Tissue expression
Cell line expression

HECW2

gene product
KIAA1301, NEDL2 
This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
More gene data

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189 antibodies from 26 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
4 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
Atlas Antibodies
1 antibody
LifeSpan BioSciences, Inc.
25 antibodies
Affinity Biosciences
1 antibody
antibodies-online
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Biorbyt
14 antibodies
Novus Biologicals
3 antibodies
St John's Laboratory
2 antibodies
GeneTex
5 antibodies
Abgent
3 antibodies
Boster Biological Technology
1 antibody
Aviva Systems Biology
3 antibodies
Abnova Corporation
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Acris Antibodies GmbH
1 antibody
OriGene
1 antibody
MilliporeSigma / Merck KGaA
3 antibodies
Creative Diagnostics
4 antibodies
MyBioSource
3 antibodies
Abbexa
3 antibodies
Creative Biolabs
3 antibodies
United States Biological
38 antibodies
Leading Biology
2 antibodies
ProSci
2 antibodies
Everest Biotech
1 antibody