Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 16620-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16620-1-AP, RRID:AB_2127274
- Product name
- INTS3 antibody
- Antibody type
- Polyclonal
- Description
- INTS3 antibody (Cat. #16620-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NELF prevents transcriptional readthrough into DNA replication zones in cancer cells.
DSS1 is required for proper Integrator-PP2A function.
Mutual regulation between cell cycle and transcription termination factor TTF2.
Integrator Complex Subunit 3 Knockdown Has Minimal Effect on Lytic Herpes Simplex Virus Type-1 Infection in Fibroblast Cells.
CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer.
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II.
A combinatorial approach to uncover an additional Integrator subunit.
PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.
INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex.
Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture.
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence.
Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.
Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes.
Nakayama C, Fang Q, Daigaku Y, Aoi Y, Ito S, Takahashi M, Shimatani R, Minamisawa T, Ozturk Y, Kimura H, Shilatifard A, Tellier M, Nojima T
EMBO reports 2026 Apr;27(7):1720-1758
EMBO reports 2026 Apr;27(7):1720-1758
DSS1 is required for proper Integrator-PP2A function.
Xu C, Zhou QX, Zheng H, Song A, Zhao WY, Xu TT, Xiong Y, Zhang YJ, Huang Z, Xu Y, Cheng J, Chen FX
Nature communications 2025 Jul 5;16(1):6206
Nature communications 2025 Jul 5;16(1):6206
Mutual regulation between cell cycle and transcription termination factor TTF2.
Hu Y, Xu L, Feng B, Wu Q, Wang Y, Gong W, Lv M, Zhao H, Chen J, Li J, Zhang W, Zhan Q
Science China. Life sciences 2025 Aug;68(8):2348-2362
Science China. Life sciences 2025 Aug;68(8):2348-2362
Integrator Complex Subunit 3 Knockdown Has Minimal Effect on Lytic Herpes Simplex Virus Type-1 Infection in Fibroblast Cells.
Heath JR, Fromuth DP, Dembowski JA
microPublication biology 2024;2024
microPublication biology 2024;2024
CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer.
Wang Z, Zhang C, Guo J, Yang Y, Li P, Wang Z, Liu S, Zhang L, Zeng X, Zhai J, Wang X, Zhao Q, Chen Z, Zhu P, He Q
iScience 2024 May 17;27(5):109676
iScience 2024 May 17;27(5):109676
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II.
Hu S, Peng L, Song A, Ji YX, Cheng J, Wang M, Chen FX
Molecular cell 2023 May 18;83(10):1588-1604.e5
Molecular cell 2023 May 18;83(10):1588-1604.e5
A combinatorial approach to uncover an additional Integrator subunit.
Offley SR, Pfleiderer MM, Zucco A, Fraudeau A, Welsh SA, Razew M, Galej WP, Gardini A
Cell reports 2023 Mar 28;42(3):112244
Cell reports 2023 Mar 28;42(3):112244
PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.
Rambout X, Cho H, Blanc R, Lyu Q, Miano JM, Chakkalakal JV, Nelson GM, Yalamanchili HK, Adelman K, Maquat LE
Molecular cell 2023 Jan 19;83(2):186-202.e11
Molecular cell 2023 Jan 19;83(2):186-202.e11
INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex.
Mascibroda LG, Shboul M, Elrod ND, Colleaux L, Hamamy H, Huang KL, Peart N, Singh MK, Lee H, Merriman B, Jodoin JN, Sitaram P, Lee LA, Fathalla R, Al-Rawashdeh B, Ababneh O, El-Khateeb M, Escande-Beillard N, Nelson SF, Wu Y, Tong L, Kenney LJ, Roy S, Russell WK, Amiel J, Reversade B, Wagner EJ
Nature communications 2022 Oct 13;13(1):6054
Nature communications 2022 Oct 13;13(1):6054
Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture.
Jiang Y, Huang J, Tian K, Yi X, Zheng H, Zhu Y, Guo T, Ji X
Genome biology 2022 Nov 28;23(1):246
Genome biology 2022 Nov 28;23(1):246
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Vervoort SJ, Welsh SA, Devlin JR, Barbieri E, Knight DA, Offley S, Bjelosevic S, Costacurta M, Todorovski I, Kearney CJ, Sandow JJ, Fan Z, Blyth B, McLeod V, Vissers JHA, Pavic K, Martin BP, Gregory G, Demosthenous E, Zethoven M, Kong IY, Hawkins ED, Hogg SJ, Kelly MJ, Newbold A, Simpson KJ, Kauko O, Harvey KF, Ohlmeyer M, Westermarck J, Gray N, Gardini A, Johnstone RW
Cell 2021 Jun 10;184(12):3143-3162.e32
Cell 2021 Jun 10;184(12):3143-3162.e32
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.
Huang KL, Jee D, Stein CB, Elrod ND, Henriques T, Mascibroda LG, Baillat D, Russell WK, Adelman K, Wagner EJ
Molecular cell 2020 Oct 15;80(2):345-358.e9
Molecular cell 2020 Oct 15;80(2):345-358.e9
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Zheng H, Qi Y, Hu S, Cao X, Xu C, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX, Xu Y
Science (New York, N.Y.) 2020 Nov 27;370(6520)
Science (New York, N.Y.) 2020 Nov 27;370(6520)
Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence.
Nojima T, Tellier M, Foxwell J, Ribeiro de Almeida C, Tan-Wong SM, Dhir S, Dujardin G, Dhir A, Murphy S, Proudfoot NJ
Molecular cell 2018 Dec 20;72(6):970-984.e7
Molecular cell 2018 Dec 20;72(6):970-984.e7
Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.
Wu Y, Albrecht TR, Baillat D, Wagner EJ, Tong L
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4394-4399
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4394-4399
Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes.
Stadelmayer B, Micas G, Gamot A, Martin P, Malirat N, Koval S, Raffel R, Sobhian B, Severac D, Rialle S, Parrinello H, Cuvier O, Benkirane M
Nature communications 2014 Nov 20;5:5531
Nature communications 2014 Nov 20;5:5531
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The INTS3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human INTS3. This antibody recognizes human, mouse, rat antigen. The INTS3 antibody has been validated for the following applications: ELISA, WB analysis.
