60315-1-Ig

antibody from Proteintech Group

Targeting: SRC ASV, c-src, SRC1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

60315-1-Ig

Provider

Proteintech Group

Product name

c-SRC antibody

Antibody type

Monoclonal

Description

c-SRC antibody (Cat. #60315-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, hamster, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat, Hamster

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

5E10C4

Vial size

20ul, 150ul

References

Submitted references

Mechanisms of Yiqi Huoxue Granule in Atherosclerosis Treatment: Insights from UPLC-Q-Exactive Orbitrap-MS Analysis, Network Pharmacology, Molecular Docking, and Experimental Verification.

Wang X, Liu S, Lei Z, Cao P, Shi W, Gao S, Wu H
Journal of inflammation research 2026;19:566368

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Tumoral IL-10-activated SHP2 in macrophages promotes mammary carcinoma progression.

Gao J, Chen Z, Wang Y, Guo L, Fan M, Zhou L, Wang L, Huang Y, Sun Y, Guo W, Shen Y, Xu Q
Fundamental research 2026 Mar;6(2):1203-1214

---

Investigating the mechanisms by which bisphenol A affects osteoarthritis through a novel network toxicology framework and experimental validation.

He Q, Li S, Chen Y, Liu Y, Li Y, Min S, Yi S, Li F, Zhou X
BMC pharmacology & toxicology 2026 Feb 25;27(1)

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Branched-Chain α Keto-Acid Dehydrogenase Kinase-Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance.

Tian Q, Wang J, Li Q, Liu Y, Chen Y, Feng J, Lei ZN, Patel H, Cai CY, Xu Y, Quan C, Fei L, Xiao Z, Fang S, Lin T, Chen ZS, Liu Y, Zeng L, Pan Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e11081

---

The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinoma.

Zhu L, Cui X, Xu H, Yang M, Han L
Cell death & disease 2025 Oct 16;16(1):731

---

Ionizable networks mediate pH-dependent allostery in the SH2 domain-containing signaling proteins SHP2 and SRC.

Van Dyck PK, Piszkin L, Gorski EA, Nascimento ET, Abebe JA, Hoffmann LM, Peng JW, White KA
Science signaling 2025 Nov 11;18(912):eadt3018

---

CLDND1 as a prognostic ferroptosis-associated biomarker in oral squamous cell carcinoma.

Zang X, Yan D, Liu Y, Sun X, Zhang S, Li X, Wang X
Biochemical and biophysical research communications 2025 Nov 1;787:152788

---

Ionizable networks mediate pH-dependent allostery in SH2 signaling proteins.

Van Dyck PK, Piszkin L, Gorski EA, Nascimento ET, Abebe JA, Hoffmann LM, Peng JW, White KA
bioRxiv : the preprint server for biology 2025 May 6;

---

KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway.

Wang JM, Zhang FH, Xie HY, Liu ZX, Tang YJ, Shu X, Wu YQ, Lu DH, Sun JZ, Ying YF, Ma XY, Zheng XY, Wang X, Liu B, Li JF, Xie LP, Luo JD
Cell reports 2025 May 27;44(5):115595

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Paeoniflorin inhibits chronic restraint stress-induced progression of hepatocellular carcinoma through suppressing norepinephrine-induced activation of hepatic stellate cells via SRC/AKT/ERK pathways.

Luo Y, Lin W, Xiang S, Shi Y, Fu M, Zhai X, Ling C, Cheng B
Journal of ethnopharmacology 2025 Mar 26;344:119517

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Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis.

Cho S, Rhee S, Madl CM, Caudal A, Thomas D, Kim H, Kojic A, Shin HS, Mahajan A, Jahng JW, Wang X, Thai PN, Paik DT, Wang M, Mullen M, Baker NM, Leitz J, Mukherjee S, Winn VD, Woo YJ, Blau HM, Wu JC
Nature 2025 Jun;642(8068):766-775

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Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway.

Wang P, Ma Y, Rao X, Luo Q, Xiao X, Wang T, Long F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156701

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CYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway.

Liu YF, Feng LY, Zhang WY, Zhang X, Shao LJ, Zhao XM, Ji JB, Guo XL
Acta pharmacologica Sinica 2025 Jul;46(7):2029-2040

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Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response.

Wu J, Lu Q, Hou J, Qiu Y, Tian M, Wang L, Gao K, Yang X, Jiang Z
Veterinary research 2025 Jan 20;56(1):16

---

Unlocking the Anti-Breast Cancer Potential of Aralia chinensis L.

Xue J, Li L, Shu Y, Xie C, Lu T, Chai H
Current issues in molecular biology 2025 Aug 16;47(8)

---

Systematic pharmacology-based strategy to investigate the mechanism of beta-sitosterol for the treatment of rheumarthritis.

Wang X, Mao J
Frontiers in genetics 2024;15:1507606

---

Substrate-Mediated Regulation of Src Expression Drives Osteoclastogenesis Divergence.

Hu B, Chen Y, Li Y, Deng C, Niu Y, Hu Z, Li Y, Sun S, Huang Y, Deng X, Wei Y
Genes 2024 Sep 18;15(9)

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StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway.

Zhou S, Li J, Ying T, Wang Y, Wang Q, Li X, Zhao F
iScience 2024 May 17;27(5):109682

---

Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells.

Xia L, Liu JY, Yang MY, Zhang XH, Jiang Y, Yin QQ, Luo CH, Liu HC, Kang ZJ, Zhang CT, Gao BB, Zhou AW, Cai HY, Waller EK, Yan JS, Lu Y
Cancer research 2024 Feb 1;84(3):479-492

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Identification and validation of the surface proteins FIBG, PDGF-β, and TGF-β on serum extracellular vesicles for non-invasive detection of colorectal cancer: experimental study.

Huang Z, Deng C, Ma C, He G, Tao J, Zhang L, Hu X, Mo Y, Qiu L, Zhang N, Luo C, Xing S, Xie J, Yin H
International journal of surgery (London, England) 2024 Aug 1;110(8):4672-4687

---

Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.

Zheng W, Guo Y, Zhang G, Bai J, Song Y, Song X, Zhu Q, Bao X, Wu G, Zhang C
PloS one 2023;18(6):e0287133

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Src family kinases engage differential pathways for encapsulation into extracellular vesicles.

Ye C, Gosser C, Runyon ED, Zha J, Cai J, Beharry Z, Rickman CB, Klingeborn M, Liu Y, Xie J, Cai H
Journal of extracellular biology 2023 Jun;2(6)

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Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells.

Faria M, Vareda J, Miranda M, Bugalho MJ, Silva AL, Matos P
Cancers 2022 Oct 31;14(21)

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Mesopore Controls the Responses of Blood Clot-Immune Complex via Modulating Fibrin Network.

Wu S, Shan Z, Xie L, Su M, Zeng P, Huang P, Zeng L, Sheng X, Li Z, Zeng G, Chen Z, Chen Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(3):e2103608

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Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production.

Zhang S, Gui X, Ding Y, Tong H, Ju W, Li Y, Li Z, Zeng L, Xu K, Qiao J
Frontiers in pharmacology 2021;12:717725

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Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.

Liao X, Song G, Xu Z, Bu Y, Chang F, Jia F, Xiao X, Ren X, Zhang M, Jia Q
BMC cancer 2020 Jan 13;20(1):31

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Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy.

Wu JH, Li YN, Chen AQ, Hong CD, Zhang CL, Wang HL, Zhou YF, Li PC, Wang Y, Mao L, Xia YP, He QW, Jin HJ, Yue ZY, Hu B
EMBO molecular medicine 2020 Feb 7;12(2):e10154

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Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress.

Lu M, Wu J, Hao ZW, Shang YK, Xu J, Nan G, Li X, Chen ZN, Bian H
Hepatology (Baltimore, Md.) 2018 Jul;68(1):317-332

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KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.

Zhang H, Ma RR, Wang XJ, Su ZX, Chen X, Shi DB, Guo XY, Liu HT, Gao P
Oncogene 2017 Oct 5;36(40):5609-5619

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Endothelial cell SHP-2 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1-VE-cadherin interaction.

Yan M, Zhang X, Chen A, Gu W, Liu J, Ren X, Zhang J, Wu X, Place AT, Minshall RD, Liu G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Nov;31(11):4759-4769

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Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.

Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY, Sun JP
Nature communications 2015 Sep 8;6:8202

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

CHO cells were subjected to SDS PAGE followed by western blot with 60315-1-Ig( c-SRC Antibody) at dilution of 1:1000

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The c-SRC antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human c-SRC. This antibody recognizes human, hamster antigen. The c-SRC antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

60315-1-Ig.pdf

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