S100A2

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]

Description

S100 calcium binding protein A2

Tissue specificity

Tissue enhanced (esophagus, urinary bladder)

Subcell location

Nucleoplasm, Nucleoli, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (153561108 - 153567890)

Ensembl ID

ENSG00000196754  (ver. 103.38)

Orthologs

Mouse S100a2: ENSMUSG00000094018

UniProt

P29034

neXtProt

NX_P29034

Human splice variants
Mouse splice variants

Protein structure