605401

antibody from BioLegend

Targeting: SRC ASV, c-src, SRC1

Antibody data

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Validation data

Product number: 605401 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#605401, RRID:AB_2255392
Product name: Purified anti-c-Src
Antibody type: Polyclonal
Antigen: Recombinant (partial), N-terminal
Description: c-Src (proto-oncogene tyrosine-protein kinase Src) is a 60 kD tyrosine protein kinase family containing both SH2 and SH3 domains. c-Src is expressed at high levels in differentiated cells including neurons, platelets, macrophages, many tumors. c-Src is a lipid-modified signaling molecule (myristolyated) involved in cell-cell interactions, cell migration, and proliferation through the phosphorylation of many substrates including β-catenin, paxillin, and vinculin. Phosphorylation of c-Src on Tyr-526 by Csk (c-Src kinase) represses activity; c-Src is activated by phospholipase D, insulin-like growth factor receptor, EGF-receptor, fibroblast growth factor receptor, and prolactin receptor binding. c-Src has been shown to be phosphorylated on multiple sites and to interact with polyoma virus middle T antigen, PYK2, HSP72, and caveolin. The Poly6054 antibody recognizes the N-terminal region of human and mouse c-Src and has been shown to be useful for Western blotting.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Vial size: 50 µl
Storage: Upon receipt, store frozen at -20° C.

SRC protein structure - 605401 shown in red.