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- References [16]
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- Product number
- GTX75742 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX75742, RRID:AB_377004
- Product name
- TLR4 antibody [HTA125]
- Antibody type
- Monoclonal
- Reactivity
- Human, Mouse, Canine, Feline, Guinea Pig, Porcine
- Host
- Mouse
Submitted references Cryptotanshinone inhibits prostaglandin E2 production and COX-2 expression via suppression of TLR4/NF-κB signaling pathway in LPS-stimulated Caco-2 cells.
3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways.
Zanthoxylum bungeanum pericarp extract prevents dextran sulfate sodium-induced experimental colitis in mice via the regulation of TLR4 and TLR4-related signaling pathways.
Mycobacterium tuberculosis Upregulates TNF-α Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells.
Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages.
Omega-3 fatty acid intervention suppresses lipopolysaccharide-induced inflammation and weight loss in mice.
Anti-inflammatory effects of triptolide in LPS-induced acute lung injury in mice.
Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways.
Bruton's tyrosine kinase mediates FcγRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils.
Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-γ in THP-1-derived macrophages.
Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes.
Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages.
Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans.
Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans.
Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts.
Cao SG, Chen R, Wang H, Lin LM, Xia XP
Microbial pathogenesis 2018 Mar;116:313-317
Microbial pathogenesis 2018 Mar;116:313-317
3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways.
Chao W, Deng JS, Huang SS, Li PY, Liang YC, Huang GJ
International immunopharmacology 2017 Sep;50:77-86
International immunopharmacology 2017 Sep;50:77-86
Zanthoxylum bungeanum pericarp extract prevents dextran sulfate sodium-induced experimental colitis in mice via the regulation of TLR4 and TLR4-related signaling pathways.
Zhang Z, Liu J, Shen P, Cao Y, Lu X, Gao X, Fu Y, Liu B, Zhang N
International immunopharmacology 2016 Dec;41:127-135
International immunopharmacology 2016 Dec;41:127-135
Mycobacterium tuberculosis Upregulates TNF-α Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells.
Chen WL, Sheu JR, Chen RJ, Hsiao SH, Hsiao CJ, Chou YC, Chung CL, Hsiao G
PloS one 2015;10(9):e0137979
PloS one 2015;10(9):e0137979
Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages.
Previtera ML, Sengupta A
PloS one 2015;10(12):e0145813
PloS one 2015;10(12):e0145813
Omega-3 fatty acid intervention suppresses lipopolysaccharide-induced inflammation and weight loss in mice.
Liu YH, Li XY, Chen CY, Zhang HM, Kang JX
Marine drugs 2015 Feb 13;13(2):1026-36
Marine drugs 2015 Feb 13;13(2):1026-36
Anti-inflammatory effects of triptolide in LPS-induced acute lung injury in mice.
Wei D, Huang Z
Inflammation 2014 Aug;37(4):1307-16
Inflammation 2014 Aug;37(4):1307-16
Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways.
Fu Y, Liu B, Zhang N, Liu Z, Liang D, Li F, Cao Y, Feng X, Zhang X, Yang Z
Journal of ethnopharmacology 2013 Jan 9;145(1):193-9
Journal of ethnopharmacology 2013 Jan 9;145(1):193-9
Bruton's tyrosine kinase mediates FcγRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils.
Krupa A, Fudala R, Florence JM, Tucker T, Allen TC, Standiford TJ, Luchowski R, Fol M, Rahman M, Gryczynski Z, Gryczynski I, Kurdowska AK
American journal of respiratory cell and molecular biology 2013 Feb;48(2):240-9
American journal of respiratory cell and molecular biology 2013 Feb;48(2):240-9
Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-γ in THP-1-derived macrophages.
Hu K, Yang Y, Tu Q, Luo Y, Ma R
European journal of pharmacology 2013 Dec 5;721(1-3):96-102
European journal of pharmacology 2013 Dec 5;721(1-3):96-102
Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes.
Tzeng HP, Fan J, Vallejo JG, Dong JW, Chen X, Houser SR, Mann DL
American journal of physiology. Heart and circulatory physiology 2008 Mar;294(3):H1490-6
American journal of physiology. Heart and circulatory physiology 2008 Mar;294(3):H1490-6
Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages.
Henning LN, Azad AK, Parsa KV, Crowther JE, Tridandapani S, Schlesinger LS
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 15;180(12):7847-58
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 15;180(12):7847-58
Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
Flo TH, Ryan L, Latz E, Takeuchi O, Monks BG, Lien E, Halaas Ø, Akira S, Skjåk-Braek G, Golenbock DT, Espevik T
The Journal of biological chemistry 2002 Sep 20;277(38):35489-95
The Journal of biological chemistry 2002 Sep 20;277(38):35489-95
Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans.
Uehara A, Sugawara S, Takada H
Journal of medical microbiology 2002 Aug;51(8):626-34
Journal of medical microbiology 2002 Aug;51(8):626-34
Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans.
Uehara A, Sugawara S, Takada H
Journal of medical microbiology 2002 Aug;51(8):626-34
Journal of medical microbiology 2002 Aug;51(8):626-34
Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts.
Tabeta K, Yamazaki K, Akashi S, Miyake K, Kumada H, Umemoto T, Yoshie H
Infection and immunity 2000 Jun;68(6):3731-5
Infection and immunity 2000 Jun;68(6):3731-5
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Staining of human peripheral blood monocytes with Mouse anti Human TLR4 (GTX75737)
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Staining of human peripheral blood monocytes with Mouse anti Human TLR4: FITC (GTX28378)
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Staining of human peripheral blood monocytes with Mouse anti Human TLR4: Low Endotoxin (GTX75740)
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Staining of U937 cells with Mouse anti Human TLR4:RPE (GTX11227)
