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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [317]
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- Product number
- 66350-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- TLR4 antibody
- Antibody type
- Monoclonal
- Description
- TLR4 antibody (Cat. #66350-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3G9A4
- Vial size
- 20ul, 150ul
Submitted references Paeoniflorin Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by SYK/SH3BP2 Signaling Pathway.
Rosamultin Alleviates LPS-Induced Acute Kidney Injury by Promoting Autophagy and Inhibiting the NF-κB Signaling Pathway.
Mechanism Study of Yi-Qi-Dao-Zhi Formula in Improving Postoperative Ileus by Targeting the TLR4/NF-κB/MAPK Signaling Pathways.
Modified Dachengqi Decoction ameliorates sepsis-induced lung injury via the gut microbiota-bile acid axis.
Live and heat-treated Lactiplantibacillus plantarum induce distinct metabolic and immune responses in intestinal epithelial cells.
Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis.
Exercise training alleviates myocardial injury in mice with heart failure with preserved ejection fraction via the TLR4-mediated necroptosis pathway.
Bushen Huoxue Recipe enhances the immune microenvironment at the maternal-fetal interface via the Hippo signaling pathway in mice with recurrent spontaneous abortion.
Lactobacillus paragasseri LPG-9 reduces placental inflammation in intrahepatic cholestasis of pregnancy by regulating TGR5 in mice.
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.
Unraveling the therapeutic mechanisms of cinnamaldehyde in allergic rhinitis: a network Pharmacology and experimental approach.
Numb attenuates LPS-induced neuroinflammation via autophagic regulation of Ifi204 in microglia.
Xue-Jie-San alleviates Crohn's disease through suppressing endothelial cell pyroptosis via the TLR4/NF-κB/NLRP3 pathway.
6-Gingerol alleviates NNK-induced lung carcinogenesis by boosting antioxidation and reducing inflammation.
Bushen Huoxue formula component β-Estradiol 3-acetate treats osteoarthritis through enhancing the TLR4 ubiquitination.
Palmitic acid induces macrophage sialylation via TLR4/MyD88/TRAF6/NF-κB signaling.
Electroacupuncture at Zusanli (ST36) alleviates paclitaxel-induced neuropathic pain in rats via regulating TLR4 signaling pathway in the spinal cord.
Mannose-modified Prunus persica kernel protein nanoparticles loading baicalin coated with Lycium barbarum polysaccharide for ulcerative colitis treatment.
Bawei Chenxiang Pills Exert Anti-Myocardial Ischemia Effect by Inhibiting Inflammation Through the TLR4/NF-κB/NLRP3 Signaling Pathway.
MD2 mediates COPD pathogenesis by inducing airway inflammation and ferroptosis through the TLR4/MyD88 pathway.
Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway.
Artemisia Extracts Suppress H1N1 Influenza A Virus Infection by Targeting Viral HA/NA Proteins and Modulating the TLR4/MyD88/NF-κB Signaling Axis.
Microplastic-Induced Macrophage Dysfunction Drives Lung Tumor Progression through Glutathione Imbalance.
Synergistic effects of Clostridium butyricum and Akkermansia muciniphila-derived postbiotics ameliorate DSS-induced colitis and associated tumorigenesis through immunomodulation and microbiota regulation in mice.
Hypoxia-preconditioned cardiomyocyte-derived extracellular vesicles alleviate myocardial ischemic injury by reprogramming macrophage polarization via the Fgl2/NF-κB pathway.
Potential of quercitrin in psoriasis intervention: Dual regulation of the oxidative stress-NF-κB axis and gut microbiota homeostasis.
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.
Cornus officinalis Siebold & Zucc. ethanol extract alleviates primary dysmenorrhea via anti-inflammatory and spasmolytic effects: network pharmacology and experimental verification.
Gallic acid attenuates LPS-induced hepatic injury via SIRT-1-dependent immunomodulation and anti-apoptotic mechanisms in rats.
Remote mobilization of gut Tregs exosomes serves as nanoshuttles for targeted cardioprotection against ischemia/reperfusion injury by ginseng polysaccharides.
Dehydroepiandrosterone alleviates pulmonary fibrosis by modulating the TLR4/NF-κB/NLRP3 signaling cascade in macrophages.
Gut microbiota: A critical regulator of oxaliplatin-induced peripheral neurotoxicity development.
Intermittent fasting protects MPTP-induced Parkinson's disease mouse model through regulating gut microbiota dysbiosis.
Puerarin Alleviates Depression via Integrated Regulation of TLR4/MyD88/NF-κB Signaling and Gut Microbiota-Metabolic Axis.
tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination.
Modulation of EGR1 Expression by Hyperglycemia in Swine Rotator Cuff Tendons.
Ginsenoside Rh2-Pretreated Mesenchymal Stem Cell Exosomes Ameliorate Collagen-Induced Arthritis via N6-Methyladenosine Methylation.
HMGB1 Exacerbates Intestinal Barrier Damage by Inducing Ferroptosis Through the TLR4/NF-κB/GPX4 Pathway in Ulcerative Colitis.
Curcumin modulated gut microbiota and alleviated renal fibrosis in 5/6 nephrectomy-induced chronic kidney disease rats.
Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway.
Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation.
Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways.
Amomum tsaoko flavonoids attenuate ulcerative colitis by inhibiting TLR4/NF-κB/NLRP3 signaling pathway and modulating gut microbiota in mice.
Identification of novel amino acid variants in the Han Chinese population that impair toll-like receptor 4 signaling and confer hyporesponsiveness to lipopolysaccharide.
Exploring the possible mechanism of low-dose naloxone exposure improving the immune microenvironment of gastric cancer tumors.
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells.
Mn(3)O(4) nanozyme-based anti-inflammatory therapy modulates microglial phenotype by downregulating TLR4/NOX2 expression and further alleviates Alzheimer's disease pathology.
Decoding the exosomal nucleic acid delivery system axis of macrophage autophagy and immune reprogramming via multi-omics analysis.
Methionine ameliorates intestinal injury in senescence-accelerated mouse prone-8 mice by reducing sulfate-reducing bacteria and enhancing barrier function.
Bacteroides fragilis 839 ameliorates anti-tuberculosis drugs-induced liver injury by suppressing inflammation and regulating gut microbiota in mice.
Polycyclic Polyprenylated Acylphloroglucinols from Hypericum himalaicum.
Icaritin protects against airway inflammation by inhibiting the TLR4/NF-κB pathway in vivo and in vitro.
miR-29a regulates scleral remodelling via TLR7/8-dependent inflammatory signalling in myopia.
Ferulic acid promotes thrombopoiesis via TLR4/JAK2/STAT3 signaling: A novel therapeutic strategy for thrombocytopenia.
Environmental enrichment attenuates social isolation-exacerbated postoperative cognitive dysfunction in aged mice via inhibition of RAGE-HMGB1 proinflammatory signaling.
Composition and anti-colitis efficacy analysis of ethanol and aqueous extraction of Moringa oleifera leaves.
Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia-Reperfusion Injury.
Alfalfa Polysaccharide Alleviates Colitis by Regulating Intestinal Microbiota and the Intestinal Barrier Against the TLR4/MyD88/NF-κB Pathway.
HMGB1 contributes to pancreatic fibrosis by regulating TLR4-mediated autophagy and the NLRP3 inflammasome pathway in chronic pancreatitis.
Chlorogenic Acid Improves Salicylic Acid-Induced Cochlear Injury by Reducing Oxidative Stress and Inflammatory Response Through TLR4/NF-κB Signalling Pathway.
Akkermansia muciniphila-derived hypoacylated rough-type lipopolysaccharides alleviate diet-induced obesity via activation of TLR4-IL-23-IL-22 immune axis.
Ginseng-derived nanoparticles accelerate diabetic wound healing by modulating macrophage polarization and restoring endothelial cell function.
The pyranocoumarin-enriched extract from the leaves of Calophyllum membranaceum alleviates LPS-induced acute lung injury in mice by inhibiting the TLR4/MD2 interaction.
Anti-β2GPI antibodies induce trophoblast pyroptosis and placental inflammation through TLR4/NLRP3/GSDMD axis.
Unlocking the gut-lung axis: Feixin decoction as a novel modulator in hypoxic pulmonary hypertension.
Melatonin alleviates diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome by modulating of the TLR4/MyD88/NF-κB pathway.
Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages.
Toxoplasma gondii-induced adverse pregnancy outcomes: insight into the inhibitory role of Trem2 on TLR4/TRAF6/JNK signaling pathway.
The effect of anthocyanin extract from Lycium ruthenicum Murray on intestinal barrier function in Bamei ternary pigs.
MSC-derived small extracellular vesicles attenuate diabetic retinopathy through miR-29a-3p regulated microglia M1-like polarization.
Protection against stroke-induced blood-brain barrier disruption by Guanxinning injection and its active-component combination via TLR4/NF-κB/MMP9-mediated neuroinflammation.
The total xanthones from Gentianella acuta alleviate acute myocardial infarction by targeting BRD4-mediated cardiomyocyte pyroptosis and inflammation.
Ferulic acid ameliorates TLR4-mediated macrophage activation by irreversibly binding to peroxiredoxin 1 to inhibit its dimerization and secretion.
LuoFuShan Rheumatism Plaster ameliorates neuropathic pain in mice by suppressing TLR4/TNF-α signaling.
Tetramethylpyrazine-caffeic Acid Hybrid CT-011 Exerts Dopaminergic Neuroprotection Through Inhibiting Microglia-mediated Neuroinflammation.
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
Antibacterial hyaluronic acid hydrogel with sustained release of larazotide as effective colitis treatment.
Glycyrrhizin Attenuates White Matter Injury by Inhibiting Neuroinflammation through the HMGB1/TLR4 Pathway.
Hippocampal GPR35 is involved in the depression-like behaviors induced by inflammation and mediates the antidepressant effects of fluoxetine in mice.
Forsythoside A Alleviates Acute Alcoholic Liver Injury by Binding to TLR4 to Inhibit the Activation of the NF-κB Pathway.
Xiao-Chai-Hu granule alleviates influenza virus-induced pneumonia by regulating TLR4-PI3K-Akt/p38 MAPK-NF-κB pathways.
The Role of TLR4 in Lung Epithelial Cell Injury Caused by Influenza Virus Combined with Staphylococcus aureus.
Gut microbiota contributes to obstructive sleep apnea-induced hypertension by gut-heart axis in mice.
Bletilla ochracea Schltr. protects against ethanol-induced acute gastric ulcers by alleviating oxidative stress and inflammation and modulating gut microbiota.
SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota.
Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation.
The stems of Syringa oblata Lindl. exert cardioprotective effects against acute myocardial ischemia by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome signaling pathways in mice.
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Macrophages hijack carbapenem-resistance hypervirulent Klebsiella pneumoniae by blocking SLC7A11/GSH-manipulated iron oxidative stress.
Multi-omics approaches reveal the therapeutic mechanism of Naoxintong capsule against ischemic stroke.
GSK3β Substrate-competitive Inhibitors Regulate the gut Homeostasis and Barrier Function to Inhibit Neuroinflammation in Scopolamine-induced Alzheimer's Disease Model Mice.
CMTM7 inhibits TLR4 signaling pathway via promoting Rab5 activation and alleviates acute liver injury.
Stilbene Dimers, Phenylpropanoids, and Aurones from the Rhizomes of Heterosmilax japonica and Their Anti-inflammatory Activities.
Tissue geometry spatiotemporally drives bacterial infections.
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
Platelet-rich plasma improves cyclophosphamide-induced interstitial cystitis in rat models through the toll-like receptor 4/nuclear factor-kappa B signalling pathway.
P-Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating TLR4/MyD88/NF-κB-Mediated Inflammation and Oxidative Stress.
Psoralen alleviates acute lung injury by covalently targeting Cys106 of HMGB1 in macrophages to inhibit inflammatory responses.
Combating Traumatic Brain Injury: A Dual-Mechanism Hydrogel Delivering Salvianolic Acid A and Hydroxysafflor Yellow A to Block TLR4/NF-κB and Boost Angiogenesis.
Protective Effects of Ginseng Soluble Dietary Fiber and Its Fecal Microbiota Extract on Antibiotic-Induced Gut Dysbiosis Obese Mice.
Transcriptional and post-translational mechanisms of ECM remodeling in rotator cuff tendons under hyperlipidemic conditions.
Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by Aβ(1-42) in Mice.
Cathepsin L of Fasciola hepatica meliorates colitis by altering the gut microbiome and inflammatory macrophages.
ROS Responsive Cerium Oxide Biomimetic Nanoparticles Alleviates Calcium Oxalate Crystals Induced Kidney Injury via Suppressing Oxidative Stress and M1 Macrophage Polarization.
Neutrophil membrane-coated nanoparticles for targeted delivery of toll-like receptor 4 siRNA ameliorate LPS-induced acute lung injury.
FuKe QianJin capsule alleviates endometritis via inhibiting inflammation and pyroptosis through modulating TLR4/ NF-κB /NLRP3 pathway.
Elucidation of the mechanism of the Yinhua Miyanling Tablet against urinary tract infection based on a combined strategy of network pharmacology, multi-omics and molecular biology.
Integrated network pharmacology, transcriptomics and metabolomics to explore the material basis and mechanism of Danggui-Baishao herb pair for treating hepatic fibrosis.
Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota.
Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects.
Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling.
Exploring the effects of lactulose on lung-intestinal tissue-associated factors and the TLR4/NF-κB signaling pathway in COPD rats based on lung-gut axis theory.
Luteolin alleviates olfactory dysfunction in eosinophilic chronic rhinosinusitis through modulation of the TLR4/NF-κB signaling pathway.
Probiotics alleviate painful diabetic neuropathy by modulating the microbiota-gut-nerve axis in rats.
Atractylodes macrocephala Rhizoma alleviates blood hyperviscosity induced by high-fat, high-sugar, and high-salt diet by inhibiting gut-liver inflammation and fibrinogen synthesis.
Molecular insights into α-Lactalbumin-Chlorogenic acid interaction: Peptide design and anti-inflammatory mechanisms.
Guilongwan Promoted Diabetic Wound Healing via Inhibition of TLR4/NLRP3 Signaling Pathway in Macrophages.
The Therapeutic Potential of Lactobacillus crispatus for Chronic Endometritis: A Comprehensive Clinical Trial and Experimental Investigation.
Adipose-Derived Mesenchymal Stem Cells Improve Acute Liver Injury: A Mechanistic Study Based on the TLR4/MyD88/NF-κB Pathway.
Melatonin attenuates glandular cystitis via modulation of THBS1 and TLR4/p38 MAPK/STAT3 signaling.
Vaginal Weissella confusa MV0113 suppresses pathogens and restores microbiota to alleviate bacterial vaginosis: integrated genomic and in vivo evidence.
Protective Effects of Arecoline on LPS-Induced Neuroinflammation in BV2 Microglial Cells.
Integrative analysis of gut microbiome and serum metabolomics explores the therapeutic mechanism of tongfeng qingxiao prescription in treating gouty arthritis.
Volvariella volvacea polysaccharides alleviate acute liver injury by modulating Nrf2/NF-κB pathway in a dual manner.
Gut microbiota as a central mediator in hydrogen gas-induced alleviation of colitis via TLR4/NF-κB and Nrf2 pathway regulation.
Gegen Qinlian Decoction improves Alzheimer's disease through TLR4/NF-κB/NLRP3 pathway.
Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility.
Dehydroabietic acid protects against cerebral ischaemia-reperfusion injury by modulating microglia-mediated neuroinflammation via targeting PKCδ.
EZH2-mediated suppression of TIMP1 in spinal GABAergic interneurons drives microglial activation via MMP-9-TLR2/4-NLRP3 signaling in neuropathic pain.
S100a8 inhibitor Paquinimod attenuates coal dust-induced pulmonary fibrosis via blocking neutrophils-S100a8-Tlr4-macrophages signaling axis.
Harnessing dual-channel probiotics to synergistically correct intestinal and vaginal dysbiosis after antibiotic disruption.
CXCL10 secreted by SPRY1-deficient epidermal keratinocytes fuels joint inflammation in psoriatic arthritis via CD14 signaling.
Neuroimmune regulation of IFITM3 via γ-secretase in astrocytes during cerebral ischemia-reperfusion.
Fermented Cordyceps Powder alleviates silica-induced inflammation and fibrosis by inhibiting M1 macrophage polarization via the HMGB1-TLR4-NF-κB pathway.
Shuxuetong injection inhibits pyroptosis in acute ischemic stroke via CD44/NLRP3/GSDMD signal.
Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty Acids and Alleviate Neuroinflammation-Related Cognitive Impairment in Alzheimer's Disease.
TAK-242 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TLR4/NF-κB pathway in rat experimental autoimmune neuritis.
Evobrutinib mitigates neuroinflammation after ischemic stroke by targeting M1 microglial polarization via the TLR4/Myd88/NF-κB pathway.
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation.
Exploration of Berberine Against Ulcerative Colitis via TLR4/NF-κB/HIF-1α Pathway by Bioinformatics and Experimental Validation.
Brozopine ameliorates cognitive impairment via upregulating Nrf2, antioxidation and anti-inflammation activities.
Jianpi Huayu Prescription Prevents Atherosclerosis by Improving Inflammation and Reshaping the Intestinal Microbiota in ApoE(-/-) Mice.
Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway.
The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury.
Prunus persica (L.) Batsch blossom soluble dietary fiber synergia polyphenol improving loperamide-induced constipation in mice via regulating stem cell factor/C-kit, NF-κB signaling pathway and gut microbiota.
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
Dihydroartemisinin Modulates Enteric Glial Cell Heterogeneity to Alleviate Colitis.
Bioinformatics analysis of ferroptosis in frozen shoulder.
Disulfiram attenuates cell and tissue damage and blood‒brain barrier dysfunction after intracranial haemorrhage by inhibiting the classical pyroptosis pathway.
Caspase-8 promotes NLRP3 inflammasome activation mediates eye development defects in zebrafish larvae exposed to perfulorooctane sulfonate (PFOS).
Electroacupuncture inhibits TLR4/NF-κB signaling in the dorsal root ganglion of rats with spared nerve injury.
Activation of NF-κB/MAPK signaling and induction of apoptosis by salicylate synthase NbtS in Nocardia farcinica promotes neuroinflammation development.
Gestational diabetes exacerbates intrauterine microbial exposure induced intestinal microbiota change in offspring contributing to increased immune response.
Ruscogenin Exerts Anxiolytic-Like Effect via Microglial NF-κB/MAPKs/NLRP3 Signaling Pathways in Mouse Model of Chronic Inflammatory Pain.
Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice.
β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice.
CCRR regulate MYZAP-PKP2-Nav1.5 signaling pathway in atrial fibrillation following myocardial infarction.
Timing, initiation and function: An in-depth exploration of the interaction network among neutrophil extracellular traps related genes in acute pancreatitis.
Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization.
Chaihu Guizhi Ganjiang Decoction attenuates nonalcoholic steatohepatitis by enhancing intestinal barrier integrity and ameliorating PPARα mediated lipotoxicity.
Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects.
Amelioration of obesity and inflammation by polysaccharide from unripe fruits of raspberry via gut microbiota regulation.
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation.
OR11H1 Missense Variant Confers the Susceptibility to Vogt-Koyanagi-Harada Disease by Mediating Gadd45g Expression.
MSR405: Inhibiting Neuroinflammation after Spinal Cord Injury in Rats.
Dietary Restriction Improves Perioperative Neurocognitive Disorders by Inhibiting Neuroinflammation and Gut Microbial Dysbiosis.
Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice.
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model.
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
Gut microbiota mediates the protective effects of β-hydroxybutyrate against cisplatin-induced acute kidney injury.
The Combination of Bacillus natto JLCC513 and Ginseng Soluble Dietary Fiber Attenuates Ulcerative Colitis by Modulating the LPS/TLR4/NF-κB Pathway and Gut Microbiota.
ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway.
Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury.
The short peptide encoded by long non-coding RNA RNF217-AS1 inhibits stomach cancer tumorigenesis, macrophage recruitment, and pro-inflammatory responses.
Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis.
Serum amyloid A aggravates endotoxin-induced ocular inflammation through the regulation of retinal microglial activation.
Chitosan-coated artesunate protects against ulcerative colitis via STAT6-mediated macrophage M2 polarization and intestinal barrier protection.
NaAsO(2) regulates TLR4/MyD88/NF-κB signaling pathway through DNMT1/SOCS1 to cause apoptosis and inflammation in hepatic BRL-3A cells.
Liriodendrin exerts protective effects against chronic endometritis in rats by modulating gut microbiota composition and the arginine/nitric oxide metabolic pathway.
The protective effect of apolipoprotein H in paediatric sepsis.
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer's disease mice.
Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways.
Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis.
Three Artemisia pollens trigger the onset of allergic rhinitis via TLR4/MyD88 signaling pathway.
Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4/MyD88/NF-κB pathway.
Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.
Extracellular CIRP induces abnormal activation of fibroblast-like synoviocytes from patients with RA via the TLR4-mediated HDAC3 pathways.
Moluodan promotes DSS-induced intestinal inflammation involving the reprogram of macrophage function and polarization.
S100A9 regulates M1 macrophage polarization and exacerbates steatotic liver ischemia-reperfusion injury.
S100A8 promotes tumor progression by inducing phenotypic polarization of microglia through the TLR4/IL-10 signaling pathway in glioma.
Engineering of phosphatidylserine-targeting ROS-responsive polymeric prodrug for the repair of ischemia-reperfusion-induced acute kidney injury.
Fucoidan ameliorates rotenone-induced Parkinsonism in mice by regulating the microbiota-gut-brain axis.
Alleviatory Role of Panax Notoginseng Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications.
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy.
Mechanism of Xue-Jie-San treating Crohn's disease complicated by atherosclerosis: Network pharmacology, molecular docking and experimental validation.
Polystyrene microplastics induce activation and cell death of neutrophils through strong adherence and engulfment.
Ecliptasaponin A protects heart against acute ischemia-induced myocardial injury by inhibition of the HMGB1/TLR4/NF-κB pathway.
Toralactone alleviates cisplatin-induced acute kidney injury by modulating the gut microbiota-renal axis.
Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury.
Administration of Alistipes indistinctus prevented the progression from nonalcoholic fatty liver disease to nonalcoholic steatohepatitis by enhancing the gut barrier and increasing Lactobacillus spp.
Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Validation.
Preventive effects of matrine on LPS-induced inflammation in RAW 264.7 cells and intestinal damage in mice through the TLR4/NF-κB/MAPK pathway.
Discovery of pyrazolo[1,5-a]pyrimidine derivatives targeting TLR4-TLR4∗ homodimerization via AI-powered next-generation screening.
Methyltransferase METTL3 regulates neuropathic pain through m6A methylation modification of SOCS1.
Neutrophil extracellular traps mediate the crosstalk between plaque microenvironment and unstable carotid plaque formation.
Aucubin suppresses TLR4/NF-κB signalling to shift macrophages toward M2 phenotype in glucocorticoid-associated osteonecrosis of the femoral head.
Inhaled aerosolized algal polysaccharides: A novel and reliable strategy for treating pneumonia through inflammation and oxidative stress inhibition.
Adipose-derived stem cell exosomes loaded with icariin attenuated M1 polarization of macrophages via inhibiting the TLR4/Myd88/NF-κB signaling pathway.
Inhaled tea polyphenol-loaded nanoparticles coated with platelet membranes largely attenuate asthmatic inflammation.
Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis.
Effect of an Airbag-selective Portal Vein Blood Arrester on the Liver after Hepatectomy: A New Technique for Selective Clamping of the Portal Vein.
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 signaling in microglia.
Mechanically tough, adhesive, self-healing hydrogel promotes annulus fibrosus repair via autologous cell recruitment and microenvironment regulation.
Huoxiang Zhengqi Oral Liquid Attenuates LPS-Induced Acute Lung Injury by Modulating Short-Chain Fatty Acid Levels and TLR4/NF-κB p65 Pathway.
Dexmedetomidine Protects against Airway Inflammation and Airway Remodeling in a Murine Model of Chronic Asthma through TLR4/NF-κB Signaling Pathway.
The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure.
Lactiplantibacillus plantarum L47 and inulin alleviate enterotoxigenic Escherichia coli induced ileal inflammation in piglets by upregulating the levels of α-linolenic acid and 12,13-epoxyoctadecenoic acid.
Hesperidin inhibits methylation and autophagy in LPS and high glucose-induced human villous trophoblasts.
Red Rice Seed Coat Targeting SPHK2 Ameliorated Alcoholic Liver Disease via Restored Intestinal Barrier and Improved Gut Microbiota in Mice.
Gram-Negative Bacteria and Lipopolysaccharides as Risk Factors for the Occurrence of Diabetic Foot.
Babao Dan alleviates gut immune and microbiota disorders while impacting the TLR4/MyD88/NF-кB pathway to attenuate 5-Fluorouracil-induced intestinal injury.
N-Acetyl-l-cysteine-Derived Carbonized Polymer Dots with ROS Scavenging via Keap1-Nrf2 Pathway Regulate Alveolar Bone Homeostasis in Periodontitis.
Glucosamine Improves Non-Alcoholic Fatty Liver Disease Induced by High-Fat and High-Sugar Diet through Regulating Intestinal Barrier Function, Liver Inflammation, and Lipid Metabolism.
Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5.
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
Hypoxia-induced CCL2/CCR2 axis in adipose-derived stem cells (ADSCs) promotes angiogenesis by human dermal microvascular endothelial cells (HDMECs) in flap tissues.
Lipopolysaccharide exacerbates to the migration, invasion, and epithelial-mesenchymal transition of esophageal cancer cells by TLR4/NF-κB axis.
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.
METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.
CCR7 Mediated Mimetic Dendritic Cell Vaccine Homing in Lymph Node for Head and Neck Squamous Cell Carcinoma Therapy.
Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.
The protective effects of sophocarpine on sepsis-induced cardiomyopathy.
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation.
Tea Polyphenols Protects Tracheal Epithelial Tight Junctions in Lung during Actinobacillus pleuropneumoniae Infection via Suppressing TLR-4/MAPK/PKC-MLCK Signaling.
Targeting extracellular CIRP with an X-aptamer shows therapeutic potential in acute pancreatitis.
Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway.
Allergen-specific immunotherapy with Alutard SQ improves allergic inflammation in house-dust mites-induced allergic asthma rats through inactivation of the HMGB1/TLR4/NF-κB pathway.
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway.
Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2.
Xianglian Pill attenuates ulcerative colitis through TLR4/MyD88/NF-κB signaling pathway.
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Thyroid-stimulating hormone may participate in insulin resistance by activating toll-like receptor 4 in liver tissues of subclinical hypothyroid rats.
POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6.
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.
Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation.
The outer membrane protein of Fusobacterium necrophorum, 43K OMP, stimulates inflammatory cytokine production through nuclear factor kappa B activation.
Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease.
Palmitic acid combined with γ-interferon inhibits gastric cancer progression by modulating tumor-associated macrophages' polarization via the TLR4 pathway.
Holothuria leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice.
Donkey Oil-Based Ketogenic Diet Prevents Tumor Progression by Regulating Intratumor Inflammation, Metastasis and Angiogenesis in CT26 Tumor-Bearing Mice.
Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model via inhibiting TLRs/MyD88 pathway.
NF-κB and AP-1 are required for the lipopolysaccharide-induced expression of MCP-1, CXCL1, and Cx43 in cultured rat dorsal spinal cord astrocytes.
TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage.
Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway.
LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing.
MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome.
N-Acetyldopamine Dimer Attenuates DSS-Induced Ulcerative Colitis by Suppressing NF-κB and MAPK Pathways.
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Polyvinylpyrrolidone-Modified Taxifolin Liposomes Promote Liver Repair by Modulating Autophagy to Inhibit Activation of the TLR4/NF-κB Signaling Pathway.
Quercetin Administration Following Hypoxia-Induced Neonatal Brain Damage Attenuates Later-Life Seizure Susceptibility and Anxiety-Related Behavior: Modulating Inflammatory Response.
Hawk Tea Flavonoids as Natural Hepatoprotective Agents Alleviate Acute Liver Damage by Reshaping the Intestinal Microbiota and Modulating the Nrf2 and NF-κB Signaling Pathways.
An injectable co-assembled hydrogel blocks reactive oxygen species and inflammation cycle resisting myocardial ischemia-reperfusion injury.
Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway.
pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance "One Stone Four Birds" Effect of Rhein on Ulcerative Colitis.
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway.
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
FG-4592 protects the intestine from irradiation-induced injury by targeting the TLR4 signaling pathway.
Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells.
Kir2.1 channel regulates macrophage polarization via the Ca2+/CaMK II/ERK/NF-κB signaling pathway.
Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.
Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier.
Immunomodulatory Effect of Serum Exosomes From Crohn Disease on Macrophages via Let-7b-5p/TLR4 Signaling.
Catalpol relieved angiotensin II-induced blood-brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells.
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.
Monophosphoryl lipid A ameliorates radiation-induced lung injury by promoting the polarization of macrophages to the M1 phenotype.
Deficiency of mindin reduces renal injury after ischemia reperfusion.
Monosodium urate crystals with controlled shape and aspect ratio for elucidating the pathological progress of acute gout.
EZH2 Regulates Lipopolysaccharide-Induced Periodontal Ligament Stem Cell Proliferation and Osteogenesis through TLR4/MyD88/NF-κB Pathway.
Decreased miR-4512 Levels in Monocytes and Macrophages of Individuals With Systemic Lupus Erythematosus Contribute to Innate Immune Activation and Neutrsophil NETosis by Targeting TLR4 and CXCL2.
Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice.
Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages.
Structure elucidation and anti-inflammatory mechanism of difengpienol C, a new neolignan isolated from Illicium difengpi.
Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p.
Ovotransferrin exerts bidirectional immunomodulatory activities via TLR4-mediated signal transduction pathways in RAW264.7 cells.
Platycodon grandiflorum extract attenuates lipopolysaccharide-induced acute lung injury via TLR4/NF-κBp65 pathway in rats.
Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage.
Anti-nociceptive effects of Sedum Lineare Thunb. on spared nerve injury-induced neuropathic pain by inhibiting TLR4/NF-κB signaling in the spinal cord in rats.
Protective effect of scorpion venom heat-resistant synthetic peptide against PM(2.5)-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
Effect of HMGB1 on monocyte immune function in respiratory syncytial virus bronchiolitis.
Aureonitol Analogues and Orsellinic Acid Esters Isolated from Chaetomium elatum and Their Antineuroinflammatory Activity.
Rosmanol and Carnosol Synergistically Alleviate Rheumatoid Arthritis through Inhibiting TLR4/NF-κB/MAPK Pathway.
CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis.
Let-7i-5p Regulation of Cell Morphology and Migration Through Distinct Signaling Pathways in Normal and Pathogenic Urethral Fibroblasts.
Lipopolysaccharide inhibits osteogenic differentiation of periodontal ligament stem cells partially through toll-like receptor 4-mediated ephrinB2 downregulation.
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin.
Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway.
Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome.
Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation.
Therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy in mice.
Electroacupuncture Alleviates Spared Nerve Injury-Induced Neuropathic Pain And Modulates HMGB1/NF-κB Signaling Pathway In The Spinal Cord.
Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation.
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways.
Geniposide attenuates Aβ(25-35)-induced neurotoxicity via the TLR4/NF-κB pathway in HT22 cells.
Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling.
Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway.
Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy.
Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.
Liu Y, Tao J, Tan D, Zheng F, Su Z, Yuan J, Zhu C, Zheng Z, Zhou X, Luo D
Research (Washington, D.C.) 2026;9:1100
Research (Washington, D.C.) 2026;9:1100
Rosamultin Alleviates LPS-Induced Acute Kidney Injury by Promoting Autophagy and Inhibiting the NF-κB Signaling Pathway.
Huang X, Zhang Z, Cai W
Drug design, development and therapy 2026;20:574424
Drug design, development and therapy 2026;20:574424
Mechanism Study of Yi-Qi-Dao-Zhi Formula in Improving Postoperative Ileus by Targeting the TLR4/NF-κB/MAPK Signaling Pathways.
Yu J, Zhao X, Zhang L, Chen Y, Zhang T, Wang Y, Yi C, Pan H, Wang H, Ge M, Jiang Z, Wang G
Journal of inflammation research 2026;19:589449
Journal of inflammation research 2026;19:589449
Modified Dachengqi Decoction ameliorates sepsis-induced lung injury via the gut microbiota-bile acid axis.
Wu L, Peng W, Li Y, Yu L, Huang P, Ye Y, Feng Y, Chen B, Chen L
Frontiers in cellular and infection microbiology 2026;16:1661639
Frontiers in cellular and infection microbiology 2026;16:1661639
Live and heat-treated Lactiplantibacillus plantarum induce distinct metabolic and immune responses in intestinal epithelial cells.
Matsumoto K, Takada Y, Imamura Y, Yoshida H, Sonomura K, Takahashi M, Moritoki N, Shindo T, Yamamoto J, Albarracin L, Ikeda-Ohtsubo W, Hori M, Villena J, Namai F, Tsujikawa Y, Hashimoto T, Nishiyama K, Kitazawa H
iScience 2026 May 15;29(5):115516
iScience 2026 May 15;29(5):115516
Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis.
Zhu Y, Li G, Guo Y, He Y, Zhang W, Gao L, Zhang J, Guo P, Lin H, Zhang W, Wei Z, Xia Y, Dai Y
The Journal of clinical investigation 2026 May 15;136(10)
The Journal of clinical investigation 2026 May 15;136(10)
Exercise training alleviates myocardial injury in mice with heart failure with preserved ejection fraction via the TLR4-mediated necroptosis pathway.
Dong J, Wang H, Feng Y, Jiang X, Yin Y, Zhang E, Wang C, Xing J
International immunopharmacology 2026 May 1;176:116513
International immunopharmacology 2026 May 1;176:116513
Bushen Huoxue Recipe enhances the immune microenvironment at the maternal-fetal interface via the Hippo signaling pathway in mice with recurrent spontaneous abortion.
Xia L, Huang S, Huang H, Han X, Dong L, Xia Y
Journal of traditional and complementary medicine 2026 Mar;16(2):154-164
Journal of traditional and complementary medicine 2026 Mar;16(2):154-164
Lactobacillus paragasseri LPG-9 reduces placental inflammation in intrahepatic cholestasis of pregnancy by regulating TGR5 in mice.
Huang W, Zhang J, Shan J, Shen W, Du P, Liu J, Guo X, Chen Z, Zeng W, Lin Q, Fan H
Communications biology 2026 Mar 26;9(1)
Communications biology 2026 Mar 26;9(1)
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.
Zhang M, Wang B, Sun D, Chen X, Zhou Y, Yao J, Du L, Zhang Z, Li H, Qu Z, Chen L, Luo Q, Zhang J, Jin X, Cheng X, Niu J, Xing Q, Tan X, Wang T, Liu J, Li L, Song Q, Chen X, Chen Y
JCI insight 2026 Mar 23;11(6)
JCI insight 2026 Mar 23;11(6)
Unraveling the therapeutic mechanisms of cinnamaldehyde in allergic rhinitis: a network Pharmacology and experimental approach.
Yan Z, Gu G, Wei R, Zhang X, Liu X
Journal of bioenergetics and biomembranes 2026 Mar 18;
Journal of bioenergetics and biomembranes 2026 Mar 18;
Numb attenuates LPS-induced neuroinflammation via autophagic regulation of Ifi204 in microglia.
Zhang S, Zang L, Li Y, Zhang Y, Chen X, Xin Y, He G, Zhou Z, Halalmeh I, Liang Y, Li W, Yang J, Geng J, Xiong X
Neurobiology of disease 2026 Jun 1;223:107386
Neurobiology of disease 2026 Jun 1;223:107386
Xue-Jie-San alleviates Crohn's disease through suppressing endothelial cell pyroptosis via the TLR4/NF-κB/NLRP3 pathway.
Gao Y, Zhu YQ, Liu KH, Wu D, Wang Z, Zheng HY, Yang X, Wen K, Sun XL
Journal of ethnopharmacology 2026 Jul 15;366:121648
Journal of ethnopharmacology 2026 Jul 15;366:121648
6-Gingerol alleviates NNK-induced lung carcinogenesis by boosting antioxidation and reducing inflammation.
Qu Z, Ding Y, Zhang L, Sun J, Wang T, Zhuang C
Free radical research 2026 Jan;60(1):1-15
Free radical research 2026 Jan;60(1):1-15
Bushen Huoxue formula component β-Estradiol 3-acetate treats osteoarthritis through enhancing the TLR4 ubiquitination.
Liu X, Wang S, Kuang C, Deng Y, Yuan S, Zou J
The Journal of steroid biochemistry and molecular biology 2026 Jan;255:106862
The Journal of steroid biochemistry and molecular biology 2026 Jan;255:106862
Palmitic acid induces macrophage sialylation via TLR4/MyD88/TRAF6/NF-κB signaling.
Wu N, Wang P, Ran X, Li L, She Y, Wang J, Zeng D, Li X, Jia Y, Huang Y
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168064
Biochimica et biophysica acta. Molecular basis of disease 2026 Jan;1872(1):168064
Electroacupuncture at Zusanli (ST36) alleviates paclitaxel-induced neuropathic pain in rats via regulating TLR4 signaling pathway in the spinal cord.
Wang MN, Zhou YX, Zhao YX, Tan JW, Sang X
Molecular pain 2026 Jan-Dec;22:17448069251413879
Molecular pain 2026 Jan-Dec;22:17448069251413879
Mannose-modified Prunus persica kernel protein nanoparticles loading baicalin coated with Lycium barbarum polysaccharide for ulcerative colitis treatment.
Tao C, Luo F, Wang Y, Gao X, Cao Y, Wang K, Xie Y
Carbohydrate polymers 2026 Jan 1;371:124489
Carbohydrate polymers 2026 Jan 1;371:124489
Bawei Chenxiang Pills Exert Anti-Myocardial Ischemia Effect by Inhibiting Inflammation Through the TLR4/NF-κB/NLRP3 Signaling Pathway.
Kang L, Yang G, Ding Q, Wang J, Tosheel UB, Xiao Y, Zhou F, Gao X, Norbu K, Chai X
Chemistry & biodiversity 2026 Feb;23(2):e03537
Chemistry & biodiversity 2026 Feb;23(2):e03537
MD2 mediates COPD pathogenesis by inducing airway inflammation and ferroptosis through the TLR4/MyD88 pathway.
Xi X, Chen H, Ji H, Xiao T, Liu Z, Chen J, Ge X, Zhang Y, Zhu X
Biochimica et biophysica acta. Molecular basis of disease 2026 Feb;1872(2):168099
Biochimica et biophysica acta. Molecular basis of disease 2026 Feb;1872(2):168099
Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway.
Liu X, Li C, Yang J, Zhang W, Hu Z, Zhang X, Jianati R, Tian F, Dai X, Xu Z, Chen B, Zhu X
Immunity, inflammation and disease 2026 Feb;14(2):e70318
Immunity, inflammation and disease 2026 Feb;14(2):e70318
Artemisia Extracts Suppress H1N1 Influenza A Virus Infection by Targeting Viral HA/NA Proteins and Modulating the TLR4/MyD88/NF-κB Signaling Axis.
Hu Z, Liu H, Wu W, Ali T, Junka A, Sharopov FS, Zou X, Fang S, Sun Y
Pharmaceuticals (Basel, Switzerland) 2026 Feb 6;19(2)
Pharmaceuticals (Basel, Switzerland) 2026 Feb 6;19(2)
Microplastic-Induced Macrophage Dysfunction Drives Lung Tumor Progression through Glutathione Imbalance.
Kim B, Park KM, Lee H, Hyun YM
ACS nano 2026 Feb 24;20(7):5489-5505
ACS nano 2026 Feb 24;20(7):5489-5505
Synergistic effects of Clostridium butyricum and Akkermansia muciniphila-derived postbiotics ameliorate DSS-induced colitis and associated tumorigenesis through immunomodulation and microbiota regulation in mice.
Hua D, Yang Q, Zhou X, Wu D, Kang Y, Tang L, Li B, Zhang Z, Wang X, Hong W, Chen Z, Cui G
mSystems 2026 Feb 17;11(2):e0068925
mSystems 2026 Feb 17;11(2):e0068925
Hypoxia-preconditioned cardiomyocyte-derived extracellular vesicles alleviate myocardial ischemic injury by reprogramming macrophage polarization via the Fgl2/NF-κB pathway.
Zhang Z, Shen H, Zhang S, Zhou J, Zhang M, Wang Y, Zheng Y, Chang Y, Liang X, Hu X, Gao W
International immunopharmacology 2026 Feb 1;170:116077
International immunopharmacology 2026 Feb 1;170:116077
Potential of quercitrin in psoriasis intervention: Dual regulation of the oxidative stress-NF-κB axis and gut microbiota homeostasis.
Guo D, Wang R, Liu S, Liu W, Wang X
Cellular signalling 2026 Aug;144:112504
Cellular signalling 2026 Aug;144:112504
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.
Li Z, Tan D, Lin J, Zhang T, Liu B, Zhao B, Liang D, Li L, Wei X, Lv Z, Wang R, Hu M
Journal of advanced research 2026 Apr;82:845-862
Journal of advanced research 2026 Apr;82:845-862
Cornus officinalis Siebold & Zucc. ethanol extract alleviates primary dysmenorrhea via anti-inflammatory and spasmolytic effects: network pharmacology and experimental verification.
Xu Y, Zhang J, Zhang M, Sun J, Chen Z, Liang Q, Chen S, Hu C, Zhao YT
Fitoterapia 2026 Apr;190:107176
Fitoterapia 2026 Apr;190:107176
Gallic acid attenuates LPS-induced hepatic injury via SIRT-1-dependent immunomodulation and anti-apoptotic mechanisms in rats.
Bindal A, Aşçı H, Karabacak P, Garlı S, Kolay Ö, Elmas A, Bindal GT, Oğuzlar FÇ, Özmen Ö
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr;1872(4):168194
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr;1872(4):168194
Remote mobilization of gut Tregs exosomes serves as nanoshuttles for targeted cardioprotection against ischemia/reperfusion injury by ginseng polysaccharides.
Li YY, Sun L, Wang Y, Yang HY, Xu DS, Zhong YZ, Zhang JH, Li Y, Pi FC, Li QL, Li ZR, Wang WT, Chen MT, Liu MN, Sun QD, Peng MM, Leung EL, Wu QB, Han YL, Liu L, Xie Y, Zhou YF, Zhou H
Pharmacological research 2026 Apr 28;228:108217
Pharmacological research 2026 Apr 28;228:108217
Dehydroepiandrosterone alleviates pulmonary fibrosis by modulating the TLR4/NF-κB/NLRP3 signaling cascade in macrophages.
Xie Q, Zhao X, Lu Y, Shuai S
The Journal of steroid biochemistry and molecular biology 2026 Apr 27;262:107028
The Journal of steroid biochemistry and molecular biology 2026 Apr 27;262:107028
Gut microbiota: A critical regulator of oxaliplatin-induced peripheral neurotoxicity development.
Liu Z, Zhang T, Wang S, Yin H, Shao X, Gao L, Lu X
Neurotoxicology 2026 Apr 21;114:103460
Neurotoxicology 2026 Apr 21;114:103460
Intermittent fasting protects MPTP-induced Parkinson's disease mouse model through regulating gut microbiota dysbiosis.
Qu Y, Wang P, Wang D, Li B, Yang F
International immunopharmacology 2026 Apr 15;175:116447
International immunopharmacology 2026 Apr 15;175:116447
Puerarin Alleviates Depression via Integrated Regulation of TLR4/MyD88/NF-κB Signaling and Gut Microbiota-Metabolic Axis.
Cao XY, Tian JJ, Zhang W, Chen CL, Ma H
Neurochemical research 2026 Apr 10;51(2)
Neurochemical research 2026 Apr 10;51(2)
tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination.
Wang C, Yu B, Zhou H, Li H, Li S, Li X, Wang W, Feng Y, Yu T
Research (Washington, D.C.) 2025;8:0574
Research (Washington, D.C.) 2025;8:0574
Modulation of EGR1 Expression by Hyperglycemia in Swine Rotator Cuff Tendons.
Day J, Rajalekshmi R, Agrawal DK
Journal of orthopaedics and sports medicine 2025;7(3):337-344
Journal of orthopaedics and sports medicine 2025;7(3):337-344
Ginsenoside Rh2-Pretreated Mesenchymal Stem Cell Exosomes Ameliorate Collagen-Induced Arthritis via N6-Methyladenosine Methylation.
Zhou Z, Wu S, Li Y, Shao P, Jiang J
Biomaterials research 2025;29:0220
Biomaterials research 2025;29:0220
HMGB1 Exacerbates Intestinal Barrier Damage by Inducing Ferroptosis Through the TLR4/NF-κB/GPX4 Pathway in Ulcerative Colitis.
Zhu N, Ge X, Zhang L, Chen X, Xiang W, Mei Q
Mediators of inflammation 2025;2025:2395557
Mediators of inflammation 2025;2025:2395557
Curcumin modulated gut microbiota and alleviated renal fibrosis in 5/6 nephrectomy-induced chronic kidney disease rats.
Li C, Chen X, Yao J, Zha W, Li M, Shen J, Jiang H, Tian P
PloS one 2025;20(1):e0314029
PloS one 2025;20(1):e0314029
Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway.
Shi Y, Tang Y, Sun Z, Sui P, Shao Y, Wang Z, Zhang J, Gao M
Drug design, development and therapy 2025;19:51-64
Drug design, development and therapy 2025;19:51-64
Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation.
Yang Z, Kao X, Zhang L, Huang N, Chen J, He M
Drug design, development and therapy 2025;19:349-368
Drug design, development and therapy 2025;19:349-368
Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways.
Liu H, Yang Q, Wang S, Wang T, Pan L, Wang X, Chi Y, Jin Z
Frontiers in pharmacology 2025;16:1660599
Frontiers in pharmacology 2025;16:1660599
Amomum tsaoko flavonoids attenuate ulcerative colitis by inhibiting TLR4/NF-κB/NLRP3 signaling pathway and modulating gut microbiota in mice.
Huang Z, Zhao Y, Yang W, Duan C, Sheng J, Tian Y, Peng L, Gao X
Frontiers in microbiology 2025;16:1557778
Frontiers in microbiology 2025;16:1557778
Identification of novel amino acid variants in the Han Chinese population that impair toll-like receptor 4 signaling and confer hyporesponsiveness to lipopolysaccharide.
Zhou B, Lv Z, Zu R, Liu J, Yang Y, Zhou Z, Li Y
Frontiers in immunology 2025;16:1556600
Frontiers in immunology 2025;16:1556600
Exploring the possible mechanism of low-dose naloxone exposure improving the immune microenvironment of gastric cancer tumors.
Min X, Ma Y, Lv M, Li X, Lv R, Zhao X, Leng Y
Frontiers in immunology 2025;16:1524930
Frontiers in immunology 2025;16:1524930
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells.
Liu J, Shu T, Mu Y, Zheng W, Lu X, Tao H
Frontiers in immunology 2025;16:1503355
Frontiers in immunology 2025;16:1503355
Mn(3)O(4) nanozyme-based anti-inflammatory therapy modulates microglial phenotype by downregulating TLR4/NOX2 expression and further alleviates Alzheimer's disease pathology.
Xie J, Cao K, Liu L, Zhang L, Yang Y, Gong H, Luo H
Theranostics 2025;15(15):7467-7488
Theranostics 2025;15(15):7467-7488
Decoding the exosomal nucleic acid delivery system axis of macrophage autophagy and immune reprogramming via multi-omics analysis.
Zhu Z, Xiang W, Zhang P, Yasin P, Song X
Frontiers in molecular biosciences 2025;12:1711082
Frontiers in molecular biosciences 2025;12:1711082
Methionine ameliorates intestinal injury in senescence-accelerated mouse prone-8 mice by reducing sulfate-reducing bacteria and enhancing barrier function.
Wu Y, Zhang Y, Zhou M, Liu P, Rao X, Zhang Y, Mi M
Frontiers in nutrition 2025;12:1698518
Frontiers in nutrition 2025;12:1698518
Bacteroides fragilis 839 ameliorates anti-tuberculosis drugs-induced liver injury by suppressing inflammation and regulating gut microbiota in mice.
Li Q, Wu C, Zhang K, Zhou Z, Li J, Bai J, Cao J, Shi X
Frontiers in medicine 2025;12:1538528
Frontiers in medicine 2025;12:1538528
Polycyclic Polyprenylated Acylphloroglucinols from Hypericum himalaicum.
Liu GH, Wu F, Huo XY, Sun HB, Jin ZL, Gu YC, Guo DL, Zhou Y
Planta medica 2025 Sep;91(10-11):576-589
Planta medica 2025 Sep;91(10-11):576-589
Icaritin protects against airway inflammation by inhibiting the TLR4/NF-κB pathway in vivo and in vitro.
Xiao B, Zhou G, Hou L, Yang L, Li Z, Cai Y, Zhao A, Mo B, Yao D
Pulmonary pharmacology & therapeutics 2025 Sep;90:102380
Pulmonary pharmacology & therapeutics 2025 Sep;90:102380
miR-29a regulates scleral remodelling via TLR7/8-dependent inflammatory signalling in myopia.
Lv L, Shao Q, Zhou J, Zhu Y
Experimental eye research 2025 Sep;258:110474
Experimental eye research 2025 Sep;258:110474
Ferulic acid promotes thrombopoiesis via TLR4/JAK2/STAT3 signaling: A novel therapeutic strategy for thrombocytopenia.
Liao R, Huang M, Liu Z, Wang X, Gan X, Hao L, Jiang P, Luo J, Huang Q, Mei Q, Wu A, Wang L, Wu J
Biochemical pharmacology 2025 Sep;239:117088
Biochemical pharmacology 2025 Sep;239:117088
Environmental enrichment attenuates social isolation-exacerbated postoperative cognitive dysfunction in aged mice via inhibition of RAGE-HMGB1 proinflammatory signaling.
Li S, Wang H, Qin M, Huang W, Gao H, Song X, Chen X, Li B
Brain research bulletin 2025 Sep;229:111462
Brain research bulletin 2025 Sep;229:111462
Composition and anti-colitis efficacy analysis of ethanol and aqueous extraction of Moringa oleifera leaves.
Feng Y, Huang J, Gong J, Peng W, Yu C, Huai Y, Chen C, Bo R, Liu M, Li J
Fitoterapia 2025 Sep;185:106720
Fitoterapia 2025 Sep;185:106720
Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia-Reperfusion Injury.
Jin H, Li Z, Tan S, Xiao Q, Li Q, Ye J, Zhou Y, Wan Y, Liu Q, Menon BK, Hu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e03722
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e03722
Alfalfa Polysaccharide Alleviates Colitis by Regulating Intestinal Microbiota and the Intestinal Barrier Against the TLR4/MyD88/NF-κB Pathway.
La S, Abaidullah M, Li H, Cui Y, Liu B, Shi Y
Nutrients 2025 Sep 19;17(18)
Nutrients 2025 Sep 19;17(18)
HMGB1 contributes to pancreatic fibrosis by regulating TLR4-mediated autophagy and the NLRP3 inflammasome pathway in chronic pancreatitis.
Li C, Cui L, Zuo Y, Pan J, Li X, Xu X, Zhang L, Zhuo Y, Yao G, Wang Z, Zhang S
Experimental cell research 2025 Sep 1;452(1):114745
Experimental cell research 2025 Sep 1;452(1):114745
Chlorogenic Acid Improves Salicylic Acid-Induced Cochlear Injury by Reducing Oxidative Stress and Inflammatory Response Through TLR4/NF-κB Signalling Pathway.
Lin Y, Li L, Cheng J
Clinical and experimental pharmacology & physiology 2025 Oct;52(10):e70067
Clinical and experimental pharmacology & physiology 2025 Oct;52(10):e70067
Akkermansia muciniphila-derived hypoacylated rough-type lipopolysaccharides alleviate diet-induced obesity via activation of TLR4-IL-23-IL-22 immune axis.
Sun L, Zhang Y, Dong W, Sun J, Wang T, Shao F, Dai H, Han J, Wang W, Wang S, Zhao T, Wang L, Liu C, Liu S, Liu H
iMeta 2025 Oct;4(5):e70066
iMeta 2025 Oct;4(5):e70066
Ginseng-derived nanoparticles accelerate diabetic wound healing by modulating macrophage polarization and restoring endothelial cell function.
Fan L, Jia X, Dong F, Yang S, Li W, Zhao R, Yin L, Zhao D, Wang J
Materials today. Bio 2025 Oct;34:102143
Materials today. Bio 2025 Oct;34:102143
The pyranocoumarin-enriched extract from the leaves of Calophyllum membranaceum alleviates LPS-induced acute lung injury in mice by inhibiting the TLR4/MD2 interaction.
Li Y, Qian J, Mi Y, He S, Shen W, Wang R, Fan H, Kuai H, Zhao Z, Xiong F, Shi X, Hu X, Wang H
Fitoterapia 2025 Oct;186:106796
Fitoterapia 2025 Oct;186:106796
Anti-β2GPI antibodies induce trophoblast pyroptosis and placental inflammation through TLR4/NLRP3/GSDMD axis.
Xu M, Ji X, Zhang H, Zeng D, Zhao Z, Liu J, Zhang L, Dong T, Chen P, Wang X
Placenta 2025 Oct;170:64-74
Placenta 2025 Oct;170:64-74
Unlocking the gut-lung axis: Feixin decoction as a novel modulator in hypoxic pulmonary hypertension.
Wang FY, Yi J, Zhou LL, Tan JL, Cao XY, Zhang C, Wan JJ, Song L, Dai AG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157118
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157118
Melatonin alleviates diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome by modulating of the TLR4/MyD88/NF-κB pathway.
Yuan Z, Yang X, Wang X, Shi X, Chen J, Huang L, Yang J, Shi Y, Zhang L, Mai P
BMC gastroenterology 2025 Oct 9;25(1):715
BMC gastroenterology 2025 Oct 9;25(1):715
Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages.
Gu D, Hu L, Yang K, Yuan W, Shan D, Gao J, Li J, Gimple RC, Dixit D, Zhu Z, Li D, Wu Q, Shi Z, Wang Y, Zhao N, Yang K, Shao J, Lin F, Wang Q, Jin G, Chen Y, Qian X, Hu Z, Li C, Zhang N, You Y, Liu J, Zhang Q, Zhang J, Rich JN, Wang X
Developmental cell 2025 Oct 6;60(19):2558-2575.e6
Developmental cell 2025 Oct 6;60(19):2558-2575.e6
Toxoplasma gondii-induced adverse pregnancy outcomes: insight into the inhibitory role of Trem2 on TLR4/TRAF6/JNK signaling pathway.
Cao Y, Fu F, Ju F, Wu C, Yao T, Yang M, Sun B, Chen J
Parasites & vectors 2025 Oct 6;18(1):396
Parasites & vectors 2025 Oct 6;18(1):396
The effect of anthocyanin extract from Lycium ruthenicum Murray on intestinal barrier function in Bamei ternary pigs.
Wang W, Wu H, Li J, Chen Z, Liu J, Xu E, Hassanin AA, Rahman SU, Chen L, Zheng R
Protoplasma 2025 Nov;262(6):1451-1468
Protoplasma 2025 Nov;262(6):1451-1468
MSC-derived small extracellular vesicles attenuate diabetic retinopathy through miR-29a-3p regulated microglia M1-like polarization.
Tong J, Chen Y, Zhang Y, Liu C, He C, Liu Y, Liao Y, Chen F, Yao G, Xie Z
Experimental eye research 2025 Nov;260:110586
Experimental eye research 2025 Nov;260:110586
Protection against stroke-induced blood-brain barrier disruption by Guanxinning injection and its active-component combination via TLR4/NF-κB/MMP9-mediated neuroinflammation.
Fan S, Du H, Yao Y, Wang H, Zhang M, Shi X, Yan J, Peng L, Xiao G, He S, Lyu M, Zhu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157162
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157162
The total xanthones from Gentianella acuta alleviate acute myocardial infarction by targeting BRD4-mediated cardiomyocyte pyroptosis and inflammation.
Dai C, Sun J, Yang G, Zhang C, Zhang Y, Song Q, Liu X, Duan X, Yang H, Li A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157156
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157156
Ferulic acid ameliorates TLR4-mediated macrophage activation by irreversibly binding to peroxiredoxin 1 to inhibit its dimerization and secretion.
Gao J, Yan J, Zu X, Xu Y, Wang S, Li Y, Zhao Z, Hou Y, Bai G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157254
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157254
LuoFuShan Rheumatism Plaster ameliorates neuropathic pain in mice by suppressing TLR4/TNF-α signaling.
Fu Y, Tan W, Li X, Lin R, Liu S, Ye L
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Nov 20;45(11):2285-2296
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Nov 20;45(11):2285-2296
Tetramethylpyrazine-caffeic Acid Hybrid CT-011 Exerts Dopaminergic Neuroprotection Through Inhibiting Microglia-mediated Neuroinflammation.
Xie M, Cheng Y, Yang L, Lin Z, Shen H, Zhou X, Liu Z, Xing J, Zhou S, Chen H
Molecular neurobiology 2025 Nov 15;63(1):44
Molecular neurobiology 2025 Nov 15;63(1):44
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
Yang H, Shen T, Qi Z, Yang Z, Zhang M, Jiang J, Sun Z, Lu C
Neuropharmacology 2025 Nov 15;279:110638
Neuropharmacology 2025 Nov 15;279:110638
Antibacterial hyaluronic acid hydrogel with sustained release of larazotide as effective colitis treatment.
Yu F, Chen Y, Ouyang S, Tong B, Jiang Z, Wang J, Ding B, Mao K, Wu W, Xu H
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114205
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114205
Glycyrrhizin Attenuates White Matter Injury by Inhibiting Neuroinflammation through the HMGB1/TLR4 Pathway.
Lou J, Ding B, Fang M, Xie W, Wang X, Wang X, Guo X, Zhu J
Molecular neurobiology 2025 May;62(5):6070-6087
Molecular neurobiology 2025 May;62(5):6070-6087
Hippocampal GPR35 is involved in the depression-like behaviors induced by inflammation and mediates the antidepressant effects of fluoxetine in mice.
Kang X, Xie Z, Yang Y, Wu L, Xu H, Zhang S, Liang Y, Wu X
Brain, behavior, and immunity 2025 May;126:189-213
Brain, behavior, and immunity 2025 May;126:189-213
Forsythoside A Alleviates Acute Alcoholic Liver Injury by Binding to TLR4 to Inhibit the Activation of the NF-κB Pathway.
Wang Y, Ma Y, Tuo P, Naeem A, Tang Y, Su Q, Li H, Gao X, Wang X
Phytotherapy research : PTR 2025 May 8;
Phytotherapy research : PTR 2025 May 8;
Xiao-Chai-Hu granule alleviates influenza virus-induced pneumonia by regulating TLR4-PI3K-Akt/p38 MAPK-NF-κB pathways.
Li JJ, Chen ZH, Liang WT, Yang YD, Xie TY, Chen DJ, Yang X, Wu PL, Liang XW, Zou HP, Zhang JH, Shi W, Zhang FX
Journal of ethnopharmacology 2025 May 28;348:119760
Journal of ethnopharmacology 2025 May 28;348:119760
The Role of TLR4 in Lung Epithelial Cell Injury Caused by Influenza Virus Combined with Staphylococcus aureus.
Chen B, Chen C, Lu F, Wang X, Zhang X, Wang Z, Liu H
Microorganisms 2025 May 24;13(6)
Microorganisms 2025 May 24;13(6)
Gut microbiota contributes to obstructive sleep apnea-induced hypertension by gut-heart axis in mice.
Zhang X, Yin Y, Chen Y, Lin L, Shen S, Fang F, Wang Q
International immunopharmacology 2025 May 16;155:114667
International immunopharmacology 2025 May 16;155:114667
Bletilla ochracea Schltr. protects against ethanol-induced acute gastric ulcers by alleviating oxidative stress and inflammation and modulating gut microbiota.
Li X, Liu S, Zhang Y, Huang C, Lou D
Fitoterapia 2025 Mar;181:106397
Fitoterapia 2025 Mar;181:106397
SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota.
Chen M, Zhang Y, Hou L, Zhao Z, Tang P, Sun Q, Zhao J, Wang Q
NPJ Parkinson's disease 2025 Mar 6;11(1):43
NPJ Parkinson's disease 2025 Mar 6;11(1):43
Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation.
Yu L, Luo Q, Rao X, Xiao X, Wang P
Scientific reports 2025 Mar 3;15(1):7410
Scientific reports 2025 Mar 3;15(1):7410
The stems of Syringa oblata Lindl. exert cardioprotective effects against acute myocardial ischemia by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome signaling pathways in mice.
Xu J, Kang L, Tai B, Liu C, Zhang Z, Ding Q, Yang G, Shen Y, Chai X, Gao X
Journal of ethnopharmacology 2025 Mar 26;344:119563
Journal of ethnopharmacology 2025 Mar 26;344:119563
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Ma C, Zhang L, Huang Q, Deng Q, Huang F, Xu J
Food & function 2025 Mar 17;16(6):2589-2597
Food & function 2025 Mar 17;16(6):2589-2597
Macrophages hijack carbapenem-resistance hypervirulent Klebsiella pneumoniae by blocking SLC7A11/GSH-manipulated iron oxidative stress.
Yu Q, Yang J, Chen H, Liu R, Hu R, Cai J, Yang S, Zheng B, Guo P, Cai Z, Zhang S, Zhang G
Free radical biology & medicine 2025 Mar 16;230:234-247
Free radical biology & medicine 2025 Mar 16;230:234-247
Multi-omics approaches reveal the therapeutic mechanism of Naoxintong capsule against ischemic stroke.
Li Y, Zhang J, Lei Y, Chang M, Xu J, Tang S
Journal of ethnopharmacology 2025 Mar 13;343:119435
Journal of ethnopharmacology 2025 Mar 13;343:119435
GSK3β Substrate-competitive Inhibitors Regulate the gut Homeostasis and Barrier Function to Inhibit Neuroinflammation in Scopolamine-induced Alzheimer's Disease Model Mice.
Zhang L, Jiang Z, Hu S, Ni H, Zhao Y, Tan X, Lang Y, Na R, Li Y, Du Q, Li QX, Dong Y
Inflammation 2025 Jun;48(3):1438-1459
Inflammation 2025 Jun;48(3):1438-1459
CMTM7 inhibits TLR4 signaling pathway via promoting Rab5 activation and alleviates acute liver injury.
Sun Y, Guo Z, Huo Y, Zhang H, Li T, Wang P, Han W
Cellular and molecular life sciences : CMLS 2025 Jun 9;82(1):229
Cellular and molecular life sciences : CMLS 2025 Jun 9;82(1):229
Stilbene Dimers, Phenylpropanoids, and Aurones from the Rhizomes of Heterosmilax japonica and Their Anti-inflammatory Activities.
Sun Y, Gao X, Huang Z, Li C, Cheng Y, Tian LW
Journal of natural products 2025 Jun 27;88(6):1481-1490
Journal of natural products 2025 Jun 27;88(6):1481-1490
Tissue geometry spatiotemporally drives bacterial infections.
Han Y, Liu X, Qu S, Duan X, Xiang Y, Jiang N, Yang S, Fang X, Xu L, Wen H, Yu Y, Huang S, Huang J, Zhu K
Cell 2025 Jun 26;188(13):3459-3476.e21
Cell 2025 Jun 26;188(13):3459-3476.e21
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
Ding Y, Zhang L, Zhao W, Wang T, Shi Y, Zhuang C, Qu Z
Molecular nutrition & food research 2025 Jul;69(13):e70103
Molecular nutrition & food research 2025 Jul;69(13):e70103
Platelet-rich plasma improves cyclophosphamide-induced interstitial cystitis in rat models through the toll-like receptor 4/nuclear factor-kappa B signalling pathway.
Wu Y, Chen L, Xu M, Yao L, Yang S, Ang X, Chen W
Clinical and experimental nephrology 2025 Jul;29(7):995-1004
Clinical and experimental nephrology 2025 Jul;29(7):995-1004
P-Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating TLR4/MyD88/NF-κB-Mediated Inflammation and Oxidative Stress.
Wang H, Zhang C, He J, He Z, Yan S, Zhang Y, Huang S, Yan Y, Chen Y, Xian Z, Hu R, Wang Y, Xiao W, Wang M
Journal of cellular and molecular medicine 2025 Jul;29(14):e70659
Journal of cellular and molecular medicine 2025 Jul;29(14):e70659
Psoralen alleviates acute lung injury by covalently targeting Cys106 of HMGB1 in macrophages to inhibit inflammatory responses.
Wang Y, Zhang J, Xu S, Li J, Liu W, Jiang M, Bai G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156807
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156807
Combating Traumatic Brain Injury: A Dual-Mechanism Hydrogel Delivering Salvianolic Acid A and Hydroxysafflor Yellow A to Block TLR4/NF-κB and Boost Angiogenesis.
Zhou G, Yan Y, Nguyen L, Fan J, Zhang X, Gan L, Yan T, Wan H
Polymers 2025 Jul 9;17(14)
Polymers 2025 Jul 9;17(14)
Protective Effects of Ginseng Soluble Dietary Fiber and Its Fecal Microbiota Extract on Antibiotic-Induced Gut Dysbiosis Obese Mice.
Yang L, Hua M, Li D, Li F, He Y, Miao X, Sun M, Niu H, An F, Wang J, Yang M, Lu J, Xu H, Wang J
Journal of microbiology and biotechnology 2025 Jul 14;35:e2502013
Journal of microbiology and biotechnology 2025 Jul 14;35:e2502013
Transcriptional and post-translational mechanisms of ECM remodeling in rotator cuff tendons under hyperlipidemic conditions.
Rajalekshmi R, Agrawal DK
Life sciences 2025 Jul 1;372:123647
Life sciences 2025 Jul 1;372:123647
Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by Aβ(1-42) in Mice.
Liang Y, Yang Y, Jie Z, Kang X, Xu H, Zhang H, Wu X
Molecular neurobiology 2025 Jan;62(1):557-582
Molecular neurobiology 2025 Jan;62(1):557-582
Cathepsin L of Fasciola hepatica meliorates colitis by altering the gut microbiome and inflammatory macrophages.
Gong JZ, Huang JJ, Pan M, Jin QW, Fan YM, Shi WQ, Huang SY
International journal of biological macromolecules 2025 Jan;286:138270
International journal of biological macromolecules 2025 Jan;286:138270
ROS Responsive Cerium Oxide Biomimetic Nanoparticles Alleviates Calcium Oxalate Crystals Induced Kidney Injury via Suppressing Oxidative Stress and M1 Macrophage Polarization.
He Y, Peng E, Ba X, Wu J, Deng W, Huang Q, Tong Y, Shang H, Zhong Z, Liu X, Zhang Y, Ye T, Yang X, Wang K, Xie Y, Jiang K, Xia D, Chen Z, Tang K
Small (Weinheim an der Bergstrasse, Germany) 2025 Jan;21(3):e2405417
Small (Weinheim an der Bergstrasse, Germany) 2025 Jan;21(3):e2405417
Neutrophil membrane-coated nanoparticles for targeted delivery of toll-like receptor 4 siRNA ameliorate LPS-induced acute lung injury.
Cao L, Du M, Cai M, Feng Y, Miao J, Sun J, Song J, Du B
International journal of pharmaceutics 2025 Jan 5;668:124960
International journal of pharmaceutics 2025 Jan 5;668:124960
FuKe QianJin capsule alleviates endometritis via inhibiting inflammation and pyroptosis through modulating TLR4/ NF-κB /NLRP3 pathway.
Xiong S, Xu C, Yang C, Luo H, Xie J, Xia B, Zhang Z, Liao Y, Li C, Li Y, Lin L
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118962
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118962
Elucidation of the mechanism of the Yinhua Miyanling Tablet against urinary tract infection based on a combined strategy of network pharmacology, multi-omics and molecular biology.
Zheng H, Yu X, Wang C, Guo X, Gao C, Chen K, Wang G, Lin H, Liu C, Liu J, Wang F
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118835
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118835
Integrated network pharmacology, transcriptomics and metabolomics to explore the material basis and mechanism of Danggui-Baishao herb pair for treating hepatic fibrosis.
Zhang Z, Wu G, Yang J, Liu X, Chen Z, Liu D, Huang Y, Yang F, Luo W
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118834
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118834
Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota.
Li B, Liu M, Du W, Wang S, Xu Z, Zhang X, Zhang Y, Hua S
BMC veterinary research 2025 Jan 29;21(1):39
BMC veterinary research 2025 Jan 29;21(1):39
Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects.
Xu ZH, Xie MM, Xie CL, Yang XW, Wang JS
Marine drugs 2025 Jan 20;23(1)
Marine drugs 2025 Jan 20;23(1)
Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling.
Chen Z, Ruan F, Wu D, Yu X, Jiang Y, Bao W, Wen H, Hu J, Bi H, Chen L, Le K
Inflammopharmacology 2025 Feb;33(2):865-883
Inflammopharmacology 2025 Feb;33(2):865-883
Exploring the effects of lactulose on lung-intestinal tissue-associated factors and the TLR4/NF-κB signaling pathway in COPD rats based on lung-gut axis theory.
Liu X, Ding R, Wu K, Zhang A, Fan H, Yang J, Li M
Microbial pathogenesis 2025 Feb;199:107245
Microbial pathogenesis 2025 Feb;199:107245
Luteolin alleviates olfactory dysfunction in eosinophilic chronic rhinosinusitis through modulation of the TLR4/NF-κB signaling pathway.
Shi J, Dai L, Gu J, Liu L, Chen Y, Jiang Y, Yu Y
International immunopharmacology 2025 Feb 20;148:114189
International immunopharmacology 2025 Feb 20;148:114189
Probiotics alleviate painful diabetic neuropathy by modulating the microbiota-gut-nerve axis in rats.
Jiang Y, Yang J, Wei M, Shou J, Shen S, Yu Z, Zhang Z, Cai J, Lyu Y, Yang D, Han Y, Zhu J, Liu Z, Ma D, Xing GG, Li M
Journal of neuroinflammation 2025 Feb 2;22(1):30
Journal of neuroinflammation 2025 Feb 2;22(1):30
Atractylodes macrocephala Rhizoma alleviates blood hyperviscosity induced by high-fat, high-sugar, and high-salt diet by inhibiting gut-liver inflammation and fibrinogen synthesis.
Lin Q, Chen Y, Yu B, Chen Z, Zhou H, Su J, Yu J, Yan M, Chen S, Lv G
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119034
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119034
Molecular insights into α-Lactalbumin-Chlorogenic acid interaction: Peptide design and anti-inflammatory mechanisms.
Zheng S, Han C, Zhang T, Zeng X, Bao W, Pan D, Tu M, Wu Z
Food research international (Ottawa, Ont.) 2025 Dec;221(Pt 2):117365
Food research international (Ottawa, Ont.) 2025 Dec;221(Pt 2):117365
Guilongwan Promoted Diabetic Wound Healing via Inhibition of TLR4/NLRP3 Signaling Pathway in Macrophages.
Wang WY, Zhang X, Lv XT, Wang F, Yao YF, Wang FJ, Wang GE
Chemistry & biodiversity 2025 Dec;22(12):e01030
Chemistry & biodiversity 2025 Dec;22(12):e01030
The Therapeutic Potential of Lactobacillus crispatus for Chronic Endometritis: A Comprehensive Clinical Trial and Experimental Investigation.
He X, Chen W, Zhou X, Hu G, Wei J, Liu Y, Cai L, Zhang Z, Chen T
Probiotics and antimicrobial proteins 2025 Dec;17(6):4047-4065
Probiotics and antimicrobial proteins 2025 Dec;17(6):4047-4065
Adipose-Derived Mesenchymal Stem Cells Improve Acute Liver Injury: A Mechanistic Study Based on the TLR4/MyD88/NF-κB Pathway.
Wang Z, Li M, Yan X, Liu Y, Yang P, Liu W, Guan W
International journal of molecular sciences 2025 Dec 6;26(24)
International journal of molecular sciences 2025 Dec 6;26(24)
Melatonin attenuates glandular cystitis via modulation of THBS1 and TLR4/p38 MAPK/STAT3 signaling.
Chen B, Gong S, Zhang J, Zhang Y, Wang H
Scientific reports 2025 Dec 24;15(1):44497
Scientific reports 2025 Dec 24;15(1):44497
Vaginal Weissella confusa MV0113 suppresses pathogens and restores microbiota to alleviate bacterial vaginosis: integrated genomic and in vivo evidence.
Luo C, Dong X, Song J, Li Y, Zhang Q, Pang Y, Yue B, Guo T, Fan Z
BMC microbiology 2025 Dec 17;26(1):51
BMC microbiology 2025 Dec 17;26(1):51
Protective Effects of Arecoline on LPS-Induced Neuroinflammation in BV2 Microglial Cells.
Zhang X, Cui J, Sun J, Fan B, Wang F, Lu C
International journal of molecular sciences 2025 Dec 16;26(24)
International journal of molecular sciences 2025 Dec 16;26(24)
Integrative analysis of gut microbiome and serum metabolomics explores the therapeutic mechanism of tongfeng qingxiao prescription in treating gouty arthritis.
Huang X, Hu L, Sun W, Shao Z, Ma W, Yuan Q, Liu J, Wu D, Cheng L, Li H
Journal of pharmaceutical and biomedical analysis 2025 Dec 15;266:117121
Journal of pharmaceutical and biomedical analysis 2025 Dec 15;266:117121
Volvariella volvacea polysaccharides alleviate acute liver injury by modulating Nrf2/NF-κB pathway in a dual manner.
Li X, Zhang F, Li Y, Cai J, Cai L, Ren Q, Fan A, Xu B, Fu J
NPJ science of food 2025 Dec 12;9(1):278
NPJ science of food 2025 Dec 12;9(1):278
Gut microbiota as a central mediator in hydrogen gas-induced alleviation of colitis via TLR4/NF-κB and Nrf2 pathway regulation.
Shi W, Xi M, Zhang K, Yang J, Cheng X, Zang H, Fan W
International immunopharmacology 2025 Dec 10;167:115671
International immunopharmacology 2025 Dec 10;167:115671
Gegen Qinlian Decoction improves Alzheimer's disease through TLR4/NF-κB/NLRP3 pathway.
Zhang B, Chen L, Kang M, Ai L, Tao Y
Tissue & cell 2025 Aug;95:102818
Tissue & cell 2025 Aug;95:102818
Astrocytic AEG-1 drives neuroinflammation and enhances seizure susceptibility.
Chen Y, Yu Y, Kou J, Qi H, Zhang C, Wang F, Zhou L, Liang X, Xu K, Zhang C, Zhang A, Liu X, Zhang C, Gan G, Sun J, Zhu X
Neurobiology of disease 2025 Aug;212:106957
Neurobiology of disease 2025 Aug;212:106957
Dehydroabietic acid protects against cerebral ischaemia-reperfusion injury by modulating microglia-mediated neuroinflammation via targeting PKCδ.
Li L, Tang H, She L, Lin Z, Yu Q, Zeng Y, Chen L, Chen F, Liang G, Zhao X, Cho N, Wang Y
British journal of pharmacology 2025 Aug;182(16):3818-3837
British journal of pharmacology 2025 Aug;182(16):3818-3837
EZH2-mediated suppression of TIMP1 in spinal GABAergic interneurons drives microglial activation via MMP-9-TLR2/4-NLRP3 signaling in neuropathic pain.
Wan L, Guo H, Hu F, Pan Y, Yang S, Jiang CY, Liu W, Wu X, Wu X
Brain, behavior, and immunity 2025 Aug;128:234-255
Brain, behavior, and immunity 2025 Aug;128:234-255
S100a8 inhibitor Paquinimod attenuates coal dust-induced pulmonary fibrosis via blocking neutrophils-S100a8-Tlr4-macrophages signaling axis.
Du M, Hu S, Cao W, Li B, Jin H, Wang F, Yan R, Li X, Xie Z, Zou Y, Tao X, Wang W, Li Y, Mu M
International immunopharmacology 2025 Aug 28;161:115020
International immunopharmacology 2025 Aug 28;161:115020
Harnessing dual-channel probiotics to synergistically correct intestinal and vaginal dysbiosis after antibiotic disruption.
Zhao X, Huang Q, Liu Y, He X, Chen W, Liu Y, Gan L, Wei J, Zhang H, Chen T
NPJ biofilms and microbiomes 2025 Aug 25;11(1):174
NPJ biofilms and microbiomes 2025 Aug 25;11(1):174
CXCL10 secreted by SPRY1-deficient epidermal keratinocytes fuels joint inflammation in psoriatic arthritis via CD14 signaling.
Xu F, Cui YZ, Yang XY, Zheng YX, Chen XB, Zhou H, Wang ZY, Zhou Y, Lu Y, Li YY, Ye LR, Fu NC, Chen SQ, Chen XY, Zheng M, Yang Y, Man XY
The Journal of clinical investigation 2025 Aug 1;135(15)
The Journal of clinical investigation 2025 Aug 1;135(15)
Neuroimmune regulation of IFITM3 via γ-secretase in astrocytes during cerebral ischemia-reperfusion.
Ni X, Pan Y, Liu X, Zhu Y, Yao X, Mo Y, Dai Q, Wang J
Biochimica et biophysica acta. Molecular basis of disease 2025 Apr;1871(4):167733
Biochimica et biophysica acta. Molecular basis of disease 2025 Apr;1871(4):167733
Fermented Cordyceps Powder alleviates silica-induced inflammation and fibrosis by inhibiting M1 macrophage polarization via the HMGB1-TLR4-NF-κB pathway.
Pu S, Meng X, Shi Y, Huang N, Zhang C, Pang A, Shao H, Jia Q
Journal of ethnopharmacology 2025 Apr 9;345:119631
Journal of ethnopharmacology 2025 Apr 9;345:119631
Shuxuetong injection inhibits pyroptosis in acute ischemic stroke via CD44/NLRP3/GSDMD signal.
Shang J, Huang G, Wang B, Wang J, Wei W, Cui Y, Liu X
Journal of ethnopharmacology 2025 Apr 9;345:119618
Journal of ethnopharmacology 2025 Apr 9;345:119618
Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty Acids and Alleviate Neuroinflammation-Related Cognitive Impairment in Alzheimer's Disease.
Song M, Zhang S, Gan Y, Ding T, Li Z, Fan X
Journal of agricultural and food chemistry 2025 Apr 30;73(17):10316-10330
Journal of agricultural and food chemistry 2025 Apr 30;73(17):10316-10330
TAK-242 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TLR4/NF-κB pathway in rat experimental autoimmune neuritis.
Li X, Yang L, Kang X, Wang G, Yuan Y, Yang H, Yang T, Wang Z
International immunopharmacology 2025 Apr 24;153:114429
International immunopharmacology 2025 Apr 24;153:114429
Evobrutinib mitigates neuroinflammation after ischemic stroke by targeting M1 microglial polarization via the TLR4/Myd88/NF-κB pathway.
Jiang Y, Wang N, Liu J, Li J, Chang L, Yang C, Chen Z, Huang W, Wang J, Lang X, Liu X, Liu Y, Sun B, Li H
Molecular medicine (Cambridge, Mass.) 2025 Apr 22;31(1):148
Molecular medicine (Cambridge, Mass.) 2025 Apr 22;31(1):148
TLR4-mediated endoplasmic reticulum stress regulates pyroptosis in macrophages infected with the Bacillus Calmette-Guérin mycobacterial.
Nie X, Miao S, Hou Y, Ma Y, Li M, Liu Y, Yang Y, Xu J, Wang Y
International immunopharmacology 2025 Apr 16;152:114346
International immunopharmacology 2025 Apr 16;152:114346
Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation.
Jia Z, Kang B, Dong Y, Fan M, Li W, Zhang W
International journal of biological sciences 2024;20(8):2994-3007
International journal of biological sciences 2024;20(8):2994-3007
Exploration of Berberine Against Ulcerative Colitis via TLR4/NF-κB/HIF-1α Pathway by Bioinformatics and Experimental Validation.
Li J, Dan W, Zhang C, Liu N, Wang Y, Liu J, Zhang S
Drug design, development and therapy 2024;18:2847-2868
Drug design, development and therapy 2024;18:2847-2868
Brozopine ameliorates cognitive impairment via upregulating Nrf2, antioxidation and anti-inflammation activities.
Fu Z, Wang X, Fan Y, Shang D, Zhang J, Xiao T, Guo J, Wang Y, Wang Z, Zhang Z, Jia Q, Zhu J, Jahromi AB, Meng Y, Gao N, Chang J, Gao Y
Frontiers in pharmacology 2024;15:1428455
Frontiers in pharmacology 2024;15:1428455
Jianpi Huayu Prescription Prevents Atherosclerosis by Improving Inflammation and Reshaping the Intestinal Microbiota in ApoE(-/-) Mice.
Zhao HR, Xian QC, Zhang XM, Ma XY, Wang FQ, Wang RS, Liu ZJ, Zhang ZG
Cell biochemistry and biophysics 2024 Sep;82(3):2297-2319
Cell biochemistry and biophysics 2024 Sep;82(3):2297-2319
Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway.
Huang J, Hu X, Li J, Gong D
Naunyn-Schmiedeberg's archives of pharmacology 2024 Sep;397(9):6647-6659
Naunyn-Schmiedeberg's archives of pharmacology 2024 Sep;397(9):6647-6659
The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury.
Li S, Yang P, Wu Z, Huang W, Zhu X, Zhong L
Brain research bulletin 2024 Sep;215:111025
Brain research bulletin 2024 Sep;215:111025
Prunus persica (L.) Batsch blossom soluble dietary fiber synergia polyphenol improving loperamide-induced constipation in mice via regulating stem cell factor/C-kit, NF-κB signaling pathway and gut microbiota.
Liang S, He Z, Liang Z, Wang K, Du B, Guo R, Li P
Food research international (Ottawa, Ont.) 2024 Sep;192:114761
Food research international (Ottawa, Ont.) 2024 Sep;192:114761
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
Long L, Dai X, Yao T, Zhang X, Jiang G, Cheng X, Jiang M, He Y, Peng Z, Hu G, Tao L, Meng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
Dihydroartemisinin Modulates Enteric Glial Cell Heterogeneity to Alleviate Colitis.
Qiu P, Chang Y, Chen X, Wang S, Nie H, Hong Y, Zhang M, Wang H, Xiao C, Chen Y, Liu L, Zhao Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2403461
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2403461
Bioinformatics analysis of ferroptosis in frozen shoulder.
Zhang H, Zhou J, Liu Z, Wang K, Jiang H
BMC medical genomics 2024 Sep 27;17(1):234
BMC medical genomics 2024 Sep 27;17(1):234
Disulfiram attenuates cell and tissue damage and blood‒brain barrier dysfunction after intracranial haemorrhage by inhibiting the classical pyroptosis pathway.
Xu C, Jiang F, Mao Y, Wei W, Song J, Jia F, Du X, Zhong D, Li G
Scientific reports 2024 Sep 19;14(1):21860
Scientific reports 2024 Sep 19;14(1):21860
Caspase-8 promotes NLRP3 inflammasome activation mediates eye development defects in zebrafish larvae exposed to perfulorooctane sulfonate (PFOS).
Wu LY, Zhang JL, Zeeshan M, Zhou Y, Zhang YT, He WT, Jin N, Dai Y, Chi W, Ou Z, Dong GH, Lin LZ
Environmental pollution (Barking, Essex : 1987) 2024 Sep 1;356:124252
Environmental pollution (Barking, Essex : 1987) 2024 Sep 1;356:124252
Electroacupuncture inhibits TLR4/NF-κB signaling in the dorsal root ganglion of rats with spared nerve injury.
Xia Y, Xue M, Sun Y, Wang Y, Huang Z, Huang C
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2024 Oct;42(5):275-284
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2024 Oct;42(5):275-284
Activation of NF-κB/MAPK signaling and induction of apoptosis by salicylate synthase NbtS in Nocardia farcinica promotes neuroinflammation development.
Shen J, Ji Xz, Han L, Yao J, Liang Y, Yuan M, Xu S, Li Z
mSystems 2024 Oct 22;9(10):e0089324
mSystems 2024 Oct 22;9(10):e0089324
Gestational diabetes exacerbates intrauterine microbial exposure induced intestinal microbiota change in offspring contributing to increased immune response.
Liu J, Chen Y, Laurent I, Yang P, Xiao X, Li X
Nutrition & diabetes 2024 Oct 19;14(1):87
Nutrition & diabetes 2024 Oct 19;14(1):87
Ruscogenin Exerts Anxiolytic-Like Effect via Microglial NF-κB/MAPKs/NLRP3 Signaling Pathways in Mouse Model of Chronic Inflammatory Pain.
Qi JY, Jin YC, Wang XS, Yang LK, Lu L, Yue J, Yang F, Liu YS, Jiang YL, Song DK, Lv T, Li XB, Zhang K, Liu SB
Phytotherapy research : PTR 2024 Nov;38(11):5417-5440
Phytotherapy research : PTR 2024 Nov;38(11):5417-5440
Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice.
Wang Z, Zhu M, Li Q, Cao J, Zhong Q, Jin Z, Huang Y, Lan Q, Gao Y, Xiong Z
Molecular medicine (Cambridge, Mass.) 2024 Nov 27;30(1):235
Molecular medicine (Cambridge, Mass.) 2024 Nov 27;30(1):235
β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice.
Wang R, Yang X, Wang L, Wang R, Zhang W, Ji Y, Li Z, Li H, Cui L
European journal of pharmacology 2024 Nov 15;983:176959
European journal of pharmacology 2024 Nov 15;983:176959
CCRR regulate MYZAP-PKP2-Nav1.5 signaling pathway in atrial fibrillation following myocardial infarction.
Xuan L, Guo J, Luo H, Cui S, Sun F, Wang G, Yang X, Li S, Zhang H, Zhang Q, Yang H, Wang S, Hu X, Yang B, Sun L
iScience 2024 Nov 15;27(11):111102
iScience 2024 Nov 15;27(11):111102
Timing, initiation and function: An in-depth exploration of the interaction network among neutrophil extracellular traps related genes in acute pancreatitis.
Zhang H, Wang Z, Li J, Jia Y, Li F
International immunopharmacology 2024 Nov 15;141:112923
International immunopharmacology 2024 Nov 15;141:112923
Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization.
Lu S, Jin H, Nong T, Li D, Long K, Chen Y, Li Y, Xing H, Pan T, He S, Jiang K, Zhong F
Free radical biology & medicine 2024 Nov 1;224:506-520
Free radical biology & medicine 2024 Nov 1;224:506-520
Chaihu Guizhi Ganjiang Decoction attenuates nonalcoholic steatohepatitis by enhancing intestinal barrier integrity and ameliorating PPARα mediated lipotoxicity.
Wu H, Lou T, Pan M, Wei Z, Yang X, Liu L, Feng M, Shi L, Qu B, Cong S, Chen K, Yang H, Liu J, Li Y, Jia Z, Xiao H
Journal of ethnopharmacology 2024 May 23;326:117841
Journal of ethnopharmacology 2024 May 23;326:117841
Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects.
Zhang Z, Ge M, Wu D, Li W, Chen W, Liu P, Zhang H, Yang Y
Carbohydrate polymers 2024 May 15;332:121916
Carbohydrate polymers 2024 May 15;332:121916
Amelioration of obesity and inflammation by polysaccharide from unripe fruits of raspberry via gut microbiota regulation.
Huang Y, Hu J, Xia Q, Tang M, Wang Y, Wang G, Shao X, Yuan H, Li S, Huang P, Peng C, Guo J, Gui S
International journal of biological macromolecules 2024 Mar;261(Pt 2):129825
International journal of biological macromolecules 2024 Mar;261(Pt 2):129825
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation.
Peng Z, Li XJ, Zhou Y, Zhang JT, Zhu Q, Sun JQ, Hang CH, Li W, Zhang QR, Zhuang Z
Free radical biology & medicine 2024 Mar;215:79-93
Free radical biology & medicine 2024 Mar;215:79-93
OR11H1 Missense Variant Confers the Susceptibility to Vogt-Koyanagi-Harada Disease by Mediating Gadd45g Expression.
Li X, Wang G, Wang X, Li W, Li N, Liu X, Fan W, He S, Han Y, Su G, Cao Q, Yang P, Hou S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306563
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306563
MSR405: Inhibiting Neuroinflammation after Spinal Cord Injury in Rats.
Liu Y, Xiao Y, Gao J, Gao J, Li R, Qi Z, Liu X
Biomedicines 2024 Mar 8;12(3)
Biomedicines 2024 Mar 8;12(3)
Dietary Restriction Improves Perioperative Neurocognitive Disorders by Inhibiting Neuroinflammation and Gut Microbial Dysbiosis.
Ren L, Liang H, Zhu L, Yang X, Zhang H, Sun N, Huang D, Feng J, Wu Y, Xiong L, Ke X, Li M, Zhang A
Neuroscience 2024 Mar 5;540:48-67
Neuroscience 2024 Mar 5;540:48-67
Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice.
Zhu M, Huang Y, Wang Z, Jin Z, Cao J, Zhong Q, Xiong Z
Aging and disease 2024 Mar 21;16(2):1180-1198
Aging and disease 2024 Mar 21;16(2):1180-1198
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model.
Zhu Y, Fang Y, Wang Y, Han D, Liu J, Tian L, Xu M, Wang Y, Cao F
ACS biomaterials science & engineering 2024 Mar 11;10(3):1530-1543
ACS biomaterials science & engineering 2024 Mar 11;10(3):1530-1543
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
Yi G, Zhang R, Li M, Song X, Li S
International immunopharmacology 2024 Mar 10;129:111629
International immunopharmacology 2024 Mar 10;129:111629
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Li W, Zhang W, Zhang D, Shi C, Wang Y
International immunopharmacology 2024 Mar 10;129:111612
International immunopharmacology 2024 Mar 10;129:111612
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
Shen J, Hao C, Yuan S, Chen W, Tong T, Chen Y, Shahzad Aslam M, Yan S, Li J, Zeng J, Liu S, Chen Y, Jiang Y, Li P, Meng X
Brain research 2024 Mar 1;1826:148715
Brain research 2024 Mar 1;1826:148715
Gut microbiota mediates the protective effects of β-hydroxybutyrate against cisplatin-induced acute kidney injury.
Tian R, Wang X, Tang S, Zhao L, Hao Y, Li R, Zhou X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116752
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116752
The Combination of Bacillus natto JLCC513 and Ginseng Soluble Dietary Fiber Attenuates Ulcerative Colitis by Modulating the LPS/TLR4/NF-κB Pathway and Gut Microbiota.
Ma M, Li Y, He Y, Li D, Niu H, Sun M, Miao X, Su Y, Zhang H, Hua M, Wang J
Journal of microbiology and biotechnology 2024 Jun 28;34(6):1287-1298
Journal of microbiology and biotechnology 2024 Jun 28;34(6):1287-1298
ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway.
Feng Y, Zhou C, Zhao F, Ma T, Xiao Y, Peng K, Xia R
Gene 2024 Jun 20;912:148365
Gene 2024 Jun 20;912:148365
Disulfiram downregulates ferredoxin 1 to maintain copper homeostasis and inhibit inflammation in cerebral ischemia/reperfusion injury.
Yang S, Li X, Yan J, Jiang F, Fan X, Jin J, Zhang W, Zhong D, Li G
Scientific reports 2024 Jul 2;14(1):15175
Scientific reports 2024 Jul 2;14(1):15175
The short peptide encoded by long non-coding RNA RNF217-AS1 inhibits stomach cancer tumorigenesis, macrophage recruitment, and pro-inflammatory responses.
Ma Q, Ma F, Zhang B, Zhang Y, Peng L, Li X
Amino acids 2024 Jul 15;56(1):45
Amino acids 2024 Jul 15;56(1):45
Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis.
Xu Z, Li J, Zhou K, Wang K, Hu H, Hu Y, Gao Y, Luo Z, Huang J
Journal of ethnopharmacology 2024 Jul 15;329:118162
Journal of ethnopharmacology 2024 Jul 15;329:118162
Serum amyloid A aggravates endotoxin-induced ocular inflammation through the regulation of retinal microglial activation.
Feng H, Zhou W, Yang Y, Zhang X, Mao R, Zhou Y, Cheng T, Xiao H, Rao Y, He J, Zhao P, Li J, Jiang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23389
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23389
Chitosan-coated artesunate protects against ulcerative colitis via STAT6-mediated macrophage M2 polarization and intestinal barrier protection.
Tao Y, Xu L, Liu X, Wang P, Wei S, Huang Y, Gu W, Bo R, Liu M, Yu J, Li J
International journal of biological macromolecules 2024 Jan;254(Pt 1):127680
International journal of biological macromolecules 2024 Jan;254(Pt 1):127680
NaAsO(2) regulates TLR4/MyD88/NF-κB signaling pathway through DNMT1/SOCS1 to cause apoptosis and inflammation in hepatic BRL-3A cells.
Li S, Zhang J, Ma M, Zhang M, Li L, Chen W, Li S
Biological trace element research 2024 Jan;202(1):258-267
Biological trace element research 2024 Jan;202(1):258-267
Liriodendrin exerts protective effects against chronic endometritis in rats by modulating gut microbiota composition and the arginine/nitric oxide metabolic pathway.
Cheng F, Li D, Ma X, Wang Y, Lu L, Hu B, Cui S
International immunopharmacology 2024 Jan 5;126:111235
International immunopharmacology 2024 Jan 5;126:111235
The protective effect of apolipoprotein H in paediatric sepsis.
Yu Z, Xiao C, Liu R, Pi D, Jin B, Zou Z, Xu F
Critical care (London, England) 2024 Jan 30;28(1):36
Critical care (London, England) 2024 Jan 30;28(1):36
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
Lin S, Chen Z, Wu Z, Fei F, Xu Z, Tong Y, Sun W, Wang P
Neurochemical research 2024 Feb;49(2):477-491
Neurochemical research 2024 Feb;49(2):477-491
Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer's disease mice.
Ni H, Liu M, Cao M, Zhang L, Zhao Y, Yi L, Li Y, Liu L, Wang P, Du Q, Zhou H, Dong Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116190
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116190
Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways.
Zheng SL, Wang YM, Chi CF, Wang B
Antioxidants (Basel, Switzerland) 2024 Feb 28;13(3)
Antioxidants (Basel, Switzerland) 2024 Feb 28;13(3)
Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis.
Hu X, Zou M, Zheng W, Zhu M, Hou Q, Gao H, Zhang X, Liu Y, Cheng Z
Respiratory research 2024 Feb 24;25(1):100
Respiratory research 2024 Feb 24;25(1):100
Three Artemisia pollens trigger the onset of allergic rhinitis via TLR4/MyD88 signaling pathway.
Zhang J, Gao L, Yu D, Song Y, Zhao Y, Feng Y
Molecular biology reports 2024 Feb 23;51(1):319
Molecular biology reports 2024 Feb 23;51(1):319
Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4/MyD88/NF-κB pathway.
Wang G, Li R, Feng C, Li K, Liu S, Fu Q
Cell death discovery 2024 Feb 20;10(1):92
Cell death discovery 2024 Feb 20;10(1):92
Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.
Wang C, Chen Q, Chen S, Fan L, Gan Z, Zhao M, Shi L, Bin P, Yang G, Zhou X, Ren W
Molecular cell 2024 Feb 15;84(4):744-759.e6
Molecular cell 2024 Feb 15;84(4):744-759.e6
Extracellular CIRP induces abnormal activation of fibroblast-like synoviocytes from patients with RA via the TLR4-mediated HDAC3 pathways.
Yao F, Zhao Y, Yu Q, Hu W, Lin Y, Chen Y, Li L, Sun C, Li S, Wang K, Yang M, Zhou R, Hu W
International immunopharmacology 2024 Feb 15;128:111525
International immunopharmacology 2024 Feb 15;128:111525
Moluodan promotes DSS-induced intestinal inflammation involving the reprogram of macrophage function and polarization.
Zhao M, Qiao C, Cui Z, Zhang W, Yang S, Zhu C, Du F, Ning T, Xie S, Liu S, Li P, Xu J, Zhu S
Journal of ethnopharmacology 2024 Feb 10;320:117393
Journal of ethnopharmacology 2024 Feb 10;320:117393
S100A9 regulates M1 macrophage polarization and exacerbates steatotic liver ischemia-reperfusion injury.
Sheng M, Liu W, Lu Z, Lin Y, Yu W
Transplant immunology 2024 Dec;87:102134
Transplant immunology 2024 Dec;87:102134
S100A8 promotes tumor progression by inducing phenotypic polarization of microglia through the TLR4/IL-10 signaling pathway in glioma.
Yang Y, Cui H, Li D, Chen L, Liu Y, Zhou C, Li L, Feng M, Chen X, Cao Y, Gao Y
Journal of the National Cancer Center 2024 Dec;4(4):369-381
Journal of the National Cancer Center 2024 Dec;4(4):369-381
Engineering of phosphatidylserine-targeting ROS-responsive polymeric prodrug for the repair of ischemia-reperfusion-induced acute kidney injury.
Wang JH, Mao HB, Hu JB, Cheng S, Su H
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:1100-1114
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:1100-1114
Fucoidan ameliorates rotenone-induced Parkinsonism in mice by regulating the microbiota-gut-brain axis.
Yang X, Zhang X, Ma Y, Li S, Wang Q, Hong JS, Yu G, Qi B, Wang J, Liu C, Shang Q, Wu X, Zhao J
International journal of biological macromolecules 2024 Dec;283(Pt 2):137373
International journal of biological macromolecules 2024 Dec;283(Pt 2):137373
Alleviatory Role of Panax Notoginseng Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications.
Hu Y, Fan Q, Qiao B, Xu O, Lv B, Han N, Zhang X
COPD 2024 Dec;21(1):2329282
COPD 2024 Dec;21(1):2329282
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy.
Li X, Li J, Ji J, Li S, Yao X, Fan H, Yao R
Journal of neurochemistry 2024 Dec;168(12):3982-4000
Journal of neurochemistry 2024 Dec;168(12):3982-4000
Mechanism of Xue-Jie-San treating Crohn's disease complicated by atherosclerosis: Network pharmacology, molecular docking and experimental validation.
Wu D, Lin Q, Wang Z, Huang H, Song X, Gao Y, Yang X, Wen K, Sun X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156169
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156169
Polystyrene microplastics induce activation and cell death of neutrophils through strong adherence and engulfment.
Park KM, Kim B, Woo W, Kim LK, Hyun YM
Journal of hazardous materials 2024 Dec 5;480:136100
Journal of hazardous materials 2024 Dec 5;480:136100
Ecliptasaponin A protects heart against acute ischemia-induced myocardial injury by inhibition of the HMGB1/TLR4/NF-κB pathway.
Ge S, Wu S, Yin Q, Tan M, Wang S, Yang Y, Chen Z, Xu L, Zhang H, Meng C, Xia Y, Asakawa N, Wei W, Gong K, Pan X
Journal of ethnopharmacology 2024 Dec 5;335:118612
Journal of ethnopharmacology 2024 Dec 5;335:118612
Toralactone alleviates cisplatin-induced acute kidney injury by modulating the gut microbiota-renal axis.
Tian Y, Tian R, He J, Guo Y, Yan P, Chen Y, Li R, Wang B
International immunopharmacology 2024 Dec 5;142(Pt A):113115
International immunopharmacology 2024 Dec 5;142(Pt A):113115
Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury.
Liu L, Zheng C, Xu Z, Wang Z, Zhong Y, He Z, Zhang W, Zhang Y
Microbiology spectrum 2024 Dec 5;12(12):e0210824
Microbiology spectrum 2024 Dec 5;12(12):e0210824
Administration of Alistipes indistinctus prevented the progression from nonalcoholic fatty liver disease to nonalcoholic steatohepatitis by enhancing the gut barrier and increasing Lactobacillus spp.
Xu X, Wang Y, Wu X, Cai T, Dong L, Liang S, Zhu L, Song X, Dong Y, Zheng Y, Li L, Sun W
Biochemical and biophysical research communications 2024 Dec 31;741:151033
Biochemical and biophysical research communications 2024 Dec 31;741:151033
Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Validation.
Xu Y, Cai Q, Zhao C, Zhang W, Xu X, Lin H, Lin Y, Chen D, Lin S, Jia P, Wang M, Zhang L, Lin W
Pharmaceuticals (Basel, Switzerland) 2024 Dec 25;18(1)
Pharmaceuticals (Basel, Switzerland) 2024 Dec 25;18(1)
Preventive effects of matrine on LPS-induced inflammation in RAW 264.7 cells and intestinal damage in mice through the TLR4/NF-κB/MAPK pathway.
Mao N, Yu Y, Lu X, Yang Y, Liu Z, Wang D
International immunopharmacology 2024 Dec 25;143(Pt 2):113432
International immunopharmacology 2024 Dec 25;143(Pt 2):113432
Discovery of pyrazolo[1,5-a]pyrimidine derivatives targeting TLR4-TLR4∗ homodimerization via AI-powered next-generation screening.
Jiang YY, Yan ST, Zhang SZ, Wang M, Diao WM, Li J, Fang XM, Yin H
European journal of medicinal chemistry 2024 Dec 15;280:116945
European journal of medicinal chemistry 2024 Dec 15;280:116945
Methyltransferase METTL3 regulates neuropathic pain through m6A methylation modification of SOCS1.
Wu L, Ning P, Liang Y, Wang T, Chen L, Lu D, Tang H
Neuropharmacology 2024 Dec 15;261:110176
Neuropharmacology 2024 Dec 15;261:110176
Neutrophil extracellular traps mediate the crosstalk between plaque microenvironment and unstable carotid plaque formation.
Cao Y, Chen M, Jiao X, Li S, Wang D, Zhan Y, Li J, Hao Z, Li Q, Liu Y, Feng Y, Li R, Wang H, Liu M, Fu Q, Li Y
Experimental & molecular medicine 2024 Aug;56(8):1717-1735
Experimental & molecular medicine 2024 Aug;56(8):1717-1735
Aucubin suppresses TLR4/NF-κB signalling to shift macrophages toward M2 phenotype in glucocorticoid-associated osteonecrosis of the femoral head.
Yue C, Cui G, Cheng Y, Zhang X, Sheng HF, Yang Y, Guo J, Liu Y, Xu B
Journal of cellular and molecular medicine 2024 Aug;28(15):e18583
Journal of cellular and molecular medicine 2024 Aug;28(15):e18583
Inhaled aerosolized algal polysaccharides: A novel and reliable strategy for treating pneumonia through inflammation and oxidative stress inhibition.
Zhang X, Lv D, Li B, Ding Y
International immunopharmacology 2024 Aug 20;137:112532
International immunopharmacology 2024 Aug 20;137:112532
Adipose-derived stem cell exosomes loaded with icariin attenuated M1 polarization of macrophages via inhibiting the TLR4/Myd88/NF-κB signaling pathway.
Yan Q, Song C, Liu H, Li Y, Ma J, Zhao Y, Song Z, Chen Y, Zhu R, Zhang Z
International immunopharmacology 2024 Aug 20;137:112448
International immunopharmacology 2024 Aug 20;137:112448
Inhaled tea polyphenol-loaded nanoparticles coated with platelet membranes largely attenuate asthmatic inflammation.
Ouyang S, Lu P, Li J, Jin H, Wu W, Luo R, Wang B, Huang X, Lian X, Huang G
Respiratory research 2024 Aug 17;25(1):311
Respiratory research 2024 Aug 17;25(1):311
Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis.
Liu J, Liao X, Li N, Xu Z, Yang W, Zhou H, Liu Y, Zhang Z, Wang G, Hou S
MedComm 2024 Apr;5(4):e534
MedComm 2024 Apr;5(4):e534
Effect of an Airbag-selective Portal Vein Blood Arrester on the Liver after Hepatectomy: A New Technique for Selective Clamping of the Portal Vein.
Fu CX, Qin XR, Chen JS, Zhong J, Xie YX, Li BD, Fu QQ, Li F, Zheng JF
Current medical science 2024 Apr;44(2):380-390
Current medical science 2024 Apr;44(2):380-390
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 signaling in microglia.
Cai Q, Zhao C, Xu Y, Lin H, Jia B, Huang B, Lin S, Chen D, Jia P, Wang M, Lin W, Zhang L, Chu J, Peng J
Journal of ethnopharmacology 2024 Apr 24;324:117712
Journal of ethnopharmacology 2024 Apr 24;324:117712
Mechanically tough, adhesive, self-healing hydrogel promotes annulus fibrosus repair via autologous cell recruitment and microenvironment regulation.
Wei Z, Ye H, Li Y, Li X, Liu Y, Chen Y, Yu J, Wang J, Ye X
Acta biomaterialia 2024 Apr 1;178:50-67
Acta biomaterialia 2024 Apr 1;178:50-67
Huoxiang Zhengqi Oral Liquid Attenuates LPS-Induced Acute Lung Injury by Modulating Short-Chain Fatty Acid Levels and TLR4/NF-κB p65 Pathway.
Tang R, Zhang J, Zhang R, Li X, Lv R, Nan H, Liu J, Zhao Z, He W, Wang L
BioMed research international 2023;2023:6183551
BioMed research international 2023;2023:6183551
Dexmedetomidine Protects against Airway Inflammation and Airway Remodeling in a Murine Model of Chronic Asthma through TLR4/NF-κB Signaling Pathway.
Zhou Y, Du X, Wang Q, Xiao S, Zhi J, Gao H, Yang D
Mediators of inflammation 2023;2023:3695469
Mediators of inflammation 2023;2023:3695469
The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure.
Fu Y, Xiang Y, Wang Y, Liu Z, Yang D, Zha J, Tang C, Cai J, Chen G, Dong Z
Theranostics 2023;13(9):2757-2773
Theranostics 2023;13(9):2757-2773
Lactiplantibacillus plantarum L47 and inulin alleviate enterotoxigenic Escherichia coli induced ileal inflammation in piglets by upregulating the levels of α-linolenic acid and 12,13-epoxyoctadecenoic acid.
Cui L, Zeng H, Hou M, Li Z, Mu C, Zhu W, Hang S
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Sep;14:370-382
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Sep;14:370-382
Hesperidin inhibits methylation and autophagy in LPS and high glucose-induced human villous trophoblasts.
Chen Q, Hu K, Shi J, Li H, Li W
Biochemical and biophysical research communications 2023 Sep 3;671:278-285
Biochemical and biophysical research communications 2023 Sep 3;671:278-285
Red Rice Seed Coat Targeting SPHK2 Ameliorated Alcoholic Liver Disease via Restored Intestinal Barrier and Improved Gut Microbiota in Mice.
Chen Y, Zhao Z, Guo S, Li Y, Yin H, Tian L, Cheng G, Li Y
Nutrients 2023 Sep 27;15(19)
Nutrients 2023 Sep 27;15(19)
Gram-Negative Bacteria and Lipopolysaccharides as Risk Factors for the Occurrence of Diabetic Foot.
Zhang S, Li S, Huang J, Ding X, Qiu Y, Luo X, Meng J, Hu Y, Zhou H, Fan H, Cao Y, Gao F, Xue Y, Zou M
The Journal of clinical endocrinology and metabolism 2023 Sep 18;108(10):2604-2614
The Journal of clinical endocrinology and metabolism 2023 Sep 18;108(10):2604-2614
Babao Dan alleviates gut immune and microbiota disorders while impacting the TLR4/MyD88/NF-кB pathway to attenuate 5-Fluorouracil-induced intestinal injury.
Huang B, Gui M, An H, Shen J, Ye F, Ni Z, Zhan H, Che L, Lai Z, Zeng J, Peng J, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115387
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115387
N-Acetyl-l-cysteine-Derived Carbonized Polymer Dots with ROS Scavenging via Keap1-Nrf2 Pathway Regulate Alveolar Bone Homeostasis in Periodontitis.
Liu X, Hou Y, Yang M, Xin X, Deng Y, Fu R, Xiang X, Cao N, Liu X, Yu W, Yang B, Zhou Y
Advanced healthcare materials 2023 Oct;12(26):e2300890
Advanced healthcare materials 2023 Oct;12(26):e2300890
Glucosamine Improves Non-Alcoholic Fatty Liver Disease Induced by High-Fat and High-Sugar Diet through Regulating Intestinal Barrier Function, Liver Inflammation, and Lipid Metabolism.
Li F, Zhang Z, Bai Y, Che Q, Cao H, Guo J, Su Z
Molecules (Basel, Switzerland) 2023 Oct 3;28(19)
Molecules (Basel, Switzerland) 2023 Oct 3;28(19)
Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5.
Li Y, Wu W, Xu W, Wang Y, Wan S, Chen W, Yang D, Zhang M, Wu X, Yang X, Du X, Wang C, Han M, Chen Y, Li N, Hua J
Theriogenology 2023 Nov;211:65-75
Theriogenology 2023 Nov;211:65-75
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
Zhou W, Kang S, Wang F, Qin Y, Liu J, Xiao X, Chen X, Zhang D
European journal of pharmacology 2023 Nov 5;958:176043
European journal of pharmacology 2023 Nov 5;958:176043
Hypoxia-induced CCL2/CCR2 axis in adipose-derived stem cells (ADSCs) promotes angiogenesis by human dermal microvascular endothelial cells (HDMECs) in flap tissues.
Fang B, Wang X, Sun Y, Xiong X, Meng X, Li W, Yi Z
Journal of physiology and biochemistry 2023 May;79(2):327-339
Journal of physiology and biochemistry 2023 May;79(2):327-339
Lipopolysaccharide exacerbates to the migration, invasion, and epithelial-mesenchymal transition of esophageal cancer cells by TLR4/NF-κB axis.
Peng Z, Wan P, Deng Y, Shen W, Liu R
Environmental toxicology 2023 May;38(5):1090-1099
Environmental toxicology 2023 May;38(5):1090-1099
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway.
Zhao L, Miao Y, Shan B, Zhao C, Peng C, Gong J
Foods (Basel, Switzerland) 2023 Mar 30;12(7)
Foods (Basel, Switzerland) 2023 Mar 30;12(7)
METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.
Luo S, Liao C, Zhang L, Ling C, Zhang X, Xie P, Su G, Chen Z, Zhang L, Lai T, Tang J
Cell reports 2023 Mar 28;42(3):112259
Cell reports 2023 Mar 28;42(3):112259
CCR7 Mediated Mimetic Dendritic Cell Vaccine Homing in Lymph Node for Head and Neck Squamous Cell Carcinoma Therapy.
Xu J, Liu H, Wang T, Wen Z, Chen H, Yang Z, Li L, Yu S, Gao S, Yang L, Li K, Li J, Li X, Liu L, Liao G, Chen Y, Liang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(17):e2207017
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(17):e2207017
Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.
Cui Y, Zhang F, Xu W, Li Z, Zou J, Gao P, Hu J
BMC complementary medicine and therapies 2023 Jun 2;23(1):180
BMC complementary medicine and therapies 2023 Jun 2;23(1):180
The protective effects of sophocarpine on sepsis-induced cardiomyopathy.
Fu Y, Zhang HJ, Zhou W, Lai ZQ, Dong YF
European journal of pharmacology 2023 Jul 5;950:175745
European journal of pharmacology 2023 Jul 5;950:175745
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation.
Sun W, Wang Q, Zhang R, Zhang N
Food & function 2023 Jul 31;14(15):7247-7269
Food & function 2023 Jul 31;14(15):7247-7269
Tea Polyphenols Protects Tracheal Epithelial Tight Junctions in Lung during Actinobacillus pleuropneumoniae Infection via Suppressing TLR-4/MAPK/PKC-MLCK Signaling.
Li X, Liu Z, Gao T, Liu W, Yang K, Guo R, Li C, Tian Y, Wang N, Zhou D, Bei W, Yuan F
International journal of molecular sciences 2023 Jul 24;24(14)
International journal of molecular sciences 2023 Jul 24;24(14)
Targeting extracellular CIRP with an X-aptamer shows therapeutic potential in acute pancreatitis.
Liu W, Bi J, Ren Y, Chen H, Zhang J, Wang T, Wang M, Zhang L, Zhao J, Wu Z, Lv Y, Liu B, Wu R
iScience 2023 Jul 21;26(7):107043
iScience 2023 Jul 21;26(7):107043
Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway.
Zou YF, Li CY, Fu YP, JiZe XP, Zhao YZ, Peng X, Wang JY, Yin ZQ, Li YP, Song X, Li LX, Zhao XH, Feng B, Huang C, Ye G, Tang HQ, Chen J, Li R, Chen XF, Tian ML
International journal of biological macromolecules 2023 Jul 1;242(Pt 1):124689
International journal of biological macromolecules 2023 Jul 1;242(Pt 1):124689
Allergen-specific immunotherapy with Alutard SQ improves allergic inflammation in house-dust mites-induced allergic asthma rats through inactivation of the HMGB1/TLR4/NF-κB pathway.
Zhai Y, Zheng P, Sun B, Li J, Wang B
Journal of thoracic disease 2023 Jan 31;15(1):77-89
Journal of thoracic disease 2023 Jan 31;15(1):77-89
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway.
Zhu Y, Han Q, Wang L, Wang B, Chen J, Cai B, Wu C, Zhu X, Liu F, Han D, Dong H, Jia Y, Liu Y
Journal of ethnopharmacology 2023 Jan 30;301:115763
Journal of ethnopharmacology 2023 Jan 30;301:115763
Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2.
Wu S, Tian X, Mao Q, Peng C
Clinical epigenetics 2023 Jan 23;15(1):12
Clinical epigenetics 2023 Jan 23;15(1):12
Xianglian Pill attenuates ulcerative colitis through TLR4/MyD88/NF-κB signaling pathway.
Dai Y, Lu Q, Li P, Zhu J, Jiang J, Zhao T, Hu Y, Ding K, Zhao M
Journal of ethnopharmacology 2023 Jan 10;300:115690
Journal of ethnopharmacology 2023 Jan 10;300:115690
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Tao H, Zhao H, Mo A, Shao L, Ge D, Liu J, Hu W, Xu K, Ma Q, Wang W, Wang W, Cao H, Mu M, Tao X, Wang J
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Thyroid-stimulating hormone may participate in insulin resistance by activating toll-like receptor 4 in liver tissues of subclinical hypothyroid rats.
Bao S, Li F, Duan L, Li J, Jiang X
Molecular biology reports 2023 Dec;50(12):10637-10650
Molecular biology reports 2023 Dec;50(12):10637-10650
POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6.
Yang W, Cui X, Sun D, Sun G, Yan Z, Wei M, Wang Z, Yu W
Cell death & disease 2023 Dec 7;14(12):802
Cell death & disease 2023 Dec 7;14(12):802
RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma.
Yang Q, Meng X, Chen J, Li X, Huang Y, Xiao X, Li R, Wu X
Cell death discovery 2023 Dec 5;9(1):440
Cell death discovery 2023 Dec 5;9(1):440
Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation.
Chen P, Liu W, Wei Y
Translational andrology and urology 2023 Dec 31;12(12):1859-1870
Translational andrology and urology 2023 Dec 31;12(12):1859-1870
The outer membrane protein of Fusobacterium necrophorum, 43K OMP, stimulates inflammatory cytokine production through nuclear factor kappa B activation.
He X, Liu J, Jiang K, Lian S, Shi Y, Fu S, Zhao P, Xiao J, Sun D, Guo D
Anaerobe 2023 Aug;82:102768
Anaerobe 2023 Aug;82:102768
Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease.
Wang M, Gong K, Zhu X, Chen S, Zhou J, Zhang H, Han J, Ma L, Duan Y
MedComm 2023 Aug;4(4):e320
MedComm 2023 Aug;4(4):e320
Palmitic acid combined with γ-interferon inhibits gastric cancer progression by modulating tumor-associated macrophages' polarization via the TLR4 pathway.
Zhang YY, Li J, Li F, Xue S, Xu QY, Zhang YQ, Feng L
Journal of cancer research and clinical oncology 2023 Aug;149(10):7053-7067
Journal of cancer research and clinical oncology 2023 Aug;149(10):7053-7067
Holothuria leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice.
Zhao F, Ma T, Zhang X, Zhao Q, Zhu K, Cao J, Liu Z, Shen X, Li C
Molecular nutrition & food research 2023 Apr;67(8):e2200317
Molecular nutrition & food research 2023 Apr;67(8):e2200317
Donkey Oil-Based Ketogenic Diet Prevents Tumor Progression by Regulating Intratumor Inflammation, Metastasis and Angiogenesis in CT26 Tumor-Bearing Mice.
Zhang H, Xie L, Zhang N, Qi X, Lu T, Xing J, Akhtar MF, Li L, Liu G
Genes 2023 Apr 30;14(5)
Genes 2023 Apr 30;14(5)
Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model via inhibiting TLRs/MyD88 pathway.
Cao Y, Zhong Q, Tang F, Yao X, Liu Z, Zhang X
Allergologia et immunopathologia 2022;50(6):107-114
Allergologia et immunopathologia 2022;50(6):107-114
NF-κB and AP-1 are required for the lipopolysaccharide-induced expression of MCP-1, CXCL1, and Cx43 in cultured rat dorsal spinal cord astrocytes.
Lu Y, Li B, Xu A, Liang X, Xu T, Jin H, Xie Y, Wang R, Liu X, Gao X, Han Y, Zeng J
Frontiers in molecular neuroscience 2022;15:859558
Frontiers in molecular neuroscience 2022;15:859558
TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage.
Liu S, Cao X, Wu Z, Deng S, Fu H, Wang Y, Liu F
Frontiers in aging neuroscience 2022;14:967825
Frontiers in aging neuroscience 2022;14:967825
Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway.
Huo XY, Lei LR, Guo WX, Hu YJ, Kuang QX, Liu MD, Peng W, Dai YF, Wang D, Gu YC, Guo DL, Deng Y
Frontiers in microbiology 2022;13:999996
Frontiers in microbiology 2022;13:999996
LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing.
Li N, Li Y, Han X, Zhang J, Han J, Jiang X, Wang W, Xu Y, Xu Y, Fu Y, Si S
Frontiers in pharmacology 2022;13:973612
Frontiers in pharmacology 2022;13:973612
MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome.
Tan W, Dai F, Yang D, Deng Z, Gu R, Zhao X, Cheng Y
Frontiers in immunology 2022;13:967151
Frontiers in immunology 2022;13:967151
N-Acetyldopamine Dimer Attenuates DSS-Induced Ulcerative Colitis by Suppressing NF-κB and MAPK Pathways.
Huang LJ, Wang YM, Gong LQ, Hu C, Gui Y, Zhang C, Tan X, Yu XK, Liao YL, Luo Y, Tang YQ, Dai YF, Deng Y, Wang D, Guo DL
Frontiers in pharmacology 2022;13:842730
Frontiers in pharmacology 2022;13:842730
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Wang FF, Zhao PY, He XJ, Jiang K, Wang TS, Xiao JW, Sun DB, Guo DH
Frontiers in cellular and infection microbiology 2022;12:827750
Frontiers in cellular and infection microbiology 2022;12:827750
Polyvinylpyrrolidone-Modified Taxifolin Liposomes Promote Liver Repair by Modulating Autophagy to Inhibit Activation of the TLR4/NF-κB Signaling Pathway.
Ding Q, Liu W, Liu X, Ding C, Zhao Y, Dong L, Chen H, Sun S, Zhang Y, Zhang J, Wu M
Frontiers in bioengineering and biotechnology 2022;10:860515
Frontiers in bioengineering and biotechnology 2022;10:860515
Quercetin Administration Following Hypoxia-Induced Neonatal Brain Damage Attenuates Later-Life Seizure Susceptibility and Anxiety-Related Behavior: Modulating Inflammatory Response.
Wu Y, Wei H, Li P, Zhao H, Li R, Yang F
Frontiers in pediatrics 2022;10:791815
Frontiers in pediatrics 2022;10:791815
Hawk Tea Flavonoids as Natural Hepatoprotective Agents Alleviate Acute Liver Damage by Reshaping the Intestinal Microbiota and Modulating the Nrf2 and NF-κB Signaling Pathways.
Xu T, Hu S, Liu Y, Sun K, Luo L, Zeng L
Nutrients 2022 Sep 5;14(17)
Nutrients 2022 Sep 5;14(17)
An injectable co-assembled hydrogel blocks reactive oxygen species and inflammation cycle resisting myocardial ischemia-reperfusion injury.
Liao X, Song X, Li J, Li L, Fan X, Qin Q, Zhong C, Yang P, Zhan J, Cai Y
Acta biomaterialia 2022 Sep 1;149:82-95
Acta biomaterialia 2022 Sep 1;149:82-95
Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway.
Zhang X, Li X, Xiong G, Yun F, Feng Y, Ni Q, Wu N, Yang L, Yi Z, Zhang Q, Yang Z, Kuang Y, Sai B, Zhu Y
Metabolites 2022 Nov 17;12(11)
Metabolites 2022 Nov 17;12(11)
pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance "One Stone Four Birds" Effect of Rhein on Ulcerative Colitis.
Qi S, Luo R, Han X, Nie W, Ye N, Fu C, Gao F
ACS applied materials & interfaces 2022 Nov 16;14(45):50692-50709
ACS applied materials & interfaces 2022 Nov 16;14(45):50692-50709
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Zhou W, Fu Y, Xu JS
Molecules (Basel, Switzerland) 2022 Nov 15;27(22)
Molecules (Basel, Switzerland) 2022 Nov 15;27(22)
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
Zhao R, Wang L, Wang T, Xian P, Wang H, Long Q
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway.
Ye J, Zheng J, Tian X, Xu B, Yuan F, Wang B, Yang Z, Huang F
Marine drugs 2022 Mar 25;20(4)
Marine drugs 2022 Mar 25;20(4)
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Liu Y, Xu Z, Huang H, Xue Y, Zhang D, Zhang Y, Li W, Li X
International journal of biological macromolecules 2022 Mar 15;201:616-629
International journal of biological macromolecules 2022 Mar 15;201:616-629
FG-4592 protects the intestine from irradiation-induced injury by targeting the TLR4 signaling pathway.
Feng Z, Xu Q, He X, Wang Y, Fang L, Zhao J, Cheng Y, Liu C, Du J, Cai J
Stem cell research & therapy 2022 Jun 21;13(1):271
Stem cell research & therapy 2022 Jun 21;13(1):271
Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells.
Yu C, Wang D, Li Q, Tong Y, Yang Z, Wang T
International immunopharmacology 2022 Jul;108:108872
International immunopharmacology 2022 Jul;108:108872
Kir2.1 channel regulates macrophage polarization via the Ca2+/CaMK II/ERK/NF-κB signaling pathway.
Chen K, Man Q, Miao J, Xu W, Zheng Y, Zhou X, Gao Z
Journal of cell science 2022 Jul 1;135(13)
Journal of cell science 2022 Jul 1;135(13)
Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.
Wang Z, Liu D, Yan Q, Liu F, Zhan M, Qi S, Fang Q, Yao L, Wang W, Zhang R, Du J, Chen L
Transplantation 2022 Jul 1;106(7):1351-1364
Transplantation 2022 Jul 1;106(7):1351-1364
Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier.
Ge L, Qi J, Shao B, Ruan Z, Ren Y, Sui S, Wu X, Sun X, Liu S, Li S, Xu C, Song W
Gut microbes 2022 Jan-Dec;14(1):2013764
Gut microbes 2022 Jan-Dec;14(1):2013764
Immunomodulatory Effect of Serum Exosomes From Crohn Disease on Macrophages via Let-7b-5p/TLR4 Signaling.
Gong L, Xiao J, Yi J, Xiao J, Lu F, Liu X
Inflammatory bowel diseases 2022 Jan 5;28(1):96-108
Inflammatory bowel diseases 2022 Jan 5;28(1):96-108
Catalpol relieved angiotensin II-induced blood-brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells.
Xia Y, Lu YW, Hao RJ, Yu GR
Pharmaceutical biology 2022 Dec;60(1):2210-2218
Pharmaceutical biology 2022 Dec;60(1):2210-2218
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.
Shi K, Xiao Y, Dong Y, Wang D, Xie Y, Tu J, Xu K, Zhou Z, Cao G, Liu Y
International journal of molecular sciences 2022 Dec 17;23(24)
International journal of molecular sciences 2022 Dec 17;23(24)
Monophosphoryl lipid A ameliorates radiation-induced lung injury by promoting the polarization of macrophages to the M1 phenotype.
Guo X, Du L, Ma N, Zhang P, Wang Y, Han Y, Huang X, Zhang Q, Tan X, Lei X, Qu B
Journal of translational medicine 2022 Dec 14;20(1):597
Journal of translational medicine 2022 Dec 14;20(1):597
Deficiency of mindin reduces renal injury after ischemia reperfusion.
Bai T, Wang X, Qin C, Yang K, Duan Z, Cao Z, Liang J, Wang L, Yuan J, Luo P
Molecular medicine (Cambridge, Mass.) 2022 Dec 12;28(1):152
Molecular medicine (Cambridge, Mass.) 2022 Dec 12;28(1):152
Monosodium urate crystals with controlled shape and aspect ratio for elucidating the pathological progress of acute gout.
Chen C, Wang J, Liang Z, Li M, Fu D, Zhang L, Yang X, Guo Y, Ge D, Liu Y, Sun B
Biomaterials advances 2022 Aug;139:213005
Biomaterials advances 2022 Aug;139:213005
EZH2 Regulates Lipopolysaccharide-Induced Periodontal Ligament Stem Cell Proliferation and Osteogenesis through TLR4/MyD88/NF-κB Pathway.
Wang P, Tian H, Zhang Z, Wang Z
Stem cells international 2021;2021:7625134
Stem cells international 2021;2021:7625134
Decreased miR-4512 Levels in Monocytes and Macrophages of Individuals With Systemic Lupus Erythematosus Contribute to Innate Immune Activation and Neutrsophil NETosis by Targeting TLR4 and CXCL2.
Yang B, Huang X, Xu S, Li L, Wu W, Dai Y, Ge MX, Yuan L, Cao W, Yang M, Wu Y, Deng D
Frontiers in immunology 2021;12:756825
Frontiers in immunology 2021;12:756825
Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice.
Liu X, Lin S, Zhong Y, Shen J, Zhang X, Luo S, Huang L, Zhang L, Zhou S, Tang J
Frontiers in pharmacology 2021;12:739603
Frontiers in pharmacology 2021;12:739603
Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages.
Jiang R, Xu J, Zhang Y, Zhu X, Liu J, Tan Y
Frontiers in pharmacology 2021;12:680512
Frontiers in pharmacology 2021;12:680512
Structure elucidation and anti-inflammatory mechanism of difengpienol C, a new neolignan isolated from Illicium difengpi.
Li LC, Ning DS, Fu YX, Pan ZH
Fitoterapia 2021 Sep;153:104949
Fitoterapia 2021 Sep;153:104949
Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p.
Bai Y, Liu X, Chen Q, Chen T, Jiang N, Guo Z
Scientific reports 2021 Oct 4;11(1):19637
Scientific reports 2021 Oct 4;11(1):19637
Ovotransferrin exerts bidirectional immunomodulatory activities via TLR4-mediated signal transduction pathways in RAW264.7 cells.
Ru Z, Xu M, Zhu G, Tu Y, Jiang Y, Du H
Food science & nutrition 2021 Nov;9(11):6162-6175
Food science & nutrition 2021 Nov;9(11):6162-6175
Platycodon grandiflorum extract attenuates lipopolysaccharide-induced acute lung injury via TLR4/NF-κBp65 pathway in rats.
Si-Cong L, Chaoqin R, Ge L, Xu-Ting L, Jin-Liang L, Bin W, Min Z, Wei H, Liang C, Xue G
Pakistan journal of pharmaceutical sciences 2021 Nov;34(6):2213-2218
Pakistan journal of pharmaceutical sciences 2021 Nov;34(6):2213-2218
Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage.
Sun L, He L, Wu W, Luo L, Han M, Liu Y, Shi S, Zhong K, Yang J, Li J
International journal of oral science 2021 Nov 16;13(1):39
International journal of oral science 2021 Nov 16;13(1):39
Anti-nociceptive effects of Sedum Lineare Thunb. on spared nerve injury-induced neuropathic pain by inhibiting TLR4/NF-κB signaling in the spinal cord in rats.
Wang XY, Ma HJ, Xue M, Sun YL, Ren A, Li MQ, Huang ZH, Huang C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111215
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111215
Protective effect of scorpion venom heat-resistant synthetic peptide against PM(2.5)-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
Xu X, Xu H, Ren F, Huang L, Xu J, Li F
Journal of neuroimmunology 2021 Jun 15;355:577567
Journal of neuroimmunology 2021 Jun 15;355:577567
Effect of HMGB1 on monocyte immune function in respiratory syncytial virus bronchiolitis.
Niu M, Jiang Z, Xin X, Zhu J, Yang J, Diao M, Qi G, Qi B
Experimental and therapeutic medicine 2021 Jan;21(1):75
Experimental and therapeutic medicine 2021 Jan;21(1):75
Aureonitol Analogues and Orsellinic Acid Esters Isolated from Chaetomium elatum and Their Antineuroinflammatory Activity.
Ju F, Kuang QX, Li QZ, Huang LJ, Guo WX, Gong LQ, Dai YF, Wang L, Gu YC, Wang D, Deng Y, Guo DL
Journal of natural products 2021 Dec 24;84(12):3044-3054
Journal of natural products 2021 Dec 24;84(12):3044-3054
Rosmanol and Carnosol Synergistically Alleviate Rheumatoid Arthritis through Inhibiting TLR4/NF-κB/MAPK Pathway.
Li L, Pan Z, Ning D, Fu Y
Molecules (Basel, Switzerland) 2021 Dec 23;27(1)
Molecules (Basel, Switzerland) 2021 Dec 23;27(1)
CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.
Liu B, Li H, Liu X, Li F, Chen W, Kuang Y, Zhao X, Li L, Yu B, Jin X, Li Q
Cellular signalling 2021 Aug;84:110012
Cellular signalling 2021 Aug;84:110012
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis.
Chibaatar E, Le K, Abdoulaye IA, Wu S, Guo Y
Journal of molecular neuroscience : MN 2021 Apr;71(4):691-701
Journal of molecular neuroscience : MN 2021 Apr;71(4):691-701
Let-7i-5p Regulation of Cell Morphology and Migration Through Distinct Signaling Pathways in Normal and Pathogenic Urethral Fibroblasts.
Zhang K, Yang R, Chen J, Qi E, Zhou S, Wang Y, Fu Q, Chen R, Fang X
Frontiers in bioengineering and biotechnology 2020;8:428
Frontiers in bioengineering and biotechnology 2020;8:428
Lipopolysaccharide inhibits osteogenic differentiation of periodontal ligament stem cells partially through toll-like receptor 4-mediated ephrinB2 downregulation.
Wang W, Yuan C, Geng T, Liu Y, Zhu S, Zhang C, Liu Z, Wang P
Clinical oral investigations 2020 Oct;24(10):3407-3416
Clinical oral investigations 2020 Oct;24(10):3407-3416
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin.
Le K, Wu S, Chibaatar E, Ali AI, Guo Y
ACS chemical neuroscience 2020 Mar 18;11(6):979-993
ACS chemical neuroscience 2020 Mar 18;11(6):979-993
Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway.
Yang K, Zhan L, Lu T, Zhou C, Chen X, Dong Y, Lv G, Chen S
Cytokine 2020 Jun;130:155058
Cytokine 2020 Jun;130:155058
Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome.
Sun M, Sun B, Qiao S, Feng X, Li Y, Zhang S, Lin Y, Hou L
Fertility and sterility 2020 Jun;113(6):1275-1285.e2
Fertility and sterility 2020 Jun;113(6):1275-1285.e2
Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation.
Le K, Song Z, Deng J, Peng X, Zhang J, Wang L, Zhou L, Bi H, Liao Z, Feng Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Dec;69(12):1201-1213
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 Dec;69(12):1201-1213
Therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy in mice.
Li N, Zhang EF, Zhang J, Zhang L, Liu YE, Jin HX, Gao Y, Hou LC
International immunopharmacology 2020 Apr;81:106280
International immunopharmacology 2020 Apr;81:106280
Electroacupuncture Alleviates Spared Nerve Injury-Induced Neuropathic Pain And Modulates HMGB1/NF-κB Signaling Pathway In The Spinal Cord.
Xia YY, Xue M, Wang Y, Huang ZH, Huang C
Journal of pain research 2019;12:2851-2863
Journal of pain research 2019;12:2851-2863
Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation.
Wang D, Dong X, Wang B, Liu Y, Li S
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10079-10088
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10079-10088
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Le K, Chibaatar Daliv E, Wu S, Qian F, Ali AI, Yu D, Guo Y
International immunopharmacology 2019 Oct;75:105779
International immunopharmacology 2019 Oct;75:105779
Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways.
Zhang L, Tao X, Fu Q, Ge C, Li R, Li Z, Zhu Y, Tian H, Li Q, Liu M, Hu H, Zeng B, Lin Z, Li C, Luo R, Song X
Oncology reports 2019 Nov;42(5):1843-1855
Oncology reports 2019 Nov;42(5):1843-1855
Geniposide attenuates Aβ(25-35)-induced neurotoxicity via the TLR4/NF-κB pathway in HT22 cells.
Huang XF, Li JJ, Tao YG, Wang XQ, Zhang RL, Zhang JL, Su ZQ, Huang QH, Deng YH
RSC advances 2018 May 22;8(34):18926-18937
RSC advances 2018 May 22;8(34):18926-18937
Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling.
Ren B, Luo S, Tian X, Jiang Z, Zou G, Xu F, Yin T, Huang Y, Liu J
Oncology reports 2018 Aug;40(2):895-901
Oncology reports 2018 Aug;40(2):895-901
Electroacupuncture Alleviates Postoperative Cognitive Dysfunction in Aged Rats by Inhibiting Hippocampal Neuroinflammation Activated via Microglia/TLRs Pathway.
Feng PP, Deng P, Liu LH, Ai Q, Yin J, Liu Z, Wang GM
Evidence-based complementary and alternative medicine : eCAM 2017;2017:6421260
Evidence-based complementary and alternative medicine : eCAM 2017;2017:6421260
Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy.
Li Y, Tatsui CE, Rhines LD, North RY, Harrison DS, Cassidy RM, Johansson CA, Kosturakis AK, Edwards DD, Zhang H, Dougherty PM
Pain 2017 Mar;158(3):417-429
Pain 2017 Mar;158(3):417-429
Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.
Tian Y, Li Z, Shen B, Zhang Q, Feng H
International immunopharmacology 2017 Apr;45:148-155
International immunopharmacology 2017 Apr;45:148-155
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