11097-1-AP

antibody from Proteintech Group

Targeting: SRC ASV, c-src, SRC1

Provider product page for 11097-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [67]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [1]
Flow cytometry [1]

Submit

Product number: 11097-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11097-1-AP, RRID:AB_2286705
Product name: SRC antibody
Antibody type: Polyclonal
Description: SRC antibody (Cat. #11097-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, hamster and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat, Hamster
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SRC protein structure - 11097-1-AP shown in red.

Submitted references NAMPT enhances LOX expression and promotes metastasis in human chondrosarcoma cells by inhibiting miR-26b-5p synthesis.

Lin CY, Law YY, Yu CC, Wu YY, Hou SM, Chen WL, Yang SY, Tsai CH, Lo YS, Fong YC, Tang CH
Journal of cellular physiology 2024 Sep;239(9):e31345

Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.

Lv Y, Liu Z, Deng L, Xia S, Mu Q, Xiao B, Xiu Y, Liu Z
Scientific reports 2024 Jan 10;14(1):1009

Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.

Zeng J, Liang L, Chen R, Li C, Pan L, Wen M, Lv D, Liu M, Xu Z, Huang H
European journal of pharmacology 2023 Sep 15;955:175915

Network pharmacology integrated with experimental validation revealed potential molecular mechanisms of Camellia nitidissima C. W. Chi in the treatment of lung cancer.

Zhou A, Zhou C, Wang D, Qian M, Huang L
Journal of ethnopharmacology 2023 Oct 5;314:116576

Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway.

Fu C, Zhang Y, Xi WJ, Xu K, Meng F, Ma T, Li W, Wu L, Chen Z
Journal of ethnopharmacology 2023 May 23;308:116191

Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats.

Pang S, Luo Z, Dong W, Gao S, Chen W, Liu N, Zhang X, Gao X, Li J, Gao K, Shi X, Guan F, Zhang L, Zhang L
Life science alliance 2023 Mar;6(3)

Dimethyl fumarate possesses antiplatelet and antithrombotic properties.

Chu X, Zhang J, Li Y, Yuan K, Wang X, Gui X, Sun Y, Geng C, Ju W, Xu M, Li Z, Zeng L, Xu K, Qiao J
International immunopharmacology 2023 Jul;120:110381

Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development.

Dai H, Xu W, Wang L, Li X, Sheng X, Zhu L, Li Y, Dong X, Zhou W, Han C, Mao Y, Yao L
Breast cancer research : BCR 2023 Jul 28;25(1):90

Integrin β6 mediates epithelial-mesenchymal transition in diabetic kidney disease.

Li X, Miao Y, Li T, Liu X, Xu L, Guo J, Yu X, Sun B, Zhu Y, Ai D, Chen L
Molecular and cellular endocrinology 2023 Jul 15;572:111955

Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.

Wan Q, Xu J, Zhu C, Liu X, Tu Y, Lei J, Yu J
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10349-10360

Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.

Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487

Nodakenin alleviates ovariectomy-induced osteoporosis by modulating osteoblastogenesis and osteoclastogenesis.

Liu C, Zhao M, Chen J, Xu L, Wang K, Li G
European journal of pharmacology 2023 Dec 5;960:176121

Hypoglycemia-Exacerbated Mitochondrial Connexin 43 Accumulation Aggravates Cardiac Dysfunction in Diabetic Cardiomyopathy.

Wei X, Chang ACH, Chang H, Xu S, Xue Y, Zhang Y, Lei M, Chang ACY, Zhang Q
Frontiers in cardiovascular medicine 2022;9:800185

Spheroid Formation Enhances the Regenerative Capacity of Nucleus Pulposus Cells via Regulating N-CDH and ITGβ1 Interaction.

Wang Y, Wang H, Zhuo Y, Hu Y, Li X, Xu Y, Sun B, Liu M, Zou L, Liu L, Luo L, Zhao C, Li P, Zhou Q
International journal of biological sciences 2022;18(9):3676-3696

Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.

Xiong L, Wu H, Zhong T, Luo F, Li Q, Li M, Fan Y
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)

Estrogen receptor variant ER-α36 facilitates estrogen signaling via EGFR in glioblastoma.

Qu C, Wang C, Li H, Li Y, Han C, Tao X, Guan X, Zhang Y, Chen M, Liu J, Zou W
Cell biology international 2022 Nov;46(11):1759-1774

Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.

Fan Y, Wu H, Xiong L, Luo F, Li Q, Wang D, Zhong T
Fitoterapia 2022 Nov;163:105314

Strategies to Attenuate Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Pigment Epithelium-Derived Factor.

Zhang H, Li Z, Quan X, Liu X, Sun T, Wei T, Pan J, Liu Z, Wang M, Dong H, Zhang Z
Human gene therapy 2022 Mar;33(5-6):330-345

Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.

Zhong T, Li M, Wu H, Wang D, Liu J, Xu Y, Fan Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041

Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis.

Li C, Wu B, Li Y, Chen J, Ye Z, Tian X, Wang J, Xu X, Pan S, Zheng Y, Cai X, Jiang L, Zhao M
Cell stem cell 2022 Jul 7;29(7):1119-1134.e7

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626

TNFSF9 promotes metastasis of pancreatic cancer by regulating M2 polarization of macrophages through Src/FAK/p-Akt/IL-1β signaling.

Wu J, Wang Y, Yang Y, Liu F, Jiang Z, Jiang Z
International immunopharmacology 2022 Jan;102:108429

Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer.

Xue W, Li X, Li W, Wang Y, Jiang C, Zhou L, Gao J, Yu Y, Shen Y, Xu Q
Signal transduction and targeted therapy 2022 Feb 4;7(1):35

Angiopoietin2-mediated caveolin1 phosphorylation regulating transcytosis of renal tubular epithelial cell contributes to the occurrence of albuminuria under high glucose exposure.

Liu J, Yao J, Zhao Y, Su J, Ye J, Wang Y
Journal of translational medicine 2022 Apr 25;20(1):185

lncRNA Gm16410 Mediates PM(2).(5)-Induced Macrophage Activation via PI3K/AKT Pathway.

Xu J, Xu H, Ma K, Wang Y, Niu B, Zhang L, Li F
Frontiers in cell and developmental biology 2021;9:618045

The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer's Disease: Implications for Treatment.

Kong Y, Huang L, Li W, Liu X, Zhou Y, Liu C, Zhang S, Xie F, Zhang Z, Jiang D, Zhou W, Ni R, Zhang C, Sun B, Wang J, Guan Y
Frontiers in cell and developmental biology 2021;9:609908

Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway.

Wisanwattana W, Wongkrajang K, Cao DY, Shi XK, Zhang ZH, Zhou ZY, Li F, Mei QG, Wang C, Suksamrarn A, Zhang GL, Wang F
Frontiers in endocrinology 2021;12:636784

Identification of a Novel Ferroptosis-Related Gene Prognostic Signature in Bladder Cancer.

Sun J, Yue W, You J, Wei X, Huang Y, Ling Z, Hou J
Frontiers in oncology 2021;11:730716

A network pharmacology strategy to investigate the anti-osteoarthritis mechanism of main lignans components of Schisandrae Fructus.

Min L, Wu Y, Cao G, Mi D, Chen C
International immunopharmacology 2021 Sep;98:107873

Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signaling.

Liu A, Xie H, Li R, Ren L, Yang B, Dai L, Lu W, Liu B, Ren D, Zhang X, Chen Q, Huang Y, Shi K
Molecular therapy oncolytics 2021 Sep 24;22:195-208

TNFSF9 promotes metastasis of pancreatic cancer through Wnt/Snail signaling and M2 polarization of macrophages.

Wu J, Wang Y, Yang Y, Liu F, Chen J, Jiang Z, Jiang Z
Aging 2021 Sep 13;13(17):21571-21586

Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway.

Liu CD, Liu NN, Zhang S, Ma GD, Yang HG, Kong LL, Du GH
Acta pharmacologica Sinica 2021 Mar;42(3):370-381

A network-based analysis and experimental validation of traditional Chinese medicine Yuanhu Zhitong Formula in treating neuropathic pain.

Liu T, Li T, Chen X, Zhang K, Li M, Yao W, Zhang C, Wan L
Journal of ethnopharmacology 2021 Jun 28;274:114037

VEGF/Src signaling mediated pleural barrier damage and increased permeability contributes to subpleural pulmonary fibrosis.

Lu YZ, Liang LM, Cheng PP, Xiong L, Wang M, Song LJ, Yu F, He XL, Xiong L, Wang XR, Xin JB, Ye H, Ma WL
American journal of physiology. Lung cellular and molecular physiology 2021 Jun 1;320(6):L990-L1004

Protein tyrosine phosphatase 1B(PTP1B) promotes melanoma cells progression through Src activation.

Wang Q, Pan Y, Zhao L, Qi F, Liu J
Bioengineered 2021 Dec;12(1):8396-8406

Qihuzha granule attenuated LPS-induced acute spleen injury in mice via Src/MAPK/Stat3 signal pathway.

Zhong T, Feng M, Su M, Wang D, Li Q, Jia S, Luo F, Wang H, Hu E, Yang X, Fan Y
Journal of ethnopharmacology 2021 Dec 5;281:114458

Quantitative proteomics revealed modulation of macrophages by MetQ gene of Streptococcus suis serotype 2.

Pei X, Liu J, Liu M, Zhou H, Wang X, Fan H
AMB Express 2020 Oct 30;10(1):195

Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression.

Du L, Li CR, He QF, Li XH, Yang LF, Zou Y, Yang ZX, Zhang D, Xing XW
Molecular medicine (Cambridge, Mass.) 2020 Oct 27;26(1):96

Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes.

Han P, Hanlon D, Arshad N, Lee JS, Tatsuno K, Robinson E, Filler R, Sobolev O, Cote C, Rivera-Molina F, Toomre D, Fahmy T, Edelson R
Science advances 2020 Mar;6(11):eaaz1580

The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein.

Zhu L, Qin C, Li T, Ma X, Qiu Y, Lin Y, Ma D, Qin Z, Sun C, Shen X, Zhao Y, Han L
Cell death and differentiation 2020 Jun;27(6):1819-1831

Targeting LRIG2 overcomes resistance to EGFR inhibitor in glioblastoma by modulating GAS6/AXL/SRC signaling.

Dong M, Xiao Q, Hu J, Cheng F, Zhang P, Zong W, Tang Q, Li X, Mao F, He Y, Yu X, Wan F, Lei T, Guo D, Wang B
Cancer gene therapy 2020 Dec;27(12):878-897

A non-canonical rhodopsin-mediated insulin receptor signaling pathway in retinal photoreceptor neurons.

Rajala A, Rajala RVS
Cell biology international 2020 Apr;44(4):1020-1027

SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis.

Liu R, Shuai Y, Luo J, Zhang Z
Frontiers in oncology 2019;9:1035

Antimetastatic Effect of Fucoidan-Sargassum against Liver Cancer Cell Invadopodia Formation via Targeting Integrin αVβ3 and Mediating αVβ3/Src/E2F1 Signaling.

Pan TJ, Li LX, Zhang JW, Yang ZS, Shi DM, Yang YK, Wu WZ
Journal of Cancer 2019;10(20):4777-4792

TRIM50 acts as a novel Src suppressor and inhibits ovarian cancer progression.

Qiu Y, Liu P, Ma X, Ma X, Zhu L, Lin Y, You Y, Yu W, Ma D, Sun C, Qin Z, Zhao Y, Shi J, Han L
Biochimica et biophysica acta. Molecular cell research 2019 Sep;1866(9):1412-1420

Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy.

Wang W, Wang M, Ruan Y, Tan J, Wang H, Yang T, Li J, Zhou Q
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10097-10106

DR region specific antibody ameliorated but ouabain worsened renal injury in nephrectomized rats through regulating Na,K-ATPase mediated signaling pathways.

Wang J, Ullah SH, Li M, Zhang M, Zhang F, Zheng J, Yan X
Aging 2019 Feb 26;11(4):1151-1162

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis.

Qiao J, Wu X, Luo Q, Wei G, Xu M, Wu Y, Liu Y, Li X, Zi J, Ju W, Fu L, Chen C, Wu Q, Zhu S, Qi K, Li D, Li Z, Andrews RK, Zeng L, Gardiner EE, Xu K
Haematologica 2018 Sep;103(9):1568-1576

Hypoxia-Inducible Factor-1α (HIF-1α) Expression on Endothelial Cells in Juvenile Nasopharyngeal Angiofibroma: A Review of 70 cases and Tissue Microarray Analysis.

Song X, Yang C, Zhang H, Wang J, Sun X, Hu L, Liu Z, Wang D
The Annals of otology, rhinology, and laryngology 2018 Jun;127(6):357-366

DRm217 attenuates myocardial ischemia-reperfusion injury via stabilizing plasma membrane Na(+)-K(+)-ATPase, inhibiting Na(+)-K(+)-ATPase/ROS pathway and activating PI3K/Akt and ERK1/2.

Yan X, Xun M, Wu L, Du X, Zhang F, Zheng J
Toxicology and applied pharmacology 2018 Jun 15;349:62-71

Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis.

Cheng Z, Liu L, Wang Z, Cai Y, Xu Q, Chen P
International journal of molecular sciences 2018 Feb 15;19(2)

ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis.

Ma S, Lu CC, Yang LY, Wang JJ, Wang BS, Cai HQ, Hao JJ, Xu X, Cai Y, Zhang Y, Wang MR
Journal of experimental & clinical cancer research : CR 2018 Aug 6;37(1):183

Histochemical evidence of IGF2 mRNA-binding protein 2-mediated regulation of osteoclast function and adhesive ability.

Liu H, Li D, Liu S, Liu Z, Li M
Histochemistry and cell biology 2018 Apr;149(4):343-351

Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics.

Yin L, Qi Y, Xu Y, Xu L, Han X, Tao X, Song S, Peng J
Frontiers in pharmacology 2017;8:665

PALLD Regulates Phagocytosis by Enabling Timely Actin Polymerization and Depolymerization.

Sun HM, Chen XL, Chen XJ, Liu J, Ma L, Wu HY, Huang QH, Xi XD, Yin T, Zhu J, Chen Z, Chen SJ
Journal of immunology (Baltimore, Md. : 1950) 2017 Sep 1;199(5):1817-1826

Regulation of Na(+)-K(+)-ATPase effected high glucose-induced myocardial cell injury through c-Src dependent NADPH oxidase/ROS pathway.

Yan X, Xun M, Dou X, Wu L, Han Y, Zheng J
Experimental cell research 2017 Aug 15;357(2):243-251

Activation of Na(+)-K(+)-ATPase with DRm217 attenuates oxidative stress-induced myocardial cell injury via closing Na(+)-K(+)-ATPase/Src/Ros amplifier.

Yan X, Xun M, Dou X, Wu L, Zhang F, Zheng J
Apoptosis : an international journal on programmed cell death 2017 Apr;22(4):531-543

Extracellular matrix protein ITGBL1 promotes ovarian cancer cell migration and adhesion through Wnt/PCP signaling and FAK/SRC pathway.

Sun L, Wang D, Li X, Zhang L, Zhang H, Zhang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Jul;81:145-151

Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation.

Zheng J, Huang X, Tan W, Yu D, Du Z, Chang J, Wei L, Han Y, Wang C, Che X, Zhou Y, Miao X, Jiang G, Yu X, Yang X, Cao G, Zuo C, Li Z, Wang C, Cheung ST, Jia Y, Zheng X, Shen H, Wu C, Lin D
Nature genetics 2016 Jul;48(7):747-57

Gefitinib enhances oxaliplatin-induced apoptosis mediated by Src and PKC-modulated gap junction function.

Wu JF, Ji J, Dong SY, Li BB, Yu ML, Wu DD, Tao L, Tong XH
Oncology reports 2016 Dec;36(6):3251-3258

Paper-based microreactor array for rapid screening of cell signaling cascades.

Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20

Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence.

El Azzouzi K, Wiesner C, Linder S
The Journal of cell biology 2016 Apr 11;213(1):109-25

Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors.

Chernyavsky AI, Shchepotin IB, Grando SA
International immunopharmacology 2015 Nov;29(1):36-44

Histochemical evidence of zoledronate inhibiting c-src expression and interfering with CD44/OPN-mediated osteoclast adhesion in the tibiae of mice.

Liu H, Cui J, Sun J, Du J, Feng W, Sun B, Li J, Han X, Liu B, Yimin, Oda K, Amizuka N, Li M
Journal of molecular histology 2015 Jun;46(3):313-23

EphB2 contributes to human naive B-cell activation and is regulated by miR-185.

Yu M, Liang W, Wen S, Zhao T, Zhu MX, Li HH, Long Q, Wang M, Cheng X, Liao YH, Yuan J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Aug;28(8):3609-17

Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model.

Chen Q, Chen L, Zhao R, Yang XD, Imran K, Xing CG
Journal of cancer research and clinical oncology 2013 Jul;139(7):1169-78

Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains.

Satoh J, Tabunoki H, Ishida T, Yagishita S, Jinnai K, Futamura N, Kobayashi M, Toyoshima I, Yoshioka T, Enomoto K, Arai N, Saito Y, Arima K
Neuropathology : official journal of the Japanese Society of Neuropathology 2012 Apr;32(2):149-57

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A431 cells were subjected to SDS PAGE followed by western blot with 11097-1-AP(SRC antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-SRC (IP:11097-1-AP, 5ug; Detection:11097-1-AP 1:1000) with SH-SY5Y cells lysate 2900ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 11097-1-AP(SRC antibody) at dilution of 1:10 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SRC antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SRC. This antibody recognizes human, mouse, rat, hamster antigen. The SRC antibody has been validated for the following applications: ELISA, WB, IHC, IP, FC analysis.
Appendix: 11097-1-AP.pdf

: Show more