15940-1-AP

antibody from Proteintech Group

Targeting: TNFAIP8L2 FLJ23467

Provider product page for 15940-1-AP

Western blot

ELISA

Immunocytochemistry

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [35]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]

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Product number: 15940-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15940-1-AP, RRID:AB_2204663
Product name: TIPE2 antibody
Antibody type: Polyclonal
Description: KD/KO validated TIPE2 antibody (Cat. #15940-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TNFAIP8L2 protein structure - 15940-1-AP shown in red.

Submitted references TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling.

Yu J, Zamani A, Goldsmith JR, Etwebi Z, Lee CN, Chen YH, Sun H
Journal of leukocyte biology 2024 Feb 23;115(3):511-524

TIPE2 regulates periodontal inflammation by inhibiting NF-κB p65 phosphorylation.

DU Y, Liu X, Xiao C, Li J, Sheng Z, Wang Y, Wang R, Yu X
Journal of applied oral science : revista FOB 2023;31:e20230162

Deciphering the role of TNF‑α‑induced protein 8‑like 2 in the pathogenesis of necrotizing enterocolitis in neonatal rats.

Luo J, Yu S, Xu J, Sun X, Wang R
Experimental and therapeutic medicine 2023 Sep;26(3):443

Tumor necrosis factor-α-induced protein 8-like 2 alleviates morphine antinociceptive tolerance through reduction of ROS-mediated apoptosis and MAPK/NF-κB signaling pathways.

Yang Z, Zhang F, Abdul M, Jiang J, Li Y, Li Y, Yin C, Xing Y, Liu S, Lu C
Neuropharmacology 2023 Nov 1;238:109667

TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cells.

Bi J, Huang C, Jin X, Zheng C, Huang Y, Zheng X, Tian Z, Sun H
Journal for immunotherapy of cancer 2023 Feb;11(2)

TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma.

Shi B, Hao Y, Li W, Dong H, Xu M, Gao P
Frontiers in immunology 2022;13:883885

TLR2/TLR4-Enhanced TIPE2 Expression Is Involved in Post-Hemorrhagic Shock Mesenteric Lymph-Induced Activation of CD4+T Cells.

Du HB, Jiang SB, Zhao ZA, Zhang H, Zhang LM, Wang Z, Guo YX, Zhai JY, Wang P, Zhao ZG, Niu CY, Jiang LN
Frontiers in immunology 2022;13:838618

Exogenous TIPE2 Inhibit TAK1 to Improve Inflammation and Neuropathic Pain Induced by Sciatic Nerve Injury Through Inactivating NF-κB and JNK.

Sun X, Li X, Zhou Y, Wang Y, Liu X
Neurochemical research 2022 Oct;47(10):3167-3177

TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.

Etwebi Z, Goldsmith JR, Bou-Dargham M, Tian Y, Hood R, Spitofsky N, Li M, Sun H, Lou Y, Liu S, Lengner C, Chen YH
Inflammatory bowel diseases 2022 May 4;28(5):764-774

Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer.

Lou Y, Song M, Han M, Zhong J, Tian X, Ren Y, Song Y, Duan L, Zhao P, Song X, Zhang W, Chen YH, Wang H
Cancer immunology research 2022 Mar 1;10(3):354-367

Mettl14-Mediated m6A Modification Is Essential for Germinal Center B Cell Response.

Huang H, Zhang G, Ruan GX, Li Y, Chen W, Zou J, Zhang R, Wang J, Ji SJ, Xu S, Ou X
Journal of immunology (Baltimore, Md. : 1950) 2022 Apr 15;208(8):1924-1936

A novel prognostic factor TIPE2 inhibits cell proliferation and promotes apoptosis in pancreatic ductal adenocarcinoma (PDAC).

Sun Y, Cao S, Li Z, Liu X, Xu J, Tian Y, Shen S, Zhou Y
International journal of medical sciences 2021;18(9):2051-2062

Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages.

Zou Z, Li M, Zhou Y, Li J, Pan T, Lai L, Wang Q, Zhang L, Wang Q, Song Y, Zhang Y
Frontiers in immunology 2021;12:642715

TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway.

Feng F, Liu C, Bian H, Cai W, Zhou Y, Zhou L, Zhuang Z
Frontiers in oncology 2021;11:680985

TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.

Bi J, Cheng C, Zheng C, Huang C, Zheng X, Wan X, Chen YH, Tian Z, Sun H
Science advances 2021 Sep 17;7(38):eabi6515

Decreased expression of TIPE2 in the eye under high-glucose conditions tested in vivo and in vitro.

Suo LG, Qin RX, Cui YY, Qin XJ
International immunopharmacology 2021 Jun;95:107517

TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.

Li W, Li Y, Guan Y, Du Y, Zhao M, Chen X, Zhu F, Guo C, Jia Y, Li Y, Wang X, Wang X, Shi Y, Wang Q, Li Y, Zhang L
Autophagy 2021 Jun;17(6):1410-1425

Expression of TIPE family members in human colorectal cancer.

Zhong M, Chen Z, Yan Y, Bahet A, Cai X, Chen H, Ran H, Qu K, Han Z, Zhuang G, Zhang S, Wang Y
Oncology letters 2021 Feb;21(2):118

Erythropoietin Protects against Diffuse Alveolar Hemorrhage in Mice by Regulating Macrophage Polarization through the EPOR/JAK2/STAT3 Axis.

Yang Z, Yan L, Cao H, Gu Y, Zhou P, Shi M, Li G, Jiao X, Li N, Li X, Sun K, Shao F
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 15;206(8):1752-1764

TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.

Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, Tang A, Ruan Q, Yang X, Chen YH, Wan X
The Journal of experimental medicine 2020 Feb 3;217(2)

The SCF(β-TrCP) E3 Ubiquitin Ligase Regulates Immune Receptor Signaling by Targeting the Negative Regulatory Protein TIPE2.

Lou Y, Han M, Song Y, Zhong J, Zhang W, Chen YH, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 15;204(8):2122-2132

Mesenteric lymph drainage alleviates hemorrhagic shock-induced spleen injury and inflammation.

Zhang H, Zhai JY, Du HB, Zhang LM, Li LF, Bian AQ, Jiang LN, Zhao ZG
Acta cirurgica brasileira 2019;34(9):e201900903

Overexpression of TIPE2, a Negative Regulator of Innate and Adaptive Immunity, Attenuates Cognitive Deficits in APP/PS1 Mice.

Miao Y, Wang N, Shao W, Xu Z, Yang Z, Wang L, Ju C, Zhang R, Zhang F
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2019 Sep;14(3):519-529

TIPE2 gene transfer with adeno-associated virus 9 ameliorates dystrophic pathology in mdx mice.

Gao S, Lu A, Amra S, Guo P, Huard J
Human molecular genetics 2019 May 15;28(10):1608-1619

TIPE2 Suppresses Pseudomonas aeruginosa Keratitis by Inhibiting NF-κB Signaling and the Infiltration of Inflammatory Cells.

Wang Q, Ma L, Liu T, Ge C, Zhou Q, Wei C, Shi W
The Journal of infectious diseases 2019 Aug 9;220(6):1008-1018

TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation.

Lin Z, Liu W, Xiao C, Fan Y, Zhuang G, Qi Z
Oncology reports 2018 Sep;40(3):1307-1316

Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism.

Li T, Wang W, Gong S, Sun H, Zhang H, Yang AG, Chen YH, Li X
Molecular immunology 2018 Jul;99:154-162

Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells.

Liu W, Fan Y, Shi Y, Lin Z, Huang X, Huang W, Shen D, Qi Z
BMC cancer 2018 Aug 29;18(1):857

TIPE2 is negatively correlated with tissue factor and thrombospondin-1 expression in patients with bronchial asthma.

Shi G, Zhao JW, Sun XX, Ma JF, Wang P, He FC, Ming L
Experimental and therapeutic medicine 2018 Apr;15(4):3449-3454

Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is associated with immune phases of patients with chronic hepatitis B.

Fan YC, Zhang YY, Wang N, Sun YY, Wang K
Oncotarget 2017 May 9;8(19):30781-30792

Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.

Fayngerts SA, Wang Z, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH
Nature immunology 2017 Dec;18(12):1353-1360

TIPE2 (Tumor Necrosis Factor α-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal.

Oho M, Nakano R, Nakayama R, Sakurai W, Miyamoto A, Masuhiro Y, Hanazawa S
The Journal of biological chemistry 2016 Oct 21;291(43):22650-22660

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.

Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, Yuan Z
Nature immunology 2013 Aug;14(8):793-803

TIPE2, a novel regulator of immunity, protects against experimental stroke.

Zhang Y, Wei X, Liu L, Liu S, Wang Z, Zhang B, Fan B, Yang F, Huang S, Jiang F, Chen YH, Yi F
The Journal of biological chemistry 2012 Sep 21;287(39):32546-55

Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy.

Zhang S, Zhang Y, Wei X, Zhen J, Wang Z, Li M, Miao W, Ding H, Du P, Zhang W, He M, Yi F
Biochimica et biophysica acta 2010 Nov;1802(11):1078-86

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 15940-1-AP(TNFAIP8L2 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TNFAIP8L2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TNFAIP8L2. This antibody recognizes human,mouse,rat antigen. The TNFAIP8L2 antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.
Appendix: 15940-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-TNFAIP8L2 (IP:15940-1-AP, 3ug; Detection:15940-1-AP 1:500) with mouse cerebellum tissue lysate 4000ug.
Sample type: tissue