientific reports 2016 Aug 12;6:31158

Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.

Karner CM, Esen E, Okunade AL, Patterson BW, Long F
The Journal of clinical investigation 2015 Feb;125(2):551-62

A small subunit processome protein promotes cancer by altering translation.

Yang HW, Kim TM, Song SS, Menon L, Jiang X, Huang W, Black PM, Park PJ, Carroll RS, Johnson MD
Oncogene 2015 Aug 20;34(34):4471-81

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.

Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44

A cell engineering strategy to enhance the safety of stem cell therapies.

Oricchio E, Papapetrou EP, Lafaille F, Ganat YM, Kriks S, Ortega-Molina A, Mark WH, Teruya-Feldstein J, Huse JT, Reuter V, Sadelain M, Studer L, Wendel HG
Cell reports 2014 Sep 25;8(6):1677-1685

The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.

Corbet C, Draoui N, Polet F, Pinto A, Drozak X, Riant O, Feron O
Cancer research 2014 Oct 1;74(19):5507-19

Modulation of immune function by glutamatergic neurons in the cerebellar interposed nucleus via hypothalamic and sympathetic pathways.

Xu FF, Huang Y, Wang XQ, Qiu YH, Peng YP
Brain, behavior, and immunity 2014 May;38:263-71

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.

Masamha CP, Xia Z, Yang J, Albrecht TR, Li M, Shyu AB, Li W, Wagner EJ
Nature 2014 Jun 19;510(7505):412-6

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.

Yeo H, Lyssiotis CA, Zhang Y, Ying H, Asara JM, Cantley LC, Paik JH
The EMBO journal 2013 Oct 2;32(19):2589-602

Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism.

Shimmura C, Suzuki K, Iwata Y, Tsuchiya KJ, Ohno K, Matsuzaki H, Iwata K, Kameno Y, Takahashi T, Wakuda T, Nakamura K, Hashimoto K, Mori N
Molecular autism 2013 Mar 26;4(1):6

The NF-κB member p65 controls glutamine metabolism through miR-23a.

Rathore MG, Saumet A, Rossi JF, de Bettignies C, Tempé D, Lecellier CH, Villalba M
The international journal of biochemistry & cell biology 2012 Sep;44(9):1448-56

Systemic elevation of PTEN induces a tumor-suppressive metabolic state.

Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP
Cell 2012 Mar 30;149(1):49-62

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW, Phang JM
Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 5;109(23):8983-8

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 12855-1-AP(GLS antibody) at dilution of 1:800
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-GLS (IP:12855-1-AP, 4ug; Detection:12855-1-AP 1:500) with mouse brain tissue lysate 8000ug.
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The KGA/GAC antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human KGA/GAC. This antibody recognizes human,mouse,rat antigen. The KGA/GAC antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.
Appendix: 12855-1-AP.pdf

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