10-3010

antibody from ABEOMICS Inc.

Targeting: TLR4 ARMD10, CD284, hToll, TLR-4

Antibody data

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Validation data

Product number: 10-3010 - Provider product page
Provider: ABEOMICS Inc.
Product name: Anti-TLR4 Antibody
Antibody type: Monoclonal
Description: TLR4 (Toll-like receptor-4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It primarily mediates cellular signaling induced by Gram negative bacteria. TLR4 is highly specific for LPS and it is associated with CD14, a co-receptor for LPS. The downstream signaling pathway of TLR4 leads to the activation of NF-kappaB through myeloid differentiation protein (MyD88) and IL-1 receptor-associated kinase in various cell types. Keratinocytes express TLR4 at the mRNA and protein levels whereas TLR4 are also present in the normal human epidermis in vivo and their expression is regulated by microbial components. TLR4 is expressed on CD4+ T cells as well, the functional significance of which is unclear.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Antigen sequence: A partial length recombinant TLR4 p rotein (amino acids 45-320) was use d as the immunogen for this antibod y.
Isotype: IgG
Antibody clone number: ABM19C4
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing

TLR4 protein structure - 10-3010 shown in red.