19530-1-AP

antibody from Proteintech Group

Targeting: GATA4

Provider product page for 19530-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [47]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 19530-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19530-1-AP, RRID:AB_10642003
Product name: GATA4-Specific antibody
Antibody type: Polyclonal
Description: KD/KO validated GATA4-Specific antibody (Cat. #19530-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GATA4 protein structure - 19530-1-AP shown in red.

Submitted references SIRT1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis.

Duan Y, Luo Y, Han X, Yu H, Liu H, Zhou Y, Gao Y, Xu Q, Wei Y, Min R, Hong Y, Ji X, Jia H, Li Y, Zhang Y
Cell death & disease 2026 Mar 23;17(1)

Injectable BMSC-Based Extracellular Matrix-Mimicking Microtissue for Myocardial Infarction Repair.

Yao L, An H, Fan C, Lan Q, Zhong H, Zhang Y, Zhou L, Hao P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e00299

Suppressing Endothelial-Mesenchymal Transition Through the Histone Deacetylase 1/GATA Binding Protein 4 Pathway: The Mechanism of Protocatechuic Acid Against Myocardial Fibrosis Revealed by an Integrated Study.

Jin C, Shao C, Xu G, Wan H
Biology 2026 Jan 22;15(2)

Ubiquitination degradation of GATA4 by CUL4B promotes ovarian cancer metastasis by inducing lysosomal acidification.

Yin X, Gao R, Geng Y, Mu X, Zhang Y, Ma Y, Chen X, Han F, Chen Z, Li F, He J
Genome biology 2026 Feb 9;27(1)

Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling.

Wang M, Liu Z, Ma Y, Li D, Lin Y, Wang Y, Fu D, Guo H, Hu L
MedComm 2025 Nov;6(11):e70421

Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation.

Kang D, Lee J, Yook G, Jeong S, Shin J, Kim MS, Kim YJ, Jung H, Ahn J, Kim TW, Chang MJ, Chang CB, Kang SB, Yang WH, Lee YH, Cho JW, Yi EC, Kang C, Kim JH
Nature communications 2025 Feb 4;16(1):1094

Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype.

Joung J, Heo Y, Kim Y, Kim J, Choi H, Jeon T, Jang Y, Kim EJ, Lee SH, Suh JM, Elledge SJ, Kim MS, Kang C
Nature communications 2025 Feb 17;16(1):1696

Ubiquitous MEIS transcription factors actuate lineage-specific transcription to establish cell fate.

Darieva Z, Zarrineh P, Phillips N, Mallen J, Garcia Mora A, Donaldson I, Bridoux L, Douglas M, Dias Henriques SF, Schulte D, Birket MJ, Bobola N
The EMBO journal 2025 Apr;44(8):2232-2262

3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.

Luo L, Zhang S, Gong J, Zhang J, Xie P, Yin J, Zhang M, Zhang C, Chen H, Liu Y, Ni B, Li C, Tian Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151

Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.

Xu AL, Shen Z, Wang SH, Luan HY, Xu Y, Kang ZC, Liao ZQ, Liu J, Duan XL, Bian WH, Sun H, Xie X
Frontiers in pharmacology 2024;15:1496380

Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNα production.

Kuga T, Chiba A, Murayama G, Hosomi K, Nakagawa T, Yahagi Y, Noto D, Kusaoi M, Kawano F, Yamaji K, Tamura N, Miyake S
Frontiers in immunology 2024;15:1320444

Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.

Dasgupta N, Lei X, Shi CH, Arnold R, Teneche MG, Miller KN, Rajesh A, Davis A, Anschau V, Campos AR, Gilson R, Havas A, Yin S, Chua ZM, Liu T, Proulx J, Alcaraz M, Rather MI, Baeza J, Schultz DC, Yip KY, Berger SL, Adams PD
Molecular cell 2024 Sep 5;84(17):3271-3287.e8

BRG1 enhances porcine iPSC pluripotency through WNT/β-catenin and autophagy pathways.

Ren X, Xu J, Xue Q, Tong Y, Xu T, Wang J, Yang T, Chen Y, Shi D, Li X
Theriogenology 2024 Feb;215:10-23

GATA4 inhibits odontoblastic differentiation of dental pulp stem cells through targeting IGFBP3.

Zhang Y, Qiao W, Ji Y, Meng L
Archives of oral biology 2023 Oct;154:105756

Bmi-1 Overexpression Improves Sarcopenia Induced by 1,25(OH)(2) D(3) Deficiency and Downregulates GATA4-Dependent Rela Transcription.

Wang Q, Zhao J, Chen H, Zhou J, Chen A, Zhang J, Wang Y, Mao Z, Wang J, Qiu X, Chen Y, Wang R, Zhang Y, Miao D, Jin J
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Mar;38(3):427-442

Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice.

Murayama M, Hirata H, Shiraki M, Iovanna JL, Yamaza T, Kukita T, Komori T, Moriishi T, Ueno M, Morimoto T, Mawatari M, Kukita A
Journal of cellular physiology 2023 Mar;238(3):566-581

Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells.

Cao L, Wang R, Liu G, Zhang Y, Thorne RF, Zhang XD, Li J, Xia Y, Guo L, Shao F, Gu H, Wu M
EMBO reports 2023 Mar 6;24(3):e55683

Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs.

Shi Y, Qin B, Fan X, Li Y, Wang Y, Yuan W, Jiang Z, Zhu P, Chen J, Chen Y, Li F, Wan Y, Wu X, Zhuang J
Cell and tissue research 2023 Jul;393(1):163-179

ZipperCells Exhibit Enhanced Accumulation and Retention at the Site of Myocardial Infarction.

Jasiewicz NE, Mei KC, Oh HM, Chansoria P, Hendy DA, Bonacquisti EE, Bachelder EM, Ainslie KM, Yin H, Qian L, Jensen BC, Nguyen J
Advanced healthcare materials 2023 Feb;12(4):e2201094

Jagged/Notch proteins promote endothelial-mesenchymal transition-mediated pulmonary arterial hypertension via upregulation of the expression of GATAs.

Lin KC, Yeh JN, Shao PL, Chiang JY, Sung PH, Huang CR, Chen YL, Yip HK, Guo J
Journal of cellular and molecular medicine 2023 Apr;27(8):1110-1130

Overexpression of PYGO1 promotes early cardiac lineage development in human umbilical cord mesenchymal stromal/stem cells by activating the Wnt/β-catenin pathway.

Shen J, Wu X, Zhu P, Zhuang J, Qin B, Sun F, Yuan W, Fan X, Jiang Z, Li F, Li Y, Wang Y, Zhao M
Human cell 2022 Nov;35(6):1722-1735

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564

Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-κB signaling pathway mediated by the DNA damage response.

Ma Y, Li S, Ye S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2022 Jul 1;239:113645

Activation of GATA-binding protein 4 regulates monocyte chemoattractant protein-1 and chemotaxis in periodontal ligament cells.

Zhu N, Zheng X, Qiao W, Huang W, Li R, Song Y
Journal of periodontal research 2022 Jan;57(1):195-204

Identification of differential microRNAs and messenger RNAs resulting from ASXL transcriptional regulator 3 knockdown during during heart development.

Liu ZQ, Cheng M, Fu F, Li R, Han J, Yang X, Deng Q, Li LS, Lei TY, Li DZ, Liao C
Bioengineered 2022 Apr;13(4):9948-9961

Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4.

Chen H, Zhou J, Chen H, Liang J, Xie C, Gu X, Wang R, Mao Z, Zhang Y, Li Q, Zuo G, Miao D, Jin J
Clinical and translational medicine 2022 Apr;12(4):e574

Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.

Luo L, Gong J, Zhang H, Qin J, Li C, Zhang J, Tang Y, Zhang Y, Chen J, Zhou Y, Tian Z, Liu Y, Liu M
Frontiers in cell and developmental biology 2021;9:648201

Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells.

Cheng L, Xie M, Qiao W, Song Y, Zhang Y, Geng Y, Xu W, Wang L, Wang Z, Huang K, Dong N, Sun Y
Communications biology 2021 Sep 6;4(1):1039

Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer.

Su W, Zhu S, Chen K, Yang H, Tian M, Fu Q, Shi G, Feng S, Ren D, Jin X, Yang C
Journal of experimental & clinical cancer research : CR 2021 Mar 1;40(1):88

Proteome landscape and spatial map of mouse primordial germ cells.

Wang P, Miao Y, Li XH, Zhang N, Wang Q, Yue W, Sun SC, Xiong B, Qiao J, Li M
Science China. Life sciences 2021 Jun;64(6):966-981

Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy.

Chen L, Mei G, Jiang C, Cheng X, Li D, Zhao Y, Chen H, Wan C, Yao P, Gao C, Tang Y
Cell proliferation 2021 Jun;54(6):e13052

Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse Sertoli cells.

Zhang Y, Tang Y, Luo Y, Luo L, Shen F, Huang Z
Toxicology and applied pharmacology 2021 Aug 15;425:115606

ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4.

Sun X, Yu W, Li L, Sun Y
Frontiers in cell and developmental biology 2020;8:553

Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition.

Guo F, Zhang CC, Yin XH, Li T, Fang CH, He XB
Cell death & disease 2020 Sep 19;11(9):783

Genome-wide translational reprogramming of genes important for myocyte functions in overload-induced heart failure.

Guo Q, Zhang Y, Zhang S, Jin J, Pang S, Wu X, Zhang W, Bi X, Zhang Y, Zhang Q, Jiang F
Biochimica et biophysica acta. Molecular basis of disease 2020 Mar 1;1866(3):165649

Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4.

Li H, Xu JD, Fang XH, Zhu JN, Yang J, Pan R, Yuan SJ, Zeng N, Yang ZZ, Yang H, Wang XP, Duan JZ, Wang S, Luo JF, Wu SL, Shan ZX
Cardiovascular research 2020 Jun 1;116(7):1323-1334

Placental P-glycoprotein inhibition enhances susceptibility to Di-(2-ethylhexyl)-phthalate induced cardiac malformations in mice: A possibly promising target for congenital heart defects prevention.

Tang C, Luo C, Hua Y, Zhou K, Duan H, Ma F, Zhang Y, Li Y, Qiu D, Wang C
PloS one 2019;14(5):e0214873

GATA3 recruits UTX for gene transcriptional activation to suppress metastasis of breast cancer.

Yu W, Huang W, Yang Y, Qiu R, Zeng Y, Hou Y, Sun G, Shi H, Leng S, Feng D, Chen Y, Wang S, Teng X, Yu H, Wang Y
Cell death & disease 2019 Nov 4;10(11):832

Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4.

Liang J, Wang N, He J, Du J, Guo Y, Li L, Wu W, Yao C, Li Z, Kee K
eLife 2019 Nov 11;8

miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1.

Wang T, Liu Y, Lv M, Xing Q, Zhang Z, He X, Xu Y, Wei Z, Cao Y
Gene 2019 Jan 30;683:87-100

Silver Nanoparticles Compromise Female Embryonic Stem Cell Differentiation through Disturbing X Chromosome Inactivation.

Zhang J, Chen Y, Gao M, Wang Z, Liu R, Xia T, Liu S
ACS nano 2019 Feb 26;13(2):2050-2061

The effect of maternal exposure to di-(2-ethylhexyl)-phthalate on fetal cardiac development in mice.

Tang C, Deng Y, Duan H, Zhang Y, Li Y, Qiu D, Zhou K, Hua Y, Wang C
Journal of applied toxicology : JAT 2018 Jun;38(6):834-842

GATA4 is upregulated in nasopharyngeal cancer and facilitates epithelial-mesenchymal transition and metastasis through regulation of SLUG.

Zhou Y, Chang H, Yang B
Experimental and therapeutic medicine 2018 Dec;16(6):5318-5326

miR-200c regulates endothelin-1 induced PASMCs abnormal proliferation and apoptosis.

Yuan C, Xu M, Rong R, Mei Y, Cai W, Li L, Xue Y, Zhu B, Sun K, Han L
IUBMB life 2017 Nov;69(11):877-886

Apelin-13 infusion salvages the peri-infarct region to preserve cardiac function after severe myocardial injury.

Chung WJ, Cho A, Byun K, Moon J, Ge X, Seo HS, Moon E, Dash R, Yang PC
International journal of cardiology 2016 Nov 1;222:361-367

Restoration of miR-98 relieves the inhibitory effect of nicotine on the differentiation of P19 cells into cardiomyocytes.

Ai F, Zhang Y, Peng B
Biotechnology letters 2016 Apr;38(4):579-87

Identification of functional mutations in GATA4 in patients with congenital heart disease.

Wang E, Sun S, Qiao B, Duan W, Huang G, An Y, Xu S, Zheng Y, Su Z, Gu X, Jin L, Wang H
PloS one 2013;8(4):e62138

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse liver tissue were subjected to SDS PAGE followed by western blot with 19530-1-AP(GATA4-Specific antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The GATA4-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human GATA4-Specific. This antibody recognizes human,mouse,rat antigen. The GATA4-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 19530-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human testis using 19530-1-AP(GATA4-Specific antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue